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Items: 1 to 50 of 59

1.

A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.

Roewenstrunk J, Di Vona C, Chen J, Borras E, Dong C, Arató K, Sabidó E, Huen MSY, de la Luna S.

Sci Rep. 2019 Apr 12;9(1):6014. doi: 10.1038/s41598-019-42445-x.

2.

Impaired development of neocortical circuits contributes to the neurological alterations in DYRK1A haploinsufficiency syndrome.

Arranz J, Balducci E, Arató K, Sánchez-Elexpuru G, Najas S, Parras A, Rebollo E, Pijuan I, Erb I, Verde G, Sahun I, Barallobre MJ, Lucas JJ, Sánchez MP, de la Luna S, Arbonés ML.

Neurobiol Dis. 2019 Jul;127:210-222. doi: 10.1016/j.nbd.2019.02.022. Epub 2019 Mar 1.

3.

DYRK1A modulates c-MET in pancreatic ductal adenocarcinoma to drive tumour growth.

Luna J, Boni J, Cuatrecasas M, Bofill-De Ros X, Núñez-Manchón E, Gironella M, Vaquero EC, Arbones ML, de la Luna S, Fillat C.

Gut. 2019 Aug;68(8):1465-1476. doi: 10.1136/gutjnl-2018-316128. Epub 2018 Oct 20.

PMID:
30343272
4.

DYRK1A Kinase Positively Regulates Angiogenic Responses in Endothelial Cells.

Rozen EJ, Roewenstrunk J, Barallobre MJ, Di Vona C, Jung C, Figueiredo AF, Luna J, Fillat C, Arbonés ML, Graupera M, Valverde MA, de la Luna S.

Cell Rep. 2018 May 8;23(6):1867-1878. doi: 10.1016/j.celrep.2018.04.008.

5.

Key Role of Amino Acid Repeat Expansions in the Functional Diversification of Duplicated Transcription Factors.

Radó-Trilla N, Arató K, Pegueroles C, Raya A, de la Luna S, Albà MM.

Mol Biol Evol. 2015 Sep;32(9):2263-72. doi: 10.1093/molbev/msv103. Epub 2015 Apr 29.

6.

Chromatin-wide profiling of DYRK1A reveals a role as a gene-specific RNA polymerase II CTD kinase.

Di Vona C, Bezdan D, Islam AB, Salichs E, López-Bigas N, Ossowski S, de la Luna S.

Mol Cell. 2015 Feb 5;57(3):506-20. doi: 10.1016/j.molcel.2014.12.026. Epub 2015 Jan 22.

7.

DYRK1A-mediated phosphorylation of GluN2A at Ser(1048) regulates the surface expression and channel activity of GluN1/GluN2A receptors.

Grau C, Arató K, Fernández-Fernández JM, Valderrama A, Sindreu C, Fillat C, Ferrer I, de la Luna S, Altafaj X.

Front Cell Neurosci. 2014 Oct 17;8:331. doi: 10.3389/fncel.2014.00331. eCollection 2014.

8.

Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity.

Papadopoulos C, Arato K, Lilienthal E, Zerweck J, Schutkowski M, Chatain N, Müller-Newen G, Becker W, de la Luna S.

J Biol Chem. 2011 Feb 18;286(7):5494-505. doi: 10.1074/jbc.M110.157909. Epub 2010 Dec 2.

9.

DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles.

Aranda S, Laguna A, de la Luna S.

FASEB J. 2011 Feb;25(2):449-62. doi: 10.1096/fj.10-165837. Epub 2010 Nov 3. Review.

PMID:
21048044
10.

Regulated segregation of kinase Dyrk1A during asymmetric neural stem cell division is critical for EGFR-mediated biased signaling.

Ferron SR, Pozo N, Laguna A, Aranda S, Porlan E, Moreno M, Fillat C, de la Luna S, Sánchez P, Arbonés ML, Fariñas I.

Cell Stem Cell. 2010 Sep 3;7(3):367-79. doi: 10.1016/j.stem.2010.06.021.

11.

Characterization of a mouse model overexpressing beta-site APP-cleaving enzyme 2 reveals a new role for BACE2.

Azkona G, Amador-Arjona A, Obradors-Tarragó C, Varea E, Arqué G, Pinacho R, Fillat C, de la Luna S, Estivill X, Dierssen M.

Genes Brain Behav. 2010 Mar 1;9(2):160-72. doi: 10.1111/j.1601-183X.2009.00538.x. Epub 2009 Sep 22.

12.

The RCAN carboxyl end mediates calcineurin docking-dependent inhibition via a site that dictates binding to substrates and regulators.

Martínez-Martínez S, Genescà L, Rodríguez A, Raya A, Salichs E, Were F, López-Maderuelo MD, Redondo JM, de la Luna S.

Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6117-22. doi: 10.1073/pnas.0812544106. Epub 2009 Mar 30.

13.

Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment.

Salichs E, Ledda A, Mularoni L, Albà MM, de la Luna S.

PLoS Genet. 2009 Mar;5(3):e1000397. doi: 10.1371/journal.pgen.1000397. Epub 2009 Mar 6.

14.

Intersectin 1 forms a complex with adaptor protein Ruk/CIN85 in vivo independently of epidermal growth factor stimulation.

Nikolaienko O, Skrypkina I, Tsyba L, Fedyshyn Y, Morderer D, Buchman V, de la Luna S, Drobot L, Rynditch A.

Cell Signal. 2009 May;21(5):753-9. doi: 10.1016/j.cellsig.2009.01.013. Epub 2009 Jan 8.

PMID:
19166927
15.

The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development.

Laguna A, Aranda S, Barallobre MJ, Barhoum R, Fernández E, Fotaki V, Delabar JM, de la Luna S, de la Villa P, Arbonés ML.

Dev Cell. 2008 Dec;15(6):841-53. doi: 10.1016/j.devcel.2008.10.014.

16.

Sprouty2-mediated inhibition of fibroblast growth factor signaling is modulated by the protein kinase DYRK1A.

Aranda S, Alvarez M, Turró S, Laguna A, de la Luna S.

Mol Cell Biol. 2008 Oct;28(19):5899-911. doi: 10.1128/MCB.00394-08. Epub 2008 Aug 4.

17.

Identification of PatL1, a human homolog to yeast P body component Pat1.

Scheller N, Resa-Infante P, de la Luna S, Galao RP, Albrecht M, Kaestner L, Lipp P, Lengauer T, Meyerhans A, Díez J.

Biochim Biophys Acta. 2007 Dec;1773(12):1786-92. Epub 2007 Sep 6.

18.
19.

Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin.

Davies KJ, Ermak G, Rothermel BA, Pritchard M, Heitman J, Ahnn J, Henrique-Silva F, Crawford D, Canaider S, Strippoli P, Carinci P, Min KT, Fox DS, Cunningham KW, Bassel-Duby R, Olson EN, Zhang Z, Williams RS, Gerber HP, Pérez-Riba M, Seo H, Cao X, Klee CB, Redondo JM, Maltais LJ, Bruford EA, Povey S, Molkentin JD, McKeon FD, Duh EJ, Crabtree GR, Cyert MS, de la Luna S, Estivill X.

FASEB J. 2007 Oct;21(12):3023-8. Epub 2007 Jun 26. No abstract available.

PMID:
17595344
20.

DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding.

Alvarez M, Altafaj X, Aranda S, de la Luna S.

Mol Biol Cell. 2007 Apr;18(4):1167-78. Epub 2007 Jan 17.

21.

Cooperation to amplify gene-dosage-imbalance effects.

de la Luna S, Estivill X.

Trends Mol Med. 2006 Oct;12(10):451-4. Epub 2006 Aug 17.

PMID:
16919501
22.

The molecular basis of glutamate formiminotransferase deficiency.

Hilton JF, Christensen KE, Watkins D, Raby BA, Renaud Y, de la Luna S, Estivill X, MacKenzie RE, Hudson TJ, Rosenblatt DS.

Hum Mutat. 2003 Jul;22(1):67-73. Erratum in: Hum Mutat. 2003 Nov;22(5):416.

PMID:
12815595
23.

Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life.

Genescà L, Aubareda A, Fuentes JJ, Estivill X, De La Luna S, Pérez-Riba M.

Biochem J. 2003 Sep 1;374(Pt 2):567-75.

24.

DYRK1A accumulates in splicing speckles through a novel targeting signal and induces speckle disassembly.

Alvarez M, Estivill X, de la Luna S.

J Cell Sci. 2003 Aug 1;116(Pt 15):3099-107. Epub 2003 Jun 10.

25.

Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system.

Martí E, Altafaj X, Dierssen M, de la Luna S, Fotaki V, Alvarez M, Pérez-Riba M, Ferrer I, Estivill X.

Brain Res. 2003 Feb 28;964(2):250-63.

PMID:
12576186
26.

The human intersectin genes and their spliced variants are differentially expressed.

Pucharcos C, Casas C, Nadal M, Estivill X, de la Luna S.

Biochim Biophys Acta. 2001 Oct 31;1521(1-3):1-11.

PMID:
11690630
27.

Structural determinants of KvLQT1 control by the KCNE family of proteins.

Melman YF, Domènech A, de la Luna S, McDonald TV.

J Biol Chem. 2001 Mar 2;276(9):6439-44. Epub 2000 Dec 4.

28.

A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase.

Solans A, Estivill X, de La Luna S.

Cytogenet Cell Genet. 2000;89(3-4):177-84.

PMID:
10965118
29.

Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus.

Aragón T, de la Luna S, Novoa I, Carrasco L, Ortín J, Nieto A.

Mol Cell Biol. 2000 Sep;20(17):6259-68.

30.

Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis.

Pucharcos C, Estivill X, de la Luna S.

FEBS Lett. 2000 Jul 28;478(1-2):43-51.

31.

DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways.

Fuentes JJ, Genescà L, Kingsbury TJ, Cunningham KW, Pérez-Riba M, Estivill X, de la Luna S.

Hum Mol Genet. 2000 Jul 1;9(11):1681-90.

PMID:
10861295
32.

Cloning and characterization of human FTCD on 21q22.3, a candidate gene for glutamate formiminotransferase deficiency.

Solans A, Estivill X, de la Luna S.

Cytogenet Cell Genet. 2000;88(1-2):43-9.

PMID:
10773664
33.

Cold shock induces the insertion of a cryptic exon in the neurofibromatosis type 1 (NF1) mRNA.

Ars E, Serra E, de la Luna S, Estivill X, Lázaro C.

Nucleic Acids Res. 2000 Mar 15;28(6):1307-12.

34.

Alu-splice cloning of human Intersectin (ITSN), a putative multivalent binding protein expressed in proliferating and differentiating neurons and overexpressed in Down syndrome.

Pucharcós C, Fuentes JJ, Casas C, de la Luna S, Alcántara S, Arbonés ML, Soriano E, Estivill X, Pritchard M.

Eur J Hum Genet. 1999 Sep;7(6):704-12.

35.
36.

Influenza virus NS1 protein interacts with viral transcription-replication complexes in vivo.

Marión RM, Zürcher T, de la Luna S, Ortín J.

J Gen Virol. 1997 Oct;78 ( Pt 10):2447-51.

PMID:
9349463
37.

Distinct mechanisms of nuclear accumulation regulate the functional consequence of E2F transcription factors.

Allen KE, de la Luna S, Kerkhoven RM, Bernards R, La Thangue NB.

J Cell Sci. 1997 Nov;110 ( Pt 22):2819-31.

38.
39.
40.

The amino-terminal one-third of the influenza virus PA protein is responsible for the induction of proteolysis.

Sanz-Ezquerro JJ, Zürcher T, de la Luna S, Ortín J, Nieto A.

J Virol. 1996 Mar;70(3):1905-11.

41.

Mutational analysis identifies functional domains in the influenza A virus PB2 polymerase subunit.

Perales B, de la Luna S, Palacios I, Ortín J.

J Virol. 1996 Mar;70(3):1678-86.

43.

Epitope mapping of cross-reactive monoclonal antibodies specific for the influenza A virus PA and PB2 polypeptides.

Ochoa M, Bárcena J, de la Luna S, Melero JA, Douglas AR, Nieto A, Ortín J, Skehel JJ, Portela A.

Virus Res. 1995 Aug;37(3):305-15.

PMID:
8533465
44.

Influenza virus NS1 protein enhances the rate of translation initiation of viral mRNAs.

de la Luna S, Fortes P, Beloso A, Ortín J.

J Virol. 1995 Apr;69(4):2427-33.

45.

Individual expression of influenza virus PA protein induces degradation of coexpressed proteins.

Sanz-Ezquerro JJ, de la Luna S, Ortín J, Nieto A.

J Virol. 1995 Apr;69(4):2420-6.

46.

Monoclonal antibodies against influenza virus PB2 and NP polypeptides interfere with the initiation step of viral mRNA synthesis in vitro.

Bárcena J, Ochoa M, de la Luna S, Melero JA, Nieto A, Ortín J, Portela A.

J Virol. 1994 Nov;68(11):6900-9.

47.

Synthesis of biologically active influenza virus core proteins using a vaccinia virus-T7 RNA polymerase expression system.

Mena I, de la Luna S, Albo C, Martín J, Nieto A, Ortín J, Portela A.

J Gen Virol. 1994 Aug;75 ( Pt 8):2109-14.

PMID:
8046417
48.

Overexpression of tau protein in COS-1 cells results in the stabilization of centrosome-independent microtubules and extension of cytoplasmic processes.

Montejo de Garcini E, de la Luna S, Dominguez JE, Avila J.

Mol Cell Biochem. 1994 Jan 26;130(2):187-96.

PMID:
8028597
49.

Complex structure of the nuclear translocation signal of influenza virus polymerase PA subunit.

Nieto A, de la Luna S, Bárcena J, Portela A, Ortín J.

J Gen Virol. 1994 Jan;75 ( Pt 1):29-36.

PMID:
8113737

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