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Items: 26

1.

Dual direction CRISPR transcriptional regulation screening uncovers gene networks driving drug resistance.

le Sage C, Lawo S, Panicker P, Scales TME, Rahman SA, Little AS, McCarthy NJ, Moore JD, Cross BCS.

Sci Rep. 2017 Dec 18;7(1):17693. doi: 10.1038/s41598-017-18172-6.

2.

Synthetic lethality between PAXX and XLF in mammalian development.

Balmus G, Barros AC, Wijnhoven PW, Lescale C, Hasse HL, Boroviak K, le Sage C, Doe B, Speak AO, Galli A, Jacobsen M, Deriano L, Adams DJ, Blackford AN, Jackson SP.

Genes Dev. 2016 Oct 1;30(19):2152-2157.

3.

microRNAs with AAGUGC seed motif constitute an integral part of an oncogenic signaling network.

Zhou Y, Frings O, Branca RM, Boekel J, le Sage C, Fredlund E, Agami R, Orre LM.

Oncogene. 2017 Feb 9;36(6):731-745. doi: 10.1038/onc.2016.242. Epub 2016 Aug 1.

4.

CRISPR-Cas9(D10A) nickase-based genotypic and phenotypic screening to enhance genome editing.

Chiang TW, le Sage C, Larrieu D, Demir M, Jackson SP.

Sci Rep. 2016 Apr 15;6:24356. doi: 10.1038/srep24356.

5.

Neddylation promotes ubiquitylation and release of Ku from DNA-damage sites.

Brown JS, Lukashchuk N, Sczaniecka-Clift M, Britton S, le Sage C, Calsou P, Beli P, Galanty Y, Jackson SP.

Cell Rep. 2015 May 5;11(5):704-14. doi: 10.1016/j.celrep.2015.03.058. Epub 2015 Apr 23.

6.

Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity.

Nishi R, Wijnhoven P, le Sage C, Tjeertes J, Galanty Y, Forment JV, Clague MJ, Urbé S, Jackson SP.

Nat Cell Biol. 2014 Oct;16(10):1016-26, 1-8. doi: 10.1038/ncb3028. Epub 2014 Sep 7.

7.

miR-155 drives telomere fragility in human breast cancer by targeting TRF1.

Dinami R, Ercolani C, Petti E, Piazza S, Ciani Y, Sestito R, Sacconi A, Biagioni F, le Sage C, Agami R, Benetti R, Mottolese M, Schneider C, Blandino G, Schoeftner S.

Cancer Res. 2014 Aug 1;74(15):4145-56. doi: 10.1158/0008-5472.CAN-13-2038. Epub 2014 May 29.

8.

Altered microRNA expression associated with chromosomal changes contributes to cervical carcinogenesis.

Wilting SM, Snijders PJ, Verlaat W, Jaspers A, van de Wiel MA, van Wieringen WN, Meijer GA, Kenter GG, Yi Y, le Sage C, Agami R, Meijer CJ, Steenbergen RD.

Oncogene. 2013 Jan 3;32(1):106-16. doi: 10.1038/onc.2012.20. Epub 2012 Feb 13.

PMID:
22330141
9.

miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1.

Korkmaz G, le Sage C, Tekirdag KA, Agami R, Gozuacik D.

Autophagy. 2012 Feb 1;8(2):165-76. doi: 10.4161/auto.8.2.18351. Epub 2012 Feb 1.

PMID:
22248718
10.

Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity.

Léveillé N, Elkon R, Davalos V, Manoharan V, Hollingworth D, Oude Vrielink J, le Sage C, Melo CA, Horlings HM, Wesseling J, Ule J, Esteller M, Ramos A, Agami R.

Nat Commun. 2011 Oct 25;2:513. doi: 10.1038/ncomms1519.

11.

Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia.

Caporali A, Meloni M, Völlenkle C, Bonci D, Sala-Newby GB, Addis R, Spinetti G, Losa S, Masson R, Baker AH, Agami R, le Sage C, Condorelli G, Madeddu P, Martelli F, Emanueli C.

Circulation. 2011 Jan 25;123(3):282-91. doi: 10.1161/CIRCULATIONAHA.110.952325. Epub 2011 Jan 10.

PMID:
21220732
12.

Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer.

Wilting SM, van Boerdonk RA, Henken FE, Meijer CJ, Diosdado B, Meijer GA, le Sage C, Agami R, Snijders PJ, Steenbergen RD.

Mol Cancer. 2010 Jun 26;9:167. doi: 10.1186/1476-4598-9-167.

13.

MicroRNA hsa-miR-135b regulates mineralization in osteogenic differentiation of human unrestricted somatic stem cells.

Schaap-Oziemlak AM, Raymakers RA, Bergevoet SM, Gilissen C, Jansen BJ, Adema GJ, Kögler G, le Sage C, Agami R, van der Reijden BA, Jansen JH.

Stem Cells Dev. 2010 Jun;19(6):877-85. doi: 10.1089/scd.2009.0112.

PMID:
19795981
14.

The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo.

Huse JT, Brennan C, Hambardzumyan D, Wee B, Pena J, Rouhanifard SH, Sohn-Lee C, le Sage C, Agami R, Tuschl T, Holland EC.

Genes Dev. 2009 Jun 1;23(11):1327-37. doi: 10.1101/gad.1777409.

15.

Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer.

Nagel R, le Sage C, Diosdado B, van der Waal M, Oude Vrielink JA, Bolijn A, Meijer GA, Agami R.

Cancer Res. 2008 Jul 15;68(14):5795-802. doi: 10.1158/0008-5472.CAN-08-0951.

16.

miR-148 targets human DNMT3b protein coding region.

Duursma AM, Kedde M, Schrier M, le Sage C, Agami R.

RNA. 2008 May;14(5):872-7. doi: 10.1261/rna.972008. Epub 2008 Mar 26.

17.

The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis.

Huang Q, Gumireddy K, Schrier M, le Sage C, Nagel R, Nair S, Egan DA, Li A, Huang G, Klein-Szanto AJ, Gimotty PA, Katsaros D, Coukos G, Zhang L, Puré E, Agami R.

Nat Cell Biol. 2008 Feb;10(2):202-10. doi: 10.1038/ncb1681. Epub 2008 Jan 13.

PMID:
18193036
18.

RNA-binding protein Dnd1 inhibits microRNA access to target mRNA.

Kedde M, Strasser MJ, Boldajipour B, Oude Vrielink JA, Slanchev K, le Sage C, Nagel R, Voorhoeve PM, van Duijse J, Ørom UA, Lund AH, Perrakis A, Raz E, Agami R.

Cell. 2007 Dec 28;131(7):1273-86.

19.

Diverse ways to control p27Kip1 function: miRNAs come into play.

le Sage C, Nagel R, Agami R.

Cell Cycle. 2007 Nov 15;6(22):2742-9. Epub 2007 Aug 16. Review.

PMID:
17986865
20.

A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors.

Voorhoeve PM, le Sage C, Schrier M, Gillis AJ, Stoop H, Nagel R, Liu YP, van Duijse J, Drost J, Griekspoor A, Zlotorynski E, Yabuta N, De Vita G, Nojima H, Looijenga LH, Agami R.

Adv Exp Med Biol. 2007;604:17-46.

PMID:
17695719
21.

Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation.

le Sage C, Nagel R, Egan DA, Schrier M, Mesman E, Mangiola A, Anile C, Maira G, Mercatelli N, Ciafrè SA, Farace MG, Agami R.

EMBO J. 2007 Aug 8;26(15):3699-708. Epub 2007 Jul 12.

22.

Telomerase-independent regulation of ATR by human telomerase RNA.

Kedde M, le Sage C, Duursma A, Zlotorynski E, van Leeuwen B, Nijkamp W, Beijersbergen R, Agami R.

J Biol Chem. 2006 Dec 29;281(52):40503-14. Epub 2006 Nov 10.

23.

Immense promises for tiny molecules: uncovering miRNA functions.

le Sage C, Agami R.

Cell Cycle. 2006 Jul;5(13):1415-21. Epub 2006 Jul 1. Review.

PMID:
16775415
24.

A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors.

Voorhoeve PM, le Sage C, Schrier M, Gillis AJ, Stoop H, Nagel R, Liu YP, van Duijse J, Drost J, Griekspoor A, Zlotorynski E, Yabuta N, De Vita G, Nojima H, Looijenga LH, Agami R.

Cell. 2006 Mar 24;124(6):1169-81.

25.

Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability.

Schwartz M, Zlotorynski E, Goldberg M, Ozeri E, Rahat A, le Sage C, Chen BP, Chen DJ, Agami R, Kerem B.

Genes Dev. 2005 Nov 15;19(22):2715-26.

26.

Accuracy of IRAS GT interferometer and potential acuity meter prediction of visual acuity after phacoemulsification: prospective comparative study.

Le Sage C, Bazalgette C, Arnaud B, Schmitt-Bernard CF.

J Cataract Refract Surg. 2002 Jan;28(1):131-8.

PMID:
11777722

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