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Altered expression of insulin-degrading enzyme and regulator of calcineurin in the rat intracerebral streptozotocin model and human apolipoprotein E-ε4-associated Alzheimer's disease.

Delikkaya B, Moriel N, Tong M, Gallucci G, de la Monte SM.

Alzheimers Dement (Amst). 2019 May 15;11:392-404. doi: 10.1016/j.dadm.2019.03.004. eCollection 2019 Dec.


The Full Spectrum of Alzheimer's Disease Is Rooted in Metabolic Derangements That Drive Type 3 Diabetes.

de la Monte SM.

Adv Exp Med Biol. 2019;1128:45-83. doi: 10.1007/978-981-13-3540-2_4. Review.


Early-Stage Alzheimer's Disease Is Associated with Simultaneous Systemic and Central Nervous System Dysregulation of Insulin-Linked Metabolic Pathways.

de la Monte SM, Tong M, Daiello LA, Ott BR.

J Alzheimers Dis. 2019;68(2):657-668. doi: 10.3233/JAD-180906.


Higher Mass Accuracy MALDI-TOF/TOF Lipid Imaging of Human Brain Tissue in Alzheimer's Disease.

O'Rourke MB, Smith CC, De La Monte SM, Sutherland GT, Padula MP.

Curr Protoc Mol Biol. 2019 Apr;126(1):e86. doi: 10.1002/cpmb.86. Epub 2019 Feb 8.


Therapeutic Advantages of Dual Targeting of PPAR-δ and PPAR-γ in an Experimental Model of Sporadic Alzheimer's Disease.

Reich D, Gallucci G, Tong M, de la Monte SM.

J Parkinsons Dis Alzheimers Dis. 2018 May;5(1). doi: 10.13188/2376-922X.1000025. Epub 2018 May 21.


Rapid Alterations in Cerebral White Matter Lipid Profiles After Ischemic-Reperfusion Brain Injury in Fetal Sheep as Demonstrated by MALDI-Mass Spectrometry.

Gallucci GM, Tong M, Chen X, Stonestreet BS, Lin A, de la Monte SM.

Pediatr Dev Pathol. 2019 Jul-Aug;22(4):344-355. doi: 10.1177/1093526619826721. Epub 2019 Jan 25.


The role of inflammation in the association between gestational diabetes and obstructive sleep apnea: A pilot study.

Bublitz MH, Carpenter M, Amin S, Okun ML, Millman R, De La Monte SM, Bourjeily G.

Obstet Med. 2018 Dec;11(4):186-191. doi: 10.1177/1753495X18780095. Epub 2018 Jul 24.


Blood-Cerebrospinal Fluid Barrier Gradients in Mild Cognitive Impairment and Alzheimer's Disease: Relationship to Inflammatory Cytokines and Chemokines.

Ott BR, Jones RN, Daiello LA, de la Monte SM, Stopa EG, Johanson CE, Denby C, Grammas P.

Front Aging Neurosci. 2018 Aug 21;10:245. doi: 10.3389/fnagi.2018.00245. eCollection 2018.


Effects of Tobacco Nicotine-Derived Nitrosamine Ketone (NNK) Exposures on Brain Alcohol Metabolizing Enzyme Activities.

Yalcin EB, Tong M, Gallucci G, de la Monte SM.

Drug Metab Lett. 2018;12(2):117-124. doi: 10.2174/1872312812666180611115418.


Nonalcoholic Fatty Liver Disease and Diabetes Are Associated with Decreased CYP3A4 Protein Expression and Activity in Human Liver.

Jamwal R, de la Monte SM, Ogasawara K, Adusumalli S, Barlock BB, Akhlaghi F.

Mol Pharm. 2018 Jul 2;15(7):2621-2632. doi: 10.1021/acs.molpharmaceut.8b00159. Epub 2018 Jun 11.


Neuroinflammation-Related Encephalopathy in an Infant Born Preterm Following Exposure to Maternal Diabetic Ketoacidosis.

Mandelbaum DE, Arsenault A, Stonestreet BS, Kostadinov S, de la Monte SM.

J Pediatr. 2018 Jun;197:286-291.e2. doi: 10.1016/j.jpeds.2018.01.052. Epub 2018 Mar 16.


Imaging mass spectrometry of frontal white matter lipid changes in human alcoholics.

de la Monte SM, Kay J, Yalcin EB, Kril JJ, Sheedy D, Sutherland GT.

Alcohol. 2018 Mar;67:51-63. doi: 10.1016/j.alcohol.2017.08.004. Epub 2017 Aug 17.


Ethanol-Induced White Matter Atrophy Is Associated with Impaired Expression of Aspartyl-Asparaginyl-β-Hydroxylase (ASPH) and Notch Signaling in an Experimental Rat Model.

Tong M, Gonzalez-Navarrete H, Kirchberg T, Gotama B, Yalcin EB, Kay J, de la Monte SM.

J Drug Alcohol Res. 2017;6. pii: 236033. doi: 10.4303/jdar/236033. Epub 2017 Aug 23.


Progressive white matter atrophy with altered lipid profiles is partially reversed by short-term abstinence in an experimental model of alcohol-related neurodegeneration.

Yalcin EB, McLean T, Tong M, de la Monte SM.

Alcohol. 2017 Dec;65:51-62. doi: 10.1016/j.alcohol.2017.05.008. Epub 2017 Sep 15.


Primary Spinal Epidural CIC-DUX4 Undifferentiated Sarcoma in a Child.

Donahue JE, Yakirevich E, Zhong S, Treaba DO, Lakis NS, Ali SM, de la Monte SM, Mangray S.

Pediatr Dev Pathol. 2018 Jul-Aug;21(4):411-417. doi: 10.1177/1093526617707856. Epub 2017 May 5.


Altered temporal lobe white matter lipid ion profiles in an experimental model of sporadic Alzheimer's disease.

Tong M, Leão R, Vimbela GV, Yalcin EB, Kay J, Krotow A, de la Monte SM.

Mol Cell Neurosci. 2017 Jul;82:23-34. doi: 10.1016/j.mcn.2017.04.010. Epub 2017 Apr 21.


The Differential Effects of Alcohol and Nicotine-Specific Nitrosamine Ketone on White Matter Ultrastructure.

Papp-Peka A, Tong M, Kril JJ, De La Monte SM, Sutherland GT.

Alcohol Alcohol. 2017 Mar 9;52(2):165-171. doi: 10.1093/alcalc/agw067. No abstract available.


Aspartate-β-hydroxylase (ASPH): A potential therapeutic target in human malignant gliomas.

Sturla LM, Tong M, Hebda N, Gao J, Thomas JM, Olsen M, de la Monte SM.

Heliyon. 2016 Dec 5;2(12):e00203. eCollection 2016 Dec.


Adverse Structural and Functional Effects of Marijuana on the Brain: Evidence Reviewed.

Mandelbaum DE, de la Monte SM.

Pediatr Neurol. 2017 Jan;66:12-20. doi: 10.1016/j.pediatrneurol.2016.09.004. Epub 2016 Sep 13. Review.


Tobacco Smoke-Induced Hepatic Injury with Steatosis, Inflammation, and Impairments in Insulin and Insulin-Like Growth Factor Signaling.

de la Monte SM, Tong M, Agarwal AR, Cadenas E.

J Clin Exp Pathol. 2016 Apr;6(2). pii: 269. Epub 2016 Apr 17.


Targeting Alzheimer's Disease Neuro-Metabolic Dysfunction with a Small Molecule Nuclear Receptor Agonist (T3D-959) Reverses Disease Pathologies.

Tong M, Dominguez C, Didsbury J, de la Monte SM.

J Alzheimers Dis Parkinsonism. 2016 Jun;6(3). pii: 238. Epub 2016 Jun 3.


Tobacco Nitrosamine Exposures Contribute to Fetal Alcohol Spectrum Disorder Associated Cerebellar Dysgenesis.

Re E, Tong M, de la Monte SM.

Int J Biol. 2016 Jul;8(3):10-21. doi: 10.5539/ijb.v8n3p10.


Serum Insulin Levels Are Reduced by Intravenous Ghrelin Administration but Do Not Correlate with Alcohol Craving in Alcohol-Dependent Individuals.

Haass-Koffler CL, Giovenco DE, Lee MR, Zywiak WH, de la Monte SM, Kenna GA, Swift RM, Leggio L.

Int J Neuropsychopharmacol. 2016 May 21. pii: pyw048. doi: 10.1093/ijnp/pyw048. [Epub ahead of print]


Potential Co-Factor Role of Tobacco Specific Nitrosamine Exposures in the Pathogenesis of Fetal Alcohol Spectrum Disorder.

Zabala V, Silbermann E, Re E, Andreani T, Tong M, Ramirez T, Gundogan F, de la Monte SM.

Gynecol Obstet Res. 2016 Apr;2(5):112-125. doi: 10.17140/GOROJ-2-125. Epub 2016 Mar 15.


The rise and fall of insulin signaling in Alzheimer's disease.

Chami B, Steel AJ, De La Monte SM, Sutherland GT.

Metab Brain Dis. 2016 Jun;31(3):497-515. doi: 10.1007/s11011-016-9806-1. Epub 2016 Feb 16. Review.


T3D-959: A Multi-Faceted Disease Remedial Drug Candidate for the Treatment of Alzheimer's Disease.

Tong M, Deochand C, Didsbury J, de la Monte SM.

J Alzheimers Dis. 2016;51(1):123-38. doi: 10.3233/JAD-151013.


Cigarette Smoke-Induced Alterations in Frontal White Matter Lipid Profiles Demonstrated by MALDI-Imaging Mass Spectrometry: Relevance to Alzheimer's Disease.

Nunez K, Kay J, Krotow A, Tong M, Agarwal AR, Cadenas E, de la Monte SM.

J Alzheimers Dis. 2016;51(1):151-63. doi: 10.3233/JAD-150916.


Differential Sphingolipid and Phospholipid Profiles in Alcohol and Nicotine-Derived Nitrosamine Ketone-Associated White Matter Degeneration.

Yalcin EB, Nunez K, Tong M, de la Monte SM.

Alcohol Clin Exp Res. 2015 Dec;39(12):2324-33. doi: 10.1111/acer.12909.


Enzymatic Responses to Alcohol and Tobacco Nicotine-Derived Nitrosamine Ketone Exposures in Long Evans Rat Livers.

Yalcin EB, Tong M, de la Monte SM.

Austin Liver. 2016;1(1). pii: 1003. Epub 2016 Dec 1.


Differential Effects of 3rd Trimester-Equivalent Binge Ethanol and Tobacco-Specific Nitrosamine Ketone Exposures on Brain Insulin Signaling in Adolescence.

Andreani T, Tong M, Gundogan F, Silbermann E, de la Monte SM.

J Diabetes Relat Disord. 2016;1(1). pii: 105. Epub 2016 Feb 26.


Comparative Analysis of Lipid Extracts and Imaging Mass Spectrometry for Evaluating Cerebral White Matter Biochemical Pathology in an Experimental Second-Hand Cigarette Smoke Exposure Model.

Krotow A, Yalcin EB, Kay J, de la Monte SM.

Mass Spectrom Purif Tech. 2016;2(1). pii: 113. doi: 10.4172/2469-9861.1000113. Epub 2016 Apr 20.


Potential Contributions of the Tobacco Nicotine-Derived Nitrosamine Ketone to White Matter Molecular Pathology in Fetal Alcohol Spectrum Disorder.

Tong M, Andreani T, Krotow A, Gundogan F, de la Monte SM.

Int J Neurol Brain Disord. 2016;3(2). doi: 10.15436/2377-1348.16.729. Epub 2016 Jul 20.


Tobacco Smoke Exposure Impairs Brain Insulin/IGF Signaling: Potential Co-Factor Role in Neurodegeneration.

Deochand C, Tong M, Agarwal AR, Cadenas E, de la Monte SM.

J Alzheimers Dis. 2016;50(2):373-86. doi: 10.3233/JAD-150664.


Potential Role of Phosphorylation as a Regulator of Aspartyl-(asparaginyl)-β-hydroxylase: Relevance to Infiltrative Spread of Human Hepatocellular Carcinoma.

Borgas DL, Gao JS, Tong M, de la Monte SM.

Liver Cancer. 2015 Sep;4(3):139-53. doi: 10.1159/000367731. Epub 2015 Jun 5.


Tobacco Smoke-Induced Brain White Matter Myelin Dysfunction: Potential Co-Factor Role of Smoking in Neurodegeneration.

Yu R, Deochand C, Krotow A, Leão R, Tong M, Agarwal AR, Cadenas E, de la Monte SM.

J Alzheimers Dis. 2016;50(1):133-48. doi: 10.3233/JAD-150751.


Leptin levels are reduced by intravenous ghrelin administration and correlated with cue-induced alcohol craving.

Haass-Koffler CL, Aoun EG, Swift RM, de la Monte SM, Kenna GA, Leggio L.

Transl Psychiatry. 2015 Sep 29;5:e646. doi: 10.1038/tp.2015.140.


Differential Contributions of Alcohol and the Nicotine-Derived Nitrosamine Ketone (NNK) to Insulin and Insulin-Like Growth Factor Resistance in the Adolescent Rat Brain.

Tong M, Yu R, Deochand C, de la Monte SM.

Alcohol Alcohol. 2015 Nov;50(6):670-9. doi: 10.1093/alcalc/agv101. Epub 2015 Sep 15.


Differential Contributions of Alcohol and Nicotine-Derived Nitrosamine Ketone (NNK) to White Matter Pathology in the Adolescent Rat Brain.

Tong M, Yu R, Silbermann E, Zabala V, Deochand C, de la Monte SM.

Alcohol Alcohol. 2015 Nov;50(6):680-9. doi: 10.1093/alcalc/agv102. Epub 2015 Sep 15.


Review of matrix-assisted laser desorption ionization-imaging mass spectrometry for lipid biochemical histopathology.

Yalcin EB, de la Monte SM.

J Histochem Cytochem. 2015 Oct;63(10):762-71. doi: 10.1369/0022155415596202. Epub 2015 Jul 24. Review.


Chronic Ethanol-Induced Impairment of Wnt/β-Catenin Signaling is Attenuated by PPAR-δ Agonist.

Xu CQ, de la Monte SM, Tong M, Huang CK, Kim M.

Alcohol Clin Exp Res. 2015 Jun;39(6):969-79. doi: 10.1111/acer.12727. Epub 2015 Apr 23.


Dose effect of gestational ethanol exposure on placentation and fetal growth.

Gundogan F, Gilligan J, Qi W, Chen E, Naram R, de la Monte SM.

Placenta. 2015 May;36(5):523-30. doi: 10.1016/j.placenta.2015.02.010. Epub 2015 Feb 25.


Restoration of Wnt/β-catenin signaling attenuates alcoholic liver disease progression in a rat model.

Huang CK, Yu T, de la Monte SM, Wands JR, Derdak Z, Kim M.

J Hepatol. 2015 Jul;63(1):191-8. doi: 10.1016/j.jhep.2015.02.030. Epub 2015 Feb 24.


Potential contributions of the tobacco nicotine-derived nitrosamine ketone (NNK) in the pathogenesis of steatohepatitis in a chronic plus binge rat model of alcoholic liver disease.

Zabala V, Tong M, Yu R, Ramirez T, Yalcin EB, Balbo S, Silbermann E, Deochand C, Nunez K, Hecht S, de la Monte SM.

Alcohol Alcohol. 2015 Mar;50(2):118-31. doi: 10.1093/alcalc/agu083. Epub 2015 Jan 24.


Type 3 diabetes is sporadic Alzheimer׳s disease: mini-review.

de la Monte SM.

Eur Neuropsychopharmacol. 2014 Dec;24(12):1954-60. doi: 10.1016/j.euroneuro.2014.06.008. Epub 2014 Jun 28. Review.

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