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Items: 1 to 50 of 365

1.

TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis.

Hao Y, Baker D, Ten Dijke P.

Int J Mol Sci. 2019 Jun 5;20(11). pii: E2767. doi: 10.3390/ijms20112767. Review.

2.

Epigenetic Reprogramming of TGF-β Signaling in Breast Cancer.

Suriyamurthy S, Baker D, Ten Dijke P, Iyengar PV.

Cancers (Basel). 2019 May 24;11(5). pii: E726. doi: 10.3390/cancers11050726. Review.

3.

Combined Inhibition of TGF-β Signaling and the PD-L1 Immune Checkpoint Is Differentially Effective in Tumor Models.

Sow HS, Ren J, Camps M, Ossendorp F, Ten Dijke P.

Cells. 2019 Apr 5;8(4). pii: E320. doi: 10.3390/cells8040320.

4.

TGF-β Family Signaling Pathways in Cellular Dormancy.

Prunier C, Baker D, Ten Dijke P, Ritsma L.

Trends Cancer. 2019 Jan;5(1):66-78. doi: 10.1016/j.trecan.2018.10.010. Epub 2018 Nov 28. Review.

PMID:
30616757
5.

Inflammation induces endothelial-to-mesenchymal transition and promotes vascular calcification through downregulation of BMPR2.

Sánchez-Duffhues G, García de Vinuesa A, van de Pol V, Geerts ME, de Vries MR, Janson SG, van Dam H, Lindeman JH, Goumans MJ, Ten Dijke P.

J Pathol. 2019 Mar;247(3):333-346. doi: 10.1002/path.5193. Epub 2019 Jan 16.

PMID:
30430573
6.

Bone morphogenetic protein receptor signal transduction in human disease.

Gomez-Puerto MC, Iyengar PV, García de Vinuesa A, Ten Dijke P, Sanchez-Duffhues G.

J Pathol. 2019 Jan;247(1):9-20. doi: 10.1002/path.5170. Epub 2018 Nov 27. Review.

PMID:
30246251
7.

The therapeutic potential of targeting the endothelial-to-mesenchymal transition.

Man S, Sanchez Duffhues G, Ten Dijke P, Baker D.

Angiogenesis. 2019 Feb;22(1):3-13. doi: 10.1007/s10456-018-9639-0. Epub 2018 Aug 3. Review.

8.

Epithelial-mesenchymal-transition-inducing transcription factors: new targets for tackling chemoresistance in cancer?

van Staalduinen J, Baker D, Ten Dijke P, van Dam H.

Oncogene. 2018 Jul 12. doi: 10.1038/s41388-018-0378-x. [Epub ahead of print] Review.

PMID:
30002444
9.

Endoglin Expression on Cancer-Associated Fibroblasts Regulates Invasion and Stimulates Colorectal Cancer Metastasis.

Paauwe M, Schoonderwoerd MJA, Helderman RFCP, Harryvan TJ, Groenewoud A, van Pelt GW, Bor R, Hemmer DM, Versteeg HH, Snaar-Jagalska BE, Theuer CP, Hardwick JCH, Sier CFM, Ten Dijke P, Hawinkels LJAC.

Clin Cancer Res. 2018 Dec 15;24(24):6331-6344. doi: 10.1158/1078-0432.CCR-18-0329. Epub 2018 Jun 26.

PMID:
29945992
10.

Bone morphogenetic protein 9 as a key regulator of liver progenitor cells in DDC-induced cholestatic liver injury.

Addante A, Roncero C, Almalé L, Lazcanoiturburu N, García-Álvaro M, Fernández M, Sanz J, Hammad S, Nwosu ZC, Lee SJ, Fabregat I, Dooley S, Ten Dijke P, Herrera B, Sánchez A.

Liver Int. 2018 Sep;38(9):1664-1675. doi: 10.1111/liv.13879. Epub 2018 May 25.

PMID:
29751359
11.

TGF-β family co-receptor function and signaling.

Nickel J, Ten Dijke P, Mueller TD.

Acta Biochim Biophys Sin (Shanghai). 2018 Jan 1;50(1):12-36. doi: 10.1093/abbs/gmx126. Review.

PMID:
29293886
12.

ALK1Fc Suppresses the Human Prostate Cancer Growth in in Vitro and in Vivo Preclinical Models.

Astrologo L, Zoni E, Karkampouna S, Gray PC, Klima I, Grosjean J, Goumans MJ, Hawinkels LJAC, van der Pluijm G, Spahn M, Thalmann GN, Ten Dijke P, Kruithof-de Julio M.

Front Cell Dev Biol. 2017 Dec 5;5:104. doi: 10.3389/fcell.2017.00104. eCollection 2017.

13.

Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7.

Zhang Z, Fan Y, Xie F, Zhou H, Jin K, Shao L, Shi W, Fang P, Yang B, van Dam H, Ten Dijke P, Zheng X, Yan X, Jia J, Zheng M, Jin J, Ding C, Ye S, Zhou F, Zhang L.

Nat Commun. 2017 Dec 13;8(1):2116. doi: 10.1038/s41467-017-02029-7.

14.

JUNB governs a feed-forward network of TGFβ signaling that aggravates breast cancer invasion.

Sundqvist A, Morikawa M, Ren J, Vasilaki E, Kawasaki N, Kobayashi M, Koinuma D, Aburatani H, Miyazono K, Heldin CH, van Dam H, Ten Dijke P.

Nucleic Acids Res. 2018 Feb 16;46(3):1180-1195. doi: 10.1093/nar/gkx1190.

15.

TGF-β-Induced Endothelial-Mesenchymal Transition in Fibrotic Diseases.

Pardali E, Sanchez-Duffhues G, Gomez-Puerto MC, Ten Dijke P.

Int J Mol Sci. 2017 Oct 17;18(10). pii: E2157. doi: 10.3390/ijms18102157. Review.

16.

Endothelial-to-mesenchymal transition in cardiovascular diseases: Developmental signaling pathways gone awry.

Sánchez-Duffhues G, García de Vinuesa A, Ten Dijke P.

Dev Dyn. 2018 Mar;247(3):492-508. doi: 10.1002/dvdy.24589. Epub 2017 Oct 25. Review.

17.

Disparate phospho-Smad2 levels in advanced type 2 diabetes patients with diabetic nephropathy and early experimental db/db mouse model.

Thomsen LH, Fog-Tonnesen M, Nielsen Fink L, Norlin J, García de Vinuesa A, Hansen TK, de Heer E, Ten Dijke P, Rosendahl A.

Ren Fail. 2017 Nov;39(1):629-642. doi: 10.1080/0886022X.2017.1361837.

18.

Bone Morphogenetic Protein 9 Protects against Neonatal Hyperoxia-Induced Impairment of Alveolarization and Pulmonary Inflammation.

Chen X, Orriols M, Walther FJ, Laghmani EH, Hoogeboom AM, Hogen-Esch ACB, Hiemstra PS, Folkerts G, Goumans MTH, Ten Dijke P, Morrell NW, Wagenaar GTM.

Front Physiol. 2017 Jul 13;8:486. doi: 10.3389/fphys.2017.00486. eCollection 2017.

19.

Targeting TGF-β Signaling in Cancer.

Colak S, Ten Dijke P.

Trends Cancer. 2017 Jan;3(1):56-71. doi: 10.1016/j.trecan.2016.11.008. Epub 2017 Jan 3. Review.

PMID:
28718426
20.

TGFβ1-induced SMAD2/3 and SMAD1/5 phosphorylation are both ALK5-kinase-dependent in primary chondrocytes and mediated by TAK1 kinase activity.

van Caam A, Madej W, Garcia de Vinuesa A, Goumans MJ, Ten Dijke P, Blaney Davidson E, van der Kraan P.

Arthritis Res Ther. 2017 May 31;19(1):112. doi: 10.1186/s13075-017-1302-4.

21.

Erratum to: BMP type II receptor as a therapeutic target in pulmonary arterial hypertension.

Orriols M, Gomez-Puerto MC, Ten Dijke P.

Cell Mol Life Sci. 2017 Aug;74(16):2997. doi: 10.1007/s00018-017-2543-8. No abstract available.

PMID:
28536788
22.

Invasive Behavior of Human Breast Cancer Cells in Embryonic Zebrafish.

Ren J, Liu S, Cui C, Ten Dijke P.

J Vis Exp. 2017 Apr 25;(122). doi: 10.3791/55459.

23.

USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling.

Zhou F, Xie F, Jin K, Zhang Z, Clerici M, Gao R, van Dinther M, Sixma TK, Huang H, Zhang L, Ten Dijke P.

EMBO J. 2017 Jun 1;36(11):1623-1639. doi: 10.15252/embj.201695372. Epub 2017 May 3.

24.

BMP type II receptor as a therapeutic target in pulmonary arterial hypertension.

Orriols M, Gomez-Puerto MC, Ten Dijke P.

Cell Mol Life Sci. 2017 Aug;74(16):2979-2995. doi: 10.1007/s00018-017-2510-4. Epub 2017 Apr 26. Review. Erratum in: Cell Mol Life Sci. 2017 May 23;:.

25.

FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis.

Xie F, Jin K, Shao L, Fan Y, Tu Y, Li Y, Yang B, van Dam H, Ten Dijke P, Weng H, Dooley S, Wang S, Jia J, Jin J, Zhou F, Zhang L.

Nat Commun. 2017 Apr 26;8:15021. doi: 10.1038/ncomms15021.

26.

Bone Morphogenetic Proteins in Vascular Homeostasis and Disease.

Goumans MJ, Zwijsen A, Ten Dijke P, Bailly S.

Cold Spring Harb Perspect Biol. 2018 Feb 1;10(2). pii: a031989. doi: 10.1101/cshperspect.a031989. Review.

PMID:
28348038
27.

TGF-β Signaling in Control of Cardiovascular Function.

Goumans MJ, Ten Dijke P.

Cold Spring Harb Perspect Biol. 2018 Feb 1;10(2). pii: a022210. doi: 10.1101/cshperspect.a022210. Review.

PMID:
28348036
28.

BMP-9 interferes with liver regeneration and promotes liver fibrosis.

Breitkopf-Heinlein K, Meyer C, König C, Gaitantzi H, Addante A, Thomas M, Wiercinska E, Cai C, Li Q, Wan F, Hellerbrand C, Valous NA, Hahnel M, Ehlting C, Bode JG, Müller-Bohl S, Klingmüller U, Altenöder J, Ilkavets I, Goumans MJ, Hawinkels LJ, Lee SJ, Wieland M, Mogler C, Ebert MP, Herrera B, Augustin H, Sánchez A, Dooley S, Ten Dijke P.

Gut. 2017 May;66(5):939-954. doi: 10.1136/gutjnl-2016-313314. Epub 2017 Mar 23.

PMID:
28336518
29.

Fluid shear stress-induced TGF-β/ALK5 signaling in renal epithelial cells is modulated by MEK1/2.

Kunnen SJ, Leonhard WN, Semeins C, Hawinkels LJAC, Poelma C, Ten Dijke P, Bakker A, Hierck BP, Peters DJM.

Cell Mol Life Sci. 2017 Jun;74(12):2283-2298. doi: 10.1007/s00018-017-2460-x. Epub 2017 Feb 6.

30.

Hepatocyte-specific Smad7 deletion accelerates DEN-induced HCC via activation of STAT3 signaling in mice.

Feng T, Dzieran J, Yuan X, Dropmann A, Maass T, Teufel A, Marhenke S, Gaiser T, Rückert F, Kleiter I, Kanzler S, Ebert MP, Vogel A, Ten Dijke P, Dooley S, Meindl-Beinker NM.

Oncogenesis. 2017 Jan 30;6(1):e294. doi: 10.1038/oncsis.2016.85.

31.

TMED10 Protein Interferes with Transforming Growth Factor (TGF)-β Signaling by Disrupting TGF-β Receptor Complex Formation.

Nakano N, Tsuchiya Y, Kako K, Umezaki K, Sano K, Ikeno S, Otsuka E, Shigeta M, Nakagawa A, Sakata N, Itoh F, Nakano Y, Iemura SI, van Dinther M, Natsume T, Ten Dijke P, Itoh S.

J Biol Chem. 2017 Mar 10;292(10):4099-4112. doi: 10.1074/jbc.M116.769109. Epub 2017 Jan 23.

32.

Smad2 Phosphorylation in Diabetic Kidney Tubule Epithelial Cells Is Associated with Modulation of Several Transforming Growth Factor-β Family Members.

Høj Thomsen L, Fog-Tonnesen M, Nielsen Fink L, Norlin J, de Vinuesa AG, Krarup Hansen T, de Heer E, Ten Dijke P, Rosendahl A.

Nephron. 2017;135(4):291-306. doi: 10.1159/000453337. Epub 2017 Jan 7.

PMID:
28064277
33.

Fish tales: The use of zebrafish xenograft human cancer cell models.

Drabsch Y, Snaar-Jagalska BE, Ten Dijke P.

Histol Histopathol. 2017 Jul;32(7):673-686. doi: 10.14670/HH-11-853. Epub 2016 Dec 9. Review.

PMID:
27933602
34.

Immunoregulation by members of the TGFβ superfamily.

Chen W, Ten Dijke P.

Nat Rev Immunol. 2016 Nov 25;16(12):723-740. doi: 10.1038/nri.2016.112. Review.

PMID:
27885276
35.

Towards a cure for Fibrodysplasia ossificans progressiva.

Sanchez-Duffhues G, de Gorter DJ, Ten Dijke P.

Ann Transl Med. 2016 Oct;4(Suppl 1):S28. No abstract available.

36.

Emerging regulators of BMP bioavailability.

Sánchez-Duffhues G, Hiepen C, Knaus P, Ten Dijke P.

Bone. 2016 Dec;93:220-221. doi: 10.1016/j.bone.2016.01.022. Epub 2016 Jan 26. No abstract available.

PMID:
26825814
37.

New function of the myostatin/activin type I receptor (ALK4) as a mediator of muscle atrophy and muscle regeneration.

Pasteuning-Vuhman S, Boertje-van der Meulen JW, van Putten M, Overzier M, Ten Dijke P, Kiełbasa SM, Arindrarto W, Wolterbeek R, Lezhnina KV, Ozerov IV, Aliper AM, Hoogaars WM, Aartsma-Rus A, Loomans CJ.

FASEB J. 2017 Jan;31(1):238-255. doi: 10.1096/fj.201600675R. Epub 2016 Oct 12.

38.

Targeting tumour vasculature by inhibiting activin receptor-like kinase (ALK)1 function.

de Vinuesa AG, Bocci M, Pietras K, Ten Dijke P.

Biochem Soc Trans. 2016 Aug 15;44(4):1142-9. doi: 10.1042/BST20160093. Review.

PMID:
27528762
39.

A current perspective on applications of macrocyclic-peptide-based high-affinity ligands.

Leenheer D, Ten Dijke P, Hipolito CJ.

Biopolymers. 2016 Nov;106(6):889-900. doi: 10.1002/bip.22900. Review.

40.

c-Myb Enhances Breast Cancer Invasion and Metastasis through the Wnt/β-Catenin/Axin2 Pathway.

Li Y, Jin K, van Pelt GW, van Dam H, Yu X, Mesker WE, Ten Dijke P, Zhou F, Zhang L.

Cancer Res. 2016 Jun 1;76(11):3364-75. doi: 10.1158/0008-5472.CAN-15-2302. Epub 2016 Apr 5.

41.

Delta-Like Ligand 4 Modulates Liver Damage by Down-Regulating Chemokine Expression.

Shen Z, Liu Y, Dewidar B, Hu J, Park O, Feng T, Xu C, Yu C, Li Q, Meyer C, Ilkavets I, Müller A, Stump-Guthier C, Munker S, Liebe R, Zimmer V, Lammert F, Mertens PR, Li H, Ten Dijke P, Augustin HG, Li J, Gao B, Ebert MP, Dooley S, Li Y, Weng HL.

Am J Pathol. 2016 Jul;186(7):1874-1889. doi: 10.1016/j.ajpath.2016.03.010. Epub 2016 May 10.

42.

Regulation of the TGF-β pathway by deubiquitinases in cancer.

Liu S, de Boeck M, van Dam H, Ten Dijke P.

Int J Biochem Cell Biol. 2016 Jul;76:135-45. doi: 10.1016/j.biocel.2016.05.001. Epub 2016 May 4. Review.

PMID:
27155333
43.

Smad6 determines BMP-regulated invasive behaviour of breast cancer cells in a zebrafish xenograft model.

de Boeck M, Cui C, Mulder AA, Jost CR, Ikeno S, Ten Dijke P.

Sci Rep. 2016 Apr 26;6:24968. doi: 10.1038/srep24968.

44.

Inhibition of Activin Signaling Slows Progression of Polycystic Kidney Disease.

Leonhard WN, Kunnen SJ, Plugge AJ, Pasternack A, Jianu SB, Veraar K, El Bouazzaoui F, Hoogaars WM, Ten Dijke P, Breuning MH, De Heer E, Ritvos O, Peters DJ.

J Am Soc Nephrol. 2016 Dec;27(12):3589-3599. Epub 2016 Mar 28.

45.

Expression of TGFβ-family signalling components in ageing cartilage: age-related loss of TGFβ and BMP receptors.

van Caam A, Madej W, Thijssen E, Garcia de Vinuesa A, van den Berg W, Goumans MJ, Ten Dijke P, Blaney Davidson E, van der Kraan PM.

Osteoarthritis Cartilage. 2016 Jul;24(7):1235-45. doi: 10.1016/j.joca.2016.02.008. Epub 2016 Mar 12.

46.

Regulatory RNAs controlling vascular (dys)function by affecting TGF-ß family signalling.

Kurakula K, Goumans MJ, Ten Dijke P.

EXCLI J. 2015 Jul 10;14:832-50. doi: 10.17179/excli2015-423. eCollection 2015. Review.

47.

The rationale for targeting TGF-β in chronic liver diseases.

Giannelli G, Mikulits W, Dooley S, Fabregat I, Moustakas A, ten Dijke P, Portincasa P, Winter P, Janssen R, Leporatti S, Herrera B, Sanchez A.

Eur J Clin Invest. 2016 Apr;46(4):349-61. doi: 10.1111/eci.12596. Epub 2016 Mar 12. Review.

PMID:
26823073
48.

TGF-β signalling and liver disease.

Fabregat I, Moreno-Càceres J, Sánchez A, Dooley S, Dewidar B, Giannelli G, Ten Dijke P; IT-LIVER Consortium.

FEBS J. 2016 Jun;283(12):2219-32. doi: 10.1111/febs.13665. Epub 2016 Feb 22. Review.

49.

Signal Transduction: Gain of Activin Turns Muscle into Bone.

Sanchez-Duffhues G, Fotsis T, ten Dijke P.

Curr Biol. 2015 Dec 7;25(23):R1136-8. doi: 10.1016/j.cub.2015.10.005.

50.

Induced Pluripotent Stem Cells to Model Human Fibrodysplasia Ossificans Progressiva.

Cai J, Orlova VV, Cai X, Eekhoff EMW, Zhang K, Pei D, Pan G, Mummery CL, Ten Dijke P.

Stem Cell Reports. 2015 Dec 8;5(6):963-970. doi: 10.1016/j.stemcr.2015.10.020. Epub 2015 Nov 26.

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