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Items: 1 to 20 of 84

1.

Pathomechanism of mutated and secreted retinoschisin in X-linked juvenile retinoschisis.

Plössl K, Schmid V, Straub K, Schmid C, Ammon M, Merkl R, Weber BHF, Friedrich U.

Exp Eye Res. 2018 Jul 21;177:23-34. doi: 10.1016/j.exer.2018.07.021. [Epub ahead of print]

PMID:
30040949
2.

Artificial Light Regulation of an Allosteric Bienzyme Complex by a Photosensitive Ligand.

Kneuttinger AC, Winter M, Simeth NA, Heyn K, Merkl R, König B, Sterner R.

Chembiochem. 2018 May 29. doi: 10.1002/cbic.201800219. [Epub ahead of print]

PMID:
29808949
3.

Hexamerization of Geranylgeranylglyceryl Phosphate Synthase Ensures Structural Integrity and Catalytic Activity at High Temperatures.

Linde M, Heyn K, Merkl R, Sterner R, Babinger P.

Biochemistry. 2018 Apr 24;57(16):2335-2348. doi: 10.1021/acs.biochem.7b01284. Epub 2018 Apr 11.

PMID:
29600842
4.

The Adaptor Protein ENY2 Is a Component of the Deubiquitination Module of the Arabidopsis SAGA Transcriptional Co-activator Complex but not of the TREX-2 Complex.

Pfab A, Bruckmann A, Nazet J, Merkl R, Grasser KD.

J Mol Biol. 2018 May 11;430(10):1479-1494. doi: 10.1016/j.jmb.2018.03.018. Epub 2018 Mar 26.

PMID:
29588169
5.

Relationship of Catalysis and Active Site Loop Dynamics in the (βα)8-Barrel Enzyme Indole-3-glycerol Phosphate Synthase.

Schlee S, Klein T, Schumacher M, Nazet J, Merkl R, Steinhoff HJ, Sterner R.

Biochemistry. 2018 Jun 12;57(23):3265-3277. doi: 10.1021/acs.biochem.8b00167. Epub 2018 Mar 8.

PMID:
29498826
6.

Evolutionary diversification of protein-protein interactions by interface add-ons.

Plach MG, Semmelmann F, Busch F, Busch M, Heizinger L, Wysocki VH, Merkl R, Sterner R.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8333-E8342. doi: 10.1073/pnas.1707335114. Epub 2017 Sep 18.

7.

Rosetta:MSF: a modular framework for multi-state computational protein design.

Löffler P, Schmitz S, Hupfeld E, Sterner R, Merkl R.

PLoS Comput Biol. 2017 Jun 12;13(6):e1005600. doi: 10.1371/journal.pcbi.1005600. eCollection 2017 Jun.

8.

AGeNNT: annotation of enzyme families by means of refined neighborhood networks.

Kandlinger F, Plach MG, Merkl R.

BMC Bioinformatics. 2017 May 25;18(1):274. doi: 10.1186/s12859-017-1689-6.

9.

Assessing in silico the recruitment and functional spectrum of bacterial enzymes from secondary metabolism.

Veprinskiy V, Heizinger L, Plach MG, Merkl R.

BMC Evol Biol. 2017 Jan 26;17(1):36. doi: 10.1186/s12862-017-0886-2.

10.

Plasmodium falciparum Nucleosomes Exhibit Reduced Stability and Lost Sequence Dependent Nucleosome Positioning.

Silberhorn E, Schwartz U, Löffler P, Schmitz S, Symelka A, de Koning-Ward T, Merkl R, Längst G.

PLoS Pathog. 2016 Dec 29;12(12):e1006080. doi: 10.1371/journal.ppat.1006080. eCollection 2016 Dec.

11.

The Arabidopsis THO/TREX component TEX1 functionally interacts with MOS11 and modulates mRNA export and alternative splicing events.

Sørensen BB, Ehrnsberger HF, Esposito S, Pfab A, Bruckmann A, Hauptmann J, Meister G, Merkl R, Schubert T, Längst G, Melzer M, Grasser M, Grasser KD.

Plant Mol Biol. 2017 Feb;93(3):283-298. doi: 10.1007/s11103-016-0561-9. Epub 2016 Dec 21.

PMID:
28004241
12.

Combining ancestral sequence reconstruction with protein design to identify an interface hotspot in a key metabolic enzyme complex.

Holinski A, Heyn K, Merkl R, Sterner R.

Proteins. 2017 Feb;85(2):312-321. doi: 10.1002/prot.25225. Epub 2017 Jan 5.

PMID:
27936490
13.

Gene silencing pathways found in the green alga Volvox carteri reveal insights into evolution and origins of small RNA systems in plants.

Dueck A, Evers M, Henz SR, Unger K, Eichner N, Merkl R, Berezikov E, Engelmann JC, Weigel D, Wenzl S, Meister G.

BMC Genomics. 2016 Nov 2;17(1):853.

14.

Ancestral Tryptophan Synthase Reveals Functional Sophistication of Primordial Enzyme Complexes.

Busch F, Rajendran C, Heyn K, Schlee S, Merkl R, Sterner R.

Cell Chem Biol. 2016 Jun 23;23(6):709-15. doi: 10.1016/j.chembiol.2016.05.009. Epub 2016 Jun 9.

15.

Long-Term Persistence of Bi-functionality Contributes to the Robustness of Microbial Life through Exaptation.

Plach MG, Reisinger B, Sterner R, Merkl R.

PLoS Genet. 2016 Jan 29;12(1):e1005836. doi: 10.1371/journal.pgen.1005836. eCollection 2016 Jan.

16.

An assessment of catalytic residue 3D ensembles for the prediction of enzyme function.

Žváček C, Friedrichs G, Heizinger L, Merkl R.

BMC Bioinformatics. 2015 Nov 4;16:359. doi: 10.1186/s12859-015-0807-6.

17.

Conversion of anthranilate synthase into isochorismate synthase: implications for the evolution of chorismate-utilizing enzymes.

Plach MG, Löffler P, Merkl R, Sterner R.

Angew Chem Int Ed Engl. 2015 Sep 14;54(38):11270-4. doi: 10.1002/anie.201505063.

PMID:
26352034
18.

Ancestral protein reconstruction: techniques and applications.

Merkl R, Sterner R.

Biol Chem. 2016 Jan;397(1):1-21. doi: 10.1515/hsz-2015-0158. Review.

PMID:
26351909
19.

The extended AT-hook is a novel RNA binding motif.

Filarsky M, Zillner K, Araya I, Villar-Garea A, Merkl R, Längst G, Németh A.

RNA Biol. 2015;12(8):864-76. doi: 10.1080/15476286.2015.1060394.

20.

Maize EMBRYO SAC family peptides interact differentially with pollen tubes and fungal cells.

Woriedh M, Merkl R, Dresselhaus T.

J Exp Bot. 2015 Aug;66(17):5205-16. doi: 10.1093/jxb/erv268. Epub 2015 Jun 12.

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