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Items: 18


Diverse small molecules prevent macrophage lysis during pyroptosis.

Loomis WP, den Hartigh AB, Cookson BT, Fink SL.

Cell Death Dis. 2019 Apr 11;10(4):326. doi: 10.1038/s41419-019-1559-4.


Pyroptosis Induction and Detection.

den Hartigh AB, Fink SL.

Curr Protoc Immunol. 2018 Jul 20:e52. doi: 10.1002/cpim.52. [Epub ahead of print]


PPARγ-mediated increase in glucose availability sustains chronic Brucella abortus infection in alternatively activated macrophages.

Xavier MN, Winter MG, Spees AM, den Hartigh AB, Nguyen K, Roux CM, Silva TM, Atluri VL, Kerrinnes T, Keestra AM, Monack DM, Luciw PA, Eigenheer RA, Bäumler AJ, Santos RL, Tsolis RM.

Cell Host Microbe. 2013 Aug 14;14(2):159-70. doi: 10.1016/j.chom.2013.07.009.


Sensing of bacterial type IV secretion via the unfolded protein response.

de Jong MF, Starr T, Winter MG, den Hartigh AB, Child R, Knodler LA, van Dijl JM, Celli J, Tsolis RM.

mBio. 2013 Feb 19;4(1):e00418-12. doi: 10.1128/mBio.00418-12.


The small protein CydX is required for function of cytochrome bd oxidase in Brucella abortus.

Sun YH, de Jong MF, den Hartigh AB, Roux CM, Rolán HG, Tsolis RM.

Front Cell Infect Microbiol. 2012 Apr 13;2:47. doi: 10.3389/fcimb.2012.00047. eCollection 2012.


Interactions of the human pathogenic Brucella species with their hosts.

Atluri VL, Xavier MN, de Jong MF, den Hartigh AB, Tsolis RM.

Annu Rev Microbiol. 2011;65:523-41. doi: 10.1146/annurev-micro-090110-102905. Review.


Coordinated host responses during pyroptosis: caspase-1-dependent lysosome exocytosis and inflammatory cytokine maturation.

Bergsbaken T, Fink SL, den Hartigh AB, Loomis WP, Cookson BT.

J Immunol. 2011 Sep 1;187(5):2748-54. doi: 10.4049/jimmunol.1100477. Epub 2011 Jul 29.


Putative ATP-binding cassette transporter is essential for Brucella ovis pathogenesis in mice.

Silva TM, Paixão TA, Costa EA, Xavier MN, Sá JC, Moustacas VS, den Hartigh AB, Carvalho Neta AV, Oliveira SC, Tsolis R, Santos RL.

Infect Immun. 2011 Apr;79(4):1706-17. doi: 10.1128/IAI.01109-10. Epub 2011 Feb 7.


Establishment of systemic Brucella melitensis infection through the digestive tract requires urease, the type IV secretion system, and lipopolysaccharide O antigen.

Paixão TA, Roux CM, den Hartigh AB, Sankaran-Walters S, Dandekar S, Santos RL, Tsolis RM.

Infect Immun. 2009 Oct;77(10):4197-208. doi: 10.1128/IAI.00417-09. Epub 2009 Aug 3.


Identification of VceA and VceC, two members of the VjbR regulon that are translocated into macrophages by the Brucella type IV secretion system.

de Jong MF, Sun YH, den Hartigh AB, van Dijl JM, Tsolis RM.

Mol Microbiol. 2008 Dec;70(6):1378-96. doi: 10.1111/j.1365-2958.2008.06487.x. Epub 2008 Oct 24.


Laboratory maintenance of Brucella abortus.

Sun YH, den Hartigh AB, Tsolis RM, Ficht TA.

Curr Protoc Microbiol. 2005 Oct;Chapter 3:Unit 3B.1. doi: 10.1002/9780471729259.mc03b01s00.


VirB3 to VirB6 and VirB8 to VirB11, but not VirB7, are essential for mediating persistence of Brucella in the reticuloendothelial system.

den Hartigh AB, Rolán HG, de Jong MF, Tsolis RM.

J Bacteriol. 2008 Jul;190(13):4427-36. doi: 10.1128/JB.00406-08. Epub 2008 May 9.


VirB12 is a serological marker of Brucella infection in experimental and natural hosts.

Rolán HG, den Hartigh AB, Kahl-McDonagh M, Ficht T, Adams LG, Tsolis RM.

Clin Vaccine Immunol. 2008 Feb;15(2):208-14. Epub 2007 Dec 12.


Evaluation of novel Brucella melitensis unmarked deletion mutants for safety and efficacy in the goat model of brucellosis.

Kahl-McDonagh MM, Elzer PH, Hagius SD, Walker JV, Perry QL, Seabury CM, den Hartigh AB, Tsolis RM, Adams LG, Davis DS, Ficht TA.

Vaccine. 2006 Jun 12;24(24):5169-77. Epub 2006 Apr 27.


Brucella abortus virB12 is expressed during infection but is not an essential component of the type IV secretion system.

Sun YH, Rolán HG, den Hartigh AB, Sondervan D, Tsolis RM.

Infect Immun. 2005 Sep;73(9):6048-54.


Differential requirements for VirB1 and VirB2 during Brucella abortus infection.

den Hartigh AB, Sun YH, Sondervan D, Heuvelmans N, Reinders MO, Ficht TA, Tsolis RM.

Infect Immun. 2004 Sep;72(9):5143-9.


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