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Items: 25


Type 2 diabetes-related proteins derived from an in vitro model of inflamed fat tissue.

Ten Klooster JP, Sotiriou A, Boeren S, Vaessen S, Vervoort J, Pieters R.

Arch Biochem Biophys. 2018 Apr 15;644:81-92. doi: 10.1016/ Epub 2018 Mar 8.


N-Docosahexaenoyl Dopamine, an Endocannabinoid-like Conjugate of Dopamine and the n-3 Fatty Acid Docosahexaenoic Acid, Attenuates Lipopolysaccharide-Induced Activation of Microglia and Macrophages via COX-2.

Wang Y, Plastina P, Vincken JP, Jansen R, Balvers M, Ten Klooster JP, Gruppen H, Witkamp R, Meijerink J.

ACS Chem Neurosci. 2017 Mar 15;8(3):548-557. doi: 10.1021/acschemneuro.6b00298. Epub 2016 Dec 6.


The Noncaloric Sweetener Rebaudioside A Stimulates Glucagon-Like Peptide 1 Release and Increases Enteroendocrine Cell Numbers in 2-Dimensional Mouse Organoids Derived from Different Locations of the Intestine.

van der Wielen N, Ten Klooster JP, Muckenschnabl S, Pieters R, Hendriks HF, Witkamp RF, Meijerink J.

J Nutr. 2016 Dec;146(12):2429-2435. Epub 2016 Oct 26.


Docosahexaenoyl serotonin, an endogenously formed n-3 fatty acid-serotonin conjugate has anti-inflammatory properties by attenuating IL-23-IL-17 signaling in macrophages.

Poland M, Ten Klooster JP, Wang Z, Pieters R, Boekschoten M, Witkamp R, Meijerink J.

Biochim Biophys Acta. 2016 Dec;1861(12 Pt A):2020-2028. doi: 10.1016/j.bbalip.2016.09.012. Epub 2016 Sep 20.


Rap2A links intestinal cell polarity to brush border formation.

Gloerich M, ten Klooster JP, Vliem MJ, Koorman T, Zwartkruis FJ, Clevers H, Bos JL.

Nat Cell Biol. 2012 Aug;14(8):793-801. doi: 10.1038/ncb2537. Epub 2012 Jul 15.


Rac controls PIP5K localisation and PtdIns(4,5)P₂ synthesis, which modulates vinculin localisation and neurite dynamics.

Halstead JR, Savaskan NE, van den Bout I, Van Horck F, Hajdo-Milasinovic A, Snell M, Keune WJ, Ten Klooster JP, Hordijk PL, Divecha N.

J Cell Sci. 2010 Oct 15;123(Pt 20):3535-46. doi: 10.1242/jcs.062679. Epub 2010 Sep 14.


A Rac1 inhibitory peptide suppresses antibody production and paw swelling in the murine collagen-induced arthritis model of rheumatoid arthritis.

Abreu JR, Dontje W, Krausz S, de Launay D, van Hennik PB, van Stalborch AM, Ten Klooster JP, Sanders ME, Reedquist KA, Vervoordeldonk MJ, Hordijk PL, Tak PP.

Arthritis Res Ther. 2010;12(1):R2. doi: 10.1186/ar2900. Epub 2010 Jan 6.


LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism.

Jansen M, Ten Klooster JP, Offerhaus GJ, Clevers H.

Physiol Rev. 2009 Jul;89(3):777-98. doi: 10.1152/physrev.00026.2008. Review.


Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.

ten Klooster JP, Jansen M, Yuan J, Oorschot V, Begthel H, Di Giacomo V, Colland F, de Koning J, Maurice MM, Hornbeck P, Clevers H.

Dev Cell. 2009 Apr;16(4):551-62. doi: 10.1016/j.devcel.2009.01.016.


Rac1-induced cell migration requires membrane recruitment of the nuclear oncogene SET.

ten Klooster JP, Leeuwen Iv, Scheres N, Anthony EC, Hordijk PL.

EMBO J. 2007 Jan 24;26(2):336-45.


Targeting and localized signalling by small GTPases.

ten Klooster JP, Hordijk PL.

Biol Cell. 2007 Jan;99(1):1-12. Review.


Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization.

Ten Klooster JP, Evers EE, Janssen L, Machesky LM, Michiels F, Hordijk P, Collard JG.

Biochem J. 2006 Jul 1;397(1):39-45.


Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix.

ten Klooster JP, Jaffer ZM, Chernoff J, Hordijk PL.

J Cell Biol. 2006 Feb 27;172(5):759-69. Epub 2006 Feb 21.


Small GTP-binding protein Ral is involved in cAMP-mediated release of von Willebrand factor from endothelial cells.

Rondaij MG, Sellink E, Gijzen KA, ten Klooster JP, Hordijk PL, van Mourik JA, Voorberg J.

Arterioscler Thromb Vasc Biol. 2004 Jul;24(7):1315-20. Epub 2004 May 6.


Calcium signaling regulates translocation and activation of Rac.

Price LS, Langeslag M, ten Klooster JP, Hordijk PL, Jalink K, Collard JG.

J Biol Chem. 2003 Oct 10;278(41):39413-21. Epub 2003 Jul 29.


The C-terminal domain of Rac1 contains two motifs that control targeting and signaling specificity.

van Hennik PB, ten Klooster JP, Halstead JR, Voermans C, Anthony EC, Divecha N, Hordijk PL.

J Biol Chem. 2003 Oct 3;278(40):39166-75. Epub 2003 Jul 21.


VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigration.

van Wetering S, van den Berk N, van Buul JD, Mul FP, Lommerse I, Mous R, ten Klooster JP, Zwaginga JJ, Hordijk PL.

Am J Physiol Cell Physiol. 2003 Aug;285(2):C343-52. Epub 2003 Apr 16.


Determination of the activity of Rho-like GTPases in cells.

Malliri A, ten Klooster JP, Olivio C, Collard JG.

Methods Mol Biol. 2002;189:99-109. No abstract available.


Reactive oxygen species mediate Rac-induced loss of cell-cell adhesion in primary human endothelial cells.

van Wetering S, van Buul JD, Quik S, Mul FP, Anthony EC, ten Klooster JP, Collard JG, Hordijk PL.

J Cell Sci. 2002 May 1;115(Pt 9):1837-46.


Rho-like GTPases in tumor cell invasion.

Evers EE, van der Kammen RA, ten Klooster JP, Collard JG.

Methods Enzymol. 2000;325:403-15. No abstract available.


Rho family proteins in cell adhesion and cell migration.

Evers EE, Zondag GC, Malliri A, Price LS, ten Klooster JP, van der Kammen RA, Collard JG.

Eur J Cancer. 2000 Jun;36(10):1269-74. Review.


Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition.

Zondag GC, Evers EE, ten Klooster JP, Janssen L, van der Kammen RA, Collard JG.

J Cell Biol. 2000 May 15;149(4):775-82.


Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior.

Sander EE, ten Klooster JP, van Delft S, van der Kammen RA, Collard JG.

J Cell Biol. 1999 Nov 29;147(5):1009-22.


Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase.

Sander EE, van Delft S, ten Klooster JP, Reid T, van der Kammen RA, Michiels F, Collard JG.

J Cell Biol. 1998 Nov 30;143(5):1385-98.


Inhibition of invasion of epithelial cells by Tiam1-Rac signaling.

Hordijk PL, ten Klooster JP, van der Kammen RA, Michiels F, Oomen LC, Collard JG.

Science. 1997 Nov 21;278(5342):1464-6.

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