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Items: 1 to 50 of 120

1.

Protein tyrosine phosphatase alpha inhibits hypothalamic leptin receptor signaling and regulates body weight in vivo.

Cohen-Sharir Y, Kuperman Y, Apelblat D, den Hertog J, Spiegel I, Knobler H, Elson A.

FASEB J. 2019 Apr;33(4):5101-5111. doi: 10.1096/fj.201800860RR. Epub 2019 Jan 7.

PMID:
30615487
2.

Impaired caudal fin-fold regeneration in zebrafish deficient for the tumor suppressor Pten.

Hale AJ, Kiai A, Sikkens J, den Hertog J.

Regeneration (Oxf). 2017 Nov 10;4(4):217-226. doi: 10.1002/reg2.88. eCollection 2017 Aug.

3.

Shp2-Mitogen-Activated Protein Kinase Signaling Drives Proliferation during Zebrafish Embryo Caudal Fin Fold Regeneration.

Hale AJ, den Hertog J.

Mol Cell Biol. 2018 Jan 29;38(4). pii: e00515-17. doi: 10.1128/MCB.00515-17. Print 2018 Feb 15.

4.

A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development.

Ciarlo C, Kaufman CK, Kinikoglu B, Michael J, Yang S, D Amato C, Blokzijl-Franke S, den Hertog J, Schlaeger TM, Zhou Y, Liao E, Zon LI.

Elife. 2017 Aug 23;6. pii: e29145. doi: 10.7554/eLife.29145.

5.

Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration.

Wu W, Hale AJ, Lemeer S, den Hertog J.

Sci Rep. 2017 Aug 16;7(1):8460. doi: 10.1038/s41598-017-07109-8.

6.

Recent advances in understanding the role of protein-tyrosine phosphatases in development and disease.

Hale AJ, Ter Steege E, den Hertog J.

Dev Biol. 2017 Aug 15;428(2):283-292. doi: 10.1016/j.ydbio.2017.03.023. Review.

7.

Hubrecht Institute Centennial - From embryos to stem cells.

den Hertog J, de Laat SW.

Dev Biol. 2017 Aug 15;428(2):261-263. doi: 10.1016/j.ydbio.2017.02.004. Review.

8.

Celebrating 100 years of Developmental Biology at the Hubrecht Institute.

den Hertog J, van Oudenaarden A.

Dev Biol. 2017 Aug 15;428(2):259-260. doi: 10.1016/j.ydbio.2017.06.001. Epub 2017 Jun 6. No abstract available.

9.

Studying Protein-Tyrosine Phosphatases in Zebrafish.

Hale AJ, den Hertog J.

Methods Mol Biol. 2016;1447:351-72. doi: 10.1007/978-1-4939-3746-2_19.

PMID:
27514815
10.

Tumor Suppressors in Zebrafish: From TP53 to PTEN and Beyond.

den Hertog J.

Adv Exp Med Biol. 2016;916:87-101. doi: 10.1007/978-3-319-30654-4_4. Review.

PMID:
27165350
11.

Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways.

Blokhuis AM, Koppers M, Groen EJ, van den Heuvel DM, Dini Modigliani S, Anink JJ, Fumoto K, van Diggelen F, Snelting A, Sodaar P, Verheijen BM, Demmers JA, Veldink JH, Aronica E, Bozzoni I, den Hertog J, van den Berg LH, Pasterkamp RJ.

Acta Neuropathol. 2016 Aug;132(2):175-96. doi: 10.1007/s00401-016-1575-8. Epub 2016 May 10.

12.

Fine-Tuning of Pten Localization and Phosphatase Activity Is Essential for Zebrafish Angiogenesis.

Stumpf M, Blokzijl-Franke S, den Hertog J.

PLoS One. 2016 May 3;11(5):e0154771. doi: 10.1371/journal.pone.0154771. eCollection 2016.

13.

Differential Requirement for Pten Lipid and Protein Phosphatase Activity during Zebrafish Embryonic Development.

Stumpf M, den Hertog J.

PLoS One. 2016 Feb 5;11(2):e0148508. doi: 10.1371/journal.pone.0148508. eCollection 2016.

14.

Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice.

Stanford SM, Svensson MN, Sacchetti C, Pilo CA, Wu DJ, Kiosses WB, Hellvard A, Bergum B, Muench GR, Elly C, Liu YC, den Hertog J, Elson A, Sap J, Mydel P, Boyle DL, Corr M, Firestein GS, Bottini N.

Arthritis Rheumatol. 2016 Feb;68(2):359-69. doi: 10.1002/art.39442.

15.

Pten function in zebrafish: anything but a fish story.

Stumpf M, Choorapoikayil S, den Hertog J.

Methods. 2015 May;77-78:191-6. doi: 10.1016/j.ymeth.2014.11.002. Epub 2014 Nov 11. Review.

PMID:
25461815
16.

Phosphoproteomics-mediated identification of Fer kinase as a target of mutant Shp2 in Noonan and LEOPARD syndrome.

Paardekooper Overman J, Preisinger C, Prummel K, Bonetti M, Giansanti P, Heck A, den Hertog J.

PLoS One. 2014 Sep 3;9(9):e106682. doi: 10.1371/journal.pone.0106682. eCollection 2014.

17.

A unified nomenclature and amino acid numbering for human PTEN.

Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, Jiang X, Lee SR, Lösche M, Malaney P, Matias-Guiu X, Molina M, Pandolfi PP, Parsons R, Pinton P, Rivas C, Rocha RM, Rodríguez MS, Ross AH, Serrano M, Stambolic V, Stiles B, Suzuki A, Tan SS, Tonks NK, Trotman LC, Wolff N, Woscholski R, Wu H, Leslie NR.

Sci Signal. 2014 Jul 1;7(332):pe15. doi: 10.1126/scisignal.2005560.

18.

Heterozygous germline mutations in A2ML1 are associated with a disorder clinically related to Noonan syndrome.

Vissers LE, Bonetti M, Paardekooper Overman J, Nillesen WM, Frints SG, de Ligt J, Zampino G, Justino A, Machado JC, Schepens M, Brunner HG, Veltman JA, Scheffer H, Gros P, Costa JL, Tartaglia M, van der Burgt I, Yntema HG, den Hertog J.

Eur J Hum Genet. 2015 Mar;23(3):317-24. doi: 10.1038/ejhg.2014.115. Epub 2014 Jun 18.

19.

PZR coordinates Shp2 Noonan and LEOPARD syndrome signaling in zebrafish and mice.

Paardekooper Overman J, Yi JS, Bonetti M, Soulsby M, Preisinger C, Stokes MP, Hui L, Silva JC, Overvoorde J, Giansanti P, Heck AJ, Kontaridis MI, den Hertog J, Bennett AM.

Mol Cell Biol. 2014 Aug;34(15):2874-89. doi: 10.1128/MCB.00135-14. Epub 2014 May 27.

20.

Mutant PTEN in Cancer: Worse Than Nothing.

Leslie NR, den Hertog J.

Cell. 2014 Apr 24;157(3):527-9. doi: 10.1016/j.cell.2014.04.008.

21.

Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish.

Bonetti M, Paardekooper Overman J, Tessadori F, Noël E, Bakkers J, den Hertog J.

Development. 2014 May;141(9):1961-70. doi: 10.1242/dev.106310. Epub 2014 Apr 9.

22.

Protein tyrosine phosphatases ε and α perform nonredundant roles in osteoclasts.

Finkelshtein E, Lotinun S, Levy-Apter E, Arman E, den Hertog J, Baron R, Elson A.

Mol Biol Cell. 2014 Jun;25(11):1808-18. doi: 10.1091/mbc.E14-03-0788. Epub 2014 Apr 2.

23.

A versatile spectrophotometric protein tyrosine phosphatase assay based on 3-nitrophosphotyrosine containing substrates.

van Ameijde J, Overvoorde J, Knapp S, den Hertog J, Ruijtenbeek R, Liskamp RM.

Anal Biochem. 2014 Mar 1;448:9-13. doi: 10.1016/j.ab.2013.11.023. Epub 2013 Dec 3.

PMID:
24309020
24.

Integrating chemical and genetic silencing strategies to identify host kinase-phosphatase inhibitor networks that control bacterial infection.

Albers HM, Kuijl C, Bakker J, Hendrickx L, Wekker S, Farhou N, Liu N, Blasco-Moreno B, Scanu T, den Hertog J, Celie P, Ovaa H, Neefjes J.

ACS Chem Biol. 2014 Feb 21;9(2):414-22. doi: 10.1021/cb400421a. Epub 2013 Nov 25.

25.

A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality.

Noël ES, Verhoeven M, Lagendijk AK, Tessadori F, Smith K, Choorapoikayil S, den Hertog J, Bakkers J.

Nat Commun. 2013;4:2754. doi: 10.1038/ncomms3754.

PMID:
24212328
26.

Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish.

Choorapoikayil S, Kers R, Herbomel P, Kissa K, den Hertog J.

Blood. 2014 Jan 9;123(2):184-90. doi: 10.1182/blood-2013-05-501544. Epub 2013 Oct 11.

27.

Zebrafish as a model to study PTPs during development.

Paardekooper Overman J, den Hertog J.

Methods. 2014 Jan 15;65(2):247-53. doi: 10.1016/j.ymeth.2013.08.018. Epub 2013 Aug 22. Review.

PMID:
23974070
28.

Loss of Pten promotes angiogenesis and enhanced vegfaa expression in zebrafish.

Choorapoikayil S, Weijts B, Kers R, de Bruin A, den Hertog J.

Dis Model Mech. 2013 Sep;6(5):1159-66. doi: 10.1242/dmm.012377. Epub 2013 May 29.

29.

Deriving cell lines from zebrafish embryos and tumors.

Choorapoikayil S, Overvoorde J, den Hertog J.

Zebrafish. 2013 Sep;10(3):316-25. doi: 10.1089/zeb.2013.0866. Epub 2013 May 14.

30.

Deficiency in hematopoietic phosphatase ptpn6/Shp1 hyperactivates the innate immune system and impairs control of bacterial infections in zebrafish embryos.

Kanwal Z, Zakrzewska A, den Hertog J, Spaink HP, Schaaf MJ, Meijer AH.

J Immunol. 2013 Feb 15;190(4):1631-45. doi: 10.4049/jimmunol.1200551. Epub 2013 Jan 18.

31.

Knocking down low molecular weight protein tyrosine phosphatase (LMW-PTP) reverts chemoresistance through inactivation of Src and Bcr-Abl proteins.

Ferreira PA, Ruela-de-Sousa RR, Queiroz KC, Souza AC, Milani R, Pilli RA, Peppelenbosch MP, den Hertog J, Ferreira CV.

PLoS One. 2012;7(9):e44312. doi: 10.1371/journal.pone.0044312. Epub 2012 Sep 5.

32.

Protein tyrosine phosphatases in health and disease.

Hendriks WJ, Elson A, Harroch S, Pulido R, Stoker A, den Hertog J.

FEBS J. 2013 Jan;280(2):708-30. doi: 10.1111/febs.12000. Epub 2012 Oct 1. Review.

33.

A variant in the carboxyl-terminus of connexin 40 alters GAP junctions and increases risk for tetralogy of Fallot.

Guida V, Ferese R, Rocchetti M, Bonetti M, Sarkozy A, Cecchetti S, Gelmetti V, Lepri F, Copetti M, Lamorte G, Cristina Digilio M, Marino B, Zaza A, den Hertog J, Dallapiccola B, De Luca A.

Eur J Hum Genet. 2013 Jan;21(1):69-75. doi: 10.1038/ejhg.2012.109. Epub 2012 Jun 20.

34.

Protein tyrosine phosphatase structure-function relationships in regulation and pathogenesis.

Böhmer F, Szedlacsek S, Tabernero L, Ostman A, den Hertog J.

FEBS J. 2013 Jan;280(2):413-31. doi: 10.1111/j.1742-4658.2012.08655.x. Epub 2012 Jul 2. Review.

35.

Pair-wise regulation of convergence and extension cell movements by four phosphatases via RhoA.

van Eekelen M, Runtuwene V, Masselink W, den Hertog J.

PLoS One. 2012;7(4):e35913. doi: 10.1371/journal.pone.0035913. Epub 2012 Apr 24.

36.

The defecation pattern of healthy term infants up to the age of 3 months.

den Hertog J, van Leengoed E, Kolk F, van den Broek L, Kramer E, Bakker EJ, Bakker-van Gijssel E, Bulk A, Kneepkens F, Benninga MA.

Arch Dis Child Fetal Neonatal Ed. 2012 Nov;97(6):F465-70. doi: 10.1136/archdischild-2011-300539. Epub 2012 Apr 20.

PMID:
22522220
37.

Haploinsufficiency of the genes encoding the tumor suppressor Pten predisposes zebrafish to hemangiosarcoma.

Choorapoikayil S, Kuiper RV, de Bruin A, den Hertog J.

Dis Model Mech. 2012 Mar;5(2):241-7. doi: 10.1242/dmm.008326. Epub 2011 Nov 9.

38.

Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia.

Gutierrez A, Grebliunaite R, Feng H, Kozakewich E, Zhu S, Guo F, Payne E, Mansour M, Dahlberg SE, Neuberg DS, den Hertog J, Prochownik EV, Testa JR, Harris M, Kanki JP, Look AT.

J Exp Med. 2011 Aug 1;208(8):1595-603. doi: 10.1084/jem.20101691. Epub 2011 Jul 4.

39.

Noonan syndrome gain-of-function mutations in NRAS cause zebrafish gastrulation defects.

Runtuwene V, van Eekelen M, Overvoorde J, Rehmann H, Yntema HG, Nillesen WM, van Haeringen A, van der Burgt I, Burgering B, den Hertog J.

Dis Model Mech. 2011 May;4(3):393-9. doi: 10.1242/dmm.007112. Epub 2011 Jan 24.

40.

Identification and expression of the family of classical protein-tyrosine phosphatases in zebrafish.

van Eekelen M, Overvoorde J, van Rooijen C, den Hertog J.

PLoS One. 2010 Sep 3;5(9):e12573. doi: 10.1371/journal.pone.0012573.

41.

Serine dephosphorylation of receptor protein tyrosine phosphatase alpha in mitosis induces Src binding and activation.

Vacaru AM, den Hertog J.

Mol Cell Biol. 2010 Jun;30(12):2850-61. doi: 10.1128/MCB.01202-09. Epub 2010 Apr 12.

42.

RPTPalpha and PTPepsilon signaling via Fyn/Yes and RhoA is essential for zebrafish convergence and extension cell movements during gastrulation.

van Eekelen M, Runtuwene V, Overvoorde J, den Hertog J.

Dev Biol. 2010 Apr 15;340(2):626-39. doi: 10.1016/j.ydbio.2010.02.026. Epub 2010 Feb 24.

43.

Catalytically active membrane-distal phosphatase domain of receptor protein-tyrosine phosphatase alpha is required for Src activation.

Vacaru AM, den Hertog J.

FEBS J. 2010 Mar;277(6):1562-70. doi: 10.1111/j.1742-4658.2010.07584.x. Epub 2010 Feb 11.

44.

In-depth qualitative and quantitative profiling of tyrosine phosphorylation using a combination of phosphopeptide immunoaffinity purification and stable isotope dimethyl labeling.

Boersema PJ, Foong LY, Ding VM, Lemeer S, van Breukelen B, Philp R, Boekhorst J, Snel B, den Hertog J, Choo AB, Heck AJ.

Mol Cell Proteomics. 2010 Jan;9(1):84-99. doi: 10.1074/mcp.M900291-MCP200. Epub 2009 Sep 21.

45.

The receptor protein-tyrosine phosphatase, Dep1, acts in arterial/venous cell fate decisions in zebrafish development.

Rodriguez F, Vacaru A, Overvoorde J, den Hertog J.

Dev Biol. 2008 Dec 1;324(1):122-30. doi: 10.1016/j.ydbio.2008.09.011. Epub 2008 Sep 23.

46.

NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth.

Bodrikov V, Sytnyk V, Leshchyns'ka I, den Hertog J, Schachner M.

J Cell Biol. 2008 Sep 22;182(6):1185-200. doi: 10.1083/jcb.200803045.

47.

Assessment of PTEN tumor suppressor activity in nonmammalian models: the year of the yeast.

Cid VJ, Rodríguez-Escudero I, Andrés-Pons A, Romá-Mateo C, Gil A, den Hertog J, Molina M, Pulido R.

Oncogene. 2008 Sep 18;27(41):5431-42. doi: 10.1038/onc.2008.240. Review.

PMID:
18794878
48.

Comparative phosphoproteomics of zebrafish Fyn/Yes morpholino knockdown embryos.

Lemeer S, Jopling C, Gouw J, Mohammed S, Heck AJ, Slijper M, den Hertog J.

Mol Cell Proteomics. 2008 Nov;7(11):2176-87. doi: 10.1074/mcp.M800081-MCP200. Epub 2008 Jun 11.

49.

Redox regulation of dimerization of the receptor protein-tyrosine phosphatases RPTPalpha, LAR, RPTPmu and CD45.

Groen A, Overvoorde J, van der Wijk T, den Hertog J.

FEBS J. 2008 May;275(10):2597-604. doi: 10.1111/j.1742-4658.2008.06407.x. Epub 2008 Apr 15.

50.

Online automated in vivo zebrafish phosphoproteomics: from large-scale analysis down to a single embryo.

Lemeer S, Pinkse MW, Mohammed S, van Breukelen B, den Hertog J, Slijper M, Heck AJ.

J Proteome Res. 2008 Apr;7(4):1555-64. doi: 10.1021/pr700667w. Epub 2008 Feb 29.

PMID:
18307296

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