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Items: 1 to 50 of 170

1.

Lack of Detection of the Analgesic Properties of PF-05089771, a Selective Nav 1.7 Inhibitor, Using a Battery of Pain Models in Healthy Subjects.

Siebenga P, van Amerongen G, Hay JL, McDonnell A, Gorman D, Butt R, Groeneveld GJ.

Clin Transl Sci. 2019 Oct 23. doi: 10.1111/cts.12712. [Epub ahead of print]

PMID:
31642607
2.

Lack of Middle East Respiratory Syndrome Coronavirus Transmission in Rabbits.

Widagdo W, Okba NMA, Richard M, de Meulder D, Bestebroer TM, Lexmond P, Farag EABA, Al-Hajri M, Stittelaar KJ, de Waal L, van Amerongen G, van den Brand JMA, Haagmans BL, Herfst S.

Viruses. 2019 Apr 24;11(4). pii: E381. doi: 10.3390/v11040381.

3.

Analgesic potential of PF-06372865, an α2/α3/α5 subtype-selective GABAA partial agonist, in humans.

van Amerongen G, Siebenga PS, Gurrell R, Dua P, Whitlock M, Gorman D, Okkerse P, Hay JL, Butt RP, Groeneveld GJ.

Br J Anaesth. 2019 Aug;123(2):e194-e203. doi: 10.1016/j.bja.2018.12.006. Epub 2019 Jan 31.

4.

Reproducibility of a battery of human evoked pain models to detect pharmacological effects of analgesic drugs.

Siebenga PS, van Amerongen G, Okkerse P, Denney WS, Dua P, Butt RP, Hay JL, Groeneveld GJ.

Eur J Pain. 2019 Jul;23(6):1129-1140. doi: 10.1002/ejp.1379. Epub 2019 Apr 5.

5.

The selective orexin-2 receptor antagonist seltorexant improves sleep: An exploratory double-blind, placebo controlled, crossover study in antidepressant-treated major depressive disorder patients with persistent insomnia.

Brooks S, Jacobs GE, de Boer P, Kent JM, Van Nueten L, van Amerongen G, Zuiker R, Kezic I, Luthringer R, van der Ark P, van Gerven JM, Drevets W.

J Psychopharmacol. 2019 Feb;33(2):202-209. doi: 10.1177/0269881118822258. Epub 2019 Jan 15.

PMID:
30644312
6.

The ultraviolet B inflammation model: Postinflammatory hyperpigmentation and validation of a reduced UVB exposure paradigm for inducing hyperalgesia in healthy subjects.

Siebenga PS, van Amerongen G, Klaassen ES, de Kam ML, Rissmann R, Groeneveld GJ.

Eur J Pain. 2019 May;23(5):874-883. doi: 10.1002/ejp.1353. Epub 2019 Feb 1.

7.

Influenza A/H3N2 virus infection in immunocompromised ferrets and emergence of antiviral resistance.

Roosenhoff R, van der Vries E, van der Linden A, van Amerongen G, Stittelaar KJ, Smits SL, Schutten M, Fouchier RAM.

PLoS One. 2018 Jul 19;13(7):e0200849. doi: 10.1371/journal.pone.0200849. eCollection 2018.

8.

Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects.

van Amerongen G, Siebenga P, de Kam ML, Hay JL, Groeneveld GJ.

Eur J Pain. 2018 Aug;22(7):1331-1342. doi: 10.1002/ejp.1222. Epub 2018 Apr 25.

PMID:
29635857
9.

Analysis of Mouse Brain Transcriptome After Experimental Duvenhage Virus Infection Shows Activation of Innate Immune Response and Pyroptotic Cell Death Pathway.

Koraka P, Martina BEE, van den Ham HJ, Zaaraoui-Boutahar F, van IJcken W, Roose J, van Amerongen G, Andeweg A, Osterhaus ADME.

Front Microbiol. 2018 Mar 20;9:397. doi: 10.3389/fmicb.2018.00397. eCollection 2018.

10.

Transmission of Human Respiratory Syncytial Virus in the Immunocompromised Ferret Model.

de Waal L, Smits SL, Veldhuis Kroeze EJB, van Amerongen G, Pohl MO, Osterhaus ADME, Stittelaar KJ.

Viruses. 2018 Jan 2;10(1). pii: E18. doi: 10.3390/v10010018.

11.

Needle-free delivery of measles virus vaccine to the lower respiratory tract of non-human primates elicits optimal immunity and protection.

de Swart RL, de Vries RD, Rennick LJ, van Amerongen G, McQuaid S, Verburgh RJ, Yüksel S, de Jong A, Lemon K, Nguyen DT, Ludlow M, Osterhaus ADME, Duprex WP.

NPJ Vaccines. 2017 Aug 1;2:22. doi: 10.1038/s41541-017-0022-8. eCollection 2017.

12.

Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABAA receptor positive allosteric modulator PF-06372865.

Nickolls SA, Gurrell R, van Amerongen G, Kammonen J, Cao L, Brown AR, Stead C, Mead A, Watson C, Hsu C, Owen RM, Pike A, Fish RL, Chen L, Qiu R, Morris ED, Feng G, Whitlock M, Gorman D, van Gerven J, Reynolds DS, Dua P, Butt RP.

Br J Pharmacol. 2018 Feb;175(4):708-725. doi: 10.1111/bph.14119. Epub 2018 Jan 18. Erratum in: Br J Pharmacol. 2019 Jan;176(1):127.

13.

Demonstration of an anti-hyperalgesic effect of a novel pan-Trk inhibitor PF-06273340 in a battery of human evoked pain models.

Loudon P, Siebenga P, Gorman D, Gore K, Dua P, van Amerongen G, Hay JL, Groeneveld GJ, Butt RP.

Br J Clin Pharmacol. 2018 Feb;84(2):301-309. doi: 10.1111/bcp.13448. Epub 2017 Nov 28.

14.

Pigeon paramyxovirus type 1 from a fatal human case induces pneumonia in experimentally infected cynomolgus macaques (Macaca fascicularis).

Kuiken T, Buijs P, van Run P, van Amerongen G, Koopmans M, van den Hoogen B.

Vet Res. 2017 Nov 21;48(1):80. doi: 10.1186/s13567-017-0486-6.

15.

Modified Vaccinia Virus Ankara Preferentially Targets Antigen Presenting Cells In Vitro, Ex Vivo and In Vivo.

Altenburg AF, van de Sandt CE, Li BWS, MacLoughlin RJ, Fouchier RAM, van Amerongen G, Volz A, Hendriks RW, de Swart RL, Sutter G, Rimmelzwaan GF, de Vries RD.

Sci Rep. 2017 Aug 17;7(1):8580. doi: 10.1038/s41598-017-08719-y.

16.

The effects of intranasal esketamine (84 mg) and oral mirtazapine (30 mg) on on-road driving performance: a double-blind, placebo-controlled study.

van de Loo AJAE, Bervoets AC, Mooren L, Bouwmeester NH, Garssen J, Zuiker R, van Amerongen G, van Gerven J, Singh J, der Ark PV, Fedgchin M, Morrison R, Wajs E, Verster JC.

Psychopharmacology (Berl). 2017 Nov;234(21):3175-3183. doi: 10.1007/s00213-017-4706-6. Epub 2017 Jul 28.

17.

Delineating morbillivirus entry, dissemination and airborne transmission by studying in vivo competition of multicolor canine distemper viruses in ferrets.

de Vries RD, Ludlow M, de Jong A, Rennick LJ, Verburgh RJ, van Amerongen G, van Riel D, van Run PRWA, Herfst S, Kuiken T, Fouchier RAM, Osterhaus ADME, de Swart RL, Duprex WP.

PLoS Pathog. 2017 May 8;13(5):e1006371. doi: 10.1371/journal.ppat.1006371. eCollection 2017 May.

18.

Carbohydrate fatty acid monosulphate esters are safe and effective adjuvants for humoral responses.

Hilgers LAT, Platenburg PPLI, Bajramovic J, Veth J, Sauerwein R, Roeffen W, Pohl M, van Amerongen G, Stittelaar KJ, van den Bosch JF.

Vaccine. 2017 May 31;35(24):3249-3255. doi: 10.1016/j.vaccine.2017.04.055. Epub 2017 May 4.

19.

Effects on Spasticity and Neuropathic Pain of an Oral Formulation of Δ9-tetrahydrocannabinol in Patients WithProgressive Multiple Sclerosis.

van Amerongen G, Kanhai K, Baakman AC, Heuberger J, Klaassen E, Beumer TL, Strijers RLM, Killestein J, van Gerven J, Cohen A, Groeneveld GJ.

Clin Ther. 2018 Sep;40(9):1467-1482. doi: 10.1016/j.clinthera.2017.01.016. Epub 2017 Feb 9.

PMID:
28189366
20.

The use of a battery of pain models to detect analgesic properties of compounds: a two-part four-way crossover study.

Okkerse P, van Amerongen G, de Kam ML, Stevens J, Butt RP, Gurrell R, Dahan A, van Gerven JM, Hay JL, Groeneveld GJ.

Br J Clin Pharmacol. 2017 May;83(5):976-990. doi: 10.1111/bcp.13183. Epub 2017 Jan 9.

21.

Vaccination Is More Effective Than Prophylactic Oseltamivir in Preventing CNS Invasion by H5N1 Virus via the Olfactory Nerve.

Siegers JY, van den Brand JM, Leijten LM, van de Bildt MM, van Run PR, van Amerongen G, Stittelaar KJ, Koopmans MP, Osterhaus AD, Kuiken T, van Riel D.

J Infect Dis. 2016 Aug 15;214(4):516-24. doi: 10.1093/infdis/jiw123. Epub 2016 Apr 1.

PMID:
27448390
22.

Ferrets as a Novel Animal Model for Studying Human Respiratory Syncytial Virus Infections in Immunocompetent and Immunocompromised Hosts.

Stittelaar KJ, de Waal L, van Amerongen G, Veldhuis Kroeze EJ, Fraaij PL, van Baalen CA, van Kampen JJ, van der Vries E, Osterhaus AD, de Swart RL.

Viruses. 2016 Jun 14;8(6). pii: E168. doi: 10.3390/v8060168.

23.

A literature review on the pharmacological sensitivity of human evoked hyperalgesia pain models.

van Amerongen G, de Boer MW, Groeneveld GJ, Hay JL.

Br J Clin Pharmacol. 2016 Oct;82(4):903-22. doi: 10.1111/bcp.13018. Epub 2016 Jul 8. Review.

24.

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery.

Hay JL, Okkerse P, van Amerongen G, Groeneveld GJ.

J Vis Exp. 2016 Apr 14;(110). doi: 10.3791/53800.

25.

Responsiveness of electrical nociceptive detection thresholds to capsaicin (8 %)-induced changes in nociceptive processing.

Doll RJ, van Amerongen G, Hay JL, Groeneveld GJ, Veltink PH, Buitenweg JR.

Exp Brain Res. 2016 Sep;234(9):2505-14. doi: 10.1007/s00221-016-4655-z. Epub 2016 May 3.

26.

Optimization and Dose Estimation of Aerosol Delivery to Non-Human Primates.

MacLoughlin RJ, van Amerongen G, Fink JB, Janssens HM, Duprex WP, de Swart RL.

J Aerosol Med Pulm Drug Deliv. 2016 Jun;29(3):281-7. doi: 10.1089/jamp.2015.1250. Epub 2015 Dec 8.

PMID:
26646908
27.

Pathogenicity and tissue tropism of currently circulating highly pathogenic avian influenza A virus (H5N1; clade 2.3.2) in tufted ducks (Aythya fuligula).

Bröjer C, van Amerongen G, van de Bildt M, van Run P, Osterhaus A, Gavier-Widén D, Kuiken T.

Vet Microbiol. 2015 Nov 18;180(3-4):273-80. doi: 10.1016/j.vetmic.2015.09.011. Epub 2015 Sep 25.

PMID:
26441012
28.

Long-Term Effect of Serial Infections with H13 and H16 Low-Pathogenic Avian Influenza Viruses in Black-Headed Gulls.

Verhagen JH, Höfle U, van Amerongen G, van de Bildt M, Majoor F, Fouchier RA, Kuiken T.

J Virol. 2015 Nov;89(22):11507-22. doi: 10.1128/JVI.01765-15. Epub 2015 Sep 2.

29.

Heterosubtypic immunity to H7N9 influenza virus in isogenic guinea pigs after infection with pandemic H1N1 virus.

Wiersma LC, Vogelzang-van Trierum SE, Kreijtz JH, van Amerongen G, van Run P, Ladwig M, Banneke S, Schaefer H, Fouchier RA, Kuiken T, Osterhaus AD, Rimmelzwaan GF.

Vaccine. 2015 Dec 8;33(49):6977-82. doi: 10.1016/j.vaccine.2015.08.038. Epub 2015 Aug 25.

PMID:
26319067
30.

Virus replication kinetics and pathogenesis of infection with H7N9 influenza virus in isogenic guinea pigs upon intratracheal inoculation.

Wiersma LC, Kreijtz JH, Vogelzang-van Trierum SE, van Amerongen G, van Run P, Ladwig M, Banneke S, Schaefer H, Fouchier RA, Kuiken T, Osterhaus AD, Rimmelzwaan GF.

Vaccine. 2015 Dec 8;33(49):6983-7. doi: 10.1016/j.vaccine.2015.08.050. Epub 2015 Aug 22.

PMID:
26307235
31.

Susceptibility of Carrion Crows to Experimental Infection with Lineage 1 and 2 West Nile Viruses.

Lim SM, Brault AC, van Amerongen G, Bosco-Lauth AM, Romo H, Sewbalaksing VD, Bowen RA, Osterhaus AD, Koraka P, Martina BE.

Emerg Infect Dis. 2015 Aug;21(8):1357-65. doi: 10.3201/2108.140714.

32.

Streptococcus pneumoniae Enhances Human Respiratory Syncytial Virus Infection In Vitro and In Vivo.

Nguyen DT, Louwen R, Elberse K, van Amerongen G, Yüksel S, Luijendijk A, Osterhaus AD, Duprex WP, de Swart RL.

PLoS One. 2015 May 13;10(5):e0127098. doi: 10.1371/journal.pone.0127098. eCollection 2015.

33.

Host-specific exposure and fatal neurologic disease in wild raptors from highly pathogenic avian influenza virus H5N1 during the 2006 outbreak in Germany.

van den Brand JM, Krone O, Wolf PU, van de Bildt MW, van Amerongen G, Osterhaus AD, Kuiken T.

Vet Res. 2015 Mar 5;46:24. doi: 10.1186/s13567-015-0148-5.

34.

Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits.

Haagmans BL, van den Brand JM, Provacia LB, Raj VS, Stittelaar KJ, Getu S, de Waal L, Bestebroer TM, van Amerongen G, Verjans GM, Fouchier RA, Smits SL, Kuiken T, Osterhaus AD.

J Virol. 2015 Jun;89(11):6131-5. doi: 10.1128/JVI.00661-15. Epub 2015 Mar 25.

35.

Host proteome correlates of vaccine-mediated enhanced disease in a mouse model of respiratory syncytial virus infection.

van Diepen A, Brand HK, de Waal L, Bijl M, Jong VL, Kuiken T, van Amerongen G, van den Ham HJ, Eijkemans MJ, Osterhaus AD, Hermans PW, Andeweg AC.

J Virol. 2015 May;89(9):5022-31. doi: 10.1128/JVI.03630-14. Epub 2015 Feb 18.

36.

Pathogenesis of infection with 2009 pandemic H1N1 influenza virus in isogenic guinea pigs after intranasal or intratracheal inoculation.

Wiersma LC, Vogelzang-van Trierum SE, van Amerongen G, van Run P, Nieuwkoop NJ, Ladwig M, Banneke S, Schaefer H, Kuiken T, Fouchier RA, Osterhaus AD, Rimmelzwaan GF.

Am J Pathol. 2015 Mar;185(3):643-50. doi: 10.1016/j.ajpath.2014.11.012. Epub 2014 Dec 31.

PMID:
25555619
37.

Recombinant subgroup B human respiratory syncytial virus expressing enhanced green fluorescent protein efficiently replicates in primary human cells and is virulent in cotton rats.

Lemon K, Nguyen DT, Ludlow M, Rennick LJ, Yüksel S, van Amerongen G, McQuaid S, Rima BK, de Swart RL, Duprex WP.

J Virol. 2015 Mar;89(5):2849-56. doi: 10.1128/JVI.03587-14. Epub 2014 Dec 24.

38.

Live-attenuated measles virus vaccine targets dendritic cells and macrophages in muscle of nonhuman primates.

Rennick LJ, de Vries RD, Carsillo TJ, Lemon K, van Amerongen G, Ludlow M, Nguyen DT, Yüksel S, Verburgh RJ, Haddock P, McQuaid S, Duprex WP, de Swart RL.

J Virol. 2015 Feb;89(4):2192-200. doi: 10.1128/JVI.02924-14. Epub 2014 Dec 3.

39.

Intravenously injected Newcastle disease virus in non-human primates is safe to use for oncolytic virotherapy.

Buijs PR, van Amerongen G, van Nieuwkoop S, Bestebroer TM, van Run PR, Kuiken T, Fouchier RA, van Eijck CH, van den Hoogen BG.

Cancer Gene Ther. 2014 Nov;21(11):463-71. doi: 10.1038/cgt.2014.51. Epub 2014 Sep 26.

PMID:
25257305
40.

A single immunization with modified vaccinia virus Ankara-based influenza virus H7 vaccine affords protection in the influenza A(H7N9) pneumonia ferret model.

Kreijtz JH, Wiersma LC, De Gruyter HL, Vogelzang-van Trierum SE, van Amerongen G, Stittelaar KJ, Fouchier RA, Osterhaus AD, Sutter G, Rimmelzwaan GF.

J Infect Dis. 2015 Mar 1;211(5):791-800. doi: 10.1093/infdis/jiu528. Epub 2014 Sep 22.

41.

Experimental infection of highly pathogenic avian influenza virus H5N1 in black-headed gulls (Chroicocephalus ridibundus).

Ramis A, van Amerongen G, van de Bildt M, Leijten L, Vanderstichel R, Osterhaus A, Kuiken T.

Vet Res. 2014 Aug 19;45:84. doi: 10.1186/s13567-014-0084-9.

42.

Development and pre-clinical evaluation of two LAIV strains against potentially pandemic H2N2 influenza virus.

Isakova-Sivak I, de Jonge J, Smolonogina T, Rekstin A, van Amerongen G, van Dijken H, Mouthaan J, Roholl P, Kuznetsova V, Doroshenko E, Tsvetnitsky V, Rudenko L.

PLoS One. 2014 Jul 24;9(7):e102339. doi: 10.1371/journal.pone.0102339. eCollection 2014.

43.

Activation of coagulation and tissue fibrin deposition in experimental influenza in ferrets.

Goeijenbier M, van Gorp EC, Van den Brand JM, Stittelaar K, Bakhtiari K, Roelofs JJ, van Amerongen G, Kuiken T, Martina BE, Meijers JC, Osterhaus AD.

BMC Microbiol. 2014 May 30;14:134. doi: 10.1186/1471-2180-14-134.

44.

Intranasally administered Endocine formulated 2009 pandemic influenza H1N1 vaccine induces broad specific antibody responses and confers protection in ferrets.

Maltais AK, Stittelaar KJ, Veldhuis Kroeze EJ, van Amerongen G, Dijkshoorn ML, Krestin GP, Hinkula J, Arwidsson H, Lindberg A, Osterhaus AD.

Vaccine. 2014 May 30;32(26):3307-15. doi: 10.1016/j.vaccine.2014.03.061. Epub 2014 Mar 30.

45.

Susceptibility of European jackdaws (Corvus monedula) to experimental infection with lineage 1 and 2 West Nile viruses.

Lim SM, Brault AC, van Amerongen G, Sewbalaksing VD, Osterhaus AD, Martina BE, Koraka P.

J Gen Virol. 2014 Jun;95(Pt 6):1320-9. doi: 10.1099/vir.0.063651-0. Epub 2014 Mar 26.

46.

Measles vaccination of nonhuman primates provides partial protection against infection with canine distemper virus.

de Vries RD, Ludlow M, Verburgh RJ, van Amerongen G, Yüksel S, Nguyen DT, McQuaid S, Osterhaus AD, Duprex WP, de Swart RL.

J Virol. 2014 Apr;88(8):4423-33. doi: 10.1128/JVI.03676-13. Epub 2014 Feb 5.

47.

Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus.

Raj VS, Smits SL, Provacia LB, van den Brand JM, Wiersma L, Ouwendijk WJ, Bestebroer TM, Spronken MI, van Amerongen G, Rottier PJ, Fouchier RA, Bosch BJ, Osterhaus AD, Haagmans BL.

J Virol. 2014 Feb;88(3):1834-8. doi: 10.1128/JVI.02935-13. Epub 2013 Nov 20.

48.

Infection-enhancing lipopeptides do not improve intranasal immunization of cotton rats with a delta-G candidate live-attenuated human respiratory syncytial virus vaccine.

Tien Nguyen D, Boes J, van Amerongen G, van Remmerden Y, Yüksel S, Guichelaar T, Osterhaus AD, de Swart RL.

Hum Vaccin Immunother. 2013 Dec;9(12):2578-83. doi: 10.4161/hv.26096. Epub 2013 Aug 16.

49.

Low pathogenic avian influenza A(H7N9) virus causes high mortality in ferrets upon intratracheal challenge: a model to study intervention strategies.

Kreijtz JH, Kroeze EJ, Stittelaar KJ, de Waal L, van Amerongen G, van Trierum S, van Run P, Bestebroer T, T Kuiken, Fouchier RA, Rimmelzwaan GF, Osterhaus AD.

Vaccine. 2013 Oct 9;31(43):4995-9. doi: 10.1016/j.vaccine.2013.06.071. Epub 2013 Jun 28.

PMID:
23816392
50.

Infection of lymphoid tissues in the macaque upper respiratory tract contributes to the emergence of transmissible measles virus.

Ludlow M, de Vries RD, Lemon K, McQuaid S, Millar E, van Amerongen G, Yüksel S, Verburgh RJ, Osterhaus AD, de Swart RL, Duprex WP.

J Gen Virol. 2013 Sep;94(Pt 9):1933-44. doi: 10.1099/vir.0.054650-0. Epub 2013 Jun 19.

PMID:
23784446

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