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Prelamin A mediates myocardial inflammation in dilated and HIV-associated cardiomyopathies.

Brayson D, Frustaci A, Verardo R, Chimenti C, Russo MA, Hayward R, Ahmad S, Vizcay-Barrena G, Protti A, Zammit PS, dos Remedios CG, Ehler E, Shah AM, Shanahan CM.

JCI Insight. 2019 Nov 14;4(22). pii: 126315. doi: 10.1172/jci.insight.126315.


Enhanced cardiac repair by telomerase reverse transcriptase over-expression in human cardiac mesenchymal stromal cells.

Le TYL, Pickett HA, Yang A, Ho JWK, Thavapalachandran S, Igoor S, Yang SF, Farraha M, Voges HK, Hudson JE, Dos Remedios CG, Bryan TM, Kizana E, Chong JJH.

Sci Rep. 2019 Jul 22;9(1):10579. doi: 10.1038/s41598-019-47022-w.


Protein Quality Control Activation and Microtubule Remodeling in Hypertrophic Cardiomyopathy.

Dorsch LM, Schuldt M, dos Remedios CG, Schinkel AFL, de Jong PL, Michels M, Kuster DWD, Brundel BJJM, van der Velden J.

Cells. 2019 Jul 18;8(7). pii: E741. doi: 10.3390/cells8070741.


A step towards understanding the molecular nature of human heart failure: advances using the Sydney Heart Bank collection.

Li A, Lal S, Dos Remedios CG.

Biophys Rev. 2019 Apr;11(2):241-244. doi: 10.1007/s12551-019-00514-5. Epub 2019 Mar 20. No abstract available.


Letter from the Editor.

Dos Remedios CG.

Biophys Rev. 2019 Apr;11(2):127-128. doi: 10.1007/s12551-019-00510-9. Epub 2019 Mar 4. No abstract available.


PKC and PKN in heart disease.

Marrocco V, Bogomolovas J, Ehler E, Dos Remedios CG, Yu J, Gao C, Lange S.

J Mol Cell Cardiol. 2019 Mar;128:212-226. doi: 10.1016/j.yjmcc.2019.01.029. Epub 2019 Feb 8. Review.


Reviews arising from the 2017 conference of the Australian Society for Biophysics and the Japanese Society for Biophysics.

Dos Remedios CG.

Biophys Rev. 2018 Oct;10(5):1215-1220. doi: 10.1007/s12551-018-0463-y. Epub 2018 Sep 24. No abstract available.


Author Correction: Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes.

Vikhorev PG, Smoktunowicz N, Munster AB, Copeland ON, Kostin S, Montgiraud C, Messer AE, Toliat MR, Li A, Dos Remedios CG, Lal S, Blair CA, Campbell KS, Guglin M, Richter M, Knöll R, Marston SB.

Sci Rep. 2018 Sep 24;8(1):14485. doi: 10.1038/s41598-018-32408-z.


A review of heavy metal cation binding to deoxyribonucleic acids for the creation of chemical sensors.

Kanellis VG, Dos Remedios CG.

Biophys Rev. 2018 Oct;10(5):1401-1414. doi: 10.1007/s12551-018-0455-y. Epub 2018 Sep 18. Review.


Alterations in Titin Properties and Myocardial Fibrosis Correlate With Clinical Phenotypes in Hemodynamic Subgroups of Severe Aortic Stenosis.

Gotzmann M, Grabbe S, Schöne D, von Frieling-Salewsky M, Dos Remedios CG, Strauch J, Bechtel M, Dietrich JW, Tannapfel A, Mügge A, Linke WA.

JACC Basic Transl Sci. 2018 Jun 25;3(3):335-346. doi: 10.1016/j.jacbts.2018.02.002. eCollection 2018 Jun.


Non-sarcomeric causes of heart failure: a Sydney Heart Bank perspective.

Dos Remedios CG, Li A, Lal S.

Biophys Rev. 2018 Aug;10(4):949-954. doi: 10.1007/s12551-018-0441-4. Epub 2018 Jul 18. Review. No abstract available.


Burst-Like Transcription of Mutant and Wildtype MYH7-Alleles as Possible Origin of Cell-to-Cell Contractile Imbalance in Hypertrophic Cardiomyopathy.

Montag J, Kowalski K, Makul M, Ernstberger P, Radocaj A, Beck J, Becker E, Tripathi S, Keyser B, Mühlfeld C, Wissel K, Pich A, van der Velden J, Dos Remedios CG, Perrot A, Francino A, Navarro-López F, Brenner B, Kraft T.

Front Physiol. 2018 Apr 9;9:359. doi: 10.3389/fphys.2018.00359. eCollection 2018.


Monophosphorylation of cardiac troponin-I at Ser-23/24 is sufficient to regulate cardiac myofibrillar Ca2+ sensitivity and calpain-induced proteolysis.

Martin-Garrido A, Biesiadecki BJ, Salhi HE, Shaifta Y, Dos Remedios CG, Ayaz-Guner S, Cai W, Ge Y, Avkiran M, Kentish JC.

J Biol Chem. 2018 Jun 1;293(22):8588-8599. doi: 10.1074/jbc.RA117.001292. Epub 2018 Apr 18.


Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control.

Coleman JLJ, Mouat MA, Wu J, Jancovski N, Bassi JK, Chan AY, Humphreys DT, Mrad N, Yu ZY, Ngo T, Iismaa S, Dos Remedios CG, Feneley MP, Allen AM, Graham RM, Smith NJ.

Biol Sex Differ. 2018 Apr 6;9(1):14. doi: 10.1186/s13293-018-0173-y.


Skeletal myosin binding protein-C isoforms regulate thin filament activity in a Ca2+-dependent manner.

Lin BL, Li A, Mun JY, Previs MJ, Previs SB, Campbell SG, Dos Remedios CG, Tombe PP, Craig R, Warshaw DM, Sadayappan S.

Sci Rep. 2018 Feb 8;8(1):2604. doi: 10.1038/s41598-018-21053-1.


Differences in Contractile Function of Myofibrils within Human Embryonic Stem Cell-Derived Cardiomyocytes vs. Adult Ventricular Myofibrils Are Related to Distinct Sarcomeric Protein Isoforms.

Iorga B, Schwanke K, Weber N, Wendland M, Greten S, Piep B, Dos Remedios CG, Martin U, Zweigerdt R, Kraft T, Brenner B.

Front Physiol. 2018 Jan 19;8:1111. doi: 10.3389/fphys.2017.01111. eCollection 2017.


Correction to: The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease.

Dos Remedios CG, Lal SP, Li A, McNamara J, Keogh A, Macdonald PS, Cooke R, Ehler E, Knöll R, Marston SB, Stelzer J, Granzier H, Bezzina C, van Dijk S, De Man F, Stienen GJM, Odeberg J, Pontén F, Linke WA, van der Velden J.

Biophys Rev. 2018 Jun;10(3):941. doi: 10.1007/s12551-018-0397-4.


Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes.

Krysiak J, Unger A, Beckendorf L, Hamdani N, von Frieling-Salewsky M, Redfield MM, Dos Remedios CG, Sheikh F, Gergs U, Boknik P, Linke WA.

Nat Commun. 2018 Jan 17;9(1):262. doi: 10.1038/s41467-017-02483-3.


An historical perspective of the discovery of titin filaments -Part 2.

Dos Remedios CG.

Biophys Rev. 2018 Aug;10(4):1201-1203. doi: 10.1007/s12551-017-0393-0. Epub 2018 Jan 13. Review.


Editorial for issue #1 2018.

Dos Remedios CG, Li A.

Biophys Rev. 2018 Feb;10(1):1-2. doi: 10.1007/s12551-017-0385-0. Epub 2017 Dec 26. No abstract available.


Platelet-Derived Growth Factor Receptor-Alpha Expressing Cardiac Progenitor Cells Can Be Derived from Previously Cryopreserved Human Heart Samples.

Le TYL, Pickett HA, Dos Remedios CG, Barbaro PM, Kizana E, Chong JJH.

Stem Cells Dev. 2018 Feb 1;27(3):184-198. doi: 10.1089/scd.2017.0082. Epub 2018 Jan 16.


Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes.

Vikhorev PG, Smoktunowicz N, Munster AB, Copeland O, Kostin S, Montgiraud C, Messer AE, Toliat MR, Li A, Dos Remedios CG, Lal S, Blair CA, Campbell KS, Guglin M, Richter M, Knöll R, Marston SB.

Sci Rep. 2017 Nov 1;7(1):14829. doi: 10.1038/s41598-017-13675-8. Erratum in: Sci Rep. 2018 Sep 24;8(1):14485.


Dose-Dependent Effects of the Myosin Activator Omecamtiv Mecarbil on Cross-Bridge Behavior and Force Generation in Failing Human Myocardium.

Mamidi R, Li J, Gresham KS, Verma S, Doh CY, Li A, Lal S, Dos Remedios CG, Stelzer JE.

Circ Heart Fail. 2017 Oct;10(10). pii: e004257. doi: 10.1161/CIRCHEARTFAILURE.117.004257.


Myofilament Remodeling and Function Is More Impaired in Peripartum Cardiomyopathy Compared with Dilated Cardiomyopathy and Ischemic Heart Disease.

Bollen IAE, Ehler E, Fleischanderl K, Bouwman F, Kempers L, Ricke-Hoch M, Hilfiker-Kleiner D, Dos Remedios CG, Krüger M, Vink A, Asselbergs FW, van Spaendonck-Zwarts KY, Pinto YM, Kuster DWD, van der Velden J.

Am J Pathol. 2017 Dec;187(12):2645-2658. doi: 10.1016/j.ajpath.2017.08.022. Epub 2017 Sep 19. Erratum in: Am J Pathol. 2018 Mar;188(3):828-829.


The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease.

Dos Remedios CG, Lal SP, Li A, McNamara J, Keogh A, Macdonald PS, Cooke R, Ehler E, Knöll R, Marston SB, Stelzer J, Granzier H, Bezzina C, van Dijk S, De Man F, Stienen GJM, Odeberg J, Pontén F, Linke WA, Linke W, van der Velden J.

Biophys Rev. 2017 Aug;9(4):431-441. doi: 10.1007/s12551-017-0305-3. Epub 2017 Aug 14. Review. Erratum in: Biophys Rev. 2018 Feb 1;:. Linke W [corrected to Linke WA].


Special Issue of Biophysical Reviews dedicated to the 19th IUPAB Conference in Edinburgh, Scotland (July 2017).

Hall D, Dos Remedios CG.

Biophys Rev. 2017 Aug;9(4):269-271. doi: 10.1007/s12551-017-0312-4. Epub 2017 Aug 12.


MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy.

McNamara JW, Li A, Lal S, Bos JM, Harris SP, van der Velden J, Ackerman MJ, Cooke R, Dos Remedios CG.

PLoS One. 2017 Jun 28;12(6):e0180064. doi: 10.1371/journal.pone.0180064. eCollection 2017.


New insights into real-time multiprotein fluorescence microscopy.

Dos Remedios CG.

Biophys Rev. 2017 Apr;9(2):65-66. doi: 10.1007/s12551-017-0260-z. Epub 2017 Mar 21. No abstract available.


Increased collagen within the transverse tubules in human heart failure.

Crossman DJ, Shen X, Jüllig M, Munro M, Hou Y, Middleditch M, Shrestha D, Li A, Lal S, Dos Remedios CG, Baddeley D, Ruygrok PN, Soeller C.

Cardiovasc Res. 2017 Jul 1;113(8):879-891. doi: 10.1093/cvr/cvx055.


A model of cardiac contraction based on novel measurements of tension development in human cardiomyocytes.

Land S, Park-Holohan SJ, Smith NP, Dos Remedios CG, Kentish JC, Niederer SA.

J Mol Cell Cardiol. 2017 May;106:68-83. doi: 10.1016/j.yjmcc.2017.03.008. Epub 2017 Apr 7.


Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy.

Huang ZP, Ding Y, Chen J, Wu G, Kataoka M, Hu Y, Yang JH, Liu J, Drakos SG, Selzman CH, Kyselovic J, Qu LH, Dos Remedios CG, Pu WT, Wang DZ.

Cardiovasc Res. 2016 Nov 1;112(2):543-554. doi: 10.1093/cvr/cvw201.


MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy.

Lange S, Gehmlich K, Lun AS, Blondelle J, Hooper C, Dalton ND, Alvarez EA, Zhang X, Bang ML, Abassi YA, Dos Remedios CG, Peterson KL, Chen J, Ehler E.

Nat Commun. 2016 Jun 29;7:12120. doi: 10.1038/ncomms12120.


The evolution of Biophysical Reviews.

Dos Remedios CG.

Biophys Rev. 2016 Mar;8(1):1-3. doi: 10.1007/s12551-015-0192-4. Epub 2016 Jan 15. No abstract available.


ADP-stimulated contraction: A predictor of thin-filament activation in cardiac disease.

Sequeira V, Najafi A, Wijnker PJ, Dos Remedios CG, Michels M, Kuster DW, van der Velden J.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):E7003-12. doi: 10.1073/pnas.1513843112. Epub 2015 Nov 30.


Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C.

Mamidi R, Gresham KS, Li A, dos Remedios CG, Stelzer JE.

J Mol Cell Cardiol. 2015 Aug;85:262-72. doi: 10.1016/j.yjmcc.2015.06.011. Epub 2015 Jun 20.


Cardiac gene expression data and in silico analysis provide novel insights into human and mouse taste receptor gene regulation.

Foster SR, Porrello ER, Stefani M, Smith NJ, Molenaar P, dos Remedios CG, Thomas WG, Ramialison M.

Naunyn Schmiedebergs Arch Pharmacol. 2015 Oct;388(10):1009-27. doi: 10.1007/s00210-015-1118-1. Epub 2015 May 20.


Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window.

Polizzotti BD, Ganapathy B, Walsh S, Choudhury S, Ammanamanchi N, Bennett DG, dos Remedios CG, Haubner BJ, Penninger JM, Kühn B.

Sci Transl Med. 2015 Apr 1;7(281):281ra45. doi: 10.1126/scitranslmed.aaa5171.


Special Issue on human heart failure.

Li A, Dos Remedios CG.

Biophys Rev. 2015 Mar;7(1):1-3. doi: 10.1007/s12551-014-0161-3. Epub 2015 Jan 27. No abstract available.


The role of super-relaxed myosin in skeletal and cardiac muscle.

McNamara JW, Li A, Dos Remedios CG, Cooke R.

Biophys Rev. 2015 Mar;7(1):5-14. doi: 10.1007/s12551-014-0151-5. Epub 2014 Dec 20.


Adaptations of cytoarchitecture in human dilated cardiomyopathy.

Pluess M, Daeubler G, Dos Remedios CG, Ehler E.

Biophys Rev. 2015 Mar;7(1):25-32. doi: 10.1007/s12551-014-0146-2. Epub 2014 Dec 11.


Nuclear pore rearrangements and nuclear trafficking in cardiomyocytes from rat and human failing hearts.

Chahine MN, Mioulane M, Sikkel MB, O'Gara P, Dos Remedios CG, Pierce GN, Lyon AR, Földes G, Harding SE.

Cardiovasc Res. 2015 Jan 1;105(1):31-43. doi: 10.1093/cvr/cvu218. Epub 2014 Oct 23.


Differences in the regulation of RyR2 from human, sheep, and rat by Ca²⁺ and Mg²⁺ in the cytoplasm and in the lumen of the sarcoplasmic reticulum.

Walweel K, Li J, Molenaar P, Imtiaz MS, Quail A, dos Remedios CG, Beard NA, Dulhunty AF, van Helden DF, Laver DR.

J Gen Physiol. 2014 Sep;144(3):263-71. doi: 10.1085/jgp.201311157.


The formin FHOD1 in cardiomyocytes.

Dwyer J, Pluess M, Iskratsch T, Dos Remedios CG, Ehler E.

Anat Rec (Hoboken). 2014 Sep;297(9):1560-70. doi: 10.1002/ar.22984.


Contractile dysfunction of left ventricular cardiomyocytes in patients with pulmonary arterial hypertension.

Manders E, Bogaard HJ, Handoko ML, van de Veerdonk MC, Keogh A, Westerhof N, Stienen GJ, Dos Remedios CG, Humbert M, Dorfmüller P, Fadel E, Guignabert C, van der Velden J, Vonk-Noordegraaf A, de Man FS, Ottenheijm CA.

J Am Coll Cardiol. 2014 Jul 8;64(1):28-37. doi: 10.1016/j.jacc.2014.04.031.


Phosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes.

Wijnker PJ, Sequeira V, Witjas-Paalberends ER, Foster DB, dos Remedios CG, Murphy AM, Stienen GJ, van der Velden J.

Arch Biochem Biophys. 2014 Jul 15;554:11-21. doi: 10.1016/ Epub 2014 May 9.


Quantification of thyroxine and 3,5,3'-triiodo-thyronine in human and animal hearts by a novel liquid chromatography-tandem mass spectrometry method.

Saba A, Donzelli R, Colligiani D, Raffaelli A, Nannipieri M, Kusmic C, Dos Remedios CG, Simonides WS, Iervasi G, Zucchi R.

Horm Metab Res. 2014 Aug;46(9):628-34. doi: 10.1055/s-0034-1368717. Epub 2014 Mar 3.


Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation.

Wijnker PJ, Sequeira V, Foster DB, Li Y, Dos Remedios CG, Murphy AM, Stienen GJ, van der Velden J.

Am J Physiol Heart Circ Physiol. 2014 Apr 15;306(8):H1171-81. doi: 10.1152/ajpheart.00580.2013. Epub 2014 Feb 28.


Cluster of differentiation antibody microarrays on plasma immersion ion implanted polycarbonate.

Kosobrodova E, Mohamed A, Su Y, Kondyurin A, dos Remedios CG, McKenzie DR, Bilek MM.

Mater Sci Eng C Mater Biol Appl. 2014 Feb 1;35:434-40. doi: 10.1016/j.msec.2013.11.034. Epub 2013 Dec 4.


Coxsackie and adenovirus receptor is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia.

Marsman RF, Bezzina CR, Freiberg F, Verkerk AO, Adriaens ME, Podliesna S, Chen C, Purfürst B, Spallek B, Koopmann TT, Baczko I, Dos Remedios CG, George AL Jr, Bishopric NH, Lodder EM, de Bakker JM, Fischer R, Coronel R, Wilde AA, Gotthardt M, Remme CA.

J Am Coll Cardiol. 2014 Feb 18;63(6):549-59. doi: 10.1016/j.jacc.2013.10.062. Epub 2013 Nov 27.


MicroRNA transcriptome profiling in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutations.

Kuster DW, Mulders J, Ten Cate FJ, Michels M, Dos Remedios CG, da Costa Martins PA, van der Velden J, Oudejans CB.

J Mol Cell Cardiol. 2013 Dec;65:59-66. doi: 10.1016/j.yjmcc.2013.09.012. Epub 2013 Sep 29.


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