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Items: 1 to 20 of 104

1.

Structure-activity investigation of the potentiating effect of cyano substitution on nitroaniline mutagenicity in the ames test.

Josephy PD, Dhanoa J, Elzawy G, Heney K, Petrie L, Senis C.

Environ Mol Mutagen. 2018 Mar;59(2):114-122. doi: 10.1002/em.22161. Epub 2017 Nov 27.

PMID:
29178210
2.

Acetylation of aromatic cysteine conjugates by recombinant human N-acetyltransferase 8.

Deol R, Josephy PD.

Xenobiotica. 2017 Mar;47(3):202-207. doi: 10.1080/00498254.2016.1178410. Epub 2016 May 16.

PMID:
27180734
3.

Potent mutagenicity in the Ames test of 2-cyano-4-nitroaniline and 2,6-dicyano-4-nitroaniline, components of disperse dyes.

Josephy PD, Zahid M, Dhanoa J, de Souza GB, Groom H, Lambie M.

Environ Mol Mutagen. 2016 Jan;57(1):10-6. doi: 10.1002/em.21983. Epub 2015 Sep 22. Erratum in: Environ Mol Mutagen. 2017 Jul;58(6):462.

PMID:
26394367
4.

Inhibition of human glutathione transferases by dinitronaphthalene derivatives.

Groom H, Lee M, Patil P, Josephy PD.

Arch Biochem Biophys. 2014 Aug;555-556:71-6. doi: 10.1016/j.abb.2014.06.002. Epub 2014 Jun 12.

PMID:
24929189
5.

Donor substrate specificity of bovine kidney gamma-glutamyltransferase.

Agblor AA, Josephy PD.

Chem Biol Interact. 2013 Apr 25;203(2):480-5. doi: 10.1016/j.cbi.2013.02.007. Epub 2013 Mar 7.

PMID:
23500672
6.

Reactive electrophilic metabolites of aromatic amine and amide carcinogens.

Josephy PD, Novak M.

Front Biosci (Schol Ed). 2013 Jan 1;5:341-59. Review.

PMID:
23277055
7.

Hydrolysis of S-aryl-cysteinylglycine conjugates catalyzed by porcine kidney cortex membrane dipeptidase.

Poon JC, Josephy PD.

Xenobiotica. 2012 Dec;42(12):1178-86. doi: 10.3109/00498254.2012.700427. Epub 2012 Jun 29.

PMID:
22742779
8.

Functional studies of single-nucleotide polymorphic variants of human glutathione transferase T1-1 involving residues in the dimer interface.

Josephy PD, Pan D, Ianni MD, Mannervik B.

Arch Biochem Biophys. 2011 Sep 15;513(2):87-93. doi: 10.1016/j.abb.2011.07.003. Epub 2011 Jul 14.

PMID:
21781954
9.

Genetic variations in human glutathione transferase enzymes: significance for pharmacology and toxicology.

Josephy PD.

Hum Genomics Proteomics. 2010 Jun 13;2010:876940. doi: 10.4061/2010/876940.

10.

Evaluation of self-reported progression and correlation of imatinib dose to survival in patients with metastatic gastrointestinal stromal tumors: an open cohort study.

Call J, Scherzer NJ, Josephy PD, Walentas C.

J Gastrointest Cancer. 2010 Mar;41(1):60-70. doi: 10.1007/s12029-009-9111-x.

11.

Single-nucleotide polymorphic variants of human glutathione transferase T1-1 differ in stability and functional properties.

Josephy PD, Kent M, Mannervik B.

Arch Biochem Biophys. 2009 Oct 1;490(1):24-9. doi: 10.1016/j.abb.2009.07.025. Epub 2009 Aug 6.

PMID:
19664997
12.

Northern exposures, northern risks: toxicology in Canada.

Josephy PD, Cyr DG.

Chem Res Toxicol. 2008 Oct;21(10):1909-12. doi: 10.1021/tx800295w. No abstract available.

PMID:
18928326
13.

Ames test evaluation of two commercially available zero-valent nickel compounds.

Josephy PD, Weadge JJ, Meissner J, Ng F.

Mutat Res. 2008 Jun 30;654(1):64-8. doi: 10.1016/j.mrgentox.2008.05.001. Epub 2008 May 15.

PMID:
18571463
14.
15.

Screening and characterization of variant Theta-class glutathione transferases catalyzing the activation of ethylene dibromide to a mutagen.

Josephy PD, Taylor PL, Vervaet G, Mannervik B.

Environ Mol Mutagen. 2006 Dec;47(9):657-65.

PMID:
16948056
16.

Screening and characterizing human NAT2 variants.

Savulescu MR, Mushtaq A, Josephy PD.

Methods Enzymol. 2005;400:192-215.

PMID:
16399350
17.

Microenvironmental influences on mutagenesis in mammary epithelial cells.

Papp-Szabó E, Josephy PD, Coomber BL.

Int J Cancer. 2005 Sep 20;116(5):679-85.

18.

Myeloperoxidase genotype, fruit and vegetable consumption, and breast cancer risk.

Ahn J, Gammon MD, Santella RM, Gaudet MM, Britton JA, Teitelbaum SL, Terry MB, Neugut AI, Josephy PD, Ambrosone CB.

Cancer Res. 2004 Oct 15;64(20):7634-9.

19.

Functional characterization of four allelic variants of human cytochrome P450 1A2.

Zhou H, Josephy PD, Kim D, Guengerich FP.

Arch Biochem Biophys. 2004 Feb 1;422(1):23-30.

PMID:
14725854
20.

Human acetyl CoA:arylamine N-acetyltransferase variants generated by random mutagenesis.

Summerscales JE, Josephy PD.

Mol Pharmacol. 2004 Jan;65(1):220-6.

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