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Items: 29

1.

A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat.

Jarvis MF, Burgard EC, McGaraughty S, Honore P, Lynch K, Brennan TJ, Subieta A, Van Biesen T, Cartmell J, Bianchi B, Niforatos W, Kage K, Yu H, Mikusa J, Wismer CT, Zhu CZ, Chu K, Lee CH, Stewart AO, Polakowski J, Cox BF, Kowaluk E, Williams M, Sullivan J, Faltynek C.

Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17179-84. Epub 2002 Dec 13.

2.

Protein tyrosine kinase activity assays.

Hawes BE, van Biesen T.

Curr Protoc Pharmacol. 2001 May;Chapter 3:Unit3.5. doi: 10.1002/0471141755.ph0305s05.

PMID:
21965067
3.

Modulation of BzATP and formalin induced nociception: attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X(3) allosteric modulator, cibacron blue.

Jarvis MF, Wismer CT, Schweitzer E, Yu H, van Biesen T, Lynch KJ, Burgard EC, Kowaluk EA.

Br J Pharmacol. 2001 Jan;132(1):259-69.

4.

Competitive antagonism of recombinant P2X(2/3) receptors by 2', 3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP).

Burgard EC, Niforatos W, van Biesen T, Lynch KJ, Kage KL, Touma E, Kowaluk EA, Jarvis MF.

Mol Pharmacol. 2000 Dec;58(6):1502-10.

5.

Molecular and functional characterization of human P2X(2) receptors.

Lynch KJ, Touma E, Niforatos W, Kage KL, Burgard EC, van Biesen T, Kowaluk EA, Jarvis MF.

Mol Pharmacol. 1999 Dec;56(6):1171-81.

6.

Allosteric modulation and accelerated resensitization of human P2X(3) receptors by cibacron blue.

Alexander K, Niforatos W, Bianchi B, Burgard EC, Lynch KJ, Kowaluk EA, Jarvis MF, van Biesen T.

J Pharmacol Exp Ther. 1999 Dec;291(3):1135-42.

7.

P2X receptor-mediated ionic currents in dorsal root ganglion neurons.

Burgard EC, Niforatos W, van Biesen T, Lynch KJ, Touma E, Metzger RE, Kowaluk EA, Jarvis MF.

J Neurophysiol. 1999 Sep;82(3):1590-8.

8.

Pharmacological characterization of recombinant human and rat P2X receptor subtypes.

Bianchi BR, Lynch KJ, Touma E, Niforatos W, Burgard EC, Alexander KM, Park HS, Yu H, Metzger R, Kowaluk E, Jarvis MF, van Biesen T.

Eur J Pharmacol. 1999 Jul 2;376(1-2):127-38.

PMID:
10440098
9.
10.

Regulation of mitogen-activated protein kinase pathways by catecholamine receptors.

Luttrell LM, van Biesen T, Hawes BE, Della Rocca GJ, Luttrell DK, Lefkowitz RJ.

Adv Pharmacol. 1998;42:466-70. No abstract available.

PMID:
9327940
11.
12.

Activation of Ras and mitogen-activated protein kinase pathway by terminal complement complexes is G protein dependent.

Niculescu F, Rus H, van Biesen T, Shin ML.

J Immunol. 1997 May 1;158(9):4405-12.

PMID:
9127005
13.

5-HT1A receptor activates Na+/H+ exchange in CHO-K1 cells through Gialpha2 and Gialpha3.

Garnovskaya MN, Gettys TW, van Biesen T, Prpic V, Chuprun JK, Raymond JR.

J Biol Chem. 1997 Mar 21;272(12):7770-6.

14.
15.

G-protein-coupled receptors and their regulation: activation of the MAP kinase signaling pathway by G-protein-coupled receptors.

Luttrell LM, van Biesen T, Hawes BE, Koch WJ, Krueger KM, Touhara K, Lefkowitz RJ.

Adv Second Messenger Phosphoprotein Res. 1997;31:263-77. Review.

PMID:
9344257
16.

Mitogenic signaling via G protein-coupled receptors.

van Biesen T, Luttrell LM, Hawes BE, Lefkowitz RJ.

Endocr Rev. 1996 Dec;17(6):698-714. Review. No abstract available.

PMID:
8969974
17.

Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway.

Garnovskaya MN, van Biesen T, Hawe B, Casañas Ramos S, Lefkowitz RJ, Raymond JR.

Biochemistry. 1996 Oct 29;35(43):13716-22.

PMID:
8901512
18.

Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases.

Luttrell LM, Hawes BE, van Biesen T, Luttrell DK, Lansing TJ, Lefkowitz RJ.

J Biol Chem. 1996 Aug 9;271(32):19443-50.

19.
20.

G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism.

van Biesen T, Hawes BE, Raymond JR, Luttrell LM, Koch WJ, Lefkowitz RJ.

J Biol Chem. 1996 Jan 19;271(3):1266-9.

21.

G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.

Touhara K, Hawes BE, van Biesen T, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9284-7.

22.

Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway.

van Biesen T, Hawes BE, Luttrell DK, Krueger KM, Touhara K, Porfiri E, Sakaue M, Luttrell LM, Lefkowitz RJ.

Nature. 1995 Aug 31;376(6543):781-4.

PMID:
7651538
23.

Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation.

Hawes BE, van Biesen T, Koch WJ, Luttrell LM, Lefkowitz RJ.

J Biol Chem. 1995 Jul 21;270(29):17148-53.

24.

G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor.

Luttrell LM, van Biesen T, Hawes BE, Koch WJ, Touhara K, Lefkowitz RJ.

J Biol Chem. 1995 Jul 14;270(28):16495-8.

25.

Effect of cellular expression of pleckstrin homology domains on Gi-coupled receptor signaling.

Luttrell LM, Hawes BE, Touhara K, van Biesen T, Koch WJ, Lefkowitz RJ.

J Biol Chem. 1995 Jun 2;270(22):12984-9.

26.
27.

Structural and functional analyses of the FinP antisense RNA regulatory system of the F conjugative plasmid.

van Biesen T, Söderbom F, Wagner EG, Frost LS.

Mol Microbiol. 1993 Oct;10(1):35-43.

PMID:
7526120
28.
29.

Interaction of biofilm bacteria with antibiotics in a novel in vitro chemostat system.

Anwar H, van Biesen T, Dasgupta M, Lam K, Costerton JW.

Antimicrob Agents Chemother. 1989 Oct;33(10):1824-6.

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