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Items: 1 to 50 of 176

1.

Catalytic deficiency of O-GlcNAc transferase leads to X-linked intellectual disability.

Pravata VM, Muha V, Gundogdu M, Ferenbach AT, Kakade PS, Vandadi V, Wilmes AC, Borodkin VS, Joss S, Stavridis MP, van Aalten DMF.

Proc Natl Acad Sci U S A. 2019 Jul 11. pii: 201900065. doi: 10.1073/pnas.1900065116. [Epub ahead of print]

2.

Mechanisms of redundancy and specificity of the Aspergillus fumigatus Crh transglycosylases.

Fang W, Sanz AB, Bartual SG, Wang B, Ferenbach AT, Farkaš V, Hurtado-Guerrero R, Arroyo J, van Aalten DMF.

Nat Commun. 2019 Apr 10;10(1):1669. doi: 10.1038/s41467-019-09674-0.

3.

The conserved threonine-rich region of the HCF-1PRO repeat activates promiscuous OGT:UDP-GlcNAc glycosylation and proteolysis activities.

Kapuria V, Röhrig UF, Waridel P, Lammers F, Borodkin VS, van Aalten DMF, Zoete V, Herr W.

J Biol Chem. 2018 Nov 16;293(46):17754-17768. doi: 10.1074/jbc.RA118.004185. Epub 2018 Sep 17.

4.

Evidence for substrate-assisted catalysis in N-acetylphosphoglucosamine mutase.

Raimi OG, Hurtado-Guerrero R, van Aalten DMF.

Biochem J. 2018 Aug 16;475(15):2547-2557. doi: 10.1042/BCJ20180172.

5.

Thio-Linked UDP-Peptide Conjugates as O-GlcNAc Transferase Inhibitors.

Rafie K, Gorelik A, Trapannone R, Borodkin VS, van Aalten DMF.

Bioconjug Chem. 2018 Jun 20;29(6):1834-1840. doi: 10.1021/acs.bioconjchem.8b00194. Epub 2018 May 10.

6.

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

Pao KC, Wood NT, Knebel A, Rafie K, Stanley M, Mabbitt PD, Sundaramoorthy R, Hofmann K, van Aalten DMF, Virdee S.

Nature. 2018 Apr;556(7701):381-385. doi: 10.1038/s41586-018-0026-1. Epub 2018 Apr 11.

PMID:
29643511
7.

O-GlcNAcase Fragment Discovery with Fluorescence Polarimetry.

Borodkin VS, Rafie K, Selvan N, Aristotelous T, Navratilova I, Ferenbach AT, van Aalten DMF.

ACS Chem Biol. 2018 May 18;13(5):1353-1360. doi: 10.1021/acschembio.8b00183. Epub 2018 May 2.

PMID:
29641181
8.

The O-GlcNAc Transferase Intellectual Disability Mutation L254F Distorts the TPR Helix.

Gundogdu M, Llabrés S, Gorelik A, Ferenbach AT, Zachariae U, van Aalten DMF.

Cell Chem Biol. 2018 May 17;25(5):513-518.e4. doi: 10.1016/j.chembiol.2018.03.004. Epub 2018 Mar 29.

9.

Effects of hypo-O-GlcNAcylation on Drosophila development.

Mariappa D, Ferenbach AT, van Aalten DMF.

J Biol Chem. 2018 May 11;293(19):7209-7221. doi: 10.1074/jbc.RA118.002580. Epub 2018 Mar 27.

10.

UDP-GlcNAc Analogues as Inhibitors of O-GlcNAc Transferase (OGT): Spectroscopic, Computational, and Biological Studies.

Ghirardello M, Perrone D, Chinaglia N, Sádaba D, Delso I, Tejero T, Marchesi E, Fogagnolo M, Rafie K, van Aalten DMF, Merino P.

Chemistry. 2018 May 17;24(28):7264-7272. doi: 10.1002/chem.201801083. Epub 2018 Apr 30.

PMID:
29513364
11.

Inhibitors against Fungal Cell Wall Remodeling Enzymes.

Delso I, Valero-Gonzalez J, Gomollón-Bel F, Castro-López J, Fang W, Navratilova I, van Aalten DMF, Tejero T, Merino P, Hurtado-Guerrero R.

ChemMedChem. 2018 Jan 22;13(2):128-132. doi: 10.1002/cmdc.201700720. Epub 2017 Dec 12.

PMID:
29164827
12.

Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations.

Kumar A, Tamjar J, Waddell AD, Woodroof HI, Raimi OG, Shaw AM, Peggie M, Muqit MM, van Aalten DM.

Elife. 2017 Oct 5;6. pii: e29985. doi: 10.7554/eLife.29985.

13.

Recognition of a glycosylation substrate by the O-GlcNAc transferase TPR repeats.

Rafie K, Raimi O, Ferenbach AT, Borodkin VS, Kapuria V, van Aalten DMF.

Open Biol. 2017 Jun;7(6). pii: 170078. doi: 10.1098/rsob.170078.

14.

Direct Monitoring of Protein O-GlcNAcylation by High-Resolution Native Mass Spectrometry.

Leney AC, Rafie K, van Aalten DMF, Heck AJR.

ACS Chem Biol. 2017 Aug 18;12(8):2078-2084. doi: 10.1021/acschembio.7b00371. Epub 2017 Jun 28.

15.

A mutant O-GlcNAcase enriches Drosophila developmental regulators.

Selvan N, Williamson R, Mariappa D, Campbell DG, Gourlay R, Ferenbach AT, Aristotelous T, Hopkins-Navratilova I, Trost M, van Aalten DMF.

Nat Chem Biol. 2017 Aug;13(8):882-887. doi: 10.1038/nchembio.2404. Epub 2017 Jun 12.

PMID:
28604694
16.

Mutations in N-acetylglucosamine (O-GlcNAc) transferase in patients with X-linked intellectual disability.

Willems AP, Gundogdu M, Kempers MJE, Giltay JC, Pfundt R, Elferink M, Loza BF, Fuijkschot J, Ferenbach AT, van Gassen KLI, van Aalten DMF, Lefeber DJ.

J Biol Chem. 2017 Jul 28;292(30):12621-12631. doi: 10.1074/jbc.M117.790097. Epub 2017 Jun 5.

17.

Structure and function of a broad-specificity chitin deacetylase from Aspergillus nidulans FGSC A4.

Liu Z, Gay LM, Tuveng TR, Agger JW, Westereng B, Mathiesen G, Horn SJ, Vaaje-Kolstad G, van Aalten DMF, Eijsink VGH.

Sci Rep. 2017 May 11;7(1):1746. doi: 10.1038/s41598-017-02043-1.

18.

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy.

Swamy M, Pathak S, Grzes KM, Damerow S, Sinclair LV, van Aalten DM, Cantrell DA.

Nat Immunol. 2016 Jun;17(6):712-20. doi: 10.1038/ni.3439. Epub 2016 Apr 25.

19.

Proteolysis of HCF-1 by Ser/Thr glycosylation-incompetent O-GlcNAc transferase:UDP-GlcNAc complexes.

Kapuria V, Röhrig UF, Bhuiyan T, Borodkin VS, van Aalten DM, Zoete V, Herr W.

Genes Dev. 2016 Apr 15;30(8):960-72. doi: 10.1101/gad.275925.115. Epub 2016 Apr 7.

20.

Nucleocytoplasmic human O-GlcNAc transferase is sufficient for O-GlcNAcylation of mitochondrial proteins.

Trapannone R, Mariappa D, Ferenbach AT, van Aalten DM.

Biochem J. 2016 Jun 15;473(12):1693-702. doi: 10.1042/BCJ20160092. Epub 2016 Apr 5.

21.

O-GlcNAc transferase inhibitors: current tools and future challenges.

Trapannone R, Rafie K, van Aalten DM.

Biochem Soc Trans. 2016 Feb;44(1):88-93. doi: 10.1042/BST20150189. Review.

PMID:
26862193
22.

A Trapped Covalent Intermediate of a Glycoside Hydrolase on the Pathway to Transglycosylation. Insights from Experiments and Quantum Mechanics/Molecular Mechanics Simulations.

Raich L, Borodkin V, Fang W, Castro-López J, van Aalten DM, Hurtado-Guerrero R, Rovira C.

J Am Chem Soc. 2016 Mar 16;138(10):3325-32. doi: 10.1021/jacs.5b10092. Epub 2016 Mar 1.

PMID:
26859322
23.

Dual functionality of O-GlcNAc transferase is required for Drosophila development.

Mariappa D, Zheng X, Schimpl M, Raimi O, Ferenbach AT, Müller HA, van Aalten DM.

Open Biol. 2015 Dec;5(12):150234. doi: 10.1098/rsob.150234.

24.

Evidence for a Functional O-Linked N-Acetylglucosamine (O-GlcNAc) System in the Thermophilic Bacterium Thermobaculum terrenum.

Ostrowski A, Gundogdu M, Ferenbach AT, Lebedev AA, van Aalten DM.

J Biol Chem. 2015 Dec 18;290(51):30291-305. doi: 10.1074/jbc.M115.689596. Epub 2015 Oct 21.

25.

GacA is essential for Group A Streptococcus and defines a new class of monomeric dTDP-4-dehydrorhamnose reductases (RmlD).

van der Beek SL, Le Breton Y, Ferenbach AT, Chapman RN, van Aalten DM, Navratilova I, Boons GJ, McIver KS, van Sorge NM, Dorfmueller HC.

Mol Microbiol. 2015 Dec;98(5):946-62. doi: 10.1111/mmi.13169. Epub 2015 Oct 1.

26.

The active site of O-GlcNAc transferase imposes constraints on substrate sequence.

Pathak S, Alonso J, Schimpl M, Rafie K, Blair DE, Borodkin VS, Albarbarawi O, van Aalten DMF.

Nat Struct Mol Biol. 2015 Sep;22(9):744-750. doi: 10.1038/nsmb.3063. Epub 2015 Aug 3.

27.

Tyrosine glycosylation of Rho by Yersinia toxin impairs blastomere cell behaviour in zebrafish embryos.

Jank T, Eckerle S, Steinemann M, Trillhaase C, Schimpl M, Wiese S, van Aalten DM, Driever W, Aktories K.

Nat Commun. 2015 Jul 20;6:7807. doi: 10.1038/ncomms8807.

28.

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.

Kazlauskaite A, Martínez-Torres RJ, Wilkie S, Kumar A, Peltier J, Gonzalez A, Johnson C, Zhang J, Hope AG, Peggie M, Trost M, van Aalten DM, Alessi DR, Prescott AR, Knebel A, Walden H, Muqit MM.

EMBO Rep. 2015 Aug;16(8):939-54. doi: 10.15252/embr.201540352. Epub 2015 Jun 25.

29.

The Early Metazoan Trichoplax adhaerens Possesses a Functional O-GlcNAc System.

Selvan N, Mariappa D, van den Toorn HW, Heck AJ, Ferenbach AT, van Aalten DM.

J Biol Chem. 2015 May 8;290(19):11969-82. doi: 10.1074/jbc.M114.628750. Epub 2015 Mar 16.

30.

N-myristoyltransferase is a cell wall target in Aspergillus fumigatus.

Fang W, Robinson DA, Raimi OG, Blair DE, Harrison JR, Lockhart DE, Torrie LS, Ruda GF, Wyatt PG, Gilbert IH, van Aalten DM.

ACS Chem Biol. 2015 Jun 19;10(6):1425-34. doi: 10.1021/cb5008647. Epub 2015 Feb 27.

31.

Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1.

Zhang N, Gordon SL, Fritsch MJ, Esoof N, Campbell DG, Gourlay R, Velupillai S, Macartney T, Peggie M, van Aalten DM, Cousin MA, Alessi DR.

J Neurosci. 2015 Feb 11;35(6):2492-507. doi: 10.1523/JNEUROSCI.4248-14.2015.

32.

O-GlcNAcase: promiscuous hexosaminidase or key regulator of O-GlcNAc signaling?

Alonso J, Schimpl M, van Aalten DM.

J Biol Chem. 2014 Dec 12;289(50):34433-9. doi: 10.1074/jbc.R114.609198. Epub 2014 Oct 21. Review.

33.

Screening-based discovery of Aspergillus fumigatus plant-type chitinase inhibitors.

Lockhart DE, Schuettelkopf A, Blair DE, van Aalten DM.

FEBS Lett. 2014 Aug 25;588(17):3282-90. doi: 10.1016/j.febslet.2014.07.015. Epub 2014 Jul 22.

34.

A structural and biochemical model of processive chitin synthesis.

Dorfmueller HC, Ferenbach AT, Borodkin VS, van Aalten DM.

J Biol Chem. 2014 Aug 15;289(33):23020-8. doi: 10.1074/jbc.M114.563353. Epub 2014 Jun 18.

35.

Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ESC differentiation without affecting naïve to primed cell transition.

Speakman CM, Domke TC, Wongpaiboonwattana W, Sanders K, Mudaliar M, van Aalten DM, Barton GJ, Stavridis MP.

Stem Cells. 2014 Oct;32(10):2605-15. doi: 10.1002/stem.1761.

36.

Bisubstrate UDP-peptide conjugates as human O-GlcNAc transferase inhibitors.

Borodkin VS, Schimpl M, Gundogdu M, Rafie K, Dorfmueller HC, Robinson DA, van Aalten DM.

Biochem J. 2014 Feb 1;457(3):497-502. doi: 10.1042/BJ20131272.

37.

Chemical tools to probe cellular O-GlcNAc signalling.

Ostrowski A, van Aalten DM.

Biochem J. 2013 Nov 15;456(1):1-12. doi: 10.1042/BJ20131081. Review.

PMID:
24156473
38.

Structure of a bacterial putative acetyltransferase defines the fold of the human O-GlcNAcase C-terminal domain.

Rao FV, Schüttelkopf AW, Dorfmueller HC, Ferenbach AT, Navratilova I, van Aalten DM.

Open Biol. 2013 Oct 2;3(10):130021. doi: 10.1098/rsob.130021.

39.

Yeast Mnn9 is both a priming glycosyltransferase and an allosteric activator of mannan biosynthesis.

Striebeck A, Robinson DA, Schüttelkopf AW, van Aalten DM.

Open Biol. 2013 Sep 11;3(9):130022. doi: 10.1098/rsob.130022.

40.

BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm.

Hobley L, Ostrowski A, Rao FV, Bromley KM, Porter M, Prescott AR, MacPhee CE, van Aalten DM, Stanley-Wall NR.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13600-5. doi: 10.1073/pnas.1306390110. Epub 2013 Jul 31. Erratum in: Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):E5371-5.

41.

Genetic and structural validation of Aspergillus fumigatus N-acetylphosphoglucosamine mutase as an antifungal target.

Fang W, Du T, Raimi OG, Hurtado-Guerrero R, Mariño K, Ibrahim AF, Albarbarawi O, Ferguson MA, Jin C, Van Aalten DM.

Biosci Rep. 2013 Sep 4;33(5). pii: e00063. doi: 10.1042/BSR20130053.

42.

A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei.

Urbaniak MD, Collie IT, Fang W, Aristotelous T, Eskilsson S, Raimi OG, Harrison J, Navratilova IH, Frearson JA, van Aalten DM, Ferguson MA.

ACS Chem Biol. 2013 Sep 20;8(9):1981-7. doi: 10.1021/cb400411x. Epub 2013 Jul 18.

43.

Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as an antifungal target.

Fang W, Du T, Raimi OG, Hurtado-Guerrero R, Urbaniak MD, Ibrahim AF, Ferguson MA, Jin C, van Aalten DM.

Mol Microbiol. 2013 Aug;89(3):479-93. doi: 10.1111/mmi.12290. Epub 2013 Jul 5.

44.

A sweet TET-à-tête-synergy of TET proteins and O-GlcNAc transferase in transcription.

Mariappa D, Pathak S, van Aalten DM.

EMBO J. 2013 Mar 6;32(5):612-3. doi: 10.1038/emboj.2013.26. Epub 2013 Feb 12.

45.

Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry.

Hahne H, Sobotzki N, Nyberg T, Helm D, Borodkin VS, van Aalten DM, Agnew B, Kuster B.

J Proteome Res. 2013 Feb 1;12(2):927-36. doi: 10.1021/pr300967y. Epub 2013 Jan 18.

46.

O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis.

Schimpl M, Zheng X, Borodkin VS, Blair DE, Ferenbach AT, Schüttelkopf AW, Navratilova I, Aristotelous T, Albarbarawi O, Robinson DA, Macnaughtan MA, van Aalten DM.

Nat Chem Biol. 2012 Dec;8(12):969-74. doi: 10.1038/nchembio.1108. Epub 2012 Oct 28.

47.

Structural and biochemical characterization of a trapped coenzyme A adduct of Caenorhabditis elegans glucosamine-6-phosphate N-acetyltransferase 1.

Dorfmueller HC, Fang W, Rao FV, Blair DE, Attrill H, van Aalten DM.

Acta Crystallogr D Biol Crystallogr. 2012 Aug;68(Pt 8):1019-29. doi: 10.1107/S0907444912019592. Epub 2012 Jul 17.

48.

Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide-binding properties.

Schimpl M, Rush CL, Betou M, Eggleston IM, Recklies AD, van Aalten DM.

Biochem J. 2012 Aug 15;446(1):149-57. doi: 10.1042/BJ20120377.

49.

Purification, crystallization and preliminary X-ray diffraction data of UDP-galactopyranose mutase from Aspergillus fumigatus.

Penman GA, Lockhart DE, Ferenbach A, van Aalten DM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jun 1;68(Pt 6):705-8. doi: 10.1107/S1744309112017915. Epub 2012 May 23.

50.

Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations.

Woodroof HI, Pogson JH, Begley M, Cantley LC, Deak M, Campbell DG, van Aalten DM, Whitworth AJ, Alessi DR, Muqit MM.

Open Biol. 2011 Nov;1(3):110012. doi: 10.1098/rsob.110012.

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