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Items: 35


A cell-engineered system to assess tumor cell sensitivity to CD8+ T cell-mediated cytotoxicity.

Nelson N, Lopez-Pelaez M, Palazon A, Poon E, De La Roche M, Barry S, Valge-Archer V, Wilkinson RW, Dovedi SJ, Smith PD.

Oncoimmunology. 2019 Apr 26;8(8):1599635. doi: 10.1080/2162402X.2019.1599635. eCollection 2019.


IL-7-dependent compositional changes within the γδ T cell pool in lymph nodes during ageing lead to an unbalanced anti-tumour response.

Chen HC, Eling N, Martinez-Jimenez CP, O'Brien LM, Carbonaro V, Marioni JC, Odom DT, de la Roche M.

EMBO Rep. 2019 Aug;20(8):e47379. doi: 10.15252/embr.201847379. Epub 2019 Jul 8.


Organoid culture media formulated with growth factors of defined cellular activity.

Urbischek M, Rannikmae H, Foets T, Ravn K, Hyvönen M, de la Roche M.

Sci Rep. 2019 Apr 17;9(1):6193. doi: 10.1038/s41598-019-42604-0.


Overview of the oncogenic signaling pathways in colorectal cancer: Mechanistic insights.

Farooqi AA, de la Roche M, Djamgoz MBA, Siddik ZH.

Semin Cancer Biol. 2019 Oct;58:65-79. doi: 10.1016/j.semcancer.2019.01.001. Epub 2019 Jan 8. Review.


Visceral Leishmaniasis IgG1 Rapid Monitoring of Cure vs. Relapse, and Potential for Diagnosis of Post Kala-Azar Dermal Leishmaniasis.

Marlais T, Bhattacharyya T, Singh OP, Mertens P, Gilleman Q, Thunissen C, Hinckel BCB, Pearson C, Gardner BL, Airs S, de la Roche M, Hayes K, Hafezi H, Falconar AK, Eisa O, Saad A, Khanal B, Bhattarai NR, Rijal S, Boelaert M, El-Safi S, Sundar S, Miles MA.

Front Cell Infect Microbiol. 2018 Dec 13;8:427. doi: 10.3389/fcimb.2018.00427. eCollection 2018.


Utilizing TAPBPR to promote exogenous peptide loading onto cell surface MHC I molecules.

Ilca FT, Neerincx A, Wills MR, de la Roche M, Boyle LH.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9353-E9361. doi: 10.1073/pnas.1809465115. Epub 2018 Sep 13.


Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation.

de la Roche M, Hamilton C, Mortensen R, Jeyaprakash AA, Ghosh S, Anand PK.

J Cell Biol. 2018 Oct 1;217(10):3560-3576. doi: 10.1083/jcb.201709057. Epub 2018 Jul 27.


A novel Atg5-shRNA mouse model enables temporal control of Autophagy in vivo.

Cassidy LD, Young AR, Pérez-Mancera PA, Nimmervoll B, Jaulim A, Chen HC, McIntyre DJO, Brais R, Ricketts T, Pacey S, De La Roche M, Gilbertson RJ, Rubinsztein DC, Narita M.

Autophagy. 2018;14(7):1256-1266. doi: 10.1080/15548627.2018.1458172. Epub 2018 Jul 12.


Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer.

Jenks AD, Vyse S, Wong JP, Kostaras E, Keller D, Burgoyne T, Shoemark A, Tsalikis A, de la Roche M, Michaelis M, Cinatl J Jr, Huang PH, Tanos BE.

Cell Rep. 2018 Jun 5;23(10):3042-3055. doi: 10.1016/j.celrep.2018.05.016.


Aging increases cell-to-cell transcriptional variability upon immune stimulation.

Martinez-Jimenez CP, Eling N, Chen HC, Vallejos CA, Kolodziejczyk AA, Connor F, Stojic L, Rayner TF, Stubbington MJT, Teichmann SA, de la Roche M, Marioni JC, Odom DT.

Science. 2017 Mar 31;355(6332):1433-1436. doi: 10.1126/science.aah4115.


Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase.

Xu W, Lau YH, Fischer G, Tan YS, Chattopadhyay A, de la Roche M, Hyvönen M, Verma C, Spring DR, Itzhaki LS.

J Am Chem Soc. 2017 Feb 15;139(6):2245-2256. doi: 10.1021/jacs.6b10234. Epub 2017 Feb 7.


Origins of the cytolytic synapse.

de la Roche M, Asano Y, Griffiths GM.

Nat Rev Immunol. 2016 Jul;16(7):421-32. doi: 10.1038/nri.2016.54. Epub 2016 Jun 6. Review.


LEF1 and B9L shield β-catenin from inactivation by Axin, desensitizing colorectal cancer cells to tankyrase inhibitors.

de la Roche M, Ibrahim AE, Mieszczanek J, Bienz M.

Cancer Res. 2014 Mar 1;74(5):1495-505. doi: 10.1158/0008-5472.CAN-13-2682. Epub 2014 Jan 13.


Hedgehog signaling controls T cell killing at the immunological synapse.

de la Roche M, Ritter AT, Angus KL, Dinsmore C, Earnshaw CH, Reiter JF, Griffiths GM.

Science. 2013 Dec 6;342(6163):1247-50. doi: 10.1126/science.1244689.


PakB binds to the SH3 domain of Dictyostelium Abp1 and regulates its effects on cell polarity and early development.

Yang Y, de la Roche M, Crawley SW, Li Z, Furmaniak-Kazmierczak E, Côté GP.

Mol Biol Cell. 2013 Jul;24(14):2216-27. doi: 10.1091/mbc.E12-12-0883. Epub 2013 May 22.


Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell.

Thaventhiran JE, Hoffmann A, Magiera L, de la Roche M, Lingel H, Brunner-Weinzierl M, Fearon DT.

Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):E2223-9. doi: 10.1073/pnas.1209115109. Epub 2012 Jun 27.


An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid.

de la Roche M, Rutherford TJ, Gupta D, Veprintsev DB, Saxty B, Freund SM, Bienz M.

Nat Commun. 2012 Feb 21;3:680. doi: 10.1038/ncomms1680.


Structural and functional properties of glycerol-3-phosphate dehydrogenase from a mammalian hibernator.

de la Roche M, Tessier SN, Storey KB.

Protein J. 2012 Feb;31(2):109-19. doi: 10.1007/s10930-011-9376-3.


Centrosome docking at the immunological synapse is controlled by Lck signaling.

Tsun A, Qureshi I, Stinchcombe JC, Jenkins MR, de la Roche M, Kleczkowska J, Zamoyska R, Griffiths GM.

J Cell Biol. 2011 Feb 21;192(4):663-74. doi: 10.1083/jcb.201008140.


Dvl2 promotes intestinal length and neoplasia in the ApcMin mouse model for colorectal cancer.

Metcalfe C, Ibrahim AE, Graeb M, de la Roche M, Schwarz-Romond T, Fiedler M, Winton DJ, Corfield A, Bienz M.

Cancer Res. 2010 Aug 15;70(16):6629-38. doi: 10.1158/0008-5472.CAN-10-1616. Epub 2010 Jul 27.


A role of Pygopus as an anti-repressor in facilitating Wnt-dependent transcription.

Mieszczanek J, de la Roche M, Bienz M.

Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19324-9. doi: 10.1073/pnas.0806098105. Epub 2008 Nov 26.


The function of BCL9 in Wnt/beta-catenin signaling and colorectal cancer cells.

de la Roche M, Worm J, Bienz M.

BMC Cancer. 2008 Jul 15;8:199. doi: 10.1186/1471-2407-8-199.


Wingless-independent association of Pygopus with dTCF target genes.

de la Roche M, Bienz M.

Curr Biol. 2007 Mar 20;17(6):556-61. Epub 2007 Feb 22.


Identification and characterization of an 8-kDa light chain associated with Dictyostelium discoideum MyoB, a class I myosin.

Crawley SW, de la Roche MA, Lee SF, Li Z, Chitayat S, Smith SP, Côté GP.

J Biol Chem. 2006 Mar 10;281(10):6307-15. Epub 2006 Jan 16.


Cellular distribution and functions of wild-type and constitutively activated Dictyostelium PakB.

de la Roche M, Mahasneh A, Lee SF, Rivero F, Côté GP.

Mol Biol Cell. 2005 Jan;16(1):238-47. Epub 2004 Oct 27.


Signaling pathways regulating Dictyostelium myosin II.

De la Roche MA, Smith JL, Betapudi V, Egelhoff TT, Côté GP.

J Muscle Res Cell Motil. 2002;23(7-8):703-18. Review.


Dictyostelium discoideum has a single diacylglycerol kinase gene with similarity to mammalian theta isoforms.

De La Roche MA, Smith JL, Rico M, Carrasco S, Merida I, Licate L, Côté GP, Egelhoff TT.

Biochem J. 2002 Dec 15;368(Pt 3):809-15.


Regulation of Dictyostelium myosin I and II.

de la Roche MA, Côté GP.

Biochim Biophys Acta. 2001 Mar 15;1525(3):245-61. Review.


Hydrodynamic properties of Vibrio harveyi acyl carrier protein and its fatty-acylated derivatives.

de la Roche MA, Shen Z, Byers DM.

Arch Biochem Biophys. 1997 Aug 1;344(1):159-64.


Rapid transfusion of packed red blood cells: effects of dilution, pressure, and catheter size.

de la Roche MR, Gauthier L.

Ann Emerg Med. 1993 Oct;22(10):1551-5.


Current concepts in trauma: 1. Principles and directions for development.

McMurtry RY, Nelson WR, de la Roche MR.

CMAJ. 1989 Sep 15;141(6):529-33. Review.


Is prehospital advanced life support really necessary?

de la Roche MR.

CMAJ. 1987 Dec 1;137(11):995-9. Review. No abstract available.

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