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Items: 1 to 50 of 275

1.

Specific lid-base contacts in the 26s proteasome control the conformational switching required for substrate degradation.

Greene ER, Goodall EA, de la Peña AH, Matyskiela ME, Lander GC, Martin A.

Elife. 2019 Nov 28;8. pii: e49806. doi: 10.7554/eLife.49806.

2.

Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence.

Sliepen K, Han BW, Bontjer I, Mooij P, Garces F, Behrens AJ, Rantalainen K, Kumar S, Sarkar A, Brouwer PJM, Hua Y, Tolazzi M, Schermer E, Torres JL, Ozorowski G, van der Woude P, de la Peña AT, van Breemen MJ, Camacho-Sánchez JM, Burger JA, Medina-Ramírez M, González N, Alcami J, LaBranche C, Scarlatti G, van Gils MJ, Crispin M, Montefiori DC, Ward AB, Koopman G, Moore JP, Shattock RJ, Bogers WM, Wilson IA, Sanders RW.

Nat Commun. 2019 May 29;10(1):2355. doi: 10.1038/s41467-019-10262-5.

3.

Stabilization of the V2 loop improves the presentation of V2 loop-associated broadly neutralizing antibody epitopes on HIV-1 envelope trimers.

de Taeye SW, Go EP, Sliepen K, de la Peña AT, Badal K, Medina-Ramírez M, Lee WH, Desaire H, Wilson IA, Moore JP, Ward AB, Sanders RW.

J Biol Chem. 2019 Apr 5;294(14):5616-5631. doi: 10.1074/jbc.RA118.005396. Epub 2019 Feb 6.

4.

Substrate-engaged 26S proteasome structures reveal mechanisms for ATP-hydrolysis-driven translocation.

de la Peña AH, Goodall EA, Gates SN, Lander GC, Martin A.

Science. 2018 Nov 30;362(6418). pii: eaav0725. doi: 10.1126/science.aav0725. Epub 2018 Oct 11.

5.

CGRP blockade by galcanezumab was not associated with reductions in signs and symptoms of knee osteoarthritis in a randomized clinical trial.

Jin Y, Smith C, Monteith D, Brown R, Camporeale A, McNearney TA, Deeg MA, Raddad E, Xiao N, de la Peña A, Kivitz AJ, Schnitzer TJ.

Osteoarthritis Cartilage. 2018 Dec;26(12):1609-1618. doi: 10.1016/j.joca.2018.08.019. Epub 2018 Sep 18.

6.

Low-cost customized cranioplasty using a 3D digital printing model: a case report.

De La Peña A, De La Peña-Brambila J, Pérez-De La Torre J, Ochoa M, Gallardo GJ.

3D Print Med. 2018;4(1):4. doi: 10.1186/s41205-018-0026-7. Epub 2018 Apr 12.

7.

Tracking the Sugar Rush: Incorporating Continuous Glucose Monitoring Into Multisite Early Clinical Research With Type 2 Diabetes Subjects.

Paglialunga S, Morimoto BH, de la Peña A, Fortier C.

Clin Pharmacol Drug Dev. 2018 Sep;7(7):676-683. doi: 10.1002/cpdd.437. Epub 2018 Feb 14.

8.

Baricitinib in adult patients with moderate-to-severe atopic dermatitis: A phase 2 parallel, double-blinded, randomized placebo-controlled multiple-dose study.

Guttman-Yassky E, Silverberg JI, Nemoto O, Forman SB, Wilke A, Prescilla R, de la Peña A, Nunes FP, Janes J, Gamalo M, Donley D, Paik J, DeLozier AM, Nickoloff BJ, Simpson EL.

J Am Acad Dermatol. 2019 Apr;80(4):913-921.e9. doi: 10.1016/j.jaad.2018.01.018. Epub 2018 Feb 2.

PMID:
29410014
9.

Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers.

de Taeye SW, de la Peña AT, Vecchione A, Scutigliani E, Sliepen K, Burger JA, van der Woude P, Schorcht A, Schermer EE, van Gils MJ, LaBranche CC, Montefiori DC, Wilson IA, Moore JP, Ward AB, Sanders RW.

J Biol Chem. 2018 Feb 2;293(5):1688-1701. doi: 10.1074/jbc.RA117.000709. Epub 2017 Dec 8.

10.

Efficacy of a New Recrystallized Enrofloxacin Hydrochloride-Dihydrate against Leptospirosis in a Hamster Model.

Carrascosa A, Gutierrez L, De la Peña A, Candanosa IE, Tapia G, Sumano H.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01285-17. doi: 10.1128/AAC.01285-17. Print 2017 Nov.

11.

A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human-type receptors.

de Vries RP, Tzarum N, Peng W, Thompson AJ, Ambepitiya Wickramasinghe IN, de la Pena ATT, van Breemen MJ, Bouwman KM, Zhu X, McBride R, Yu W, Sanders RW, Verheije MH, Wilson IA, Paulson JC.

EMBO Mol Med. 2017 Sep;9(9):1314-1325. doi: 10.15252/emmm.201707726.

12.

Three mutations switch H7N9 influenza to human-type receptor specificity.

de Vries RP, Peng W, Grant OC, Thompson AJ, Zhu X, Bouwman KM, de la Pena ATT, van Breemen MJ, Ambepitiya Wickramasinghe IN, de Haan CAM, Yu W, McBride R, Sanders RW, Woods RJ, Verheije MH, Wilson IA, Paulson JC.

PLoS Pathog. 2017 Jun 15;13(6):e1006390. doi: 10.1371/journal.ppat.1006390. eCollection 2017 Jun.

13.

No Dose Adjustment is Recommended for Digoxin, Warfarin, Atorvastatin or a Combination Oral Contraceptive When Coadministered with Dulaglutide.

de la Peña A, Cui X, Geiser J, Loghin C.

Clin Pharmacokinet. 2017 Nov;56(11):1415-1427. doi: 10.1007/s40262-017-0531-7.

PMID:
28357715
14.

Once-weekly dulaglutide 1.5 mg restores insulin secretion in response to intravenous glucose infusion.

de la Peña A, Loghin C, Cui X, Zhang X, Kapitza C, Kelly RP.

Diabetes Obes Metab. 2017 Apr;19(4):517-523. doi: 10.1111/dom.12847. Epub 2017 Feb 17.

PMID:
27976833
15.

What's the Key to Unlocking the Proteasome's Gate?

de la Peña AH, Lander GC.

Structure. 2016 Dec 6;24(12):2037-2038. doi: 10.1016/j.str.2016.11.011.

16.

Tuning of the Electronic Levels of Oligothiophene-Naphthalimide Assemblies by Chemical Modification.

de la Peña A, Arrechea-Marcos I, Mancheño MJ, Ruiz Delgado MC, López Navarrete JT, Segura JL, Ponce Ortiz R.

Chemistry. 2016 Sep 12;22(38):13643-52. doi: 10.1002/chem.201602082. Epub 2016 Jul 19.

PMID:
27430480
17.

Bioequivalence and comparative pharmacodynamics of insulin lispro 200 U/mL relative to insulin lispro (Humalog®) 100 U/mL.

de la Peña A, Seger M, Soon D, Scott AJ, Reddy SR, Dobbins MA, Brown-Augsburger P, Linnebjerg H.

Clin Pharmacol Drug Dev. 2016 Jan;5(1):69-75. doi: 10.1002/cpdd.221. Epub 2015 Oct 5.

18.

Differential effects of once-weekly glucagon-like peptide-1 receptor agonist dulaglutide and metformin on pancreatic β-cell and insulin sensitivity during a standardized test meal in patients with type 2 diabetes.

Mari A, Del Prato S, Ludvik B, Milicevic Z, de la Peña A, Shurzinske L, Karanikas CA, Pechtner V.

Diabetes Obes Metab. 2016 Aug;18(8):834-9. doi: 10.1111/dom.12671. Epub 2016 May 16.

PMID:
27059816
19.

Benzotrithiophene versus Benzo/Naphthodithiophene Building Blocks: The Effect of Star-Shaped versus Linear Conjugation on Their Electronic Structures.

Riaño A, Arrechea-Marcos I, Mancheño MJ, Mayorga Burrezo P, de la Peña A, Loser S, Timalsina A, Facchetti A, Marks TJ, Casado J, López Navarrete JT, Ponce Ortiz R, Segura JL.

Chemistry. 2016 Apr 25;22(18):6374-81. doi: 10.1002/chem.201504526. Epub 2016 Mar 21.

PMID:
26999589
20.

Methods and strategies for assessing uncontrolled drug-drug interactions in population pharmacokinetic analyses: results from the International Society of Pharmacometrics (ISOP) Working Group.

Bonate PL, Ahamadi M, Budha N, de la Peña A, Earp JC, Hong Y, Karlsson MO, Ravva P, Ruiz-Garcia A, Struemper H, Wade JR.

J Pharmacokinet Pharmacodyn. 2016 Apr;43(2):123-35. doi: 10.1007/s10928-016-9464-2. Epub 2016 Feb 2. Review.

PMID:
26837775
21.

DSF Guided Refolding As A Novel Method Of Protein Production.

Biter AB, de la Peña AH, Thapar R, Lin JZ, Phillips KJ.

Sci Rep. 2016 Jan 19;6:18906. doi: 10.1038/srep18906.

22.

Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans.

Garces F, Lee JH, de Val N, de la Pena AT, Kong L, Puchades C, Hua Y, Stanfield RL, Burton DR, Moore JP, Sanders RW, Ward AB, Wilson IA.

Immunity. 2015 Dec 15;43(6):1053-63. doi: 10.1016/j.immuni.2015.11.007.

23.

Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorus.

de la Peña AH, Suarez A, Duong-Ly KC, Schoeffield AJ, Pizarro-Dupuy MA, Zarr M, Pineiro SA, Amzel LM, Gabelli SB.

PLoS One. 2015 Nov 2;10(11):e0141716. doi: 10.1371/journal.pone.0141716. eCollection 2015.

24.

Chemical Cross-Linking Stabilizes Native-Like HIV-1 Envelope Glycoprotein Trimer Antigens.

Schiffner T, de Val N, Russell RA, de Taeye SW, de la Peña AT, Ozorowski G, Kim HJ, Nieusma T, Brod F, Cupo A, Sanders RW, Moore JP, Ward AB, Sattentau QJ.

J Virol. 2015 Oct 28;90(2):813-28. doi: 10.1128/JVI.01942-15. Print 2016 Jan 15.

25.

Clinical Pharmacokinetics of Dulaglutide in Patients with Type 2 Diabetes: Analyses of Data from Clinical Trials.

Geiser JS, Heathman MA, Cui X, Martin J, Loghin C, Chien JY, de la Peña A.

Clin Pharmacokinet. 2016 May;55(5):625-34. doi: 10.1007/s40262-015-0338-3.

PMID:
26507721
26.

Circulating Levels of Urokinase-Type Plasminogen Activator Receptor and D-Dimer in Patients With Hematological Malignancies.

Rubio-Jurado B, Tello-González A, Bustamante-Chávez L, de la Peña A, Riebeling-Navarro C, Nava-Zavala AH.

Clin Lymphoma Myeloma Leuk. 2015 Oct;15(10):621-6. doi: 10.1016/j.clml.2015.07.632. Epub 2015 Aug 14.

PMID:
26423703
27.

A redox regulatory system critical for mycobacterial survival in macrophages and biofilm development.

Wolff KA, de la Peña AH, Nguyen HT, Pham TH, Amzel LM, Gabelli SB, Nguyen L.

PLoS Pathog. 2015 Apr 17;11(4):e1004839. doi: 10.1371/journal.ppat.1004839. eCollection 2015 Apr.

28.

Interethnic variation of the MMP-9 microsatellite in Amerindian and Mexican Mestizo populations: considerations for genetic association studies.

Camacho-Mejorado R, Noris G, Santana C, Magaña JJ, Majluf-Cruz A, Arellano-Galindo J, De la Peña A, Hernández-Juárez J, Calderón-Aranda ES, Meraz-Ríos MA, Gómez R.

Genet Mol Res. 2015 Mar 31;14(1):2929-39. doi: 10.4238/2015.March.31.24.

29.

Timing of adjuvant surgical oophorectomy in the menstrual cycle and disease-free and overall survival in premenopausal women with operable breast cancer.

Love RR, Laudico AV, Van Dinh N, Allred DC, Uy GB, Quang le H, Salvador JD, Siguan SS, Mirasol-Lumague MR, Tung ND, Benjaafar N, Navarro NS Jr, Quy TT, De La Peña AS, Dofitas RB, Bisquera OC Jr, Linh ND, To TV, Young GS, Hade EM, Jarjoura D.

J Natl Cancer Inst. 2015 Mar 19;107(6):djv064. doi: 10.1093/jnci/djv064. Print 2015 Jun.

30.

Subcutaneous Injection Depth Does Not Affect the Pharmacokinetics or Glucodynamics of Insulin Lispro in Normal Weight or Healthy Obese Subjects.

de la Peña A, Yeo KP, Linnebjerg H, Catton E, Reddy S, Brown-Augsburger P, Morrow L, Ignaut DA.

J Diabetes Sci Technol. 2015 Jul;9(4):824-30. doi: 10.1177/1932296815573865. Epub 2015 Feb 19.

31.

Reduction of no-reflow and reperfusion injury with the synthetic 17β-aminoestrogen compound Prolame is associated with PI3K/Akt/eNOS signaling cascade.

Hernández-Reséndiz S, Palma-Flores C, De Los Santos S, Román-Anguiano NG, Flores M, de la Peña A, Flores PL, Fernández-G JM, Coral-Vázquez RM, Zazueta C.

Basic Res Cardiol. 2015 Mar;110(2):1. doi: 10.1007/s00395-015-0464-y. Epub 2015 Jan 15.

PMID:
25589055
32.

Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface.

Huang J, Kang BH, Pancera M, Lee JH, Tong T, Feng Y, Imamichi H, Georgiev IS, Chuang GY, Druz A, Doria-Rose NA, Laub L, Sliepen K, van Gils MJ, de la Peña AT, Derking R, Klasse PJ, Migueles SA, Bailer RT, Alam M, Pugach P, Haynes BF, Wyatt RT, Sanders RW, Binley JM, Ward AB, Mascola JR, Kwong PD, Connors M.

Nature. 2014 Nov 6;515(7525):138-42. doi: 10.1038/nature13601. Epub 2014 Sep 3.

33.

Distribution of ABCB1, CYP3A5, CYP2C19, and P2RY12 gene polymorphisms in a Mexican Mestizos population.

Vargas-Alarcón G, Ramírez-Bello J, de la Peña A, Calderón-Cruz B, Peña-Duque MA, Martínez-Ríos MA, Ramírez-Fuentes S, Pérez-Méndez O, Fragoso JM.

Mol Biol Rep. 2014 Oct;41(10):7023-9. doi: 10.1007/s11033-014-3590-y. Epub 2014 Aug 9.

PMID:
25106522
34.

Application of PK/PD modeling and simulation to dosing regimen optimization of high-dose human regular U-500 insulin.

de la Peña A, Ma X, Reddy S, Ovalle F, Bergenstal RM, Jackson JA.

J Diabetes Sci Technol. 2014 Jul;8(4):821-9. doi: 10.1177/1932296814532326. Epub 2014 May 12.

35.

Low level of HIV-1 evolution after transmission from mother to child.

Gijsbers EF, van Nuenen AC, de la Peňa AT, Bowles EJ, Stewart-Jones GB, Schuitemaker H, Kootstra NA.

Sci Rep. 2014 May 28;4:5079. doi: 10.1038/srep05079.

36.

Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers.

Blattner C, Lee JH, Sliepen K, Derking R, Falkowska E, de la Peña AT, Cupo A, Julien JP, van Gils M, Lee PS, Peng W, Paulson JC, Poignard P, Burton DR, Moore JP, Sanders RW, Wilson IA, Ward AB.

Immunity. 2014 May 15;40(5):669-80. doi: 10.1016/j.immuni.2014.04.008. Epub 2014 Apr 24.

37.

A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies.

Sanders RW, Derking R, Cupo A, Julien JP, Yasmeen A, de Val N, Kim HJ, Blattner C, de la Peña AT, Korzun J, Golabek M, de Los Reyes K, Ketas TJ, van Gils MJ, King CR, Wilson IA, Ward AB, Klasse PJ, Moore JP.

PLoS Pathog. 2013 Sep;9(9):e1003618. doi: 10.1371/journal.ppat.1003618. Epub 2013 Sep 19.

38.

Bone mineral density following surgical oophorectomy and tamoxifen adjuvant therapy for breast cancer.

Love RR, Young GS, Laudico AV, Van Dinh N, Uy GB, Quang le H, De La Peña AS, Dofitas RB, Bisquera OC Jr, Siguan SS, Salvador JD, Mirasol-Lumague MR, Navarro NS Jr, Linh ND, Jarjoura D.

Cancer. 2013 Nov 1;119(21):3746-52. doi: 10.1002/cncr.28302. Epub 2013 Aug 20.

39.

Comparative properties of U-500 and U-100 regular human insulin.

Brusko C, Jackson JA, de la Peña A.

Am J Health Syst Pharm. 2013 Aug 1;70(15):1283-4. doi: 10.2146/130117. No abstract available.

PMID:
23867483
40.

[Vascular risk in outpatient from Internal Medicine departments. MICARE Study].

de la Peña A, Roca-Cusachs A, Suárez C, Bonet S; en nombre del grupo MICARE.

Med Clin (Barc). 2013 Mar 16;140(6):246-54. doi: 10.1016/j.medcli.2012.05.043. Epub 2012 Nov 28. Spanish.

PMID:
23199827
41.

The effects on metabolic clearance when administering a potent CYP3A autoinducer with the prototypic CYP3A inhibitor, ketoconazole.

Ayan-Oshodi MA, Willis BA, Annes WF, Lowe SL, Friedrich S, de la Peña A, Zhang W, Brown T, Wise SD, Hall SD.

Drug Metab Dispos. 2012 Oct;40(10):1945-52. doi: 10.1124/dmd.112.046060. Epub 2012 Jul 12.

PMID:
22789530
42.

Ischemic stroke in the setting of chronic immune thrombocytopenia in an elderly patient--a therapeutic dilemma.

De La Peña A, Fareed J, Thethi I, Morales-Vidal S, Schneck MJ, Shafer D.

Clin Appl Thromb Hemost. 2012 Jun;18(3):324-6. doi: 10.1177/1076029611425380. Epub 2011 Nov 14.

PMID:
22084414
43.

Pharmacokinetics and pharmacodynamics of high-dose human regular U-500 insulin versus human regular U-100 insulin in healthy obese subjects.

de la Peña A, Riddle M, Morrow LA, Jiang HH, Linnebjerg H, Scott A, Win KM, Hompesch M, Mace KF, Jacobson JG, Jackson JA.

Diabetes Care. 2011 Dec;34(12):2496-501. doi: 10.2337/dc11-0721. Epub 2011 Oct 12. Erratum in: Diabetes Care. 2014 Aug;37(8):2414.

44.

Mifepristone (RU 486) induces vasodilation and inhibits platelet aggregation: nongenomic and genomic action to cause hemorrhage.

Perusquía M, Espinoza J, de la Peña A.

Contraception. 2011 Aug;84(2):169-77. doi: 10.1016/j.contraception.2010.12.009. Epub 2011 Feb 11.

PMID:
21757059
45.

Semagacestat pharmacokinetics are not significantly affected by formulation, food, or time of dosing in healthy participants.

Willis BA, Zhang W, Ayan-Oshodi M, Lowe SL, Annes WF, Sirois PJ, Friedrich S, de la Peña A.

J Clin Pharmacol. 2012 Jun;52(6):904-13. doi: 10.1177/0091270011407195. Epub 2011 Jul 1.

PMID:
21724950
46.

Separation and determination of 11 marker pteridines in human urine by liquid chromatography and fluorimetric detection.

de Llanos AM, Espinosa-Mansilla A, Cañada-Cañada F, de la Peña AM.

J Sep Sci. 2011 Jun;34(11):1283-92. doi: 10.1002/jssc.201000900. Epub 2011 Apr 20.

PMID:
21509936
47.

The combined use of the Thermofluor assay and ThermoQ analytical software for the determination of protein stability and buffer optimization as an aid in protein crystallization.

Phillips K, de la Peña AH.

Curr Protoc Mol Biol. 2011 Apr;Chapter 10:Unit10.28. doi: 10.1002/0471142727.mb1028s94.

PMID:
21472694
48.

Usability assessment of ASIBOT: a portable robot to aid patients with spinal cord injury.

Jardón A, Gil ÁM, de la Peña AI, Monje CA, Balaguer C.

Disabil Rehabil Assist Technol. 2011;6(4):320-30. doi: 10.3109/17483107.2010.528144. Epub 2010 Oct 22.

PMID:
20969432
49.

AIR insulin capsules of different dose strengths may be combined to yield equivalent pharmacokinetics and glucodynamics.

de la Peña A, Seger M, Rave K, Heinemann L, Silverman B, Muchmore DB.

Diabetes Technol Ther. 2009 Sep;11 Suppl 2:S75-80. doi: 10.1089/dia.2009.0057.

PMID:
19772452
50.

The antithrombotic effect of the aminoestrogen prolame (N-(3-hydroxy-1,3,5(10)-estratrien-17B-YL)-3-hydroxypropylamine) is linked to an increase in nitric oxide production by platelets and endothelial cells.

González G, Alvarado-Vasquez N, Fernández-G JM, Cruz-Robles D, Del Valle L, Pinzón E, Torres I, Rodriguez E, Zapata E, Gómez-Vidales V, Montaño LF, de la Peña A.

Atherosclerosis. 2010 Jan;208(1):62-8. doi: 10.1016/j.atherosclerosis.2009.06.017. Epub 2009 Jun 18.

PMID:
19615684

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