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Selective deletion of MyD88 signaling in α-SMA positive cells ameliorates experimental intestinal fibrosis via post-transcriptional regulation.

Zhao S, Dejanovic D, Yao P, Bhilocha S, Sadler T, Schirbel A, West G, Doyon G, Lopez R, Mao R, Kurada S, El Ouali S, Grassl G, Fox PL, Cruise M, Worthley DL, de la Motte C, Fiocchi C, Rieder F.

Mucosal Immunol. 2020 Feb 4. doi: 10.1038/s41385-020-0259-9. [Epub ahead of print]


Insights Image for "Hyaluronan 35 kDa enhances epithelial barrier function and protects against the development of murine necrotizing enterocolitis".

Gunasekaran A, Eckert J, Burge K, Zheng W, Yu Z, Kessler S, de la Motte C, Chaaban H.

Pediatr Res. 2020 Jan 22. doi: 10.1038/s41390-020-0773-1. [Epub ahead of print] No abstract available.


Hyaluronan 35 kDa enhances epithelial barrier function and protects against the development of murine necrotizing enterocolitis.

Gunasekaran A, Eckert J, Burge K, Zheng W, Yu Z, Kessler S, de la Motte C, Chaaban H.

Pediatr Res. 2019 Sep 9. doi: 10.1038/s41390-019-0563-9. [Epub ahead of print]


Platelet hyaluronidase-2 regulates the early stages of inflammatory disease in colitis.

Petrey AC, Obery DR, Kessler SP, Zawerton A, Flamion B, de la Motte CA.

Blood. 2019 Aug 29;134(9):765-775. doi: 10.1182/blood.2018893594. Epub 2019 Jul 1.


Specifically Sized Hyaluronan (35 kDa) Prevents Ethanol-Induced Disruption of Epithelial Tight Junctions Through a layilin-Dependent Mechanism in Caco-2 Cells.

Bellos DA, Sharma D, McMullen MR, Wat J, Saikia P, de la Motte CA, Nagy LE.

Alcohol Clin Exp Res. 2019 Sep;43(9):1848-1858. doi: 10.1111/acer.14140. Epub 2019 Jul 16.


Safety of Hyaluronan 35 in Healthy Human Subjects: A Pilot Study.

Bellar A, Kessler SP, Obery DR, Sangwan N, Welch N, Nagy LE, Dasarathy S, de la Motte C.

Nutrients. 2019 May 22;11(5). pii: E1135. doi: 10.3390/nu11051135.


Mutual Regulation of TLR/NLR and CEACAM1 in the Intestinal Microvasculature: Implications for IBD Pathogenesis and Therapy.

Schirbel A, Rebert N, Sadler T, West G, Rieder F, Wagener C, Horst A, Sturm A, de la Motte C, Fiocchi C.

Inflamm Bowel Dis. 2019 Jan 10;25(2):294-305. doi: 10.1093/ibd/izy316.


Hyaluronan in inflammatory bowel disease: Cross-linking inflammation and coagulation.

Petrey AC, de la Motte CA.

Matrix Biol. 2019 May;78-79:314-323. doi: 10.1016/j.matbio.2018.03.011. Epub 2018 Mar 21. Review.


Multifunctional Role of 35 Kilodalton Hyaluronan in Promoting Defense of the Intestinal Epithelium.

Kessler SP, Obery DR, Nickerson KP, Petrey AC, McDonald C, de la Motte CA.

J Histochem Cytochem. 2018 Apr;66(4):273-287. doi: 10.1369/0022155417746775. Epub 2018 Jan 1.


Hyaluronic acid 35 normalizes TLR4 signaling in Kupffer cells from ethanol-fed rats via regulation of microRNA291b and its target Tollip.

Saikia P, Roychowdhury S, Bellos D, Pollard KA, McMullen MR, McCullough RL, McCullough AJ, Gholam P, de la Motte C, Nagy LE.

Sci Rep. 2017 Nov 15;7(1):15671. doi: 10.1038/s41598-017-15760-4.


Layilin is critical for mediating hyaluronan 35kDa-induced intestinal epithelial tight junction protein ZO-1 in vitro and in vivo.

Kim Y, West GA, Ray G, Kessler SP, Petrey AC, Fiocchi C, McDonald C, Longworth MS, Nagy LE, de la Motte CA.

Matrix Biol. 2018 Mar;66:93-109. doi: 10.1016/j.matbio.2017.09.003. Epub 2017 Oct 1.


The extracellular matrix in IBD: a dynamic mediator of inflammation.

Petrey AC, de la Motte CA.

Curr Opin Gastroenterol. 2017 Jul;33(4):234-238. doi: 10.1097/MOG.0000000000000368. Review.


MicroRNA 181b-3p and its target importin α5 regulate toll-like receptor 4 signaling in Kupffer cells and liver injury in mice in response to ethanol.

Saikia P, Bellos D, McMullen MR, Pollard KA, de la Motte C, Nagy LE.

Hepatology. 2017 Aug;66(2):602-615. doi: 10.1002/hep.29144. Epub 2017 Jul 4.


Crohn's Disease Fibroblasts Overproduce the Novel Protein KIAA1199 to Create Proinflammatory Hyaluronan Fragments.

Soroosh A, Albeiroti S, West GA, Willard B, Fiocchi C, de la Motte CA.

Cell Mol Gastroenterol Hepatol. 2016 Jan 13;2(3):358-368.e4. eCollection 2016 May.


Hyaluronan 35kDa treatment protects mice from Citrobacter rodentium infection and induces epithelial tight junction protein ZO-1 in vivo.

Kim Y, Kessler SP, Obery DR, Homer CR, McDonald C, de la Motte CA.

Matrix Biol. 2017 Oct;62:28-39. doi: 10.1016/j.matbio.2016.11.001. Epub 2016 Nov 11.


Thrombin Cleavage of Inter-α-inhibitor Heavy Chain 1 Regulates Leukocyte Binding to an Inflammatory Hyaluronan Matrix.

Petrey AC, de la Motte CA.

J Biol Chem. 2016 Nov 18;291(47):24324-24334. Epub 2016 Sep 27.


Hyaluronan Depolymerization by Megakaryocyte Hyaluronidase-2 Is Required for Thrombopoiesis.

Petrey AC, Obery DR, Kessler SP, Flamion B, de la Motte CA.

Am J Pathol. 2016 Sep;186(9):2390-403. doi: 10.1016/j.ajpath.2016.05.004. Epub 2016 Jul 8.


Hyaluronan's Role in Fibrosis: A Pathogenic Factor or a Passive Player?

Albeiroti S, Soroosh A, de la Motte CA.

Biomed Res Int. 2015;2015:790203. doi: 10.1155/2015/790203. Epub 2015 Oct 25. Review.


Deficiency of hyaluronan synthase 1 (Has1) results in chronic joint inflammation and widespread intra-articular fibrosis in a murine model of knee joint cartilage damage.

Chan DD, Xiao WF, Li J, de la Motte CA, Sandy JD, Plaas A.

Osteoarthritis Cartilage. 2015 Nov;23(11):1879-89. doi: 10.1016/j.joca.2015.06.021.


Hyaluronan Synthase 3 Null Mice Exhibit Decreased Intestinal Inflammation and Tissue Damage in the DSS-Induced Colitis Model.

Kessler SP, Obery DR, de la Motte C.

Int J Cell Biol. 2015;2015:745237. doi: 10.1155/2015/745237. Epub 2015 Sep 10.


Advances in Hyaluronan Biology: Signaling, Regulation, and Disease Mechanisms.

Simpson MA, de la Motte C, Sherman LS, Weigel PH.

Int J Cell Biol. 2015;2015:690572. doi: 10.1155/2015/690572. Epub 2015 Sep 13. No abstract available.


The role of hyaluronan in innate defense responses of the intestine.

de la Motte CA, Kessler SP.

Int J Cell Biol. 2015;2015:481301. doi: 10.1155/2015/481301. Epub 2015 Mar 30. Review.


The epithelial danger signal IL-1α is a potent activator of fibroblasts and reactivator of intestinal inflammation.

Scarpa M, Kessler S, Sadler T, West G, Homer C, McDonald C, de la Motte C, Fiocchi C, Stylianou E.

Am J Pathol. 2015 Jun;185(6):1624-37. doi: 10.1016/j.ajpath.2015.02.018. Epub 2015 Apr 10.


Chromosome-associated protein D3 promotes bacterial clearance in human intestinal epithelial cells by repressing expression of amino acid transporters.

Schuster AT, Homer CR, Kemp JR, Nickerson KP, Deutschman E, Kim Y, West G, Sadler T, Stylianou E, Krokowski D, Hatzoglou M, de la Motte C, Rubin BP, Fiocchi C, McDonald C, Longworth MS.

Gastroenterology. 2015 Jun;148(7):1405-1416.e3. doi: 10.1053/j.gastro.2015.02.013. Epub 2015 Feb 18.


Acute and chronic rejection: compartmentalization and kinetics of counterbalancing signals in cardiac transplants.

Kaul AM, Goparaju S, Dvorina N, Iida S, Keslar KS, de la Motte CA, Valujskikh A, Fairchild RL, Baldwin WM 3rd.

Am J Transplant. 2015 Feb;15(2):333-45. doi: 10.1111/ajt.13014. Epub 2015 Jan 12.


Determination of hyaluronan molecular mass distribution in human breast milk.

Yuan H, Amin R, Ye X, de la Motte CA, Cowman MK.

Anal Biochem. 2015 Apr 1;474:78-88. doi: 10.1016/j.ab.2014.12.020. Epub 2015 Jan 9.


Platelet hyaluronidase-2: an enzyme that translocates to the surface upon activation to function in extracellular matrix degradation.

Albeiroti S, Ayasoufi K, Hill DR, Shen B, de la Motte CA.

Blood. 2015 Feb 26;125(9):1460-9. doi: 10.1182/blood-2014-07-590513. Epub 2014 Nov 19.


Analysis of the heavy-chain modification and TSG-6 activity in pathological hyaluronan matrices.

Lauer ME, Loftis J, de la Motte C, Hascall VC.

Methods Mol Biol. 2015;1229:543-8. doi: 10.1007/978-1-4939-1714-3_42.


The dietary polysaccharide maltodextrin promotes Salmonella survival and mucosal colonization in mice.

Nickerson KP, Homer CR, Kessler SP, Dixon LJ, Kabi A, Gordon IO, Johnson EE, de la Motte CA, McDonald C.

PLoS One. 2014 Jul 7;9(7):e101789. doi: 10.1371/journal.pone.0101789. eCollection 2014.


Hyaluronan, a crucial regulator of inflammation.

Petrey AC, de la Motte CA.

Front Immunol. 2014 Mar 11;5:101. doi: 10.3389/fimmu.2014.00101. eCollection 2014. Review.


Molecular mass dependence of hyaluronan detection by sandwich ELISA-like assay and membrane blotting using biotinylated hyaluronan binding protein.

Yuan H, Tank M, Alsofyani A, Shah N, Talati N, LoBello JC, Kim JR, Oonuki Y, de la Motte CA, Cowman MK.

Glycobiology. 2013 Nov;23(11):1270-80. doi: 10.1093/glycob/cwt064. Epub 2013 Aug 19.


Human milk hyaluronan enhances innate defense of the intestinal epithelium.

Hill DR, Rho HK, Kessler SP, Amin R, Homer CR, McDonald C, Cowman MK, de la Motte CA.

J Biol Chem. 2013 Oct 4;288(40):29090-104. doi: 10.1074/jbc.M113.468629. Epub 2013 Aug 15.


Specific-sized hyaluronan fragments promote expression of human β-defensin 2 in intestinal epithelium.

Hill DR, Kessler SP, Rho HK, Cowman MK, de la Motte CA.

J Biol Chem. 2012 Aug 31;287(36):30610-24. doi: 10.1074/jbc.M112.356238. Epub 2012 Jul 3.


Increased levels of survivin, via association with heat shock protein 90, in mucosal T cells from patients with Crohn's disease.

de Souza HS, West GA, Rebert N, de la Motte C, Drazba J, Fiocchi C.

Gastroenterology. 2012 Oct;143(4):1017-26.e9. doi: 10.1053/j.gastro.2012.06.039. Epub 2012 Jun 26.


Utility of fecal and serum anti-Saccharomyces cerevisiae antibodies in the diagnosis of Crohn's disease-like condition of the pouch.

Tang LY, Cai H, Navaneethan U, Boone JH, Rhodes SJ, Moore L, Rho H, de La Motte C, Queener E, Shen B.

Int J Colorectal Dis. 2012 Nov;27(11):1455-63. doi: 10.1007/s00384-012-1444-4. Epub 2012 Mar 20.


Protective role of macrophage-derived ceruloplasmin in inflammatory bowel disease.

Bakhautdin B, Febbraio M, Goksoy E, de la Motte CA, Gulen MF, Childers EP, Hazen SL, Li X, Fox PL.

Gut. 2013 Feb;62(2):209-19. doi: 10.1136/gutjnl-2011-300694. Epub 2012 Feb 16.


Inflammation-induced endothelial-to-mesenchymal transition: a novel mechanism of intestinal fibrosis.

Rieder F, Kessler SP, West GA, Bhilocha S, de la Motte C, Sadler TM, Gopalan B, Stylianou E, Fiocchi C.

Am J Pathol. 2011 Nov;179(5):2660-73. doi: 10.1016/j.ajpath.2011.07.042. Epub 2011 Sep 21.


Hyaluronan in intestinal homeostasis and inflammation: implications for fibrosis.

de la Motte CA.

Am J Physiol Gastrointest Liver Physiol. 2011 Dec;301(6):G945-9. doi: 10.1152/ajpgi.00063.2011. Epub 2011 Aug 18. Review.


Agarose and polyacrylamide gel electrophoresis methods for molecular mass analysis of 5- to 500-kDa hyaluronan.

Bhilocha S, Amin R, Pandya M, Yuan H, Tank M, LoBello J, Shytuhina A, Wang W, Wisniewski HG, de la Motte C, Cowman MK.

Anal Biochem. 2011 Oct 1;417(1):41-9. doi: 10.1016/j.ab.2011.05.026. Epub 2011 May 27.


Viewing hyaluronan: imaging contributes to imagining new roles for this amazing matrix polymer.

de la Motte CA, Drazba JA.

J Histochem Cytochem. 2011 Mar;59(3):252-7. doi: 10.1369/0022155410397760. Review.


Hyaluronan matrices in pathobiological processes.

Wang A, de la Motte C, Lauer M, Hascall V.

FEBS J. 2011 May;278(9):1412-8. doi: 10.1111/j.1742-4658.2011.08069.x. Epub 2011 Mar 25. Review.


Inhibition of the phosphatidylinositol-3-kinase pathway abrogates polyinosinic:polycytidylic acid-stimulated hyaluronan-mediated human mucosal smooth muscle cell binding of U937 monocytic cells.

Bandyopadhyay SK, de la Motte CA, Majors AK, Strong SA.

J Interferon Cytokine Res. 2010 Nov;30(11):809-16. doi: 10.1089/jir.2009.0061. Epub 2010 Sep 13.


Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage.

Dy P, Smits P, Silvester A, Penzo-Méndez A, Dumitriu B, Han Y, de la Motte CA, Kingsley DM, Lefebvre V.

Dev Biol. 2010 May 15;341(2):346-59. doi: 10.1016/j.ydbio.2010.02.024. Epub 2010 Mar 4.


Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines.

de la Motte C, Nigro J, Vasanji A, Rho H, Kessler S, Bandyopadhyay S, Danese S, Fiocchi C, Stern R.

Am J Pathol. 2009 Jun;174(6):2254-64. doi: 10.2353/ajpath.2009.080831. Epub 2009 May 14.


Primary murine airway smooth muscle cells exposed to poly(I,C) or tunicamycin synthesize a leukocyte-adhesive hyaluronan matrix.

Lauer ME, Mukhopadhyay D, Fulop C, de la Motte CA, Majors AK, Hascall VC.

J Biol Chem. 2009 Feb 20;284(8):5299-312. doi: 10.1074/jbc.M807965200. Epub 2008 Dec 16.


Hyaluronan-mediated leukocyte adhesion and dextran sulfate sodium-induced colitis are attenuated in the absence of signal transducer and activator of transcription 1.

Bandyopadhyay SK, de la Motte CA, Kessler SP, Hascall VC, Hill DR, Strong SA.

Am J Pathol. 2008 Nov;173(5):1361-8. doi: 10.2353/ajpath.2008.080444. Epub 2008 Sep 25.


High levels of hyaluronan in idiopathic pulmonary arterial hypertension.

Aytekin M, Comhair SA, de la Motte C, Bandyopadhyay SK, Farver CF, Hascall VC, Erzurum SC, Dweik RA.

Am J Physiol Lung Cell Mol Physiol. 2008 Nov;295(5):L789-99. doi: 10.1152/ajplung.90306.2008. Epub 2008 Sep 5.


Hyaluronan (HA) deposition precedes and promotes leukocyte recruitment in intestinal inflammation.

Kessler S, Rho H, West G, Fiocchi C, Drazba J, de la Motte C.

Clin Transl Sci. 2008 May;1(1):57-61. doi: 10.1111/j.1752-8062.2008.00025.x.


Diabetic nephropathy, inflammation, hyaluronan and interstitial fibrosis.

Lewis A, Steadman R, Manley P, Craig K, de la Motte C, Hascall V, Phillips AO.

Histol Histopathol. 2008 Jun;23(6):731-9. doi: 10.14670/HH-23.731.


Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids.

McDonald B, McAvoy EF, Lam F, Gill V, de la Motte C, Savani RC, Kubes P.

J Exp Med. 2008 Apr 14;205(4):915-27. doi: 10.1084/jem.20071765. Epub 2008 Mar 24.

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