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Cold Atmospheric Plasma-Treated PBS Eliminates Immunosuppressive Pancreatic Stellate Cells and Induces Immunogenic Cell Death of Pancreatic Cancer Cells.

Van Loenhout J, Flieswasser T, Freire Boullosa L, De Waele J, Van Audenaerde J, Marcq E, Jacobs J, Lin A, Lion E, Dewitte H, Peeters M, Dewilde S, Lardon F, Bogaerts A, Deben C, Smits E.

Cancers (Basel). 2019 Oct 19;11(10). pii: E1597. doi: 10.3390/cancers11101597.


Variability in Glycated Hemoglobin and Risk of Poor Outcomes Among People With Type 2 Diabetes in a Large Primary Care Cohort Study.

Critchley JA, Carey IM, Harris T, DeWilde S, Cook DG.

Diabetes Care. 2019 Oct 3. pii: dc190848. doi: 10.2337/dc19-0848. [Epub ahead of print]


Structural and functional characterization of the globin-coupled sensors of <i>Azotobacter vinelandii </i>and <i>Bordetella pertussis</i>.

Germani F, Nardini M, De Schutter A, Cuypers B, Berghmans H, Van Hauwaert ML, Stefano B, Mozzarelli A, Moens L, Van Doorslaer S, Bolognesi M, Pesce A, Dewilde S.

Antioxid Redox Signal. 2019 Sep 27. doi: 10.1089/ars.2018.7690. [Epub ahead of print]


Murine iPSC-derived microglia and macrophage cell culture models recapitulate distinct phenotypical and functional properties of classical and alternative neuro-immune polarisation.

Quarta A, Le Blon D, D'aes T, Pieters Z, Hamzei Taj S, Miró-Mur F, Luyckx E, Van Breedam E, Daans J, Goossens H, Dewilde S, Hens N, Pasque V, Planas AM, Hoehn M, Berneman Z, Ponsaerts P.

Brain Behav Immun. 2019 Nov;82:406-421. doi: 10.1016/j.bbi.2019.09.009. Epub 2019 Sep 13.


Influence of Cell Type and Culture Medium on Determining Cancer Selectivity of Cold Atmospheric Plasma Treatment.

Biscop E, Lin A, Boxem WV, Loenhout JV, Backer J, Deben C, Dewilde S, Smits E, Bogaerts AA.

Cancers (Basel). 2019 Sep 1;11(9). pii: E1287. doi: 10.3390/cancers11091287.


Longitudinal exposure of English primary care patients to pharmacogenomic drugs: an analysis to inform design of pre-emptive pharmacogenomic testing.

Kimpton JE, Carey IM, Threapleton CJD, Robinson A, Harris T, Cook DG, DeWilde S, Baker EH.

Br J Clin Pharmacol. 2019 Aug 27. doi: 10.1111/bcp.14100. [Epub ahead of print]


Connecting the Dots in the Neuroglobin-Protein Interaction Network of an Unstressed and Ferroptotic Cell Death Neuroblastoma Model.

Van Acker ZP, Van Raemdonck GA, Logie E, Van Acker SI, Baggerman G, Vanden Berghe W, Ponsaerts P, Dewilde S.

Cells. 2019 Aug 11;8(8). pii: E873. doi: 10.3390/cells8080873.


Synergistic Effects of Melittin and Plasma Treatment: A Promising Approach for Cancer Therapy.

Shaw P, Kumar N, Hammerschmid D, Privat-Maldonado A, Dewilde S, Bogaerts A.

Cancers (Basel). 2019 Aug 3;11(8). pii: E1109. doi: 10.3390/cancers11081109.


Neuroglobin Expression Models as a Tool to Study Its Function.

Luyckx E, Van Acker ZP, Ponsaerts P, Dewilde S.

Oxid Med Cell Longev. 2019 Jun 19;2019:5728129. doi: 10.1155/2019/5728129. eCollection 2019. Review.


Effect of pedometer-based walking interventions on long-term health outcomes: Prospective 4-year follow-up of two randomised controlled trials using routine primary care data.

Harris T, Limb ES, Hosking F, Carey I, DeWilde S, Furness C, Wahlich C, Ahmad S, Kerry S, Whincup P, Victor C, Ussher M, Iliffe S, Ekelund U, Fox-Rushby J, Ibison J, Cook DG.

PLoS Med. 2019 Jun 25;16(6):e1002836. doi: 10.1371/journal.pmed.1002836. eCollection 2019 Jun.


Non-Methylation-Linked Mechanism of REST-Induced Neuroglobin Expression Impacts Mitochondrial Phenotypes in a Mouse Model of Amyotrophic Lateral Sclerosis.

Van Acker ZP, Declerck K, Luyckx E, Vanden Berghe W, Dewilde S.

Neuroscience. 2019 Aug 1;412:233-247. doi: 10.1016/j.neuroscience.2019.05.039. Epub 2019 May 31.


Non-Thermal Plasma as a Unique Delivery System of Short-Lived Reactive Oxygen and Nitrogen Species for Immunogenic Cell Death in Melanoma Cells.

Lin A, Gorbanev Y, De Backer J, Van Loenhout J, Van Boxem W, Lemière F, Cos P, Dewilde S, Smits E, Bogaerts A.

Adv Sci (Weinh). 2019 Jan 28;6(6):1802062. doi: 10.1002/advs.201802062. eCollection 2019 Mar 20.


The combined impact of dependency on caregivers, disability, and coping strategy on quality of life after ischemic stroke.

Dewilde S, Annemans L, Lloyd A, Peeters A, Hemelsoet D, Vandermeeren Y, Desfontaines P, Brouns R, Vanhooren G, Cras P, Michielsens B, Redondo P, Thijs V.

Health Qual Life Outcomes. 2019 Feb 7;17(1):31. doi: 10.1186/s12955-018-1069-6.


Reaction of chloride anion with atomic oxygen in aqueous solutions: can cold plasma help in chemistry research?

Gorbanev Y, Van der Paal J, Van Boxem W, Dewilde S, Bogaerts A.

Phys Chem Chem Phys. 2019 Feb 20;21(8):4117-4121. doi: 10.1039/c8cp07550f.


Measuring change in trials of physical activity interventions: a comparison of self-report questionnaire and accelerometry within the PACE-UP trial.

Limb ES, Ahmad S, Cook DG, Kerry SM, Ekelund U, Whincup PH, Victor CR, Iliffe S, Ussher M, Fox-Rushby J, Furness C, Ibison J, DeWilde S, Harris T.

Int J Behav Nutr Phys Act. 2019 Jan 22;16(1):10. doi: 10.1186/s12966-018-0762-5.


Reduction of Human Glioblastoma Spheroids Using Cold Atmospheric Plasma: The Combined Effect of Short- and Long-Lived Reactive Species.

Privat-Maldonado A, Gorbanev Y, Dewilde S, Smits E, Bogaerts A.

Cancers (Basel). 2018 Oct 23;10(11). pii: E394. doi: 10.3390/cancers10110394.


Short-term and long-term cost-effectiveness of a pedometer-based exercise intervention in primary care: a within-trial analysis and beyond-trial modelling.

Anokye N, Fox-Rushby J, Sanghera S, Cook DG, Limb E, Furness C, Kerry SM, Victor CR, Iliffe S, Ussher M, Whincup PH, Ekelund U, deWilde S, Harris T.

BMJ Open. 2018 Oct 17;8(10):e021978. doi: 10.1136/bmjopen-2018-021978.


The relationship between Home-time, quality of life and costs after ischemic stroke: the impact of the need for mobility aids, home and car modifications on Home-time.

Dewilde S, Annemans L, Peeters A, Hemelsoet D, Vandermeeren Y, Desfontaines P, Brouns R, Vanhooren G, Cras P, Michielsens B, Redondo P, Thijs V.

Disabil Rehabil. 2018 Oct 2:1-7. doi: 10.1080/09638288.2018.1501438. [Epub ahead of print]


Glycemic Control and Risk of Infections Among People With Type 1 or Type 2 Diabetes in a Large Primary Care Cohort Study.

Critchley JA, Carey IM, Harris T, DeWilde S, Hosking FJ, Cook DG.

Diabetes Care. 2018 Oct;41(10):2127-2135. doi: 10.2337/dc18-0287. Epub 2018 Aug 13.


The effect of reactive oxygen and nitrogen species on the structure of cytoglobin: A potential tumor suppressor.

De Backer J, Razzokov J, Hammerschmid D, Mensch C, Hafideddine Z, Kumar N, van Raemdonck G, Yusupov M, Van Doorslaer S, Johannessen C, Sobott F, Bogaerts A, Dewilde S.

Redox Biol. 2018 Oct;19:1-10. doi: 10.1016/j.redox.2018.07.019. Epub 2018 Jul 24.


Neuroglobin Expression in the Brain: a Story of Tissue Homeostasis Preservation.

Van Acker ZP, Luyckx E, Dewilde S.

Mol Neurobiol. 2019 Mar;56(3):2101-2122. doi: 10.1007/s12035-018-1212-8. Epub 2018 Jul 10. Review.


A pedometer-based walking intervention in 45- to 75-year-olds, with and without practice nurse support: the PACE-UP three-arm cluster RCT.

Harris T, Kerry S, Victor C, Iliffe S, Ussher M, Fox-Rushby J, Whincup P, Ekelund U, Furness C, Limb E, Anokye N, Ibison J, DeWilde S, David L, Howard E, Dale R, Smith J, Normansell R, Beighton C, Morgan K, Wahlich C, Sanghera S, Cook D.

Health Technol Assess. 2018 Jun;22(37):1-274. doi: 10.3310/hta22370.


Hospital financing of ischaemic stroke: determinants of funding and usefulness of DRG subcategories based on severity of illness.

Dewilde S, Annemans L, Pincé H, Thijs V.

BMC Health Serv Res. 2018 May 11;18(1):356. doi: 10.1186/s12913-018-3134-6.


What Impact Does Venous Thromboembolism and Bleeding Have on Cancer Patients' Quality of Life?

Lloyd AJ, Dewilde S, Noble S, Reimer E, Lee AYY.

Value Health. 2018 Apr;21(4):449-455. doi: 10.1016/j.jval.2017.09.015. Epub 2017 Nov 10.


Physical activity levels in adults and older adults 3-4 years after pedometer-based walking interventions: Long-term follow-up of participants from two randomised controlled trials in UK primary care.

Harris T, Kerry SM, Limb ES, Furness C, Wahlich C, Victor CR, Iliffe S, Whincup PH, Ussher M, Ekelund U, Fox-Rushby J, Ibison J, DeWilde S, McKay C, Cook DG.

PLoS Med. 2018 Mar 9;15(3):e1002526. doi: 10.1371/journal.pmed.1002526. eCollection 2018 Mar.


Interpreting population reach of a large, successful physical activity trial delivered through primary care.

Kerry SM, Morgan KE, Limb E, Cook DG, Furness C, Carey I, DeWilde S, Victor CR, Iliffe S, Whincup P, Ussher M, Ekelund U, Fox-Rushby J, Ibison J, Harris T.

BMC Public Health. 2018 Jan 23;18(1):170. doi: 10.1186/s12889-018-5034-4.


Relating process evaluation measures to complex intervention outcomes: findings from the PACE-UP primary care pedometer-based walking trial.

Furness C, Howard E, Limb E, Cook DG, Kerry S, Wahlich C, Victor C, Ekelund U, Iliffe S, Ussher M, Whincup P, Fox-Rushby J, Ibison J, DeWilde S, Harris T.

Trials. 2018 Jan 22;19(1):58. doi: 10.1186/s13063-017-2428-z.


Loss of Neuroglobin Expression Alters Cdkn1a/Cdk6-Expression Resulting in Increased Proliferation of Neural Stem Cells.

Luyckx E, Van Leuven W, Andre D, Quarta A, Reekmans K, Fransen E, Moens L, Hankeln T, Ponsaerts P, Dewilde S.

Stem Cells Dev. 2018 Mar 15;27(6):378-390. doi: 10.1089/scd.2017.0097. Epub 2018 Feb 27.


A search for molecular mechanisms underlying male idiopathic infertility.

Bracke A, Peeters K, Punjabi U, Hoogewijs D, Dewilde S.

Reprod Biomed Online. 2018 Mar;36(3):327-339. doi: 10.1016/j.rbmo.2017.12.005. Epub 2017 Dec 27. Review.


Risk of Infection in Type 1 and Type 2 Diabetes Compared With the General Population: A Matched Cohort Study.

Carey IM, Critchley JA, DeWilde S, Harris T, Hosking FJ, Cook DG.

Diabetes Care. 2018 Mar;41(3):513-521. doi: 10.2337/dc17-2131. Epub 2018 Jan 12.


Exploring three different expression systems for recombinant expression of globins: Escherichia coli, Pichia pastoris and Spodoptera frugiperda.

Bracke A, Hoogewijs D, Dewilde S.

Anal Biochem. 2018 Feb 15;543:62-70. doi: 10.1016/j.ab.2017.11.027. Epub 2017 Dec 5.


Anti-cancer capacity of plasma-treated PBS: effect of chemical composition on cancer cell cytotoxicity.

Van Boxem W, Van der Paal J, Gorbanev Y, Vanuytsel S, Smits E, Dewilde S, Bogaerts A.

Sci Rep. 2017 Nov 28;7(1):16478. doi: 10.1038/s41598-017-16758-8.


Cytoprotective effects of transgenic neuroglobin overexpression in an acute and chronic mouse model of ischemic heart disease.

Luyckx E, Everaert BR, Van der Veken B, Van Leuven W, Timmermans JP, Vrints CJ, De Meyer GRY, Martinet W, Dewilde S.

Heart Vessels. 2018 Jan;33(1):80-88. doi: 10.1007/s00380-017-1065-5. Epub 2017 Nov 2.


Preventable Emergency Hospital Admissions Among Adults With Intellectual Disability in England.

Hosking FJ, Carey IM, DeWilde S, Harris T, Beighton C, Cook DG.

Ann Fam Med. 2017 Sep;15(5):462-470. doi: 10.1370/afm.2104. Erratum in: Ann Fam Med. 2017 Nov;15(6):503.


'I'm sure we made it a better study…': Experiences of adults with intellectual disabilities and parent carers of patient and public involvement in a health research study.

Beighton C, Victor C, Carey IM, Hosking F, DeWilde S, Cook DG, Manners P, Harris T.

J Intellect Disabil. 2019 Mar;23(1):78-96. doi: 10.1177/1744629517723485. Epub 2017 Aug 16.


Antarctic fish versus human cytoglobins - The same but yet so different.

Cuypers B, Vermeylen S, Hammerschmid D, Trashin S, Rahemi V, Konijnenberg A, De Schutter A, Cheng CC, Giordano D, Verde C, De Wael K, Sobott F, Dewilde S, Van Doorslaer S.

J Inorg Biochem. 2017 Aug;173:66-78. doi: 10.1016/j.jinorgbio.2017.04.025. Epub 2017 Apr 28.


Characterization of the Heme Pocket Structure and Ligand Binding Kinetics of Non-symbiotic Hemoglobins from the Model Legume Lotus japonicus.

Calvo-Begueria L, Cuypers B, Van Doorslaer S, Abbruzzetti S, Bruno S, Berghmans H, Dewilde S, Ramos J, Viappiani C, Becana M.

Front Plant Sci. 2017 Apr 4;8:407. doi: 10.3389/fpls.2017.00407. eCollection 2017.


Impaired hypoxic tolerance in APP23 mice: a dysregulation of neuroprotective globin levels.

Van Acker ZP, Luyckx E, Van Leuven W, Geuens E, De Deyn PP, Van Dam D, Dewilde S.

FEBS Lett. 2017 May;591(10):1321-1332. doi: 10.1002/1873-3468.12651. Epub 2017 May 2.


Modified Rankin scale as a determinant of direct medical costs after stroke.

Dewilde S, Annemans L, Peeters A, Hemelsoet D, Vandermeeren Y, Desfontaines P, Brouns R, Vanhooren G, Cras P, Michielsens B, Redondo P, Thijs V.

Int J Stroke. 2017 Jun;12(4):392-400. doi: 10.1177/1747493017691984. Epub 2017 Feb 6.


Effect of a Primary Care Walking Intervention with and without Nurse Support on Physical Activity Levels in 45- to 75-Year-Olds: The Pedometer And Consultation Evaluation (PACE-UP) Cluster Randomised Clinical Trial.

Harris T, Kerry SM, Limb ES, Victor CR, Iliffe S, Ussher M, Whincup PH, Ekelund U, Fox-Rushby J, Furness C, Anokye N, Ibison J, DeWilde S, David L, Howard E, Dale R, Smith J, Cook DG.

PLoS Med. 2017 Jan 3;14(1):e1002210. doi: 10.1371/journal.pmed.1002210. eCollection 2017 Jan.


Electrochemical Evidence for Neuroglobin Activity on NO at Physiological Concentrations.

Trashin S, de Jong M, Luyckx E, Dewilde S, De Wael K.

J Biol Chem. 2016 Sep 2;291(36):18959-66. doi: 10.1074/jbc.M116.730176. Epub 2016 Jul 8.


Learning disability registers in primary care.

Carey IM, Hosking FJ, DeWilde S, Harris T, Beighton C, Cook DG.

Br J Gen Pract. 2016 Jul;66(648):351-2. doi: 10.3399/bjgp16X685861. No abstract available.


Do health checks for adults with intellectual disability reduce emergency hospital admissions? Evaluation of a natural experiment.

Carey IM, Hosking FJ, Harris T, DeWilde S, Beighton C, Shah SM, Cook DG.

J Epidemiol Community Health. 2017 Jan;71(1):52-58. doi: 10.1136/jech-2016-207557. Epub 2016 Jun 16.


Mortality Among Adults With Intellectual Disability in England: Comparisons With the General Population.

Hosking FJ, Carey IM, Shah SM, Harris T, DeWilde S, Beighton C, Cook DG.

Am J Public Health. 2016 Aug;106(8):1483-90. doi: 10.2105/AJPH.2016.303240. Epub 2016 Jun 16. Erratum in: Am J Public Health. 2016 Dec;106(12 ):e11-e12.


The role of the globin-coupled sensor YddV in a mature E. coli biofilm population.

Donné J, Van Kerckhoven M, Maes L, Cos P, Dewilde S.

Biochim Biophys Acta. 2016 Jul;1864(7):835-9. doi: 10.1016/j.bbapap.2016.04.005. Epub 2016 Apr 12.


Health state utilities in non-small cell lung cancer: An international study.

Nafees B, Lloyd AJ, Dewilde S, Rajan N, Lorenzo M.

Asia Pac J Clin Oncol. 2017 Oct;13(5):e195-e203. doi: 10.1111/ajco.12477. Epub 2016 Mar 17.


Health characteristics and consultation patterns of people with intellectual disability: a cross-sectional database study in English general practice.

Carey IM, Shah SM, Hosking FJ, DeWilde S, Harris T, Beighton C, Cook DG.

Br J Gen Pract. 2016 Apr;66(645):e264-70. doi: 10.3399/bjgp16X684301. Epub 2016 Feb 23.


The mental health and mortality impact of death of a partner with dementia.

Shah SM, Carey IM, Harris T, DeWilde S, Victor CR, Cook DG.

Int J Geriatr Psychiatry. 2016 Aug;31(8):929-37. doi: 10.1002/gps.4411. Epub 2016 Feb 2.


A redox signalling globin is essential for reproduction in Caenorhabditis elegans.

De Henau S, Tilleman L, Vangheel M, Luyckx E, Trashin S, Pauwels M, Germani F, Vlaeminck C, Vanfleteren JR, Bert W, Pesce A, Nardini M, Bolognesi M, De Wael K, Moens L, Dewilde S, Braeckman BP.

Nat Commun. 2015 Dec 1;6:8782. doi: 10.1038/ncomms9782.

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