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Young children experience little emotional burden during invasive procedures in asthma research.

Padding AM, Rutjes NW, Hashimoto S, Vos A, Staphorst MS, van Aalderen WMC, van der Schee MP.

Eur J Pediatr. 2019 Feb;178(2):207-211. doi: 10.1007/s00431-018-3265-0. Epub 2018 Nov 3.


A minimally invasive tool to study immune response and skin barrier in children with atopic dermatitis.

Hulshof L, Hack DP, Hasnoe QCJ, Dontje B, Jakasa I, Riethmüller C, McLean WHI, van Aalderen WMC, Van't Land B, Kezic S, Sprikkelman AB, Middelkamp-Hup MA.

Br J Dermatol. 2019 Mar;180(3):621-630. doi: 10.1111/bjd.16994. Epub 2018 Oct 14.


Exploring Immune Development in Infants With Moderate to Severe Atopic Dermatitis.

Hulshof L, Overbeek SA, Wyllie AL, Chu MLJN, Bogaert D, de Jager W, Knippels LMJ, Sanders EAM, van Aalderen WMC, Garssen J, Van't Land B, Sprikkelman AB; Clinical Study Group.

Front Immunol. 2018 Mar 29;9:630. doi: 10.3389/fimmu.2018.00630. eCollection 2018.


Exposure to Environmental Contaminants and Lung Function in Adolescents-Is There a Link?

Leijs MM, Koppe JG, Olie K, de Voogt P, van Aalderen WMC, Ten Tusscher GW.

Int J Environ Res Public Health. 2018 Jun 27;15(7). pii: E1352. doi: 10.3390/ijerph15071352.


Severe Paediatric Asthma Collaborative in Europe (SPACE): protocol for a European registry.

Liu NM, van Aalderen W, Carlsen KCL, Coleman C, Chalmers JD, Cunningham S, Fernandes RM, Fleming LJ, Gappa M, Karadag B, Midulla F, Pijnenburg MWH, Rutjes NW, Rusconi F, Grigg J.

Breathe (Sheff). 2018 Jun;14(2):93-98. doi: 10.1183/20734735.002018. Review.


Harmonizing the Nomenclature for Therapeutic Aerosol Particle Size: A Proposal.

Hillyer EV, Price DB, Chrystyn H, Martin RJ, Israel E, van Aalderen WMC, Papi A, Usmani OS, Roche N.

J Aerosol Med Pulm Drug Deliv. 2018 Apr;31(2):111-113. doi: 10.1089/jamp.2017.1396. Epub 2017 Nov 28. No abstract available.


Extrafine Versus Fine Inhaled Corticosteroids in Relation to Asthma Control: A Systematic Review and Meta-Analysis of Observational Real-Life Studies.

Sonnappa S, McQueen B, Postma DS, Martin RJ, Roche N, Grigg J, Guilbert T, Gouder C, Pizzichini E, Niimi A, Phipatanakul W, Chisholm A, Dandurand RJ, Kaplan A, Israel E, Papi A, van Aalderen WMC, Usmani OS, Price DB.

J Allergy Clin Immunol Pract. 2018 May - Jun;6(3):907-915.e7. doi: 10.1016/j.jaip.2017.07.032. Epub 2017 Sep 20.


Alterations in the programming of energy metabolism in adolescents with background exposure to dioxins, dl-PCBs and PBDEs.

Leijs MM, Koppe JG, Vulsma T, Olie K, van Aalderen WMC, de Voogt P, Legler J, Ten Tusscher GW.

PLoS One. 2017 Sep 12;12(9):e0184006. doi: 10.1371/journal.pone.0184006. eCollection 2017.


BMI predicts exercise induced bronchoconstriction in asthmatic boys.

van Veen WJ, Driessen JMM, Kersten ETG, van Leeuwen JC, Brusse-Keizer MGJ, van Aalderen WMC, Thio BJ.

Pediatr Pulmonol. 2017 Sep;52(9):1130-1134. doi: 10.1002/ppul.23758. Epub 2017 Jul 11.


Risk of pneumonia in obstructive lung disease: A real-life study comparing extra-fine and fine-particle inhaled corticosteroids.

Sonnappa S, Martin R, Israel E, Postma D, van Aalderen W, Burden A, Usmani OS, Price DB; Respiratory Effectiveness Group, Small Airways Study Group.

PLoS One. 2017 Jun 15;12(6):e0178112. doi: 10.1371/journal.pone.0178112. eCollection 2017.


Real-Life Outcomes for Patients with Asthma Prescribed Spacers for Use with Either Extrafine- or Fine-Particle Inhaled Corticosteroids.

Guilbert TW, Colice G, Grigg J, van Aalderen W, Martin RJ, Israel E, Postma DS, Roche N, Phipatanakul W, Hillyer EV, Evans JM, Dolovich MB, Price DB; Respiratory Effectiveness Group.

J Allergy Clin Immunol Pract. 2017 Jul - Aug;5(4):1040-1049.e4. doi: 10.1016/j.jaip.2016.11.026. Epub 2017 Jan 18.


Asthma-Related Outcomes in Patients Initiating Extrafine Ciclesonide or Fine-Particle Inhaled Corticosteroids.

Postma DS, Dekhuijzen R, van der Molen T, Martin RJ, van Aalderen W, Roche N, Guilbert TW, Israel E, van Eickels D, Khalid JM, Herings RM, Overbeek JA, Miglio C, Thomas V, Hutton C, Hillyer EV, Price DB.

Allergy Asthma Immunol Res. 2017 Mar;9(2):116-125. doi: 10.4168/aair.2017.9.2.116.


Add-on LABA in a separate inhaler as asthma step-up therapy versus increased dose of ICS or ICS/LABA combination inhaler.

Price DB, Colice G, Israel E, Roche N, Postma DS, Guilbert TW, van Aalderen WM, Grigg J, Hillyer EV, Thomas V, Martin RJ.

ERJ Open Res. 2016 May 26;2(2). pii: 00106-2015. eCollection 2016 Apr.


Erratum to: Effectiveness of initiating extrafine-particle versus fine-particle inhaled corticosteroids as asthma therapy in the Netherlands.

van der Molen T, Postma DS, Martin RJ, Herings RM, Overbeek JA, Thomas V, Miglio C, Dekhuijzen R, Roche N, Guilbert T, Israel E, van Aalderen W, Hillyer EV, van Rysewyk S, Price DB.

BMC Pulm Med. 2016 Jul 23;16(1):105. doi: 10.1186/s12890-016-0270-9. No abstract available.


Prevalence of rhinoviruses in young children of an unselected birth cohort from the Netherlands.

Wildenbeest JG, van der Schee MP, Hashimoto S, Benschop KS, Minnaar RP, Sprikkelman AB, Haarman EG, van Aalderen WM, Sterk PJ, Pajkrt D, Wolthers KC.

Clin Microbiol Infect. 2016 Aug;22(8):736.e9-736.e15. doi: 10.1016/j.cmi.2016.05.022. Epub 2016 Jun 3.


Effectiveness of initiating extrafine-particle versus fine-particle inhaled corticosteroids as asthma therapy in the Netherlands.

van der Molen T, Postma DS, Martin RJ, Herings RM, Overbeek JA, Thomas V, Miglio C, Dekhuijzen R, Roche N, Guilbert T, Israel E, van Aalderen W, Hillyer EV, van Rysewyk S, Price DB.

BMC Pulm Med. 2016 May 17;16(1):80. doi: 10.1186/s12890-016-0234-0. Erratum in: BMC Pulm Med. 2016;16(1):105.


Biomarkers in Exhaled Breath Condensate Are Not Predictive for Pulmonary Exacerbations in Children with Cystic Fibrosis: Results of a One-Year Observational Study.

van Horck M, Alonso A, Wesseling G, de Winter-de Groot K, van Aalderen W, Hendriks H, Winkens B, Rijkers G, Jöbsis Q, Dompeling E.

PLoS One. 2016 Apr 6;11(4):e0152156. doi: 10.1371/journal.pone.0152156. eCollection 2016.


CT-abnormalities, bacteriology and symptoms of sinonasal disease in children with Cystic Fibrosis.

Berkhout MC, Klerx-Melis F, Fokkens WJ, Nuijsink M, van Aalderen WM, Heijerman HG.

J Cyst Fibros. 2016 Nov;15(6):816-824. doi: 10.1016/j.jcf.2016.03.004. Epub 2016 Apr 3.



van Aalderen WM, Grigg J, Guilbert TW, Roche N, Colice G, Postma DS, Hillyer EV, Price DB.

J Allergy Clin Immunol Pract. 2016 Mar-Apr;4(2):372-3. doi: 10.1016/j.jaip.2015.12.006. No abstract available.


Stability and predictiveness of multiple trigger and episodic viral wheeze in preschoolers.

van Wonderen KE, Geskus RB, van Aalderen WM, Mohrs J, Bindels PJ, van der Mark LB, Ter Riet G.

Clin Exp Allergy. 2016 Jun;46(6):837-47. doi: 10.1111/cea.12660.


The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts.

Fleming L, Murray C, Bansal AT, Hashimoto S, Bisgaard H, Bush A, Frey U, Hedlin G, Singer F, van Aalderen WM, Vissing NH, Zolkipli Z, Selby A, Fowler S, Shaw D, Chung KF, Sousa AR, Wagers S, Corfield J, Pandis I, Rowe A, Formaggio E, Sterk PJ, Roberts G; U-BIOPRED Study Group.

Eur Respir J. 2015 Nov;46(5):1322-33. doi: 10.1183/13993003.00780-2015. Epub 2015 Sep 24. Erratum in: Eur Respir J. 2017 Jun 22;49(6):.


Small-particle Inhaled Corticosteroid as First-line or Step-up Controller Therapy in Childhood Asthma.

van Aalderen WM, Grigg J, Guilbert TW, Roche N, Israel E, Martin RJ, Colice G, Postma DS, Hillyer EV, Burden A, Thomas V, von Ziegenweidt J, Price D.

J Allergy Clin Immunol Pract. 2015 Sep-Oct;3(5):721-31.e16. doi: 10.1016/j.jaip.2015.04.012. Epub 2015 May 29.


Differential effects of inhaled corticosteroids in smokers/ex-smokers and nonsmokers with asthma.

Roche N, Postma DS, Colice G, Burden A, Guilbert TW, Israel E, Martin RJ, van Aalderen WM, Grigg J, Hillyer EV, von Ziegenweidt J, Price DB.

Am J Respir Crit Care Med. 2015 Apr 15;191(8):960-4. doi: 10.1164/rccm.201411-2116LE. No abstract available.


The Trigger Tool as a Method to Measure Harmful Medication Errors in Children.

Maaskant JM, Smeulers M, Bosman D, Busink A, van Rijn-Bikker P, van Aalderen W, Vermeulen H.

J Patient Saf. 2018 Jun;14(2):95-100. doi: 10.1097/PTS.0000000000000177.


Increased Dose of Inhaled Corticosteroid versus Add-On Long-acting β-Agonist for Step-Up Therapy in Asthma.

Israel E, Roche N, Martin RJ, Colice G, Dorinsky PM, Postma DS, Guilbert TW, van Aalderen WM, Grigg J, Hillyer EV, Burden A, von Ziegenweidt J, Thomas V, Price DB.

Ann Am Thorac Soc. 2015 Jun;12(6):798-806. doi: 10.1513/AnnalsATS.201412-580OC.


How to match the optimal currently available inhaler device to an individual child with asthma or recurrent wheeze.

van Aalderen WM, Garcia-Marcos L, Gappa M, Lenney W, Pedersen S, Dekhuijzen R, Price D.

NPJ Prim Care Respir Med. 2015 Jan 8;25:14088. doi: 10.1038/npjpcrm.2014.88. Review.


Breathomics in lung disease.

van der Schee MP, Paff T, Brinkman P, van Aalderen WMC, Haarman EG, Sterk PJ.

Chest. 2015 Jan;147(1):224-231. doi: 10.1378/chest.14-0781. Review.


Remaining symptoms in half the children treated for milk allergy.

Petrus NC, Schoemaker AF, van Hoek MW, Jansen L, Jansen-van der Weide MC, van Aalderen WM, Sprikkelman AB.

Eur J Pediatr. 2015 Jun;174(6):759-65. doi: 10.1007/s00431-014-2456-6. Epub 2014 Nov 22.


Comparing the effectiveness of small-particle versus large-particle inhaled corticosteroid in COPD.

Postma DS, Roche N, Colice G, Israel E, Martin RJ, van Aalderen WM, Grigg J, Burden A, Hillyer EV, von Ziegenweidt J, Gopalan G, Price D.

Int J Chron Obstruct Pulmon Dis. 2014 Oct 17;9:1163-86. doi: 10.2147/COPD.S68289. eCollection 2014.


Altered exhaled biomarker profiles in children during and after rhinovirus-induced wheeze.

van der Schee MP, Hashimoto S, Schuurman AC, van Driel JS, Adriaens N, van Amelsfoort RM, Snoeren T, Regenboog M, Sprikkelman AB, Haarman EG, van Aalderen WM, Sterk PJ.

Eur Respir J. 2015 Feb;45(2):440-8. doi: 10.1183/09031936.00044414. Epub 2014 Oct 16.


Cost-effectiveness of initiating extrafine- or standard size-particle inhaled corticosteroid for asthma in two health-care systems: a retrospective matched cohort study.

Martin RJ, Price D, Roche N, Israel E, van Aalderen WM, Grigg J, Postma DS, Guilbert TW, Hillyer EV, Burden A, von Ziegenweidt J, Colice G.

NPJ Prim Care Respir Med. 2014 Oct 9;24:14081. doi: 10.1038/npjpcrm.2014.81.


Inpatient treatment of children and adolescents with severe obesity in the Netherlands: a randomized clinical trial.

van der Baan-Slootweg O, Benninga MA, Beelen A, van der Palen J, Tamminga-Smeulders C, Tijssen JG, van Aalderen WM.

JAMA Pediatr. 2014 Sep;168(9):807-14. doi: 10.1001/jamapediatrics.2014.521.


Comment on: prenatal exposure to acid-suppressive drugs and the risk of allergic disease in the offspring: a cohort study.

Petrus NC, Thomasse YE, Sprikkelman AB, van Aalderen WM, ten Tusscher GW.

Clin Exp Allergy. 2014 Jul;44(7):1003-4. doi: 10.1111/cea.12336. No abstract available.


Exclusively breastfed infants at risk for false negative double blind placebo controlled milk challenge.

Petrus NC, Kole EA, Schoemaker AA, van Aalderen WM, Sprikkelman AB.

Eur Ann Allergy Clin Immunol. 2014 Jan;46(1):43-5.


Predicting asthma in preschool children at high risk presenting in primary care: development of a clinical asthma prediction score.

van der Mark LB, van Wonderen KE, Mohrs J, van Aalderen WM, ter Riet G, Bindels PJ.

Prim Care Respir J. 2014 Mar;23(1):52-9. doi: 10.4104/pcrj.2014.00003.


Abusive head trauma: differentiation between impact and non-impact cases based on neuroimaging findings and skeletal surveys.

Sieswerda-Hoogendoorn T, Robben SG, Karst WA, Moesker FM, van Aalderen WM, Laméris JS, van Rijn RR.

Eur J Radiol. 2014 Mar;83(3):584-8. doi: 10.1016/j.ejrad.2013.11.015. Epub 2013 Dec 4.


Problematic severe asthma in children treated at high altitude: tapering the dose while improving control.

van de Griendt EJ, Verkleij M, Douwes JM, van Aalderen WM, Geenen R.

J Asthma. 2014 Apr;51(3):315-9. doi: 10.3109/02770903.2013.871557. Epub 2014 Jan 9.


Prescription of inhalers in asthma and COPD: towards a rational, rapid and effective approach.

Dekhuijzen PN, Vincken W, Virchow JC, Roche N, Agusti A, Lavorini F, van Aalderen WM, Price D.

Respir Med. 2013 Dec;107(12):1817-21. doi: 10.1016/j.rmed.2013.09.013. Epub 2013 Sep 25. Review.


Preventable errors with nonopioid analgesics and antiemetic drugs may increase burden in surgical pediatric patients.

Maaskant J, Bosman D, van Rijn-Bikker P, van Aalderen W, Vermeulen H.

Eur J Pediatr Surg. 2014 Oct;24(5):381-8. doi: 10.1055/s-0033-1352526. Epub 2013 Aug 21.


High-alert medications for pediatric patients: an international modified Delphi study.

Maaskant JM, Eskes A, van Rijn-Bikker P, Bosman D, van Aalderen W, Vermeulen H.

Expert Opin Drug Saf. 2013 Nov;12(6):805-14. doi: 10.1517/14740338.2013.825247. Epub 2013 Aug 10.


Abusive head trauma in young children in the Netherlands: evidence for multiple incidents of abuse.

Sieswerda-Hoogendoorn T, Bilo RA, van Duurling LL, Karst WA, Maaskant JM, van Aalderen WM, van Rijn RR.

Acta Paediatr. 2013 Nov;102(11):e497-501. doi: 10.1111/apa.12377. Epub 2013 Aug 27.


From knemometry to final adult height: inhaled corticosteroids and their effect on growth in childhood.

de Vreede I, Haarman EG, Sprikkelman AB, van Aalderen WM.

Paediatr Respir Rev. 2013 Jun;14(2):107-11; quiz 111, 137-8. doi: 10.1016/j.prrv.2012.05.001. Epub 2012 Jun 9. Review.


Nurse versus physician-led care for the management of asthma.

Kuethe MC, Vaessen-Verberne AA, Elbers RG, Van Aalderen WM.

Cochrane Database Syst Rev. 2013 Feb 28;(2):CD009296. doi: 10.1002/14651858.CD009296.pub2. Review.


Towards better triage of infants suspected of cow's milk allergy: development of a preliminary multivariable diagnostic index.

van Thuijl A, Schoemaker AF, Menting S, van Dulmen J, Boeting J, van Aalderen W, ter Riet G, Sprikkelman A.

Eur J Pediatr. 2013 Mar;172(3):385-91. doi: 10.1007/s00431-012-1900-8. Epub 2012 Dec 8.


Gain in lung function after weight reduction in severely obese children.

van de Griendt EJ, van der Baan-Slootweg OH, van Essen-Zandvliet EE, van der Palen J, Tamminga-Smeulders CL, Benninga MA, van Aalderen WM.

Arch Dis Child. 2012 Dec;97(12):1039-42. doi: 10.1136/archdischild-2011-301304. Epub 2012 Oct 16.


A systematic review with attempted network meta-analysis of asthma therapy recommended for five to eighteen year olds in GINA steps three and four.

van der Mark LB, Lyklema PH, Geskus RB, Mohrs J, Bindels PJ, van Aalderen WM, Ter Riet G.

BMC Pulm Med. 2012 Oct 15;12:63. doi: 10.1186/1471-2466-12-63. Review.


Assessing quality of care in pediatric asthma: applicability of a revised version of the QUOTE-CNSLD questionnaire.

Kuethe MC, Sixma HJ, Vaessen-Verberne AA, Booij JC, van Aalderen WM.

J Asthma. 2012 Nov;49(9):966-76. doi: 10.3109/02770903.2012.721434. Epub 2012 Oct 1.


Response to: Cost-effectiveness of using an extensively hydrolysed formula compared to an amino acid formula as first-line treatment for cow milk allergy in the UK.

Petrus NC, Hulshof L, Rutjes NW, de Vreede I, van Aalderen WM, Sprikkelman AB.

Pediatr Allergy Immunol. 2012 Nov;23(7):686; author reply 687. doi: 10.1111/j.1399-3038.2012.01311.x. Epub 2012 Sep 18. No abstract available.


Inspiratory airflow limitation after exercise challenge in cold air in asthmatic children.

Driessen JM, van der Palen J, van Aalderen WM, de Jongh FH, Thio BJ.

Respir Med. 2012 Oct;106(10):1362-8. doi: 10.1016/j.rmed.2012.06.017. Epub 2012 Jul 11.


Thyroid hormone metabolism and environmental chemical exposure.

Leijs MM, ten Tusscher GW, Olie K, van Teunenbroek T, van Aalderen WM, de Voogt P, Vulsma T, Bartonova A, Krayer von Krauss M, Mosoiu C, Riojas-Rodriguez H, Calamandrei G, Koppe JG.

Environ Health. 2012 Jun 28;11 Suppl 1:S10. doi: 10.1186/1476-069X-11-S1-S10.

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