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Items: 1 to 50 of 58

1.

TETRABENAZINE FACILITATES EXOCYTOSIS BY ENHANCING CALCIUM-INDUCED CALCIUM RELEASE THROUGH RYANODINE RECEPTORS.

DE Pascual R, Alvarez-Ortego N, de Los Rios C, Jacob-Mazariego G, Garcia AG.

J Pharmacol Exp Ther. 2019 Jun 17. pii: jpet.119.256560. doi: 10.1124/jpet.119.256560. [Epub ahead of print]

2.

Tacrines for Alzheimer's disease therapy. III. The PyridoTacrines.

de Los Ríos C, Marco-Contelles J.

Eur J Med Chem. 2019 Mar 15;166:381-389. doi: 10.1016/j.ejmech.2019.02.005. Epub 2019 Feb 4. Review.

PMID:
30739821
3.

The Neuroprotector Benzothiazepine CGP37157 Extends Lifespan in C. elegans Worms.

García-Casas P, Arias-Del-Val J, Alvarez-Illera P, Wojnicz A, de Los Ríos C, Fonteriz RI, Montero M, Alvarez J.

Front Aging Neurosci. 2019 Jan 17;10:440. doi: 10.3389/fnagi.2018.00440. eCollection 2018.

4.

Polycyclic maleimide-based derivatives as first dual modulators of neuronal calcium channels and GSK-3β for Alzheimer's disease treatment.

Bisi A, Arribas RL, Micucci M, Budriesi R, Feoli A, Castellano S, Belluti F, Gobbi S, de Los Rios C, Rampa A.

Eur J Med Chem. 2019 Feb 1;163:394-402. doi: 10.1016/j.ejmech.2018.12.003. Epub 2018 Dec 3.

PMID:
30530190
5.

Design and synthesis of multipotent 3-aminomethylindoles and 7-azaindoles with enhanced protein phosphatase 2A-activating profile and neuroprotection.

Lajarín-Cuesta R, Arribas RL, Nanclares C, García-Frutos EM, Gandía L, de Los Ríos C.

Eur J Med Chem. 2018 Sep 5;157:294-309. doi: 10.1016/j.ejmech.2018.07.030. Epub 2018 Jul 29.

PMID:
30099252
6.

Extended Intravitreal Rabbit Eye Residence of Nanoparticles Conjugated With Cationic Arginine Peptides for Intraocular Drug Delivery: In Vivo Imaging.

Melgar-Asensio I, Kandela I, Aird F, Darjatmoko SR, de Los Rios C, Sorenson CM, Albert DM, Sheibani N, Henkin J.

Invest Ophthalmol Vis Sci. 2018 Aug 1;59(10):4071-4081. doi: 10.1167/iovs.18-24087.

7.

Modulation of serine/threonine phosphatases by melatonin: therapeutic approaches in neurodegenerative diseases.

Arribas RL, Romero A, Egea J, de Los Ríos C.

Br J Pharmacol. 2018 Aug;175(16):3220-3229. doi: 10.1111/bph.14365. Epub 2018 Jun 19. Review.

8.

Substituent effect of N-benzylated gramine derivatives that prevent the PP2A inhibition and dissipate the neuronal Ca2+ overload, as a multitarget strategy for the treatment of Alzheimer's disease.

Gonzalez D, Arribas RL, Viejo L, Lajarin-Cuesta R, de Los Rios C.

Bioorg Med Chem. 2018 May 15;26(9):2551-2560. doi: 10.1016/j.bmc.2018.04.019. Epub 2018 Apr 9.

PMID:
29656989
9.

Analysis of gene expression profiles of CR80, a neuroprotective 1,8-Naphthyridine.

Ramos E, Romero A, Egea J, Marco-Contelles J, Del Pino J, de Los Ríos C.

Future Med Chem. 2018 Jun 1;10(11):1289-1300. doi: 10.4155/fmc-2018-0004. Epub 2018 Mar 21.

PMID:
29560738
10.

Chromaffin cells as a model to evaluate mechanisms of cell death and neuroprotective compounds.

de Los Rios C, Cano-Abad MF, Villarroya M, López MG.

Pflugers Arch. 2018 Jan;470(1):187-198. doi: 10.1007/s00424-017-2044-5. Epub 2017 Aug 19. Review.

PMID:
28823085
11.

Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration.

Ramos E, Egea J, de Los Ríos C, Marco-Contelles J, Romero A.

Future Med Chem. 2017 May;9(8):765-780. doi: 10.4155/fmc-2017-0014. Epub 2017 May 12. Review.

PMID:
28498717
12.

Chagas disease immunogenetics: elusive markers of disease progression.

Ortega Zamora Y, Escamilla Rojas LJ, Villa Sandoval EM, Vela Porras JS, Cossio Contrera EY, Cubides Romero SS, Carreño Ramirez PD, Urriago Losada H, De Los Rios C, Gomez Mahecha DA, Lovera Serrano KD, Barreto Montaña JC, Narvaez Caicedo VL, Gutierrez FRS.

Expert Rev Cardiovasc Ther. 2017 Apr 19:1-10. doi: 10.1080/14779072.2017.1317591. [Epub ahead of print]

PMID:
28388241
13.

Optimization of Bicyclic Lactam Derivatives as NMDA Receptor Antagonists.

Espadinha M, Dourado J, Lajarin-Cuesta R, Herrera-Arozamena C, Gonçalves LM, Rodríguez-Franco MI, de Los Rios C, Santos MM.

ChemMedChem. 2017 Apr 6;12(7):537-545. doi: 10.1002/cmdc.201700037. Epub 2017 Mar 22.

PMID:
28218498
14.

Ischemic brain injury: New insights on the protective role of melatonin.

Ramos E, Patiño P, Reiter RJ, Gil-Martín E, Marco-Contelles J, Parada E, de Los Rios C, Romero A, Egea J.

Free Radic Biol Med. 2017 Mar;104:32-53. doi: 10.1016/j.freeradbiomed.2017.01.005. Epub 2017 Jan 6. Review.

PMID:
28065781
15.

The quantal catecholamine release from mouse chromaffin cells challenged with repeated ACh pulses is regulated by the mitochondrial Na+ /Ca2+ exchanger.

López-Gil A, Nanclares C, Méndez-López I, Martínez-Ramírez C, de Los Rios C, Padín-Nogueira JF, Montero M, Gandía L, García AG.

J Physiol. 2017 Mar 15;595(6):2129-2146. doi: 10.1113/JP273339. Epub 2017 Feb 7.

16.

Gramine Derivatives Targeting Ca(2+) Channels and Ser/Thr Phosphatases: A New Dual Strategy for the Treatment of Neurodegenerative Diseases.

Lajarín-Cuesta R, Nanclares C, Arranz-Tagarro JA, González-Lafuente L, Arribas RL, Araujo de Brito M, Gandía L, de Los Ríos C.

J Med Chem. 2016 Jul 14;59(13):6265-80. doi: 10.1021/acs.jmedchem.6b00478. Epub 2016 Jun 24.

17.

Neuroprotective Effect of the Novel Compound ITH33/IQM9.21 Against Oxidative Stress and Na(+) and Ca(2+) Overload in Motor Neuron-like NSC-34 Cells.

Moreno-Ortega AJ, Al-Achbili LM, Alonso E, de Los Ríos C, García AG, Ruiz-Nuño A, Cano-Abad MF.

Neurotox Res. 2016 Oct;30(3):380-91. doi: 10.1007/s12640-016-9623-7. Epub 2016 Apr 28.

PMID:
27126806
18.

Ligands for Ser/Thr phosphoprotein phosphatases: a patent review (2005-2015).

Lajarín-Cuesta R, Arribas RL, De Los Ríos C.

Expert Opin Ther Pat. 2016;26(3):389-407. doi: 10.1517/13543776.2016.1135903. Epub 2016 Feb 7. Review.

PMID:
26853448
19.

Neuroprotective profile of pyridothiazepines with blocking activity of the mitochondrial Na(+)/Ca(2+) exchanger.

Martínez-Sanz FJ, Lajarín-Cuesta R, González-Lafuente L, Moreno-Ortega AJ, Punzón E, Cano-Abad MF, de los Ríos C.

Eur J Med Chem. 2016 Feb 15;109:114-23. doi: 10.1016/j.ejmech.2015.12.043. Epub 2015 Dec 29.

PMID:
26774037
20.

Benzothiazepine CGP37157 Analogues Exert Cytoprotection in Various in Vitro Models of Neurodegeneration.

Martínez-Sanz FJ, Lajarín-Cuesta R, Moreno-Ortega AJ, González-Lafuente L, Fernández-Morales JC, López-Arribas R, Cano-Abad MF, de los Ríos C.

ACS Chem Neurosci. 2015 Sep 16;6(9):1626-36. doi: 10.1021/acschemneuro.5b00161. Epub 2015 Jul 31.

PMID:
26192029
21.

Benzothiazepine CGP37157 and its 2'-isopropyl analogue modulate Ca²⁺ entry through CALHM1.

Moreno-Ortega AJ, Martínez-Sanz FJ, Lajarín-Cuesta R, de Los Rios C, Cano-Abad MF.

Neuropharmacology. 2015 Aug;95:503-10. doi: 10.1016/j.neuropharm.2015.02.016. Epub 2015 Apr 20.

PMID:
25908402
22.

Indole-3-carbinol induces cMYC and IAP-family downmodulation and promotes apoptosis of Epstein-Barr virus (EBV)-positive but not of EBV-negative Burkitt's lymphoma cell lines.

Perez-Chacon G, de Los Rios C, Zapata JM.

Pharmacol Res. 2014 Nov;89:46-56. doi: 10.1016/j.phrs.2014.08.005. Epub 2014 Aug 30.

PMID:
25180456
23.

Recent patents on calcium channel blockers: emphasis on CNS diseases.

Arranz-Tagarro JA, de los Ríos C, García AG, Padín JF.

Expert Opin Ther Pat. 2014 Sep;24(9):959-77. doi: 10.1517/13543776.2014.940892. Review.

PMID:
25118673
24.

ITH12410/SC058: a new neuroprotective compound with potential in the treatment of Alzheimer's disease.

Romero A, Egea J, González-Muñoz GC, Martín de Saavedra MD, del Barrio L, Rodríguez-Franco MI, Conde S, López MG, Villarroya M, de los Ríos C.

ACS Chem Neurosci. 2014 Sep 17;5(9):770-5. doi: 10.1021/cn500131t. Epub 2014 Jul 15. Review.

PMID:
25008046
25.

A review of metal-catalyzed molecular damage: protection by melatonin.

Romero A, Ramos E, de Los Ríos C, Egea J, Del Pino J, Reiter RJ.

J Pineal Res. 2014 May;56(4):343-70. doi: 10.1111/jpi.12132. Epub 2014 Apr 5. Review.

PMID:
24628077
26.

PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice.

Lorrio S, Romero A, González-Lafuente L, Lajarín-Cuesta R, Martínez-Sanz FJ, Estrada M, Samadi A, Marco-Contelles J, Rodríguez-Franco MI, Villarroya M, López MG, de los Ríos C.

ACS Chem Neurosci. 2013 Sep 18;4(9):1267-77. doi: 10.1021/cn400050p. Epub 2013 Jun 13.

27.

Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: effect against amyloid-β-induced neurotoxicity.

Silva D, Chioua M, Samadi A, Agostinho P, Garção P, Lajarín-Cuesta R, de Los Ríos C, Iriepa I, Moraleda I, Gonzalez-Lafuente L, Mendes E, Pérez C, Rodríguez-Franco MI, Marco-Contelles J, Carmo Carreiras M.

ACS Chem Neurosci. 2013 Apr 17;4(4):547-65. doi: 10.1021/cn300178k. Epub 2013 Feb 4.

28.

Benzothiazepine CGP37157 and its isosteric 2'-methyl analogue provide neuroprotection and block cell calcium entry.

González-Lafuente L, Egea J, León R, Martínez-Sanz FJ, Monjas L, Perez C, Merino C, García-De Diego AM, Rodríguez-Franco MI, García AG, Villarroya M, López MG, de Los Ríos C.

ACS Chem Neurosci. 2012 Jul 18;3(7):519-29. doi: 10.1021/cn300009e. Epub 2012 Mar 26.

29.

Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.

Maalej E, Chabchoub F, Oset-Gasque MJ, Esquivias-Pérez M, González MP, Monjas L, Pérez C, de los Ríos C, Rodríguez-Franco MI, Iriepa I, Moraleda I, Chioua M, Romero A, Marco-Contelles J, Samadi A.

Eur J Med Chem. 2012 Aug;54:750-63. doi: 10.1016/j.ejmech.2012.06.038. Epub 2012 Jun 28.

PMID:
22795665
30.

Cholinesterase inhibitors: a patent review (2007 - 2011).

de los Ríos C.

Expert Opin Ther Pat. 2012 Aug;22(8):853-69. doi: 10.1517/13543776.2012.701619. Epub 2012 Jul 6. Review.

PMID:
22764681
31.

Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.

Samadi A, de los Ríos C, Bolea I, Chioua M, Iriepa I, Moraleda I, Bartolini M, Andrisano V, Gálvez E, Valderas C, Unzeta M, Marco-Contelles J.

Eur J Med Chem. 2012 Jun;52:251-62. doi: 10.1016/j.ejmech.2012.03.022. Epub 2012 Mar 30.

PMID:
22503231
32.
33.

Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.

Bolea I, Juárez-Jiménez J, de Los Ríos C, Chioua M, Pouplana R, Luque FJ, Unzeta M, Marco-Contelles J, Samadi A.

J Med Chem. 2011 Dec 22;54(24):8251-70. doi: 10.1021/jm200853t. Epub 2011 Nov 15.

PMID:
22023459
34.

Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues.

Martins C, Carreiras MC, León R, de los Ríos C, Bartolini M, Andrisano V, Iriepa I, Moraleda I, Gálvez E, García M, Egea J, Samadi A, Chioua M, Marco-Contelles J.

Eur J Med Chem. 2011 Dec;46(12):6119-30. doi: 10.1016/j.ejmech.2011.09.038. Epub 2011 Sep 29.

PMID:
22000936
35.

Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease.

Samadi A, Chioua M, Bolea I, de Los Ríos C, Iriepa I, Moraleda I, Bastida A, Esteban G, Unzeta M, Gálvez E, Marco-Contelles J.

Eur J Med Chem. 2011 Sep;46(9):4665-8. doi: 10.1016/j.ejmech.2011.05.048. Epub 2011 May 26.

PMID:
21669479
36.

Effects of novel tacripyrines ITH12117 and ITH12118 on rat vas deferens contractions, calcium transients and cholinesterase activity.

Pereira JD, Caricati-Neto A, Miranda-Ferreira R, Smaili SS, Godinho RO, de los Rios C, Léon R, Villaroya M, Samadi A, Marco-Contelles J, Jurkiewicz NH, Garcia AG, Jurkiewicz A.

Eur J Pharmacol. 2011 Jun 25;660(2-3):411-9. doi: 10.1016/j.ejphar.2011.03.042. Epub 2011 Apr 9.

PMID:
21497158
37.

Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9H-benzo[5,6]chromeno[2,3-b]quinolin-13-amines.

Maalej E, Chabchoub F, Samadi A, de los Ríos C, Perona A, Morreale A, Marco-Contelles J.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2384-8. doi: 10.1016/j.bmcl.2011.02.094. Epub 2011 Mar 14.

PMID:
21411323
38.

Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles.

Samadi A, Valderas C, de los Ríos C, Bastida A, Chioua M, González-Lafuente L, Colmena I, Gandía L, Romero A, Del Barrio L, Martín-de-Saavedra MD, López MG, Villarroya M, Marco-Contelles J.

Bioorg Med Chem. 2011 Jan 1;19(1):122-33. doi: 10.1016/j.bmc.2010.11.040. Epub 2010 Nov 26.

PMID:
21163662
39.

Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists.

Tomassoli I, Ismaili L, Pudlo M, de Los Ríos C, Soriano E, Colmena I, Gandía L, Rivas L, Samadi A, Marco-Contelles J, Refouvelet B.

Eur J Med Chem. 2011 Jan;46(1):1-10. doi: 10.1016/j.ejmech.2010.08.054. Epub 2010 Dec 15.

PMID:
21111515
40.

Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.

de Los Ríos C, Egea J, Marco-Contelles J, León R, Samadi A, Iriepa I, Moraleda I, Gálvez E, García AG, López MG, Villarroya M, Romero A.

J Med Chem. 2010 Jul 22;53(14):5129-43. doi: 10.1021/jm901902w.

PMID:
20575555
41.

Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate.

Soriano E, Samadi A, Chioua M, de los Ríos C, Marco-Contelles J.

Bioorg Med Chem Lett. 2010 May 1;20(9):2950-3. doi: 10.1016/j.bmcl.2010.03.010. Epub 2010 Mar 4.

PMID:
20350807
42.

Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.

Marco-Contelles J, León R, de los Ríos C, Samadi A, Bartolini M, Andrisano V, Huertas O, Barril X, Luque FJ, Rodríguez-Franco MI, López B, López MG, García AG, Carreiras Mdo C, Villarroya M.

J Med Chem. 2009 May 14;52(9):2724-32. doi: 10.1021/jm801292b.

PMID:
19374444
43.

Anthracene based compounds as new L-type Ca2+ channel blockers: design, synthesis, and full biological profile.

Bova S, Saponara S, Rampa A, Gobbi S, Cima L, Fusi F, Sgaragli G, Cavalli M, de los Rios C, Striessnig J, Bisi A.

J Med Chem. 2009 Mar 12;52(5):1259-62. doi: 10.1021/jm801589x.

PMID:
19203272
44.

New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties.

León R, de los Ríos C, Marco-Contelles J, Huertas O, Barril X, Luque FJ, López MG, García AG, Villarroya M.

Bioorg Med Chem. 2008 Aug 15;16(16):7759-69. doi: 10.1016/j.bmc.2008.07.005. Epub 2008 Jul 8.

PMID:
18640842
45.

[Abdominal pain and inadequate antidiuretic hormone secretion in a patient diagnosed with acute intermittent porphyria].

de Los Ríos CC, Durán FG, Moros ET, Martín JA, Alcol BP.

Rev Esp Enferm Dig. 2008 Apr;100(4):247-8. Spanish. No abstract available.

46.

Synthesis of 6-amino-1,4-dihydropyridines that prevent calcium overload and neuronal death.

León R, de Los Ríos C, Marco-Contelles J, López MG, García AG, Villarroya M.

Eur J Med Chem. 2008 Mar;43(3):668-74. Epub 2007 Jul 5.

PMID:
17692434
47.

Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease.

Marco-Contelles J, León R, de Los Ríos C, Guglietta A, Terencio J, López MG, García AG, Villarroya M.

J Med Chem. 2006 Dec 28;49(26):7607-10.

PMID:
17181144
48.

New multipotent tetracyclic tacrines with neuroprotective activity.

Marco-Contelles J, León R, de los Ríos C, García AG, López MG, Villarroya M.

Bioorg Med Chem. 2006 Dec 15;14(24):8176-85. Epub 2006 Sep 26.

PMID:
17005406
50.

ITH4012 (ethyl 5-amino-6,7,8,9-tetrahydro-2-methyl-4-phenylbenzol[1,8]naphthyridine-3-carboxylate), a novel acetylcholinesterase inhibitor with "calcium promotor" and neuroprotective properties.

Orozco C, de Los Rios C, Arias E, León R, García AG, Marco JL, Villarroya M, López MG.

J Pharmacol Exp Ther. 2004 Sep;310(3):987-94. Epub 2004 Apr 26.

PMID:
15111641

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