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The Matricellular Protein R-Spondin 2 Promotes Midbrain Dopaminergic Neurogenesis and Differentiation.

Gyllborg D, Ahmed M, Toledo EM, Theofilopoulos S, Yang S, Ffrench-Constant C, Arenas E.

Stem Cell Reports. 2018 Sep 11;11(3):651-664. doi: 10.1016/j.stemcr.2018.07.014. Epub 2018 Aug 23.


Microfiber drug/gene delivery platform for study of myelination.

Ong W, Lin J, Bechler ME, Wang K, Wang M, Ffrench-Constant C, Chew SY.

Acta Biomater. 2018 Jul 15;75:152-160. doi: 10.1016/j.actbio.2018.06.011. Epub 2018 Jun 7.


Seeing Is Believing: Myelin Dynamics in the Adult CNS.

Swire M, Ffrench-Constant C.

Neuron. 2018 May 16;98(4):684-686. doi: 10.1016/j.neuron.2018.05.005.


Corrigendum: Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration.

Raven A, Lu WY, Man TY, Ferreira-Gonzalez S, O'Duibhir E, Dwyer BJ, Thomson JP, Meehan RR, Bogorad R, Koteliansky V, Kotelevtsev Y, Ffrench-Constant C, Boulter L, Forbes SJ.

Nature. 2018 Mar 14;555(7696):402. doi: 10.1038/nature25996.


Regenerating CNS myelin - from mechanisms to experimental medicines.

Franklin RJM, Ffrench-Constant C.

Nat Rev Neurosci. 2017 Nov 16;18(12):753-769. doi: 10.1038/nrn.2017.136. Review.


Intrinsic and adaptive myelination-A sequential mechanism for smart wiring in the brain.

Bechler ME, Swire M, Ffrench-Constant C.

Dev Neurobiol. 2018 Feb;78(2):68-79. doi: 10.1002/dneu.22518. Epub 2017 Sep 14. Review.


Selective rab11 transport and the intrinsic regenerative ability of CNS axons.

Koseki H, Donegá M, Lam BY, Petrova V, van Erp S, Yeo GS, Kwok JC, Ffrench-Constant C, Eva R, Fawcett JW.

Elife. 2017 Aug 8;6. pii: e26956. doi: 10.7554/eLife.26956.


Gelsolin dysfunction causes photoreceptor loss in induced pluripotent cell and animal retinitis pigmentosa models.

Megaw R, Abu-Arafeh H, Jungnickel M, Mellough C, Gurniak C, Witke W, Zhang W, Khanna H, Mill P, Dhillon B, Wright AF, Lako M, Ffrench-Constant C.

Nat Commun. 2017 Aug 16;8(1):271. doi: 10.1038/s41467-017-00111-8.


Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration.

Raven A, Lu WY, Man TY, Ferreira-Gonzalez S, O'Duibhir E, Dwyer BJ, Thomson JP, Meehan RR, Bogorad R, Koteliansky V, Kotelevtsev Y, Ffrench-Constant C, Boulter L, Forbes SJ.

Nature. 2017 Jul 20;547(7663):350-354. doi: 10.1038/nature23015. Epub 2017 Jul 12. Erratum in: Nature. 2018 Mar 14;555(7696):402.


VEGF preconditioning leads to stem cell remodeling and attenuates age-related decay of adult hippocampal neurogenesis.

Licht T, Rothe G, Kreisel T, Wolf B, Benny O, Rooney AG, Ffrench-Constant C, Enikolopov G, Keshet E.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7828-E7836. Epub 2016 Nov 14.


Extracellular Matrix Regulation of Stem Cell Behavior.

Ahmed M, Ffrench-Constant C.

Curr Stem Cell Rep. 2016;2:197-206. Epub 2016 Jul 7. Review.


FAT1 mutations cause a glomerulotubular nephropathy.

Gee HY, Sadowski CE, Aggarwal PK, Porath JD, Yakulov TA, Schueler M, Lovric S, Ashraf S, Braun DA, Halbritter J, Fang H, Airik R, Vega-Warner V, Cho KJ, Chan TA, Morris LG, ffrench-Constant C, Allen N, McNeill H, Büscher R, Kyrieleis H, Wallot M, Gaspert A, Kistler T, Milford DV, Saleem MA, Keng WT, Alexander SI, Valentini RP, Licht C, Teh JC, Bogdanovic R, Koziell A, Bierzynska A, Soliman NA, Otto EA, Lifton RP, Holzman LB, Sibinga NE, Walz G, Tufro A, Hildebrandt F.

Nat Commun. 2016 Feb 24;7:10822. doi: 10.1038/ncomms10822.


Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin.

Long K, Moss L, Laursen L, Boulter L, ffrench-Constant C.

Nat Commun. 2016 Feb 3;7:10354. doi: 10.1038/ncomms10354.


Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation.

de la Fuente AG, Errea O, van Wijngaarden P, Gonzalez GA, Kerninon C, Jarjour AA, Lewis HJ, Jones CA, Nait-Oumesmar B, Zhao C, Huang JK, ffrench-Constant C, Franklin RJ.

J Cell Biol. 2015 Dec 7;211(5):975-85. doi: 10.1083/jcb.201505119.


CNS Myelin Sheath Lengths Are an Intrinsic Property of Oligodendrocytes.

Bechler ME, Byrne L, Ffrench-Constant C.

Curr Biol. 2015 Sep 21;25(18):2411-6. doi: 10.1016/j.cub.2015.07.056. Epub 2015 Aug 27.


Use of induced pluripotent stem-cell technology to understand photoreceptor cytoskeletal dynamics in retinitis pigmentosa.

Megaw R, Mellough C, Wright A, Lako M, Ffrench-Constant C.

Lancet. 2015 Feb 26;385 Suppl 1:S69. doi: 10.1016/S0140-6736(15)60384-1.


Downregulation of the microtubule associated protein tau impairs process outgrowth and myelin basic protein mRNA transport in oligodendrocytes.

Seiberlich V, Bauer NG, Schwarz L, Ffrench-Constant C, Goldbaum O, Richter-Landsberg C.

Glia. 2015 Sep;63(9):1621-35. doi: 10.1002/glia.22832. Epub 2015 Apr 4.


The polarity protein Scribble regulates myelination and remyelination in the central nervous system.

Jarjour AA, Boyd A, Dow LE, Holloway RK, Goebbels S, Humbert PO, Williams A, ffrench-Constant C.

PLoS Biol. 2015 Mar 25;13(3):e1002107. doi: 10.1371/journal.pbio.1002107. eCollection 2015 Mar.


Can the irradiated brain be salvaged by oligodendrocyte precursor transplantation?

Harrisingh MC, ffrench-Constant C.

Cell Stem Cell. 2015 Feb 5;16(2):113-4. doi: 10.1016/j.stem.2015.01.010.


Regulation of the neural stem cell compartment by extracellular matrix constituents.

Theocharidis U, Long K, ffrench-Constant C, Faissner A.

Prog Brain Res. 2014;214:3-28. doi: 10.1016/B978-0-444-63486-3.00001-3. Review.


Disc1 variation leads to specific alterations in adult neurogenesis.

Chandran JS, Kazanis I, Clapcote SJ, Ogawa F, Millar JK, Porteous DJ, Ffrench-Constant C.

PLoS One. 2014 Oct 1;9(10):e108088. doi: 10.1371/journal.pone.0108088. eCollection 2014.


Neural stem cell quiescence comes to an un-sticky end.

Long KR, Ffrench-Constant C.

Nat Cell Biol. 2014 Jul;16(7):625-7. doi: 10.1038/ncb3003.


Hypomyelinating leukodystrophies: translational research progress and prospects.

Pouwels PJ, Vanderver A, Bernard G, Wolf NI, Dreha-Kulczewksi SF, Deoni SC, Bertini E, Kohlschütter A, Richardson W, Ffrench-Constant C, Köhler W, Rowitch D, Barkovich AJ.

Ann Neurol. 2014 Jul;76(1):5-19. doi: 10.1002/ana.24194. Epub 2014 Jun 24. Review.


Neuroscience. A new wrap for neuronal activity?

Bechler ME, ffrench-Constant C.

Science. 2014 May 2;344(6183):480-1. doi: 10.1126/science.1254446. No abstract available.


M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination.

Miron VE, Boyd A, Zhao JW, Yuen TJ, Ruckh JM, Shadrach JL, van Wijngaarden P, Wagers AJ, Williams A, Franklin RJM, Ffrench-Constant C.

Nat Neurosci. 2013 Sep;16(9):1211-1218. doi: 10.1038/nn.3469. Epub 2013 Jul 21.


The late response of rat subependymal zone stem and progenitor cells to stroke is restricted to directly affected areas of their niche.

Kazanis I, Gorenkova N, Zhao JW, Franklin RJ, Modo M, Ffrench-Constant C.

Exp Neurol. 2013 Oct;248:387-97. doi: 10.1016/j.expneurol.2013.06.025. Epub 2013 Jul 2.


Individual oligodendrocytes have only a few hours in which to generate new myelin sheaths in vivo.

Czopka T, Ffrench-Constant C, Lyons DA.

Dev Cell. 2013 Jun 24;25(6):599-609. doi: 10.1016/j.devcel.2013.05.013.


Identification of endothelin 2 as an inflammatory factor that promotes central nervous system remyelination.

Yuen TJ, Johnson KR, Miron VE, Zhao C, Quandt J, Harrisingh MC, Swire M, Williams A, McFarland HF, Franklin RJ, Ffrench-Constant C.

Brain. 2013 Apr;136(Pt 4):1035-47. doi: 10.1093/brain/awt024. Epub 2013 Mar 21.


Fibronectin aggregation in multiple sclerosis lesions impairs remyelination.

Stoffels JM, de Jonge JC, Stancic M, Nomden A, van Strien ME, Ma D, Sisková Z, Maier O, Ffrench-Constant C, Franklin RJ, Hoekstra D, Zhao C, Baron W.

Brain. 2013 Jan;136(Pt 1):116-31. doi: 10.1093/brain/aws313.


Unconjugated bilirubin restricts oligodendrocyte differentiation and axonal myelination.

Barateiro A, Miron VE, Santos SD, Relvas JB, Fernandes A, Ffrench-Constant C, Brites D.

Mol Neurobiol. 2013 Apr;47(2):632-44. doi: 10.1007/s12035-012-8364-8. Epub 2012 Oct 21.


Neuroprotection and repair in multiple sclerosis.

Franklin RJ, ffrench-Constant C, Edgar JM, Smith KJ.

Nat Rev Neurol. 2012 Nov 5;8(11):624-34. doi: 10.1038/nrneurol.2012.200. Epub 2012 Oct 2. Review.


ARF6 directs axon transport and traffic of integrins and regulates axon growth in adult DRG neurons.

Eva R, Crisp S, Marland JR, Norman JC, Kanamarlapudi V, ffrench-Constant C, Fawcett JW.

J Neurosci. 2012 Jul 25;32(30):10352-64.


The extracellular matrix molecule tenascin C modulates expression levels and territories of key patterning genes during spinal cord astrocyte specification.

Karus M, Denecke B, ffrench-Constant C, Wiese S, Faissner A.

Development. 2011 Dec;138(24):5321-31. doi: 10.1242/dev.067413. Epub 2011 Nov 9.


Myelin regeneration in multiple sclerosis: targeting endogenous stem cells.

Huang JK, Fancy SP, Zhao C, Rowitch DH, Ffrench-Constant C, Franklin RJ.

Neurotherapeutics. 2011 Oct;8(4):650-8. doi: 10.1007/s13311-011-0065-x. Review.


Extracellular matrix and the neural stem cell niche.

Kazanis I, ffrench-Constant C.

Dev Neurobiol. 2011 Nov;71(11):1006-17. doi: 10.1002/dneu.20970. Review.


Individual axons regulate the myelinating potential of single oligodendrocytes in vivo.

Almeida RG, Czopka T, Ffrench-Constant C, Lyons DA.

Development. 2011 Oct;138(20):4443-50. doi: 10.1242/dev.071001. Epub 2011 Aug 31.


In vitro modeling of central nervous system myelination and remyelination.

Jarjour AA, Zhang H, Bauer N, Ffrench-Constant C, Williams A.

Glia. 2012 Jan;60(1):1-12. doi: 10.1002/glia.21231. Epub 2011 Aug 19. Review.


The number of stem cells in the subependymal zone of the adult rodent brain is correlated with the number of ependymal cells and not with the volume of the niche.

Kazanis I, Ffrench-Constant C.

Stem Cells Dev. 2012 May 1;21(7):1090-6. doi: 10.1089/scd.2011.0130. Epub 2011 Sep 7.


Integrin activation promotes axon growth on inhibitory chondroitin sulfate proteoglycans by enhancing integrin signaling.

Tan CL, Kwok JC, Patani R, Ffrench-Constant C, Chandran S, Fawcett JW.

J Neurosci. 2011 Apr 27;31(17):6289-95. doi: 10.1523/JNEUROSCI.0008-11.2011.


Retinoid X receptors as a potential avenue for regenerative medicine in multiple sclerosis.

Huang JK, Jarjour AA, Ffrench-Constant C, Franklin RJ.

Expert Rev Neurother. 2011 Apr;11(4):467-8. doi: 10.1586/ern.11.34. No abstract available.


Association of white matter integrity with genetic variation in an exonic DISC1 SNP.

Sprooten E, Sussmann JE, Moorhead TW, Whalley HC, Ffrench-Constant C, Blumberg HP, Bastin ME, Hall J, Lawrie SM, McIntosh AM.

Mol Psychiatry. 2011 Jul;16(7):685, 688-9. doi: 10.1038/mp.2011.15. Epub 2011 Mar 1. No abstract available.


Translation of myelin basic protein mRNA in oligodendrocytes is regulated by integrin activation and hnRNP-K.

Laursen LS, Chan CW, Ffrench-Constant C.

J Cell Biol. 2011 Mar 7;192(5):797-811. doi: 10.1083/jcb.201007014. Epub 2011 Feb 28.


Retinoid X receptor gamma signaling accelerates CNS remyelination.

Huang JK, Jarjour AA, Nait Oumesmar B, Kerninon C, Williams A, Krezel W, Kagechika H, Bauer J, Zhao C, Baron-Van Evercooren A, Chambon P, Ffrench-Constant C, Franklin RJM.

Nat Neurosci. 2011 Jan;14(1):45-53. doi: 10.1038/nn.2702. Epub 2010 Dec 5.


Regulatory mechanisms that mediate tenascin C-dependent inhibition of oligodendrocyte precursor differentiation.

Czopka T, von Holst A, ffrench-Constant C, Faissner A.

J Neurosci. 2010 Sep 15;30(37):12310-22. doi: 10.1523/JNEUROSCI.4957-09.2010.


Rab11 and its effector Rab coupling protein contribute to the trafficking of beta 1 integrins during axon growth in adult dorsal root ganglion neurons and PC12 cells.

Eva R, Dassie E, Caswell PT, Dick G, ffrench-Constant C, Norman JC, Fawcett JW.

J Neurosci. 2010 Sep 1;30(35):11654-69. doi: 10.1523/JNEUROSCI.2425-10.2010.


Improving the translational hit of experimental treatments in multiple sclerosis.

Vesterinen HM, Sena ES, ffrench-Constant C, Williams A, Chandran S, Macleod MR.

Mult Scler. 2010 Sep;16(9):1044-55. doi: 10.1177/1352458510379612. Epub 2010 Aug 4. Review.


Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals.

Kazanis I, Lathia JD, Vadakkan TJ, Raborn E, Wan R, Mughal MR, Eckley DM, Sasaki T, Patton B, Mattson MP, Hirschi KK, Dickinson ME, ffrench-Constant C.

J Neurosci. 2010 Jul 21;30(29):9771-81. doi: 10.1523/JNEUROSCI.0700-10.2010.


The neural stem cell microenvironment.

Kazanis I, Lathia J, Moss L, ffrench-Constant C.

StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-.
2008 Aug 31.


Adhesion molecules in the stem cell niche--more than just staying in shape?

Marthiens V, Kazanis I, Moss L, Long K, Ffrench-Constant C.

J Cell Sci. 2010 May 15;123(Pt 10):1613-22. doi: 10.1242/jcs.054312. Review.


Stem cell treatments and multiple sclerosis.

Franklin RJ, Ffrench-Constant C.

BMJ. 2010 Mar 11;340:c1387. doi: 10.1136/bmj.c1387. No abstract available.


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