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Items: 1 to 20 of 57


Mxra8 is a receptor for multiple arthritogenic alphaviruses.

Zhang R, Kim AS, Fox JM, Nair S, Basore K, Klimstra WB, Rimkunas R, Fong RH, Lin H, Poddar S, Crowe JE Jr, Doranz BJ, Fremont DH, Diamond MS.

Nature. 2018 May;557(7706):570-574. doi: 10.1038/s41586-018-0121-3. Epub 2018 May 16.


The Efficacy of the Interferon Alpha/Beta Response versus Arboviruses Is Temperature Dependent.

Lane WC, Dunn MD, Gardner CL, Lam LKM, Watson AM, Hartman AL, Ryman KD, Klimstra WB.

MBio. 2018 Apr 24;9(2). pii: e00535-18. doi: 10.1128/mBio.00535-18.


Gamma-interferon exerts a critical early restriction on replication and dissemination of yellow fever virus vaccine strain 17D-204.

Lam LKM, Watson AM, Ryman KD, Klimstra WB.

NPJ Vaccines. 2018 Jan 23;3:5. doi: 10.1038/s41541-017-0039-z. eCollection 2018.


Lower temperatures reduce type I interferon activity and promote alphaviral arthritis.

Prow NA, Tang B, Gardner J, Le TT, Taylor A, Poo YS, Nakayama E, Hirata TDC, Nakaya HI, Slonchak A, Mukhopadhyay P, Mahalingam S, Schroder WA, Klimstra W, Suhrbier A.

PLoS Pathog. 2017 Dec 27;13(12):e1006788. doi: 10.1371/journal.ppat.1006788. eCollection 2017 Dec.


Ribbon scanning confocal for high-speed high-resolution volume imaging of brain.

Watson AM, Rose AH, Gibson GA, Gardner CL, Sun C, Reed DS, Lam LKM, St Croix CM, Strick PL, Klimstra WB, Watkins SC.

PLoS One. 2017 Jul 7;12(7):e0180486. doi: 10.1371/journal.pone.0180486. eCollection 2017.


The expression level of C19MC miRNAs in early pregnancy and in response to viral infection.

Dumont TMF, Mouillet JF, Bayer A, Gardner CL, Klimstra WB, Wolf DG, Yagel S, Balmir F, Binstock A, Sanfilippo JS, Coyne CB, Larkin JC, Sadovsky Y.

Placenta. 2017 May;53:23-29. doi: 10.1016/j.placenta.2017.03.011. Epub 2017 Mar 16.


Antibody Preparations from Human Transchromosomic Cows Exhibit Prophylactic and Therapeutic Efficacy against Venezuelan Equine Encephalitis Virus.

Gardner CL, Sun C, Luke T, Raviprakash K, Wu H, Jiao JA, Sullivan E, Reed DS, Ryman KD, Klimstra WB.

J Virol. 2017 Jun 26;91(14). pii: e00226-17. doi: 10.1128/JVI.00226-17. Print 2017 Jul 15.


T Cell-Mediated Immunity towards Yellow Fever Virus and Useful Animal Models.

Watson AM, Klimstra WB.

Viruses. 2017 Apr 11;9(4). pii: E77. doi: 10.3390/v9040077. Review.


Alphaviruses suppress host immunity by preventing myeloid cell replication and antagonizing innate immune responses.

Trobaugh DW, Klimstra WB.

Curr Opin Virol. 2017 Apr;23:30-34. doi: 10.1016/j.coviro.2017.02.004. Epub 2017 Mar 10. Review.


MicroRNA Regulation of RNA Virus Replication and Pathogenesis.

Trobaugh DW, Klimstra WB.

Trends Mol Med. 2017 Jan;23(1):80-93. doi: 10.1016/j.molmed.2016.11.003. Epub 2016 Dec 16. Review.


A Role for Human Skin Mast Cells in Dengue Virus Infection and Systemic Spread.

Troupin A, Shirley D, Londono-Renteria B, Watson AM, McHale C, Hall A, Hartstone-Rose A, Klimstra WB, Gomez G, Colpitts TM.

J Immunol. 2016 Dec 1;197(11):4382-4391. Epub 2016 Oct 31.


Aedes aegypti D7 Saliva Protein Inhibits Dengue Virus Infection.

Conway MJ, Londono-Renteria B, Troupin A, Watson AM, Klimstra WB, Fikrig E, Colpitts TM.

PLoS Negl Trop Dis. 2016 Sep 15;10(9):e0004941. doi: 10.1371/journal.pntd.0004941. eCollection 2016 Sep.


The 17D-204 Vaccine Strain-Induced Protection against Virulent Yellow Fever Virus Is Mediated by Humoral Immunity and CD4+ but not CD8+ T Cells.

Watson AM, Lam LK, Klimstra WB, Ryman KD.

PLoS Pathog. 2016 Jul 27;12(7):e1005786. doi: 10.1371/journal.ppat.1005786. eCollection 2016 Jul.


Host translation shutoff mediated by non-structural protein 2 is a critical factor in the antiviral state resistance of Venezuelan equine encephalitis virus.

Bhalla N, Sun C, Metthew Lam LK, Gardner CL, Ryman KD, Klimstra WB.

Virology. 2016 Sep;496:147-165. doi: 10.1016/j.virol.2016.06.005. Epub 2016 Jun 15.


Electroporation of Alphavirus RNA Translational Reporters into Fibroblastic and Myeloid Cells as a Tool to Study the Innate Immune System.

Gardner CL, Trobaugh DW, Ryman KD, Klimstra WB.

Methods Mol Biol. 2016;1428:127-37. doi: 10.1007/978-1-4939-3625-0_8.


DNA-Launched Alphavirus Replicons Encoding a Fusion of Mycobacterial Antigens Acr and Ag85B Are Immunogenic and Protective in a Murine Model of TB Infection.

Dalmia N, Klimstra WB, Mason C, Ramsay AJ.

PLoS One. 2015 Aug 28;10(8):e0136635. doi: 10.1371/journal.pone.0136635. eCollection 2015.


The 5' and 3' ends of alphavirus RNAs--Non-coding is not non-functional.

Hyde JL, Chen R, Trobaugh DW, Diamond MS, Weaver SC, Klimstra WB, Wilusz J.

Virus Res. 2015 Aug 3;206:99-107. doi: 10.1016/j.virusres.2015.01.016. Epub 2015 Jan 25. Review.


Human trophoblasts confer resistance to viruses implicated in perinatal infection.

Bayer A, Delorme-Axford E, Sleigher C, Frey TK, Trobaugh DW, Klimstra WB, Emert-Sedlak LA, Smithgall TE, Kinchington PR, Vadia S, Seveau S, Boyle JP, Coyne CB, Sadovsky Y.

Am J Obstet Gynecol. 2015 Jan;212(1):71.e1-71.e8. doi: 10.1016/j.ajog.2014.07.060. Epub 2014 Aug 6.


Can understanding the virulence mechanisms of RNA viruses lead us to a vaccine against eastern equine encephalitis virus and other alphaviruses?

Trobaugh DW, Ryman KD, Klimstra WB.

Expert Rev Vaccines. 2014 Dec;13(12):1423-5. doi: 10.1586/14760584.2014.944168. Epub 2014 Jul 30.


In vivo imaging in an ABSL-3 regional biocontainment laboratory.

Scanga CA, Lopresti BJ, Tomko J, Frye LJ, Coleman TM, Fillmore D, Carney JP, Lin PL, Flynn JL, Gardner CL, Sun C, Klimstra WB, Ryman KD, Reed DS, Fisher DJ, Cole KS.

Pathog Dis. 2014 Jul;71(2):207-12. doi: 10.1111/2049-632X.12186. Epub 2014 Jun 18. Review.


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