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Items: 1 to 20 of 80

1.

How do chemokines navigate neutrophils to the target site: Dissecting the structural mechanisms and signaling pathways.

Rajarathnam K, Schnoor M, Richardson RM, Rajagopal S.

Cell Signal. 2019 Feb;54:69-80. doi: 10.1016/j.cellsig.2018.11.004. Epub 2018 Nov 19. Review.

PMID:
30465827
2.

Dynamics-Derived Insights into Complex Formation between the CXCL8 Monomer and CXCR1 N-Terminal Domain: An NMR Study.

Joseph PRB, Spyracopoulos L, Rajarathnam K.

Molecules. 2018 Oct 31;23(11). pii: E2825. doi: 10.3390/molecules23112825.

3.

Structural basis, stoichiometry, and thermodynamics of binding of the chemokines KC and MIP2 to the glycosaminoglycan heparin.

Sepuru KM, Nagarajan B, Desai UR, Rajarathnam K.

J Biol Chem. 2018 Nov 16;293(46):17817-17828. doi: 10.1074/jbc.RA118.004866. Epub 2018 Sep 26.

PMID:
30257866
4.

Distinct Differences in Structural States of Conserved Histidines in Two Related Proteins: NMR Studies of the Chemokines CXCL1 and CXCL8 in the Free Form and Macromolecular Complexes.

Sepuru KM, Rajarathnam K.

Biochemistry. 2018 Oct 16;57(41):5969-5977. doi: 10.1021/acs.biochem.8b00756. Epub 2018 Oct 2.

PMID:
30230320
5.

Attenuation of murine allergic airway inflammation with a CXCR1/CXCR2 chemokine receptor inhibitor.

Hosoki K, Rajarathnam K, Sur S.

Clin Exp Allergy. 2019 Jan;49(1):130-132. doi: 10.1111/cea.13275. Epub 2018 Oct 5. No abstract available.

PMID:
30218547
6.

Lysines and Arginines play non-redundant roles in mediating chemokine-glycosaminoglycan interactions.

Joseph PRB, Sawant KV, Iwahara J, Garofalo RP, Desai UR, Rajarathnam K.

Sci Rep. 2018 Aug 16;8(1):12289. doi: 10.1038/s41598-018-30697-y.

7.

Ehrlichia chaffeensis TRP120 nucleomodulin binds DNA with disordered tandem repeat domain.

Klema VJ, Sepuru KM, Füllbrunn N, Farris TR, Dunphy PS, McBride JW, Rajarathnam K, Choi KH.

PLoS One. 2018 Apr 11;13(4):e0194891. doi: 10.1371/journal.pone.0194891. eCollection 2018.

8.

Interleukin-8 mediates neutrophil-endothelial interactions in pig-to-human xenogeneic models.

French BM, Sendil S, Sepuru KM, Ranek J, Burdorf L, Harris D, Redding E, Cheng X, Laird CT, Zhao Y, Cerel B, Rajarathnam K, Pierson RN 3rd, Azimzadeh AM.

Xenotransplantation. 2018 Mar;25(2):e12385. doi: 10.1111/xen.12385. Epub 2018 Feb 9.

PMID:
29427404
9.

Direct detection of lysine side chain NH3+ in protein-heparin complexes using NMR spectroscopy.

Sepuru KM, Iwahara J, Rajarathnam K.

Analyst. 2018 Feb 7;143(3):635-638. doi: 10.1039/c7an01406f. Epub 2018 Jan 2.

PMID:
29292440
10.

Glycosaminoglycan Interactions Fine-Tune Chemokine-Mediated Neutrophil Trafficking: Structural Insights and Molecular Mechanisms.

Rajarathnam K, Sepuru KM, Joseph PRB, Sawant KV, Brown AJ.

J Histochem Cytochem. 2018 Apr;66(4):229-239. doi: 10.1369/0022155417739864. Epub 2018 Jan 1.

PMID:
29290145
11.
12.

Platelet-Derived Chemokine CXCL7 Dimer Preferentially Exists in the Glycosaminoglycan-Bound Form: Implications for Neutrophil-Platelet Crosstalk.

Brown AJ, Sepuru KM, Sawant KV, Rajarathnam K.

Front Immunol. 2017 Oct 2;8:1248. doi: 10.3389/fimmu.2017.01248. eCollection 2017.

13.

Regulation of Chemokine Function: The Roles of GAG-Binding and Post-Translational Nitration.

Thompson S, Martínez-Burgo B, Sepuru KM, Rajarathnam K, Kirby JA, Sheerin NS, Ali S.

Int J Mol Sci. 2017 Aug 3;18(8). pii: E1692. doi: 10.3390/ijms18081692. Review.

14.

Chemokine CXCL7 Heterodimers: Structural Insights, CXCR2 Receptor Function, and Glycosaminoglycan Interactions.

Brown AJ, Joseph PR, Sawant KV, Rajarathnam K.

Int J Mol Sci. 2017 Apr 1;18(4). pii: E748. doi: 10.3390/ijms18040748.

15.

Structural Basis of Native CXCL7 Monomer Binding to CXCR2 Receptor N-Domain and Glycosaminoglycan Heparin.

Brown AJ, Sepuru KM, Rajarathnam K.

Int J Mol Sci. 2017 Feb 26;18(3). pii: E508. doi: 10.3390/ijms18030508.

16.

Chemokine CXCL1 mediated neutrophil recruitment: Role of glycosaminoglycan interactions.

Sawant KV, Poluri KM, Dutta AK, Sepuru KM, Troshkina A, Garofalo RP, Rajarathnam K.

Sci Rep. 2016 Sep 14;6:33123. doi: 10.1038/srep33123.

17.

Molecular Basis of Chemokine CXCL5-Glycosaminoglycan Interactions.

Sepuru KM, Nagarajan B, Desai UR, Rajarathnam K.

J Biol Chem. 2016 Sep 23;291(39):20539-50. doi: 10.1074/jbc.M116.745265. Epub 2016 Jul 28.

18.

CXCL1/MGSA Is a Novel Glycosaminoglycan (GAG)-binding Chemokine: STRUCTURAL EVIDENCE FOR TWO DISTINCT NON-OVERLAPPING BINDING DOMAINS.

Sepuru KM, Rajarathnam K.

J Biol Chem. 2016 Feb 19;291(8):4247-55. doi: 10.1074/jbc.M115.697888. Epub 2015 Dec 31.

19.

Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions.

Joseph PR, Mosier PD, Desai UR, Rajarathnam K.

Biochem J. 2015 Nov 15;472(1):121-33. doi: 10.1042/BJ20150059. Epub 2015 Sep 14.

20.

Flexible Linker Modulates Glycosaminoglycan Affinity of Decorin Binding Protein A.

Morgan A, Sepuru KM, Feng W, Rajarathnam K, Wang X.

Biochemistry. 2015 Aug 18;54(32):5113-9. doi: 10.1021/acs.biochem.5b00253. Epub 2015 Aug 7.

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