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Items: 7

1.

Structural Basis of the Differential Binding of Engineered Knottins to Integrins αVβ3 and α5β1.

Van Agthoven JF, Shams H, Cochran FV, Alonso JL, Kintzing JR, Garakani K, Adair BD, Xiong JP, Mofrad MRK, Cochran JR, Arnaout MA.

Structure. 2019 Sep 3;27(9):1443-1451.e6. doi: 10.1016/j.str.2019.06.011. Epub 2019 Jul 25.

PMID:
31353240
2.

The α-subunit regulates stability of the metal ion at the ligand-associated metal ion-binding site in β3 integrins.

Rui X, Mehrbod M, Van Agthoven JF, Anand S, Xiong JP, Mofrad MR, Arnaout MA.

J Biol Chem. 2014 Aug 15;289(33):23256-63. doi: 10.1074/jbc.M114.581470. Epub 2014 Jun 28.

3.

Atomic basis for the species-specific inhibition of αV integrins by monoclonal antibody 17E6 is revealed by the crystal structure of αVβ3 ectodomain-17E6 Fab complex.

Mahalingam B, Van Agthoven JF, Xiong JP, Alonso JL, Adair BD, Rui X, Anand S, Mehrbod M, Mofrad MR, Burger C, Goodman SL, Arnaout MA.

J Biol Chem. 2014 May 16;289(20):13801-9. doi: 10.1074/jbc.M113.546929. Epub 2014 Apr 1.

4.

Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectin.

Van Agthoven JF, Xiong JP, Alonso JL, Rui X, Adair BD, Goodman SL, Arnaout MA.

Nat Struct Mol Biol. 2014 Apr;21(4):383-8. doi: 10.1038/nsmb.2797. Epub 2014 Mar 23.

5.

Structural characterization of the stem-stem dimerization interface between prolactin receptor chains complexed with the natural hormone.

van Agthoven J, Zhang C, Tallet E, Raynal B, Hoos S, Baron B, England P, Goffin V, Broutin I.

J Mol Biol. 2010 Nov 19;404(1):112-26. doi: 10.1016/j.jmb.2010.09.036. Epub 2010 Sep 25.

PMID:
20875426
6.

Crystal structure of an affinity-matured prolactin complexed to its dimerized receptor reveals the topology of hormone binding site 2.

Broutin I, Jomain JB, Tallet E, van Agthoven J, Raynal B, Hoos S, Kragelund BB, Kelly PA, Ducruix A, England P, Goffin V.

J Biol Chem. 2010 Mar 12;285(11):8422-33. doi: 10.1074/jbc.M109.089128. Epub 2010 Jan 6.

7.

Structural and thermodynamic bases for the design of pure prolactin receptor antagonists: X-ray structure of Del1-9-G129R-hPRL.

Jomain JB, Tallet E, Broutin I, Hoos S, van Agthoven J, Ducruix A, Kelly PA, Kragelund BB, England P, Goffin V.

J Biol Chem. 2007 Nov 9;282(45):33118-31. Epub 2007 Sep 4.

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