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Alzheimer's disease progression and risk factors: A standardized comparison between six large data sets.

Evans S, McRae-McKee K, Hadjichrysanthou C, Wong MM, Ames D, Lopez O, de Wolf F, Anderson RM; Australian Imaging Biomarkers and Lifestyle flagship study of ageing; Predictors of Cognitive Decline Among Normal Individuals (BIOCARD) study; Add Neuro Med Consortium.

Alzheimers Dement (N Y). 2019 Oct 3;5:515-523. doi: 10.1016/j.trci.2019.04.005. eCollection 2019.


Perspective: Clinical relevance of the dichotomous classification of Alzheimer's disease biomarkers: Should there be a "gray zone"?

McRae-McKee K, Udeh-Momoh CT, Price G, Bajaj S, de Jager CA, Scott D, Hadjichrysanthou C, McNaughton E, Bracoud L, Ahmadi-Abhari S, de Wolf F, Anderson RM, Middleton LT; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement. 2019 Oct;15(10):1348-1356. doi: 10.1016/j.jalz.2019.07.010. Epub 2019 Sep 26.


Combining hippocampal volume metrics to better understand Alzheimer's disease progression in at-risk individuals.

McRae-McKee K, Evans S, Hadjichrysanthou C, Wong MM, de Wolf F, Anderson RM.

Sci Rep. 2019 May 16;9(1):7499. doi: 10.1038/s41598-019-42632-w.


Quantification of biological age as a determinant of age-related diseases in the Rotterdam Study: a structural equation modeling approach.

Waziry R, Gras L, Sedaghat S, Tiemeier H, Weverling GJ, Ghanbari M, Klap J, de Wolf F, Hofman A, Ikram MA, Goudsmit J.

Eur J Epidemiol. 2019 Aug;34(8):793-799. doi: 10.1007/s10654-019-00497-3. Epub 2019 Apr 13.


Production of protein-based polymers in Pichia pastoris.

Werten MWT, Eggink G, Cohen Stuart MA, de Wolf FA.

Biotechnol Adv. 2019 Sep - Oct;37(5):642-666. doi: 10.1016/j.biotechadv.2019.03.012. Epub 2019 Mar 19. Review.


Determinants of Restoration of CD4 and CD8 Cell Counts and Their Ratio in HIV-1-Positive Individuals With Sustained Virological Suppression on Antiretroviral Therapy.

Gras L, May M, Ryder LP, Trickey A, Helleberg M, Obel N, Thiebaut R, Guest J, Gill J, Crane H, Dias Lima V, dʼArminio Monforte A, Sterling TR, Miro J, Moreno S, Stephan C, Smith C, Tate J, Shepherd L, Saag M, Rieger A, Gillor D, Cavassini M, Montero M, Ingle SM, Reiss P, Costagliola D, Wit FWNM, Sterne J, de Wolf F, Geskus R; Antiretroviral Therapy Cohort Collaboration (ART-CC).

J Acquir Immune Defic Syndr. 2019 Mar 1;80(3):292-300. doi: 10.1097/QAI.0000000000001913.


Potential Factors Associated with Cognitive Improvement of Individuals Diagnosed with Mild Cognitive Impairment or Dementia in Longitudinal Studies.

Hadjichrysanthou C, McRae-McKee K, Evans S, de Wolf F, Anderson RM; Alzheimer’s Disease Neuroimaging Initiative.

J Alzheimers Dis. 2018;66(2):587-600. doi: 10.3233/JAD-180101.


Cerebral small vessel disease and the risk of dementia: A systematic review and meta-analysis of population-based evidence.

Bos D, Wolters FJ, Darweesh SKL, Vernooij MW, de Wolf F, Ikram MA, Hofman A.

Alzheimers Dement. 2018 Nov;14(11):1482-1492. doi: 10.1016/j.jalz.2018.04.007. Epub 2018 May 21. Review.


Inflammatory markers and the risk of dementia and Alzheimer's disease: A meta-analysis.

Darweesh SKL, Wolters FJ, Ikram MA, de Wolf F, Bos D, Hofman A.

Alzheimers Dement. 2018 Nov;14(11):1450-1459. doi: 10.1016/j.jalz.2018.02.014. Epub 2018 Mar 29.


The importance of endpoint selection: How effective does a drug need to be for success in a clinical trial of a possible Alzheimer's disease treatment?

Evans S, McRae-McKee K, Wong MM, Hadjichrysanthou C, De Wolf F, Anderson R.

Eur J Epidemiol. 2018 Jul;33(7):635-644. doi: 10.1007/s10654-018-0381-0. Epub 2018 Mar 23.


The development of a stochastic mathematical model of Alzheimer's disease to help improve the design of clinical trials of potential treatments.

Hadjichrysanthou C, Ower AK, de Wolf F, Anderson RM; Alzheimer's Disease Neuroimaging Initiative.

PLoS One. 2018 Jan 29;13(1):e0190615. doi: 10.1371/journal.pone.0190615. eCollection 2018.


Temporal association patterns and dynamics of amyloid-β and tau in Alzheimer's disease.

Ower AK, Hadjichrysanthou C, Gras L, Goudsmit J, Anderson RM, de Wolf F; Alzheimer’s Disease Neuroimaging Initiative.

Eur J Epidemiol. 2018 Jul;33(7):657-666. doi: 10.1007/s10654-017-0326-z. Epub 2017 Oct 25.


A Systematic Review of Longitudinal Studies Which Measure Alzheimer's Disease Biomarkers.

Lawrence E, Vegvari C, Ower A, Hadjichrysanthou C, De Wolf F, Anderson RM.

J Alzheimers Dis. 2017;59(4):1359-1379. doi: 10.3233/JAD-170261. Review.


Precise Coating of a Wide Range of DNA Templates by a Protein Polymer with a DNA Binding Domain.

Hernandez-Garcia A, Estrich NA, Werten MW, Van Der Maarel JR, LaBean TH, de Wolf FA, Cohen Stuart MA, de Vries R.

ACS Nano. 2017 Jan 24;11(1):144-152. doi: 10.1021/acsnano.6b05938. Epub 2016 Dec 12.


Nanofibrillar hydrogel scaffolds from recombinant protein-based polymers with integrin- and proteoglycan-binding domains.

Włodarczyk-Biegun MK, Werten MW, Posadowska U, Storm IM, de Wolf FA, van den Beucken JJ, Leeuwenburgh SC, Cohen Stuart MA, Kamperman M.

J Biomed Mater Res A. 2016 Dec;104(12):3082-3092. doi: 10.1002/jbm.a.35839. Epub 2016 Aug 16.


Cross-Linking and Bundling of Self-Assembled Protein-Based Polymer Fibrils via Heterodimeric Coiled Coils.

Domeradzka NE, Werten MW, de Wolf FA, de Vries R.

Biomacromolecules. 2016 Dec 12;17(12):3893-3901. Epub 2016 Nov 7.


From clinical sample to complete genome: Comparing methods for the extraction of HIV-1 RNA for high-throughput deep sequencing.

Cornelissen M, Gall A, Vink M, Zorgdrager F, Binter Š, Edwards S, Jurriaans S, Bakker M, Ong SH, Gras L, van Sighem A, Bezemer D, de Wolf F, Reiss P, Kellam P, Berkhout B, Fraser C, van der Kuyl AC; BEEHIVE Consortium.

Virus Res. 2017 Jul 15;239:10-16. doi: 10.1016/j.virusres.2016.08.004. Epub 2016 Aug 4.


Enhanced stiffness of silk-like fibers by loop formation in the corona leads to stronger gels.

Rombouts WH, Domeradzka NE, Werten MW, Leermakers FA, de Vries RJ, de Wolf FA, van der Gucht J.

Biopolymers. 2016 Nov;105(11):795-801. doi: 10.1002/bip.22909.


How Can Viral Dynamics Models Inform Endpoint Measures in Clinical Trials of Therapies for Acute Viral Infections?

Vegvari C, Hadjichrysanthou C, Cauët E, Lawrence E, Cori A, de Wolf F, Anderson RM.

PLoS One. 2016 Jul 1;11(7):e0158237. doi: 10.1371/journal.pone.0158237. eCollection 2016.


Using Clinical Trial Simulators to Analyse the Sources of Variance in Clinical Trials of Novel Therapies for Acute Viral Infections.

Vegvari C, Cauët E, Hadjichrysanthou C, Lawrence E, Weverling GJ, de Wolf F, Anderson RM.

PLoS One. 2016 Jun 22;11(6):e0156622. doi: 10.1371/journal.pone.0156622. eCollection 2016.


Production in Pichia pastoris of complementary protein-based polymers with heterodimer-forming WW and PPxY domains.

Domeradzka NE, Werten MW, de Vries R, de Wolf FA.

Microb Cell Fact. 2016 Jun 10;15(1):105. doi: 10.1186/s12934-016-0498-3.


Understanding the within-host dynamics of influenza A virus: from theory to clinical implications.

Hadjichrysanthou C, Cauët E, Lawrence E, Vegvari C, de Wolf F, Anderson RM.

J R Soc Interface. 2016 Jun;13(119). pii: 20160289. doi: 10.1098/rsif.2016.0289.


Fibrous Hydrogels for Cell Encapsulation: A Modular and Supramolecular Approach.

Włodarczyk-Biegun MK, Farbod K, Werten MW, Slingerland CJ, de Wolf FA, van den Beucken JJ, Leeuwenburgh SC, Cohen Stuart MA, Kamperman M.

PLoS One. 2016 May 25;11(5):e0155625. doi: 10.1371/journal.pone.0155625. eCollection 2016. Erratum in: PLoS One. 2016;11(7):e0159893.


Heparin as a Bundler in a Self-Assembled Fibrous Network of Functionalized Protein-Based Polymers.

Włodarczyk-Biegun MK, Slingerland CJ, Werten MW, van Hees IA, de Wolf FA, de Vries R, Stuart MA, Kamperman M.

Biomacromolecules. 2016 Jun 13;17(6):2063-72. doi: 10.1021/acs.biomac.6b00276. Epub 2016 May 23.


Sources of HIV infection among men having sex with men and implications for prevention.

Ratmann O, van Sighem A, Bezemer D, Gavryushkina A, Jurriaans S, Wensing A, de Wolf F, Reiss P, Fraser C; ATHENA observational cohort.

Sci Transl Med. 2016 Jan 6;8(320):320ra2. doi: 10.1126/scitranslmed.aad1863.


Dispersion of the HIV-1 Epidemic in Men Who Have Sex with Men in the Netherlands: A Combined Mathematical Model and Phylogenetic Analysis.

Bezemer D, Cori A, Ratmann O, van Sighem A, Hermanides HS, Dutilh BE, Gras L, Rodrigues Faria N, van den Hengel R, Duits AJ, Reiss P, de Wolf F, Fraser C; ATHENA observational cohort.

PLoS Med. 2015 Nov 3;12(11):e1001898; discussion e1001898. doi: 10.1371/journal.pmed.1001898. eCollection 2015 Nov.


Production in Pichia pastoris of protein-based polymers with small heterodimer-forming blocks.

Domeradzka NE, Werten MW, de Vries R, de Wolf FA.

Biotechnol Bioeng. 2016 May;113(5):953-60. doi: 10.1002/bit.25861. Epub 2015 Nov 10.


Estimating HIV Incidence, Time to Diagnosis, and the Undiagnosed HIV Epidemic Using Routine Surveillance Data.

van Sighem A, Nakagawa F, De Angelis D, Quinten C, Bezemer D, de Coul EO, Egger M, de Wolf F, Fraser C, Phillips A.

Epidemiology. 2015 Sep;26(5):653-60. doi: 10.1097/EDE.0000000000000324.


Reversible Temperature-Switching of Hydrogel Stiffness of Coassembled, Silk-Collagen-Like Hydrogels.

Rombouts WH, de Kort DW, Pham TT, van Mierlo CP, Werten MW, de Wolf FA, van der Gucht J.

Biomacromolecules. 2015 Aug 10;16(8):2506-13. doi: 10.1021/acs.biomac.5b00766. Epub 2015 Jul 31.


Future challenges for clinical care of an ageing population infected with HIV: a modelling study.

Smit M, Brinkman K, Geerlings S, Smit C, Thyagarajan K, Sighem Av, de Wolf F, Hallett TB; ATHENA observational cohort.

Lancet Infect Dis. 2015 Jul;15(7):810-8. doi: 10.1016/S1473-3099(15)00056-0. Epub 2015 Jun 9. Erratum in: Lancet Infect Dis. 2015 Sep;15(9):998.


Delayed linkage to care in one-third of HIV-positive individuals in the Netherlands.

van Veen MG, Trienekens SC, Heijman T, Gotz HM, Zaheri S, Ladbury G, de Wit J, Fennema JS, de Wolf F, van der Sande MA.

Sex Transm Infect. 2015 Dec;91(8):603-9. doi: 10.1136/sextrans-2014-051980. Epub 2015 May 11.


Risk of non-AIDS-defining events among HIV-infected patients not yet on antiretroviral therapy.

Zhang S, van Sighem A, Kesselring A, Gras L, Prins JM, Hassink E, Kauffmann R, Richter C, de Wolf F, Reiss P; ATHENA national observational HIV cohort study.

HIV Med. 2015 May;16(5):265-72. doi: 10.1111/hiv.12202. Epub 2015 Jan 21.


Changes in HIV RNA and CD4 cell count after acute HCV infection in chronically HIV-infected individuals.

Gras L, de Wolf F, Smit C, Prins M, van der Meer JT, Vanhommerig JW, Zwinderman AH, Schinkel J, Geskus RB; ATHENA national observational cohort and the MOSAIC study.

J Acquir Immune Defic Syndr. 2015 Apr 15;68(5):536-42. doi: 10.1097/QAI.0000000000000514.


Design and self-assembly of simple coat proteins for artificial viruses.

Hernandez-Garcia A, Kraft DJ, Janssen AF, Bomans PH, Sommerdijk NA, Thies-Weesie DM, Favretto ME, Brock R, de Wolf FA, Werten MW, van der Schoot P, Stuart MC, de Vries R.

Nat Nanotechnol. 2014 Sep;9(9):698-702. doi: 10.1038/nnano.2014.169. Epub 2014 Aug 24.


From micelles to fibers: balancing self-assembling and random coiling domains in pH-responsive silk-collagen-like protein-based polymers.

Beun LH, Storm IM, Werten MW, de Wolf FA, Cohen Stuart MA, de Vries R.

Biomacromolecules. 2014 Sep 8;15(9):3349-57. doi: 10.1021/bm500826y. Epub 2014 Aug 27.


Genetically engineered silk-collagen-like copolymer for biomedical applications: production, characterization and evaluation of cellular response.

Włodarczyk-Biegun MK, Werten MW, de Wolf FA, van den Beucken JJ, Leeuwenburgh SC, Kamperman M, Cohen Stuart MA.

Acta Biomater. 2014 Aug;10(8):3620-9. doi: 10.1016/j.actbio.2014.05.006. Epub 2014 May 9.


Synergistic stiffening in double-fiber networks.

Rombouts WH, Giesbers M, van Lent J, de Wolf FA, van der Gucht J.

Biomacromolecules. 2014 Apr 14;15(4):1233-9. doi: 10.1021/bm401810w. Epub 2014 Mar 17.


Dilute self-healing hydrogels of silk-collagen-like block copolypeptides at neutral pH.

Golinska MD, Włodarczyk-Biegun MK, Werten MW, Cohen Stuart MA, de Wolf FA, de Vries R.

Biomacromolecules. 2014 Mar 10;15(3):699-706. doi: 10.1021/bm401682n. Epub 2014 Feb 7.


Changes in first-line cART regimens and short-term clinical outcome between 1996 and 2010 in The Netherlands.

Smit M, Smit C, Geerlings S, Gras L, Brinkman K, Hallett TB, de Wolf F; Athena Observational Cohort.

PLoS One. 2013 Sep 30;8(9):e76071. doi: 10.1371/journal.pone.0076071. eCollection 2013.


The presence of CXCR4-using HIV-1 prior to start of antiretroviral therapy is an independent predictor of delayed viral suppression.

Gijsbers EF, van Sighem A, Harskamp AM, Welkers MR, de Wolf F, Brinkman K, Prins JM, Schuitemaker H, van 't Wout AB, Kootstra NA.

PLoS One. 2013 Oct 1;8(10):e76255. doi: 10.1371/journal.pone.0076255. eCollection 2013.


Loss to follow-up and mortality rates in HIV-1-infected patients in Curaçao before and after the start of combination antiretroviral therapy.

Hermanides H, Holman R, Gras L, Winkel C, Gerstenbluth I, de Wolf F, Duits A.

AIDS Res Hum Retroviruses. 2013 Oct;29(10):1300-5. doi: 10.1089/AID.2012.0362. Epub 2013 Aug 31.


Higher rates of AIDS during the first year of antiretroviral therapy among migrants: the importance of tuberculosis.

Antiretroviral Therapy Cohort Collaboration (ART-CC), Shepherd BE, Jenkins CA, Parrish DD, Glass TR, Cescon A, Masabeu A, Chene G, de Wolf F, Crane HM, Jarrin I, Gill J, del Amo J, Abgrall S, Khaykin P, Lehmann C, Ingle SM, May MT, Sterne JA, Sterling TR.

AIDS. 2013 May 15;27(8):1321-9. doi: 10.1097/QAD.0b013e32835faa95.


Has the rate of CD4 cell count decline before initiation of antiretroviral therapy changed over the course of the Dutch HIV epidemic among MSM?

Gras L, Geskus RB, Jurriaans S, Bakker M, van Sighem A, Bezemer D, Fraser C, Prins JM, Berkhout B, de Wolf F; ATHENA National Observational Cohort.

PLoS One. 2013 May 27;8(5):e64437. doi: 10.1371/journal.pone.0064437. Print 2013.


Cohort profile: Antiretroviral Therapy Cohort Collaboration (ART-CC).

May MT, Ingle SM, Costagliola D, Justice AC, de Wolf F, Cavassini M, D'Arminio Monforte A, Casabona J, Hogg RS, Mocroft A, Lampe FC, Dabis F, Fätkenheuer G, Sterling TR, del Amo J, Gill MJ, Crane HM, Saag MS, Guest J, Brodt HR, Sterne JA; Antiretroviral Cohort Collaboration.

Int J Epidemiol. 2014 Jun;43(3):691-702. doi: 10.1093/ije/dyt010. Epub 2013 Apr 18.


High incidence of intermittent care in HIV-1-infected patients in Curaçao before and after starting cART.

Hermanides HS, Holman R, Gras L, Winkel CN, Gerstenbluth I, de Wolf F, Duits AJ.

AIDS Care. 2013;25(11):1411-7. doi: 10.1080/09540121.2013.772276. Epub 2013 Feb 21.


Prolonged decrease of CD4+ T lymphocytes in HIV-1-infected patients after radiotherapy for a solid tumor.

Sankatsing SU, Hillebregt MM, Gras L, Brinkman K, van der Ende M, de Wolf F, Stalpers LJ, Prins JM.

J Acquir Immune Defic Syndr. 2013 Apr 15;62(5):546-9. doi: 10.1097/QAI.0b013e318285d934.


Lower incidence of Pneumocystis jirovecii pneumonia among Africans in the Netherlands host or environmental factors?

Schoffelen AF, van Lelyveld SF, Barth RE, Gras L, de Wolf F, Netea MG, Hoepelman AI; ATHENA national observational cohort study.

AIDS. 2013 Apr 24;27(7):1179-84. doi: 10.1097/QAD.0b013e32835e2c90.


Fibril formation by pH and temperature responsive silk-elastin block copolymers.

Golinska MD, Pham TT, Werten MW, de Wolf FA, Cohen Stuart MA, van der Gucht J.

Biomacromolecules. 2013 Jan 14;14(1):48-55. doi: 10.1021/bm3011775. Epub 2012 Dec 27.


Resurgence of HIV infection among men who have sex with men in Switzerland: mathematical modelling study.

van Sighem A, Vidondo B, Glass TR, Bucher HC, Vernazza P, Gebhardt M, de Wolf F, Derendinger S, Jeannin A, Bezemer D, Fraser C, Low N; Swiss HIV Cohort Study.

PLoS One. 2012;7(9):e44819. Epub 2012 Sep 14.


Similar virologic response after initiation of triple-class antiretroviral therapy in primary and chronic HIV infection.

Grijsen ML, Holman R, Wit FW, Gras L, Lowe SH, Brinkman K, de Wolf F, Prins JM.

AIDS. 2012 Sep 24;26(15):1974-7. No abstract available.


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