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Items: 29


Hyperpolarized 13C-pyruvate MRI detects real-time metabolic flux in prostate cancer metastases to bone and liver: a clinical feasibility study.

Chen HY, Aggarwal R, Bok RA, Ohliger MA, Zhu Z, Lee P, Gordon JW, van Criekinge M, Carvajal L, Slater JB, Larson PEZ, Small EJ, Kurhanewicz J, Vigneron DB.

Prostate Cancer Prostatic Dis. 2019 Nov 4. doi: 10.1038/s41391-019-0180-z. [Epub ahead of print]


Kinetic Modeling of Hyperpolarized Carbon-13 Pyruvate Metabolism in the Human Brain.

Mammoli D, Gordon J, Autry A, Larson PEZ, Li Y, Chen HY, Chung B, Shin P, Van Criekinge M, Carvajal L, Slater JB, Bok R, Crane J, Xu D, Chang S, Vigneron DB.

IEEE Trans Med Imaging. 2019 Jul 2. doi: 10.1109/TMI.2019.2926437. [Epub ahead of print]


Pulse sequence considerations for quantification of pyruvate-to-lactate conversion kPL in hyperpolarized 13 C imaging.

Chen HY, Gordon JW, Bok RA, Cao P, von Morze C, van Criekinge M, Milshteyn E, Carvajal L, Hurd RE, Kurhanewicz J, Vigneron DB, Larson PEZ.

NMR Biomed. 2019 Mar;32(3):e4052. doi: 10.1002/nbm.4052. Epub 2019 Jan 21.


Translation of Carbon-13 EPI for hyperpolarized MR molecular imaging of prostate and brain cancer patients.

Gordon JW, Chen HY, Autry A, Park I, Van Criekinge M, Mammoli D, Milshteyn E, Bok R, Xu D, Li Y, Aggarwal R, Chang S, Slater JB, Ferrone M, Nelson S, Kurhanewicz J, Larson PEZ, Vigneron DB.

Magn Reson Med. 2019 Apr;81(4):2702-2709. doi: 10.1002/mrm.27549. Epub 2018 Oct 30.


Spatio-Temporally Constrained Reconstruction for Hyperpolarized Carbon-13 MRI Using Kinetic Models.

Maidens J, Gordon JW, Chen HY, Park I, Van Criekinge M, Milshteyn E, Bok R, Aggarwal R, Ferrone M, Slater JB, Kurhanewicz J, Vigneron DB, Arcak M, Larson PEZ.

IEEE Trans Med Imaging. 2018 Dec;37(12):2603-2612. doi: 10.1109/TMI.2018.2844246. Epub 2018 Jun 5.


Molecular detection of inflammation in cell models using hyperpolarized 13C-pyruvate.

Sriram R, Nguyen J, Santos JD, Nguyen L, Sun J, Vigneron S, Van Criekinge M, Kurhanewicz J, MacKenzie JD.

Theranostics. 2018 May 23;8(12):3400-3407. doi: 10.7150/thno.24322. eCollection 2018.


Technique development of 3D dynamic CS-EPSI for hyperpolarized 13 C pyruvate MR molecular imaging of human prostate cancer.

Chen HY, Larson PEZ, Gordon JW, Bok RA, Ferrone M, van Criekinge M, Carvajal L, Cao P, Pauly JM, Kerr AB, Park I, Slater JB, Nelson SJ, Munster PN, Aggarwal R, Kurhanewicz J, Vigneron DB.

Magn Reson Med. 2018 Nov;80(5):2062-2072. doi: 10.1002/mrm.27179. Epub 2018 Mar 25.


In vivo hyperpolarization transfer in a clinical MRI scanner.

von Morze C, Reed GD, Larson PE, Mammoli D, Chen AP, Tropp J, Van Criekinge M, Ohliger MA, Kurhanewicz J, Vigneron DB, Merritt ME.

Magn Reson Med. 2018 Aug;80(2):480-487. doi: 10.1002/mrm.27154. Epub 2018 Feb 27.


Detection of Bacteria-Specific Metabolism Using Hyperpolarized [2-13C]Pyruvate.

Sriram R, Sun J, Villanueva-Meyer J, Mutch C, De Los Santos J, Peters J, Korenchan DE, Neumann K, Van Criekinge M, Kurhanewicz J, Rosenberg O, Wilson D, Ohliger MA.

ACS Infect Dis. 2018 May 11;4(5):797-805. doi: 10.1021/acsinfecdis.7b00234. Epub 2018 Feb 13.


Development of methods and feasibility of using hyperpolarized carbon-13 imaging data for evaluating brain metabolism in patient studies.

Park I, Larson PEZ, Gordon JW, Carvajal L, Chen HY, Bok R, Van Criekinge M, Ferrone M, Slater JB, Xu D, Kurhanewicz J, Vigneron DB, Chang S, Nelson SJ.

Magn Reson Med. 2018 Sep;80(3):864-873. doi: 10.1002/mrm.27077. Epub 2018 Jan 10. No abstract available.


Sensitivity enhancement for detection of hyperpolarized 13 C MRI probes with 1 H spin coupling introduced by enzymatic transformation in vivo.

von Morze C, Tropp J, Chen AP, Marco-Rius I, Van Criekinge M, Skloss TW, Mammoli D, Kurhanewicz J, Vigneron DB, Ohliger MA, Merritt ME.

Magn Reson Med. 2018 Jul;80(1):36-41. doi: 10.1002/mrm.27000. Epub 2017 Nov 28.


Separation of extra- and intracellular metabolites using hyperpolarized (13)C diffusion weighted MR.

Koelsch BL, Sriram R, Keshari KR, Leon Swisher C, Van Criekinge M, Sukumar S, Vigneron DB, Wang ZJ, Larson PEZ, Kurhanewicz J.

J Magn Reson. 2016 Sep;270:115-123. doi: 10.1016/j.jmr.2016.07.002. Epub 2016 Jul 9.


Non-invasive differentiation of benign renal tumors from clear cell renal cell carcinomas using clinically translatable hyperpolarized 13C pyruvate magnetic resonance.

Sriram R, Van Criekinge M, DeLos Santos J, Keshari KR, Wilson DM, Peehl D, Kurhanewicz J, Wang ZJ.

Tomography. 2016 Mar;2(1):35-42.


Application of Good's buffers to pH imaging using hyperpolarized (13)C MRI.

Flavell RR, von Morze C, Blecha JE, Korenchan DE, Van Criekinge M, Sriram R, Gordon JW, Chen HY, Subramaniam S, Bok RA, Wang ZJ, Vigneron DB, Larson PE, Kurhanewicz J, Wilson DM.

Chem Commun (Camb). 2015 Sep 25;51(74):14119-22. doi: 10.1039/c5cc05348j.


Real-time measurement of hyperpolarized lactate production and efflux as a biomarker of tumor aggressiveness in an MR compatible 3D cell culture bioreactor.

Sriram R, Van Criekinge M, Hansen A, Wang ZJ, Vigneron DB, Wilson DM, Keshari KR, Kurhanewicz J.

NMR Biomed. 2015 Sep;28(9):1141-9. doi: 10.1002/nbm.3354. Epub 2015 Jul 23.


Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor.

Keshari KR, Wilson DM, Van Criekinge M, Sriram R, Koelsch BL, Wang ZJ, VanBrocklin HF, Peehl DM, O'Brien T, Sampath D, Carano RA, Kurhanewicz J.

Prostate. 2015 Oct;75(14):1601-9. doi: 10.1002/pros.23036. Epub 2015 Jul 14.


Handheld electromagnet carrier for transfer of hyperpolarized carbon-13 samples.

Shang H, Skloss T, von Morze C, Carvajal L, Van Criekinge M, Milshteyn E, Larson PE, Hurd RE, Vigneron DB.

Magn Reson Med. 2016 Feb;75(2):917-22. doi: 10.1002/mrm.25657. Epub 2015 Mar 11.


Noninvasive in vivo imaging of diabetes-induced renal oxidative stress and response to therapy using hyperpolarized 13C dehydroascorbate magnetic resonance.

Keshari KR, Wilson DM, Sai V, Bok R, Jen KY, Larson P, Van Criekinge M, Kurhanewicz J, Wang ZJ.

Diabetes. 2015 Feb;64(2):344-52. doi: 10.2337/db13-1829. Epub 2014 Sep 3.


High resolution (13)C MRI with hyperpolarized urea: in vivo T(2) mapping and (15)N labeling effects.

Reed GD, von Morze C, Bok R, Koelsch BL, Van Criekinge M, Smith KJ, Hong Shang, Larson PE, Kurhanewicz J, Vigneron DB.

IEEE Trans Med Imaging. 2014 Feb;33(2):362-71. doi: 10.1109/TMI.2013.2285120. Epub 2013 Oct 25.


Metabolic imaging of patients with prostate cancer using hyperpolarized [1-¹³C]pyruvate.

Nelson SJ, Kurhanewicz J, Vigneron DB, Larson PE, Harzstark AL, Ferrone M, van Criekinge M, Chang JW, Bok R, Park I, Reed G, Carvajal L, Small EJ, Munster P, Weinberg VK, Ardenkjaer-Larsen JH, Chen AP, Hurd RE, Odegardstuen LI, Robb FJ, Tropp J, Murray JA.

Sci Transl Med. 2013 Aug 14;5(198):198ra108. doi: 10.1126/scitranslmed.3006070.


Metabolic reprogramming and validation of hyperpolarized 13C lactate as a prostate cancer biomarker using a human prostate tissue slice culture bioreactor.

Keshari KR, Sriram R, Van Criekinge M, Wilson DM, Wang ZJ, Vigneron DB, Peehl DM, Kurhanewicz J.

Prostate. 2013 Aug;73(11):1171-81. doi: 10.1002/pros.22665. Epub 2013 Mar 26.


Hyperpolarized 13C-pyruvate magnetic resonance reveals rapid lactate export in metastatic renal cell carcinomas.

Keshari KR, Sriram R, Koelsch BL, Van Criekinge M, Wilson DM, Kurhanewicz J, Wang ZJ.

Cancer Res. 2013 Jan 15;73(2):529-38. doi: 10.1158/0008-5472.CAN-12-3461. Epub 2012 Nov 30.


Radiation damping and reciprocity in nuclear magnetic resonance: the replacement of the filling factor.

Tropp J, Van Criekinge M.

J Magn Reson. 2010 Sep;206(1):161-7. doi: 10.1016/j.jmr.2010.06.001. Epub 2010 Jun 8.


Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo.

Wilson DM, Keshari KR, Larson PE, Chen AP, Hu S, Van Criekinge M, Bok R, Nelson SJ, Macdonald JM, Vigneron DB, Kurhanewicz J.

J Magn Reson. 2010 Jul;205(1):141-7. doi: 10.1016/j.jmr.2010.04.012. Epub 2010 Apr 27.


Hyperpolarized (13)C spectroscopy and an NMR-compatible bioreactor system for the investigation of real-time cellular metabolism.

Keshari KR, Kurhanewicz J, Jeffries RE, Wilson DM, Dewar BJ, Van Criekinge M, Zierhut M, Vigneron DB, Macdonald JM.

Magn Reson Med. 2010 Feb;63(2):322-9. doi: 10.1002/mrm.22225.


Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imaging.

Keshari KR, Wilson DM, Chen AP, Bok R, Larson PE, Hu S, Van Criekinge M, Macdonald JM, Vigneron DB, Kurhanewicz J.

J Am Chem Soc. 2009 Dec 9;131(48):17591-6. doi: 10.1021/ja9049355.


Generation of hyperpolarized substrates by secondary labeling with [1,1-13C] acetic anhydride.

Wilson DM, Hurd RE, Keshari K, Van Criekinge M, Chen AP, Nelson SJ, Vigneron DB, Kurhanewicz J.

Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5503-7. doi: 10.1073/pnas.0810190106. Epub 2009 Mar 10.


In vivo hyperpolarized 13C MR spectroscopic imaging with 1H decoupling.

Chen AP, Tropp J, Hurd RE, Van Criekinge M, Carvajal LG, Xu D, Kurhanewicz J, Vigneron DB.

J Magn Reson. 2009 Mar;197(1):100-6. doi: 10.1016/j.jmr.2008.12.004. Epub 2008 Dec 13.


1H NMR of A beta amyloid peptide congeners in water solution. Conformational changes correlate with plaque competence.

Lee JP, Stimson ER, Ghilardi JR, Mantyh PW, Lu YA, Felix AM, Llanos W, Behbin A, Cummings M, Van Criekinge M, et al.

Biochemistry. 1995 Apr 18;34(15):5191-200.


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