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Items: 1 to 50 of 134

1.

Diet-Induced Obesity Disturbs Microglial Immunometabolism in a Time-of-Day Manner.

Milanova IV, Kalsbeek MJT, Wang XL, Korpel NL, Stenvers DJ, Wolff SEC, de Goede P, Heijboer AC, Fliers E, la Fleur SE, Kalsbeek A, Yi CX.

Front Endocrinol (Lausanne). 2019 Jun 26;10:424. doi: 10.3389/fendo.2019.00424. eCollection 2019.

2.

Stressing the importance of choice: Validity of a preclinical free-choice high-caloric diet paradigm to model behavioural, physiological and molecular adaptations during human diet-induced obesity and metabolic dysfunction.

Slomp M, Belegri E, Blancas-Velazquez AS, Diepenbroek C, Eggels L, Gumbs MCR, Joshi A, Koekkoek LL, Lamuadni K, Ugur M, Unmehopa UA, la Fleur SE, Mul JD.

J Neuroendocrinol. 2019 May;31(5):e12718. doi: 10.1111/jne.12718. Epub 2019 Apr 24. Review.

3.

Afferent neuropeptide Y projections to the ventral tegmental area in normal-weight male Wistar rats.

Gumbs MCR, Vuuregge AH, Eggels L, Unmehopa UA, Lamuadni K, Mul JD, la Fleur SE.

J Comp Neurol. 2019 Nov 1;527(16):2659-2674. doi: 10.1002/cne.24698. Epub 2019 Apr 18.

4.

Circadian clocks and insulin resistance.

Stenvers DJ, Scheer FAJL, Schrauwen P, la Fleur SE, Kalsbeek A.

Nat Rev Endocrinol. 2019 Feb;15(2):75-89. doi: 10.1038/s41574-018-0122-1. Review.

PMID:
30531917
5.

The interrelation between FGF23 and glucose metabolism in humans.

Ursem SR, Vervloet MG, Büttler RM, Ackermans MT, Oosterwerff MM, Eekhoff EMV, Lips P, Serlie MJ, la Fleur SE, Heijboer AC.

J Diabetes Complications. 2018 Sep;32(9):845-850. doi: 10.1016/j.jdiacomp.2018.06.013. Epub 2018 Jun 27.

PMID:
29996975
6.

Voluntary wheel running promotes resilience to chronic social defeat stress in mice: a role for nucleus accumbens ΔFosB.

Mul JD, Soto M, Cahill ME, Ryan RE, Takahashi H, So K, Zheng J, Croote DE, Hirshman MF, la Fleur SE, Nestler EJ, Goodyear LJ.

Neuropsychopharmacology. 2018 Aug;43(9):1934-1942. doi: 10.1038/s41386-018-0103-z. Epub 2018 May 24.

7.

Striatal dopamine regulates systemic glucose metabolism in humans and mice.

Ter Horst KW, Lammers NM, Trinko R, Opland DM, Figee M, Ackermans MT, Booij J, van den Munckhof P, Schuurman PR, Fliers E, Denys D, DiLeone RJ, la Fleur SE, Serlie MJ.

Sci Transl Med. 2018 May 23;10(442). pii: eaar3752. doi: 10.1126/scitranslmed.aar3752.

PMID:
29794060
8.

Is leptin resistance the cause or the consequence of diet-induced obesity?

de Git KCG, Peterse C, Beerens S, Luijendijk MCM, van der Plasse G, la Fleur SE, Adan RAH.

Int J Obes (Lond). 2018 Aug;42(8):1445-1457. doi: 10.1038/s41366-018-0111-4. Epub 2018 May 22.

PMID:
29789721
9.

Daily Gene Expression Rhythms in Rat White Adipose Tissue Do Not Differ Between Subcutaneous and Intra-Abdominal Depots.

van der Spek R, Fliers E, la Fleur SE, Kalsbeek A.

Front Endocrinol (Lausanne). 2018 Apr 30;9:206. doi: 10.3389/fendo.2018.00206. eCollection 2018.

10.

One-Week Exposure to a Free-Choice High-Fat High-Sugar Diet Does Not Interfere With the Lipopolysaccharide-Induced Acute Phase Response in the Hypothalamus of Male Rats.

Belegri E, Eggels L, la Fleur SE, Boelen A.

Front Endocrinol (Lausanne). 2018 Apr 30;9:186. doi: 10.3389/fendo.2018.00186. eCollection 2018.

11.

A Free-Choice High-Fat High-Sugar Diet Alters Day-Night Per2 Gene Expression in Reward-Related Brain Areas in Rats.

Blancas-Velazquez AS, Unmehopa UA, Eggels L, Koekkoek L, Kalsbeek A, Mendoza J, la Fleur SE.

Front Endocrinol (Lausanne). 2018 Apr 9;9:154. doi: 10.3389/fendo.2018.00154. eCollection 2018.

12.

Glucose-Sensing in the Reward System.

Koekkoek LL, Mul JD, la Fleur SE.

Front Neurosci. 2017 Dec 19;11:716. doi: 10.3389/fnins.2017.00716. eCollection 2017. Review.

13.

One-week exposure to a free-choice high-fat high-sugar diet does not disrupt blood-brain barrier permeability in fed or overnight fasted rats.

Rijnsburger M, Unmehopa UA, Eggels L, Serlie MJ, la Fleur SE.

Nutr Neurosci. 2019 Aug;22(8):541-550. doi: 10.1080/1028415X.2017.1418727. Epub 2017 Dec 29.

PMID:
29284375
14.

Complex interaction between circadian rhythm and diet on bile acid homeostasis in male rats.

Eggink HM, Oosterman JE, de Goede P, de Vries EM, Foppen E, Koehorst M, Groen AK, Boelen A, Romijn JA, la Fleur SE, Soeters MR, Kalsbeek A.

Chronobiol Int. 2017;34(10):1339-1353. doi: 10.1080/07420528.2017.1363226. Epub 2017 Oct 13.

PMID:
29028359
15.

The effects of overnight nutrient intake on hypothalamic inflammation in a free-choice diet-induced obesity rat model.

Belegri E, Eggels L, Unmehopa UA, Mul JD, Boelen A, la Fleur SE.

Appetite. 2018 Jan 1;120:527-535. doi: 10.1016/j.appet.2017.10.006. Epub 2017 Oct 5.

PMID:
28988760
16.

The role of central dopamine and serotonin in human obesity: lessons learned from molecular neuroimaging studies.

van Galen KA, Ter Horst KW, Booij J, la Fleur SE, Serlie MJ.

Metabolism. 2018 Aug;85:325-339. doi: 10.1016/j.metabol.2017.09.007. Epub 2017 Sep 29. Review.

PMID:
28970033
17.

Differential effects of diet composition and timing of feeding behavior on rat brown adipose tissue and skeletal muscle peripheral clocks.

de Goede P, Sen S, Oosterman JE, Foppen E, Jansen R, la Fleur SE, Challet E, Kalsbeek A.

Neurobiol Sleep Circadian Rhythms. 2017 Sep 18;4:24-33. doi: 10.1016/j.nbscr.2017.09.002. eCollection 2018 Jan.

18.

Meal timing effects on insulin sensitivity and intrahepatic triglycerides during weight loss.

Versteeg RI, Ackermans MT, Nederveen AJ, Fliers E, Serlie MJ, la Fleur SE.

Int J Obes (Lond). 2018 Feb;42(2):156-162. doi: 10.1038/ijo.2017.199. Epub 2017 Aug 16.

PMID:
28811653
19.

A novel, double intra-carotid cannulation technique to study the effect of central nutrient sensing on glucose metabolism in the rat.

Rijnsburger M, Eggels L, Castel J, Cruciani-Guglielmacci C, Ackermans MT, Luquet S, la Fleur SE.

J Neurosci Methods. 2017 Oct 1;290:79-84. doi: 10.1016/j.jneumeth.2017.07.024. Epub 2017 Jul 25.

PMID:
28754433
20.

Effects of a free-choice high-fat high-sugar diet on brain PER2 and BMAL1 protein expression in mice.

Blancas-Velazquez A, la Fleur SE, Mendoza J.

Appetite. 2017 Oct 1;117:263-269. doi: 10.1016/j.appet.2017.07.002. Epub 2017 Jul 5.

PMID:
28687372
21.

Timing of caloric intake during weight loss differentially affects striatal dopamine transporter and thalamic serotonin transporter binding.

Versteeg RI, Schrantee A, Adriaanse SM, Unmehopa UA, Booij J, Reneman L, Fliers E, la Fleur SE, Serlie MJ.

FASEB J. 2017 Oct;31(10):4545-4554. doi: 10.1096/fj.201601234R. Epub 2017 Jul 5.

PMID:
28679529
22.

Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans.

Ter Horst KW, Gilijamse PW, Versteeg RI, Ackermans MT, Nederveen AJ, la Fleur SE, Romijn JA, Nieuwdorp M, Zhang D, Samuel VT, Vatner DF, Petersen KF, Shulman GI, Serlie MJ.

Cell Rep. 2017 Jun 6;19(10):1997-2004. doi: 10.1016/j.celrep.2017.05.035.

23.

Effects of Fat and Sugar, Either Consumed or Infused toward the Brain, on Hypothalamic ER Stress Markers.

Belegri E, Rijnsburger M, Eggels L, Unmehopa U, Scheper W, Boelen A, la Fleur SE.

Front Neurosci. 2017 May 15;11:270. doi: 10.3389/fnins.2017.00270. eCollection 2017.

24.

The importance of hormonal circadian rhythms in daily feeding patterns: An illustration with simulated pigs.

Boumans IJMM, de Boer IJM, Hofstede GJ, la Fleur SE, Bokkers EAM.

Horm Behav. 2017 Jul;93:82-93. doi: 10.1016/j.yhbeh.2017.05.003. Epub 2017 May 19.

PMID:
28514644
25.

Acute Effects of Morning Light on Plasma Glucose and Triglycerides in Healthy Men and Men with Type 2 Diabetes.

Versteeg RI, Stenvers DJ, Visintainer D, Linnenbank A, Tanck MW, Zwanenburg G, Smilde AK, Fliers E, Kalsbeek A, Serlie MJ, la Fleur SE, Bisschop PH.

J Biol Rhythms. 2017 Apr;32(2):130-142. doi: 10.1177/0748730417693480. Epub 2017 Mar 20.

26.

Insulin deficiency results in reversible protein kinase A activation and tau phosphorylation.

van der Harg JM, Eggels L, Bangel FN, Ruigrok SR, Zwart R, Hoozemans JJM, la Fleur SE, Scheper W.

Neurobiol Dis. 2017 Jul;103:163-173. doi: 10.1016/j.nbd.2017.04.005. Epub 2017 Apr 8.

PMID:
28400135
27.

Diet-Induced Obesity and Circadian Disruption of Feeding Behavior.

Blancas-Velazquez A, Mendoza J, Garcia AN, la Fleur SE.

Front Neurosci. 2017 Feb 7;11:23. doi: 10.3389/fnins.2017.00023. eCollection 2017. Review.

28.

Exposure to chronic early-life stress lastingly alters the adipose tissue, the leptin system and changes the vulnerability to western-style diet later in life in mice.

Yam KY, Naninck EFG, Abbink MR, la Fleur SE, Schipper L, van den Beukel JC, Grefhorst A, Oosting A, van der Beek EM, Lucassen PJ, Korosi A.

Psychoneuroendocrinology. 2017 Mar;77:186-195. doi: 10.1016/j.psyneuen.2016.12.012. Epub 2016 Dec 23.

PMID:
28088658
29.

Infusion of fluoxetine, a serotonin reuptake inhibitor, in the shell region of the nucleus accumbens increases blood glucose concentrations in rats.

Diepenbroek C, Rijnsburger M, Eggels L, van Megen KM, Ackermans MT, Fliers E, Kalsbeek A, Serlie MJ, la Fleur SE.

Neurosci Lett. 2017 Jan 10;637:85-90. doi: 10.1016/j.neulet.2016.11.045. Epub 2016 Nov 22.

PMID:
27888043
30.

Differential effects of hypercaloric choice diets on insulin sensitivity in rats.

Diepenbroek C, Eggels L, Ackermans MT, Fliers E, Kalsbeek A, Serlie MJ, la Fleur SE.

J Endocrinol. 2017 Jan;232(1):49-57. Epub 2016 Oct 17.

PMID:
27754934
31.

Serotonin Transporter Binding in the Diencephalon Is Reduced in Insulin-Resistant Obese Humans.

Versteeg RI, Koopman KE, Booij J, Ackermans MT, Unmehopa UA, Fliers E, la Fleur SE, Serlie MJ.

Neuroendocrinology. 2017;105(2):141-149. doi: 10.1159/000450549. Epub 2016 Sep 14.

32.

Nutrition in the spotlight: metabolic effects of environmental light.

Versteeg RI, Stenvers DJ, Kalsbeek A, Bisschop PH, Serlie MJ, la Fleur SE.

Proc Nutr Soc. 2016 Nov;75(4):451-463. Epub 2016 Aug 8. Review.

PMID:
27499509
33.

The vitamin D metabolites 25(OH)D and 1,25(OH)2D are not related to either glucose metabolism or insulin action in obese women.

Ter Horst KW, Versteeg RI, Gilijamse PW, Ackermans MT, Heijboer AC, Romijn JA, la Fleur SE, Trinko R, DiLeone RJ, Serlie MJ.

Diabetes Metab. 2016 Dec;42(6):416-423. doi: 10.1016/j.diabet.2016.04.011. Epub 2016 Jun 1.

PMID:
27262368
34.

Striatal dopamine D2/3 receptor availability increases after long-term bariatric surgery-induced weight loss.

van der Zwaal EM, de Weijer BA, van de Giessen EM, Janssen I, Berends FJ, van de Laar A, Ackermans MT, Fliers E, la Fleur SE, Booij J, Serlie MJ.

Eur Neuropsychopharmacol. 2016 Jul;26(7):1190-200. doi: 10.1016/j.euroneuro.2016.04.009. Epub 2016 May 12.

PMID:
27184782
35.

The effect of obesogenic diets on brain Neuropeptide Y.

Gumbs MC, van den Heuvel JK, la Fleur SE.

Physiol Behav. 2016 Aug 1;162:161-73. doi: 10.1016/j.physbeh.2016.04.049. Epub 2016 Apr 27. Review.

PMID:
27132202
36.

The effect of diet interventions on hypothalamic nutrient sensing pathways in rodents.

Rijnsburger M, Belegri E, Eggels L, Unmehopa UA, Boelen A, Serlie MJ, la Fleur SE.

Physiol Behav. 2016 Aug 1;162:61-8. doi: 10.1016/j.physbeh.2016.04.011. Epub 2016 Apr 12. Review.

PMID:
27083123
37.

Brain dopamine and serotonin transporter binding are associated with visual attention bias for food in lean men.

Koopman KE, Roefs A, Elbers DC, Fliers E, Booij J, Serlie MJ, la Fleur SE.

Psychol Med. 2016 Jun;46(8):1707-17. doi: 10.1017/S0033291716000222. Epub 2016 Mar 17.

PMID:
26984412
38.

Melanocortin 3 Receptor Signaling in Midbrain Dopamine Neurons Increases the Motivation for Food Reward.

Pandit R, Omrani A, Luijendijk MC, de Vrind VA, Van Rozen AJ, Ophuis RJ, Garner K, Kallo I, Ghanem A, Liposits Z, Conzelmann KK, Vanderschuren LJ, la Fleur SE, Adan RA.

Neuropsychopharmacology. 2016 Aug;41(9):2241-51. doi: 10.1038/npp.2016.19. Epub 2016 Feb 8.

39.

Inhibitory Effect of the Melanocortin Receptor Agonist Melanotan-II (MTII) on Feeding Depends on Dietary Fat Content and not Obesity in Rats on Free-Choice Diets.

van den Heuvel JK, Eggels L, van Rozen AJ, Fliers E, Kalsbeek A, Adan RA, la Fleur SE.

Front Behav Neurosci. 2015 Dec 24;9:358. doi: 10.3389/fnbeh.2015.00358. eCollection 2015.

40.

Decreased Hypothalamic Glucagon-Like Peptide-1 Receptor Expression in Type 2 Diabetes Patients.

Ten Kulve JS, van Bloemendaal L, Balesar R, IJzerman RG, Swaab DF, Diamant M, la Fleur SE, Alkemade A.

J Clin Endocrinol Metab. 2016 May;101(5):2122-9. doi: 10.1210/jc.2015-3291. Epub 2015 Dec 16.

PMID:
26672638
41.

Neuroinflammation is not a Prerequisite for Diabetes-induced Tau Phosphorylation.

van der Harg JM, Eggels L, Ruigrok SR, Hoozemans JJ, la Fleur SE, Scheper W.

Front Neurosci. 2015 Nov 9;9:432. doi: 10.3389/fnins.2015.00432. eCollection 2015.

42.

Introduction to the Special Issue.

Myers KP, la Fleur SE.

Physiol Behav. 2015 Dec 1;152(Pt B):v-vi. doi: 10.1016/S0031-9384(15)00431-X. No abstract available.

PMID:
26602381
43.

Serotonin, a possible intermediate between disturbed circadian rhythms and metabolic disease.

Versteeg RI, Serlie MJ, Kalsbeek A, la Fleur SE.

Neuroscience. 2015 Aug 20;301:155-67. doi: 10.1016/j.neuroscience.2015.05.067. Epub 2015 Jun 3. Review.

PMID:
26047725
44.

Central melanocortins regulate the motivation for sucrose reward.

Pandit R, van der Zwaal EM, Luijendijk MC, Brans MA, van Rozen AJ, Oude Ophuis RJ, Vanderschuren LJ, Adan RA, la Fleur SE.

PLoS One. 2015 Mar 26;10(3):e0121768. doi: 10.1371/journal.pone.0121768. eCollection 2015.

45.

Subchronic administration of short-acting naltrexone has no effect on striatal dopamine transporter availability, food intake or body weight gain in rats.

Zaaijer ER, de Bruin K, la Fleur SE, Goudriaan AE, van den Brink W, Booij J.

J Psychopharmacol. 2015 Mar;29(3):344-8. doi: 10.1177/0269881114565380. Epub 2015 Jan 13.

PMID:
25586403
46.

Impact of nutrients on circadian rhythmicity.

Oosterman JE, Kalsbeek A, la Fleur SE, Belsham DD.

Am J Physiol Regul Integr Comp Physiol. 2015 Mar 1;308(5):R337-50. doi: 10.1152/ajpregu.00322.2014. Epub 2014 Dec 17. Review.

47.

Neuroscience of glucose homeostasis.

La Fleur SE, Fliers E, Kalsbeek A.

Handb Clin Neurol. 2014;126:341-51. doi: 10.1016/B978-0-444-53480-4.00026-6. Review.

PMID:
25410233
48.

Timing of fat and liquid sugar intake alters substrate oxidation and food efficiency in male Wistar rats.

Oosterman JE, Foppen E, van der Spek R, Fliers E, Kalsbeek A, la Fleur SE.

Chronobiol Int. 2015 Mar;32(2):289-98. doi: 10.3109/07420528.2014.971177. Epub 2014 Oct 15.

PMID:
25317718
49.

The interaction between nutrition and the brain and its consequences for body weight gain and metabolism; studies in rodents and men.

la Fleur SE, Serlie MJ.

Best Pract Res Clin Endocrinol Metab. 2014 Oct;28(5):649-59. doi: 10.1016/j.beem.2014.06.001. Epub 2014 Jun 20. Review.

PMID:
25256761
50.

Neuropeptide Y activity in the nucleus accumbens modulates feeding behavior and neuronal activity.

van den Heuvel JK, Furman K, Gumbs MC, Eggels L, Opland DM, Land BB, Kolk SM, Narayanan NS, Fliers E, Kalsbeek A, DiLeone RJ, la Fleur SE.

Biol Psychiatry. 2015 Apr 1;77(7):633-41. doi: 10.1016/j.biopsych.2014.06.008. Epub 2014 Jun 18.

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