Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 84

1.

Transcriptomic and Epigenomic Profiling of Histone Deacetylase Inhibitor Treatment Reveals Distinct Gene Regulation Profiles Leading to Impaired Neutrophil Development.

Govers AMAP, Wiggers CRM, van Boxtel R, Mokry M, Nieuwenhuis EES, Creyghton MP, Bartels M, Coffer PJ.

Hemasphere. 2019 Aug 7;3(4):e270. doi: 10.1097/HS9.0000000000000270. eCollection 2019 Aug.

PMID:
31723844
2.

The Medical Device Regulation of the European Union Intensifies Focus on Clinical Benefits of Devices.

Wilkinson B, van Boxtel R.

Ther Innov Regul Sci. 2019 Aug 27:2168479019870732. doi: 10.1177/2168479019870732. [Epub ahead of print]

PMID:
31455108
3.

Characterizing Mutational Load and Clonal Composition of Human Blood.

Huber AR, Manders F, Oka R, van Boxtel R.

J Vis Exp. 2019 Jul 11;(149). doi: 10.3791/59846.

PMID:
31355782
4.

Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer.

Jager M, Blokzijl F, Kuijk E, Bertl J, Vougioukalaki M, Janssen R, Besselink N, Boymans S, de Ligt J, Pedersen JS, Hoeijmakers J, Pothof J, van Boxtel R, Cuppen E.

Genome Res. 2019 Jul;29(7):1067-1077. doi: 10.1101/gr.246223.118. Epub 2019 Jun 20.

5.

Early divergence of mutational processes in human fetal tissues.

Kuijk E, Blokzijl F, Jager M, Besselink N, Boymans S, Chuva de Sousa Lopes SM, van Boxtel R, Cuppen E.

Sci Adv. 2019 May 29;5(5):eaaw1271. doi: 10.1126/sciadv.aaw1271. eCollection 2019 May.

6.

Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids.

Artegiani B, van Voorthuijsen L, Lindeboom RGH, Seinstra D, Heo I, Tapia P, López-Iglesias C, Postrach D, Dayton T, Oka R, Hu H, van Boxtel R, van Es JH, Offerhaus J, Peters PJ, van Rheenen J, Vermeulen M, Clevers H.

Cell Stem Cell. 2019 Jun 6;24(6):927-943.e6. doi: 10.1016/j.stem.2019.04.017. Epub 2019 May 23.

PMID:
31130514
7.

Portrait of a cancer: mutational signature analyses for cancer diagnostics.

Van Hoeck A, Tjoonk NH, van Boxtel R, Cuppen E.

BMC Cancer. 2019 May 15;19(1):457. doi: 10.1186/s12885-019-5677-2. Review.

8.

Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy.

Driehuis E, Kolders S, Spelier S, Lõhmussaar K, Willems SM, Devriese LA, de Bree R, de Ruiter EJ, Korving J, Begthel H, van Es JH, Geurts V, He GW, van Jaarsveld RH, Oka R, Muraro MJ, Vivié J, Zandvliet MMJM, Hendrickx APA, Iakobachvili N, Sridevi P, Kranenburg O, van Boxtel R, Kops GJPL, Tuveson DA, Peters PJ, van Oudenaarden A, Clevers H.

Cancer Discov. 2019 Jul;9(7):852-871. doi: 10.1158/2159-8290.CD-18-1522. Epub 2019 May 3.

PMID:
31053628
9.

Tubuloids derived from human adult kidney and urine for personalized disease modeling.

Schutgens F, Rookmaaker MB, Margaritis T, Rios A, Ammerlaan C, Jansen J, Gijzen L, Vormann M, Vonk A, Viveen M, Yengej FY, Derakhshan S, de Winter-de Groot KM, Artegiani B, van Boxtel R, Cuppen E, Hendrickx APA, van den Heuvel-Eibrink MM, Heitzer E, Lanz H, Beekman J, Murk JL, Masereeuw R, Holstege F, Drost J, Verhaar MC, Clevers H.

Nat Biotechnol. 2019 Mar;37(3):303-313. doi: 10.1038/s41587-019-0048-8. Epub 2019 Mar 4.

PMID:
30833775
10.

Immunogenicity of Influenza Vaccines: Evidence for Differential Effect of Secondary Vaccination on Humoral and Cellular Immunity.

Rosendahl Huber SK, Hendriks M, Jacobi RHJ, van de Kassteele J, Mandersloot-Oskam JC, van Boxtel RAJ, Wensing AMJ, Rots NY, Luytjes W, van Beek J.

Front Immunol. 2019 Jan 29;9:3103. doi: 10.3389/fimmu.2018.03103. eCollection 2018.

11.

Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis.

Osorio FG, Rosendahl Huber A, Oka R, Verheul M, Patel SH, Hasaart K, de la Fonteijne L, Varela I, Camargo FD, van Boxtel R.

Cell Rep. 2018 Nov 27;25(9):2308-2316.e4. doi: 10.1016/j.celrep.2018.11.014.

12.

STAT5 is essential for IL-7-mediated viability, growth, and proliferation of T-cell acute lymphoblastic leukemia cells.

Ribeiro D, Melão A, van Boxtel R, Santos CI, Silva A, Silva MC, Cardoso BA, Coffer PJ, Barata JT.

Blood Adv. 2018 Sep 11;2(17):2199-2213. doi: 10.1182/bloodadvances.2018021063.

13.

Megakaryocyte lineage development is controlled by modulation of protein acetylation.

Bartels M, Govers A, Polak R, Vervoort S, van Boxtel R, Pals C, Bierings M, van Solinge W, Egberts T, Nieuwenhuis E, Mokry M, Coffer PJ.

PLoS One. 2018 Apr 26;13(4):e0196400. doi: 10.1371/journal.pone.0196400. eCollection 2018.

14.

MutationalPatterns: comprehensive genome-wide analysis of mutational processes.

Blokzijl F, Janssen R, van Boxtel R, Cuppen E.

Genome Med. 2018 Apr 25;10(1):33. doi: 10.1186/s13073-018-0539-0.

15.

Troy/TNFRSF19 marks epithelial progenitor cells during mouse kidney development that continue to contribute to turnover in adult kidney.

Schutgens F, Rookmaaker MB, Blokzijl F, van Boxtel R, Vries R, Cuppen E, Verhaar MC, Clevers H.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11190-E11198. doi: 10.1073/pnas.1714145115. Epub 2017 Dec 13.

16.

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.

Sachs N, de Ligt J, Kopper O, Gogola E, Bounova G, Weeber F, Balgobind AV, Wind K, Gracanin A, Begthel H, Korving J, van Boxtel R, Duarte AA, Lelieveld D, van Hoeck A, Ernst RF, Blokzijl F, Nijman IJ, Hoogstraat M, van de Ven M, Egan DA, Zinzalla V, Moll J, Boj SF, Voest EE, Wessels L, van Diest PJ, Rottenberg S, Vries RGJ, Cuppen E, Clevers H.

Cell. 2018 Jan 11;172(1-2):373-386.e10. doi: 10.1016/j.cell.2017.11.010. Epub 2017 Dec 7.

17.

Measuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid cultures.

Jager M, Blokzijl F, Sasselli V, Boymans S, Janssen R, Besselink N, Clevers H, van Boxtel R, Cuppen E.

Nat Protoc. 2018 Jan;13(1):59-78. doi: 10.1038/nprot.2017.111. Epub 2017 Dec 7.

PMID:
29215633
18.

Influenza-like Illness Incidence Is Not Reduced by Influenza Vaccination in a Cohort of Older Adults, Despite Effectively Reducing Laboratory-Confirmed Influenza Virus Infections.

van Beek J, Veenhoven RH, Bruin JP, van Boxtel RAJ, de Lange MMA, Meijer A, Sanders EAM, Rots NY, Luytjes W.

J Infect Dis. 2017 Aug 15;216(4):415-424. doi: 10.1093/infdis/jix268.

PMID:
28931240
19.

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer.

Drost J, van Boxtel R, Blokzijl F, Mizutani T, Sasaki N, Sasselli V, de Ligt J, Behjati S, Grolleman JE, van Wezel T, Nik-Zainal S, Kuiper RP, Cuppen E, Clevers H.

Science. 2017 Oct 13;358(6360):234-238. doi: 10.1126/science.aao3130. Epub 2017 Sep 14.

20.

Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids.

Fumagalli A, Drost J, Suijkerbuijk SJ, van Boxtel R, de Ligt J, Offerhaus GJ, Begthel H, Beerling E, Tan EH, Sansom OJ, Cuppen E, Clevers H, van Rheenen J.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2357-E2364. doi: 10.1073/pnas.1701219114. Epub 2017 Mar 7.

21.

Acquisition of Carbapenem Resistance by Plasmid-Encoded-AmpC-Expressing Escherichia coli.

van Boxtel R, Wattel AA, Arenas J, Goessens WH, Tommassen J.

Antimicrob Agents Chemother. 2016 Dec 27;61(1). pii: e01413-16. doi: 10.1128/AAC.01413-16. Print 2017 Jan.

22.

Tissue-specific mutation accumulation in human adult stem cells during life.

Blokzijl F, de Ligt J, Jager M, Sasselli V, Roerink S, Sasaki N, Huch M, Boymans S, Kuijk E, Prins P, Nijman IJ, Martincorena I, Mokry M, Wiegerinck CL, Middendorp S, Sato T, Schwank G, Nieuwenhuis EE, Verstegen MM, van der Laan LJ, de Jonge J, IJzermans JN, Vries RG, van de Wetering M, Stratton MR, Clevers H, Cuppen E, van Boxtel R.

Nature. 2016 Oct 13;538(7624):260-264. doi: 10.1038/nature19768. Epub 2016 Oct 3.

23.

The role of the dopamine D1 receptor in social cognition: studies using a novel genetic rat model.

Homberg JR, Olivier JD, VandenBroeke M, Youn J, Ellenbroek AK, Karel P, Shan L, van Boxtel R, Ooms S, Balemans M, Langedijk J, Muller M, Vriend G, Cools AR, Cuppen E, Ellenbroek BA.

Dis Model Mech. 2016 Oct 1;9(10):1147-1158. Epub 2016 May 19.

24.

Deficiency or inhibition of lysophosphatidic acid receptor 1 protects against hyperoxia-induced lung injury in neonatal rats.

Chen X, Walther FJ, van Boxtel R, Laghmani EH, Sengers RM, Folkerts G, DeRuiter MC, Cuppen E, Wagenaar GT.

Acta Physiol (Oxf). 2016 Mar;216(3):358-75. doi: 10.1111/apha.12622. Epub 2015 Nov 11.

25.

The forkhead transcription factor FOXP1 represses human plasma cell differentiation.

van Keimpema M, Grüneberg LJ, Mokry M, van Boxtel R, van Zelm MC, Coffer P, Pals ST, Spaargaren M.

Blood. 2015 Oct 29;126(18):2098-109. doi: 10.1182/blood-2015-02-626176. Epub 2015 Aug 19.

26.

Virulence Factors of Pseudomonas aeruginosa Induce Both the Unfolded Protein and Integrated Stress Responses in Airway Epithelial Cells.

van 't Wout EF, van Schadewijk A, van Boxtel R, Dalton LE, Clarke HJ, Tommassen J, Marciniak SJ, Hiemstra PS.

PLoS Pathog. 2015 Jun 17;11(6):e1004946. doi: 10.1371/journal.ppat.1004946. eCollection 2015 Jun.

27.

Genomic landscape of rat strain and substrain variation.

Hermsen R, de Ligt J, Spee W, Blokzijl F, Schäfer S, Adami E, Boymans S, Flink S, van Boxtel R, van der Weide RH, Aitman T, Hübner N, Simonis M, Tabakoff B, Guryev V, Cuppen E.

BMC Genomics. 2015 May 6;16:357. doi: 10.1186/s12864-015-1594-1.

28.

Sequential cancer mutations in cultured human intestinal stem cells.

Drost J, van Jaarsveld RH, Ponsioen B, Zimberlin C, van Boxtel R, Buijs A, Sachs N, Overmeer RM, Offerhaus GJ, Begthel H, Korving J, van de Wetering M, Schwank G, Logtenberg M, Cuppen E, Snippert HJ, Medema JP, Kops GJ, Clevers H.

Nature. 2015 May 7;521(7550):43-7. doi: 10.1038/nature14415. Epub 2015 Apr 29.

PMID:
25924068
29.

Safety and immunogenicity of influenza whole inactivated virus vaccines: A phase I randomized clinical trial.

van Boxtel RA, Verdijk P, de Boer OJ, van Riet E, Mensinga TT, Luytjes W.

Hum Vaccin Immunother. 2015;11(4):983-90. doi: 10.1080/21645515.2015.1012004.

30.

Organoid models of human and mouse ductal pancreatic cancer.

Boj SF, Hwang CI, Baker LA, Chio II, Engle DD, Corbo V, Jager M, Ponz-Sarvise M, Tiriac H, Spector MS, Gracanin A, Oni T, Yu KH, van Boxtel R, Huch M, Rivera KD, Wilson JP, Feigin ME, Öhlund D, Handly-Santana A, Ardito-Abraham CM, Ludwig M, Elyada E, Alagesan B, Biffi G, Yordanov GN, Delcuze B, Creighton B, Wright K, Park Y, Morsink FH, Molenaar IQ, Borel Rinkes IH, Cuppen E, Hao Y, Jin Y, Nijman IJ, Iacobuzio-Donahue C, Leach SD, Pappin DJ, Hammell M, Klimstra DS, Basturk O, Hruban RH, Offerhaus GJ, Vries RG, Clevers H, Tuveson DA.

Cell. 2015 Jan 15;160(1-2):324-38. doi: 10.1016/j.cell.2014.12.021. Epub 2014 Dec 31.

31.

Long-term culture of genome-stable bipotent stem cells from adult human liver.

Huch M, Gehart H, van Boxtel R, Hamer K, Blokzijl F, Verstegen MM, Ellis E, van Wenum M, Fuchs SA, de Ligt J, van de Wetering M, Sasaki N, Boers SJ, Kemperman H, de Jonge J, Ijzermans JN, Nieuwenhuis EE, Hoekstra R, Strom S, Vries RR, van der Laan LJ, Cuppen E, Clevers H.

Cell. 2015 Jan 15;160(1-2):299-312. doi: 10.1016/j.cell.2014.11.050. Epub 2014 Dec 18.

32.

FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells.

van Keimpema M, Grüneberg LJ, Mokry M, van Boxtel R, Koster J, Coffer PJ, Pals ST, Spaargaren M.

Blood. 2014 Nov 27;124(23):3431-40. doi: 10.1182/blood-2014-01-553412. Epub 2014 Sep 29.

33.

Identification of multipotent luminal progenitor cells in human prostate organoid cultures.

Karthaus WR, Iaquinta PJ, Drost J, Gracanin A, van Boxtel R, Wongvipat J, Dowling CM, Gao D, Begthel H, Sachs N, Vries RGJ, Cuppen E, Chen Y, Sawyers CL, Clevers HC.

Cell. 2014 Sep 25;159(1):163-175. doi: 10.1016/j.cell.2014.08.017. Epub 2014 Sep 4.

34.

Increased expression levels of chromosomal AmpC β-lactamase in clinical Escherichia coli isolates and their effect on susceptibility to extended-spectrum cephalosporins.

Paltansing S, Kraakman M, van Boxtel R, Kors I, Wessels E, Goessens W, Tommassen J, Bernards A.

Microb Drug Resist. 2015 Feb;21(1):7-16. doi: 10.1089/mdr.2014.0108. Epub 2014 Sep 4.

PMID:
25188329
35.

Genome sequencing of normal cells reveals developmental lineages and mutational processes.

Behjati S, Huch M, van Boxtel R, Karthaus W, Wedge DC, Tamuri AU, Martincorena I, Petljak M, Alexandrov LB, Gundem G, Tarpey PS, Roerink S, Blokker J, Maddison M, Mudie L, Robinson B, Nik-Zainal S, Campbell P, Goldman N, van de Wetering M, Cuppen E, Clevers H, Stratton MR.

Nature. 2014 Sep 18;513(7518):422-425. doi: 10.1038/nature13448. Epub 2014 Jun 29.

36.

Canonical Wnt signaling negatively modulates regulatory T cell function.

van Loosdregt J, Fleskens V, Tiemessen MM, Mokry M, van Boxtel R, Meerding J, Pals CE, Kurek D, Baert MR, Delemarre EM, Gröne A, Koerkamp MJ, Sijts AJ, Nieuwenhuis EE, Maurice MM, van Es JH, Ten Berge D, Holstege FC, Staal FJ, Zaiss DM, Prakken BJ, Coffer PJ.

Immunity. 2013 Aug 22;39(2):298-310. doi: 10.1016/j.immuni.2013.07.019. Epub 2013 Aug 15.

37.

Forkhead Box P family members at the crossroad between tolerance and immunity: a balancing act.

Fleskens V, van Boxtel R.

Int Rev Immunol. 2014 Mar;33(2):94-109. doi: 10.3109/08830185.2013.816698. Epub 2013 Jul 25. Review.

PMID:
23886296
38.

FOXP1 acts through a negative feedback loop to suppress FOXO-induced apoptosis.

van Boxtel R, Gomez-Puerto C, Mokry M, Eijkelenboom A, van der Vos KE, Nieuwenhuis EE, Burgering BM, Lam EW, Coffer PJ.

Cell Death Differ. 2013 Sep;20(9):1219-29. doi: 10.1038/cdd.2013.81. Epub 2013 Jul 5.

39.

Antibiotic trapping by plasmid-encoded CMY-2 β-lactamase combined with reduced outer membrane permeability as a mechanism of carbapenem resistance in Escherichia coli.

Goessens WH, van der Bij AK, van Boxtel R, Pitout JD, van Ulsen P, Melles DC, Tommassen J.

Antimicrob Agents Chemother. 2013 Aug;57(8):3941-9. doi: 10.1128/AAC.02459-12. Epub 2013 Jun 3.

40.

Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling.

Eijkelenboom A, Mokry M, de Wit E, Smits LM, Polderman PE, van Triest MH, van Boxtel R, Schulze A, de Laat W, Cuppen E, Burgering BM.

Mol Syst Biol. 2013;9:638. doi: 10.1038/msb.2012.74.

41.

SOX4 mediates TGF-β-induced expression of mesenchymal markers during mammary cell epithelial to mesenchymal transition.

Vervoort SJ, Lourenço AR, van Boxtel R, Coffer PJ.

PLoS One. 2013;8(1):e53238. doi: 10.1371/journal.pone.0053238. Epub 2013 Jan 3.

42.

The role of SRY-related HMG box transcription factor 4 (SOX4) in tumorigenesis and metastasis: friend or foe?

Vervoort SJ, van Boxtel R, Coffer PJ.

Oncogene. 2013 Jul 18;32(29):3397-409. doi: 10.1038/onc.2012.506. Epub 2012 Dec 17. Review.

PMID:
23246969
43.

Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy.

van der Vos KE, Eliasson P, Proikas-Cezanne T, Vervoort SJ, van Boxtel R, Putker M, van Zutphen IJ, Mauthe M, Zellmer S, Pals C, Verhagen LP, Groot Koerkamp MJ, Braat AK, Dansen TB, Holstege FC, Gebhardt R, Burgering BM, Coffer PJ.

Nat Cell Biol. 2012 Aug;14(8):829-37. doi: 10.1038/ncb2536. Epub 2012 Jul 22.

PMID:
22820375
44.

Homozygous and heterozygous p53 knockout rats develop metastasizing sarcomas with high frequency.

van Boxtel R, Kuiper RV, Toonen PW, van Heesch S, Hermsen R, de Bruin A, Cuppen E.

Am J Pathol. 2011 Oct;179(4):1616-22. doi: 10.1016/j.ajpath.2011.06.036. Epub 2011 Aug 18.

45.

Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat.

Mul JD, van Boxtel R, Bergen DJ, Brans MA, Brakkee JH, Toonen PW, Garner KM, Adan RA, Cuppen E.

Obesity (Silver Spring). 2012 Mar;20(3):612-21. doi: 10.1038/oby.2011.81. Epub 2011 Apr 28. Erratum in: Obesity (Silver Spring). 2012 Jul;20(7):1545. Dosage error in article text.

46.

Generation of genetically modified rodents using random ENU mutagenesis.

van Boxtel R, Cuppen E.

Methods Mol Biol. 2011;693:295-308. doi: 10.1007/978-1-60761-974-1_18.

PMID:
21080288
47.

Mutation discovery by targeted genomic enrichment of multiplexed barcoded samples.

Nijman IJ, Mokry M, van Boxtel R, Toonen P, de Bruijn E, Cuppen E.

Nat Methods. 2010 Nov;7(11):913-5. doi: 10.1038/nmeth.1516. Epub 2010 Oct 17.

PMID:
20953175
48.

Rat traps: filling the toolbox for manipulating the rat genome.

van Boxtel R, Cuppen E.

Genome Biol. 2010;11(9):217. doi: 10.1186/gb-2010-11-9-217. Epub 2010 Sep 29. Review.

49.

Systematic generation of in vivo G protein-coupled receptor mutants in the rat.

van Boxtel R, Vroling B, Toonen P, Nijman IJ, van Roekel H, Verheul M, Baakman C, Guryev V, Vriend G, Cuppen E.

Pharmacogenomics J. 2011 Oct;11(5):326-36. doi: 10.1038/tpj.2010.44. Epub 2010 Jun 8.

50.

ENU mutagenesis to generate genetically modified rat models.

van Boxtel R, Gould MN, Cuppen E, Smits BM.

Methods Mol Biol. 2010;597:151-67. doi: 10.1007/978-1-60327-389-3_11.

PMID:
20013232

Supplemental Content

Loading ...
Support Center