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Items: 1 to 50 of 110

1.

Membrane organization determines barrier properties of endothelial cells and short-chain sphingolipid-facilitated doxorubicin influx.

van Hell AJ, Klymchenko A, Gueth DM, van Blitterswijk WJ, Koning GA, Verheij M.

Biochim Biophys Acta. 2014 Sep;1841(9):1301-7. doi: 10.1016/j.bbalip.2014.06.006. Epub 2014 Jun 19.

PMID:
24953779
2.

Defined lipid analogues induce transient channels to facilitate drug-membrane traversal and circumvent cancer therapy resistance.

van Hell AJ, Melo MN, van Blitterswijk WJ, Gueth DM, Braumuller TM, Pedrosa LR, Song JY, Marrink SJ, Koning GA, Jonkers J, Verheij M.

Sci Rep. 2013;3:1949. doi: 10.1038/srep01949.

3.

Improving intracellular doxorubicin delivery through nanoliposomes equipped with selective tumor cell membrane permeabilizing short-chain sphingolipids.

Pedrosa LR, van Hell A, Süss R, van Blitterswijk WJ, Seynhaeve AL, van Cappellen WA, Eggermont AM, ten Hagen TL, Verheij M, Koning GA.

Pharm Res. 2013 Jul;30(7):1883-95. doi: 10.1007/s11095-013-1031-6. Epub 2013 May 11.

PMID:
23666266
4.

Anticancer mechanisms and clinical application of alkylphospholipids.

van Blitterswijk WJ, Verheij M.

Biochim Biophys Acta. 2013 Mar;1831(3):663-74. doi: 10.1016/j.bbalip.2012.10.008. Epub 2012 Nov 5. Review.

PMID:
23137567
5.

Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor.

van Baal J, de Widt J, Divecha N, van Blitterswijk WJ.

Int J Biochem Cell Biol. 2012 Nov;44(11):1791-9. doi: 10.1016/j.biocel.2012.06.021. Epub 2012 Jun 23.

PMID:
22732145
6.

SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling.

Baldanzi G, Pighini A, Bettio V, Rainero E, Traini S, Chianale F, Porporato PE, Filigheddu N, Mesturini R, Song S, Schweighoffer T, Patrussi L, Baldari CT, Zhong XP, van Blitterswijk WJ, Sinigaglia F, Nichols KE, Rubio I, Parolini O, Graziani A.

J Immunol. 2011 Dec 1;187(11):5941-51. doi: 10.4049/jimmunol.1002476. Epub 2011 Nov 2.

7.

Phosphoinositide phosphatase SHIP-1 regulates apoptosis induced by edelfosine, Fas ligation and DNA damage in mouse lymphoma cells.

Alderliesten MC, Klarenbeek JB, van der Luit AH, van Lummel M, Jones DR, Zerp S, Divecha N, Verheij M, van Blitterswijk WJ.

Biochem J. 2011 Nov 15;440(1):127-35. doi: 10.1042/BJ20110125.

PMID:
21793801
8.

Enriching lipid nanovesicles with short-chain glucosylceramide improves doxorubicin delivery and efficacy in solid tumors.

van Lummel M, van Blitterswijk WJ, Vink SR, Veldman RJ, van der Valk MA, Schipper D, Dicheva BM, Eggermont AM, ten Hagen TL, Verheij M, Koning GA.

FASEB J. 2011 Jan;25(1):280-9. doi: 10.1096/fj.10-163709. Epub 2010 Sep 27.

PMID:
20876209
9.

Negative regulation of diacylglycerol kinase theta mediates adenosine-dependent hepatocyte preconditioning.

Baldanzi G, Alchera E, Imarisio C, Gaggianesi M, Dal Ponte C, Nitti M, Domenicotti C, van Blitterswijk WJ, Albano E, Graziani A, Carini R.

Cell Death Differ. 2010 Jun;17(6):1059-68. doi: 10.1038/cdd.2009.210. Epub 2010 Jan 8.

10.

AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis.

Zerp SF, Stoter R, Kuipers G, Yang D, Lippman ME, van Blitterswijk WJ, Bartelink H, Rooswinkel R, Lafleur V, Verheij M.

Radiat Oncol. 2009 Oct 23;4:47. doi: 10.1186/1748-717X-4-47.

11.

Fas/CD95 down-regulation in lymphoma cells through acquired alkyllysophospholipid resistance: partial role of associated sphingomyelin deficiency.

van Blitterswijk WJ, Klarenbeek JB, van der Luit AH, Alderliesten MC, van Lummel M, Verheij M.

Biochem J. 2009 Dec 14;425(1):225-34. doi: 10.1042/BJ20090455.

PMID:
19824885
12.

Anticancer alkylphospholipids: mechanisms of action, cellular sensitivity and resistance, and clinical prospects.

van Blitterswijk WJ, Verheij M.

Curr Pharm Des. 2008;14(21):2061-74. Review.

PMID:
18691116
13.

Is there a role for diacylglycerol kinase-zeta in cell cycle regulation?

Los AP, de Widt J, van Blitterswijk WJ, Divecha N.

Adv Enzyme Regul. 2008;48:31-9. doi: 10.1016/j.advenzreg.2008.02.001. Epub 2008 Feb 13. No abstract available.

PMID:
18358241
14.

Alkylphospholipids inhibit capillary-like endothelial tube formation in vitro: antiangiogenic properties of a new class of antitumor agents.

Zerp SF, Vink SR, Ruiter GA, Koolwijk P, Peters E, van der Luit AH, de Jong D, Budde M, Bartelink H, van Blitterswijk WJ, Verheij M.

Anticancer Drugs. 2008 Jan;19(1):65-75.

PMID:
18043131
15.

Diacylglycerol kinase-alpha mediates hepatocyte growth factor-induced epithelial cell scatter by regulating Rac activation and membrane ruffling.

Chianale F, Cutrupi S, Rainero E, Baldanzi G, Porporato PE, Traini S, Filigheddu N, Gnocchi VF, Santoro MM, Parolini O, van Blitterswijk WJ, Sinigaglia F, Graziani A.

Mol Biol Cell. 2007 Dec;18(12):4859-71. Epub 2007 Sep 26.

16.

Lipid rafts and metabolic energy differentially determine uptake of anti-cancer alkylphospholipids in lymphoma versus carcinoma cells.

Vink SR, van der Luit AH, Klarenbeek JB, Verheij M, van Blitterswijk WJ.

Biochem Pharmacol. 2007 Nov 15;74(10):1456-65. Epub 2007 Aug 3.

PMID:
17803969
17.

Diacylglycerol kinase-alpha phosphorylation by Src on Y335 is required for activation, membrane recruitment and Hgf-induced cell motility.

Baldanzi G, Cutrupi S, Chianale F, Gnocchi V, Rainero E, Porporato P, Filigheddu N, van Blitterswijk WJ, Parolini O, Bussolino F, Sinigaglia F, Graziani A.

Oncogene. 2008 Feb 7;27(7):942-56. Epub 2007 Aug 13.

PMID:
17700527
18.

A new class of anticancer alkylphospholipids uses lipid rafts as membrane gateways to induce apoptosis in lymphoma cells.

van der Luit AH, Vink SR, Klarenbeek JB, Perrissoud D, Solary E, Verheij M, van Blitterswijk WJ.

Mol Cancer Ther. 2007 Aug;6(8):2337-45.

19.

Rationale and clinical application of alkylphospholipid analogues in combination with radiotherapy.

Vink SR, van Blitterswijk WJ, Schellens JH, Verheij M.

Cancer Treat Rev. 2007 Apr;33(2):191-202. Epub 2007 Feb 6. Review.

PMID:
17287087
20.

Protein kinase C inhibits binding of diacylglycerol kinase-zeta to the retinoblastoma protein.

Los AP, de Widt J, Topham MK, van Blitterswijk WJ, Divecha N.

Biochim Biophys Acta. 2007 Mar;1773(3):352-7. Epub 2006 Dec 13.

21.

New physiological functions for drug-transporting P-glycoproteins?

Borst P, van Blitterswijk WJ, Borst J, Tepper AD, Schinkel AH.

Drug Resist Updat. 1998;1(5):337-9. No abstract available.

PMID:
17092814
22.
23.

Radiosensitization of squamous cell carcinoma by the alkylphospholipid perifosine in cell culture and xenografts.

Vink SR, Lagerwerf S, Mesman E, Schellens JH, Begg AC, van Blitterswijk WJ, Verheij M.

Clin Cancer Res. 2006 Mar 1;12(5):1615-22.

24.

The retinoblastoma family proteins bind to and activate diacylglycerol kinase zeta.

Los AP, Vinke FP, de Widt J, Topham MK, van Blitterswijk WJ, Divecha N.

J Biol Chem. 2006 Jan 13;281(2):858-66. Epub 2005 Nov 14.

25.

Coformulated N-octanoyl-glucosylceramide improves cellular delivery and cytotoxicity of liposomal doxorubicin.

Veldman RJ, Koning GA, van Hell A, Zerp S, Vink SR, Storm G, Verheij M, van Blitterswijk WJ.

J Pharmacol Exp Ther. 2005 Nov;315(2):704-10. Epub 2005 Jul 22.

PMID:
16040815
26.

Tumor and normal tissue pharmacokinetics of perifosine, an oral anti-cancer alkylphospholipid.

Vink SR, Schellens JH, van Blitterswijk WJ, Verheij M.

Invest New Drugs. 2005 Aug;23(4):279-86.

PMID:
16012787
27.

Activation of alpha-diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinase.

Bacchiocchi R, Baldanzi G, Carbonari D, Capomagi C, Colombo E, van Blitterswijk WJ, Graziani A, Fazioli F.

Blood. 2005 Sep 15;106(6):2175-82. Epub 2005 May 31.

PMID:
15928040
28.

Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C.

van Baal J, de Widt J, Divecha N, van Blitterswijk WJ.

J Biol Chem. 2005 Mar 18;280(11):9870-8. Epub 2005 Jan 4.

29.

Structure-activity relationship of diacylglycerol kinase theta.

Los AP, van Baal J, de Widt J, Divecha N, van Blitterswijk WJ.

Biochim Biophys Acta. 2004 Mar 22;1636(2-3):169-74.

PMID:
15164764
30.

Activation of diacylglycerol kinase alpha is required for VEGF-induced angiogenic signaling in vitro.

Baldanzi G, Mitola S, Cutrupi S, Filigheddu N, van Blitterswijk WJ, Sinigaglia F, Bussolino F, Graziani A.

Oncogene. 2004 Jun 17;23(28):4828-38.

PMID:
15122338
31.

Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport.

te Vruchte D, Lloyd-Evans E, Veldman RJ, Neville DC, Dwek RA, Platt FM, van Blitterswijk WJ, Sillence DJ.

J Biol Chem. 2004 Jun 18;279(25):26167-75. Epub 2004 Apr 12.

32.

N-hexanoyl-sphingomyelin potentiates in vitro doxorubicin cytotoxicity by enhancing its cellular influx.

Veldman RJ, Zerp S, van Blitterswijk WJ, Verheij M.

Br J Cancer. 2004 Feb 23;90(4):917-25.

33.

Different modes of internalization of apoptotic alkyl-lysophospholipid and cell-rescuing lysophosphatidylcholine.

Van Der Luit AH, Budde M, Verheij M, Van Blitterswijk WJ.

Biochem J. 2003 Sep 15;374(Pt 3):747-53.

34.

Glucosamine and chondroitin sulfate supplementation to treat symptomatic disc degeneration: biochemical rationale and case report.

van Blitterswijk WJ, van de Nes JC, Wuisman PI.

BMC Complement Altern Med. 2003 Jun 10;3:2. Epub 2003 Jun 10.

35.

Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase-Akt/PKB survival pathway.

Ruiter GA, Zerp SF, Bartelink H, van Blitterswijk WJ, Verheij M.

Anticancer Drugs. 2003 Feb;14(2):167-73.

PMID:
12569304
36.

Ceramide: second messenger or modulator of membrane structure and dynamics?

van Blitterswijk WJ, van der Luit AH, Veldman RJ, Verheij M, Borst J.

Biochem J. 2003 Jan 15;369(Pt 2):199-211. Review.

37.
38.

Alkyl-lysophospholipid accumulates in lipid rafts and induces apoptosis via raft-dependent endocytosis and inhibition of phosphatidylcholine synthesis.

van der Luit AH, Budde M, Ruurs P, Verheij M, van Blitterswijk WJ.

J Biol Chem. 2002 Oct 18;277(42):39541-7. Epub 2002 Aug 14.

39.

Sphingolipids related to apoptosis from the point of view of membrane structure and topology.

van Blitterswijk WJ, van der Luit AH, Caan W, Verheij M, Borst J.

Biochem Soc Trans. 2001 Nov;29(Pt 6):819-24. Review.

PMID:
11709081
40.

Alkyl-lysophospholipids as anticancer agents and enhancers of radiation-induced apoptosis.

Ruiter GA, Verheij M, Zerp SF, van Blitterswijk WJ.

Int J Radiat Oncol Biol Phys. 2001 Feb 1;49(2):415-9. Review.

PMID:
11173135
41.

Effect of overexpression of a neutral sphingomyelinase on CD95-induced ceramide production and apoptosis.

Tepper AD, Ruurs P, Borst J, van Blitterswijk WJ.

Biochem Biophys Res Commun. 2001 Jan 26;280(3):634-9.

PMID:
11162568
42.

Diacylglycerol kinase theta is translocated and phosphoinositide 3-kinase-dependently activated by noradrenaline but not angiotensin II in intact small arteries.

Walker AJ, Draeger A, Houssa B, van Blitterswijk WJ, Ohanian V, Ohanian J.

Biochem J. 2001 Jan 1;353(Pt 1):129-137.

43.

Properties and functions of diacylglycerol kinases.

van Blitterswijk WJ, Houssa B.

Cell Signal. 2000 Oct;12(9-10):595-605. Review.

PMID:
11080611
44.

Ceramide mass analysis by normal-phase high-performance liquid chromatography.

Tepper AD, Van Blitterswijk WJ.

Methods Enzymol. 2000;312:16-22. No abstract available.

PMID:
11070859
45.
46.

Sphingomyelin hydrolysis to ceramide during the execution phase of apoptosis results from phospholipid scrambling and alters cell-surface morphology.

Tepper AD, Ruurs P, Wiedmer T, Sims PJ, Borst J, van Blitterswijk WJ.

J Cell Biol. 2000 Jul 10;150(1):155-64.

47.

Protein kinase C activation by acidic proteins including 14-3-3.

Van Der Hoeven PC, Van Der Wal JC, Ruurs P, Van Blitterswijk WJ.

Biochem J. 2000 May 1;347 Pt 3:781-5.

48.

Diacylglycerol kinases in signal transduction.

van Blitterswijk WJ, Houssa B.

Chem Phys Lipids. 1999 Apr;98(1-2):95-108. Review.

PMID:
10358932
49.

Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis.

Ruiter GA, Zerp SF, Bartelink H, van Blitterswijk WJ, Verheij M.

Cancer Res. 1999 May 15;59(10):2457-63.

50.

Common regulation of apoptosis signaling induced by CD95 and the DNA-damaging stimuli etoposide and gamma-radiation downstream from caspase-8 activation.

Boesen-de Cock JG, Tepper AD, de Vries E, van Blitterswijk WJ, Borst J.

J Biol Chem. 1999 May 14;274(20):14255-61.

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