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Items: 1 to 50 of 137

1.

Type-I interferons in atherosclerosis.

Chen HJ, Tas SW, de Winther MPJ.

J Exp Med. 2020 Jan 6;217(1). pii: e20190459. doi: 10.1084/jem.20190459.

PMID:
31821440
2.

Peritoneal macrophages have an impaired immune response in obesity which can be reversed by subsequent weight loss.

Willemsen L, Neele AE, van der Velden S, Prange KHM, den Toom M, van Roomen CPAA, Reiche ME, Griffith GR, Gijbels MJJ, Lutgens E, de Winther MPJ.

BMJ Open Diabetes Res Care. 2019 Nov 2;7(1):e000751. doi: 10.1136/bmjdrc-2019-000751. eCollection 2019.

3.

Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis.

Luque-Martin R, Van den Bossche J, Furze RC, Neele AE, van der Velden S, Gijbels MJJ, van Roomen CPPA, Bernard SG, de Jonge WJ, Rioja I, Prinjha RK, Lewis HD, Mander PK, de Winther MPJ.

Front Pharmacol. 2019 Oct 29;10:1242. doi: 10.3389/fphar.2019.01242. eCollection 2019.

4.

Non-activatable mutant of inhibitor of kappa B kinase α (IKKα) exerts vascular site-specific effects on atherosclerosis in Apoe-deficient mice.

Tilstam PV, Soppert J, Hemmers C, Harlacher E, Döring Y, van der Vorst EPC, Schulte C, Alampour-Rajabi S, Theelen W, Asare Y, de Winther MPJ, Lawrence T, Bernhagen J, Schober A, Zernecke A, Jankowski J, Weber C, Noels H.

Atherosclerosis. 2019 Nov 2;292:23-30. doi: 10.1016/j.atherosclerosis.2019.10.023. [Epub ahead of print]

PMID:
31733453
5.

Salt increases monocyte CCR2 expression and inflammatory responses in humans.

Wenstedt EF, Verberk SG, Kroon J, Neele AE, Baardman J, Claessen N, Pasaoglu ÖT, Rademaker E, Schrooten EM, Wouda RD, de Winther MP, Aten J, Vogt L, Van den Bossche J.

JCI Insight. 2019 Nov 1;4(21). pii: 130508. doi: 10.1172/jci.insight.130508.

6.

Transcriptional and epigenetic regulation of macrophages in atherosclerosis.

Kuznetsova T, Prange KHM, Glass CK, de Winther MPJ.

Nat Rev Cardiol. 2019 Oct 2. doi: 10.1038/s41569-019-0265-3. [Epub ahead of print] Review.

PMID:
31578516
7.

Nanoparticle-Aided Characterization of Arterial Endothelial Architecture during Atherosclerosis Progression and Metabolic Therapy.

Beldman TJ, Malinova TS, Desclos E, Grootemaat AE, Misiak ALS, van der Velden S, van Roomen CPAA, Beckers L, van Veen HA, Krawczyk PM, Hoebe RA, Sluimer JC, Neele AE, de Winther MPJ, van der Wel NN, Lutgens E, Mulder WJM, Huveneers S, Kluza E.

ACS Nano. 2019 Jul 10. doi: 10.1021/acsnano.8b08875. [Epub ahead of print]

PMID:
31268670
8.

Human monocyte-to-macrophage differentiation involves highly localized gain and loss of DNA methylation at transcription factor binding sites.

Dekkers KF, Neele AE, Jukema JW, Heijmans BT, de Winther MPJ.

Epigenetics Chromatin. 2019 Jun 6;12(1):34. doi: 10.1186/s13072-019-0279-4.

9.

Leducq Epigenetics of Atherosclerosis Network.

de Winther MPJ, Glass CK.

Circ Res. 2019 Jun 7;124(12):1697-1700. doi: 10.1161/CIRCRESAHA.119.315187. Epub 2019 Jun 6. No abstract available.

PMID:
31170047
10.

The Link between Hematopoiesis and Atherosclerosis.

de Winther MPJ, Lutgens E.

N Engl J Med. 2019 May 9;380(19):1869-1871. doi: 10.1056/NEJMcibr1901397. No abstract available.

PMID:
31067380
11.

High Fat Diet Increases Circulating Endocannabinoids Accompanied by Increased Synthesis Enzymes in Adipose Tissue.

Kuipers EN, Kantae V, Maarse BCE, van den Berg SM, van Eenige R, Nahon KJ, Reifel-Miller A, Coskun T, de Winther MPJ, Lutgens E, Kooijman S, Harms AC, Hankemeier T, van der Stelt M, Rensen PCN, Boon MR.

Front Physiol. 2019 Jan 10;9:1913. doi: 10.3389/fphys.2018.01913. eCollection 2018.

12.

Introduction to the thematic review series on different levels of genetic regulation of cardiovascular disease.

de Winther MPJ, Dallinga-Thie GM.

Atherosclerosis. 2019 Feb;281:148-149. doi: 10.1016/j.atherosclerosis.2018.12.014. Epub 2018 Dec 22. No abstract available.

PMID:
30658843
13.

Circulating CD14+CD16- classical monocytes do not associate with a vulnerable plaque phenotype, and do not predict secondary events in severe atherosclerotic patients.

Meeuwsen JAL, de Vries JJ, van Duijvenvoorde A, van der Velden S, van der Laan SW, van Koeverden ID, van de Weg SM, de Borst GJ, de Winther MPJ, Kuiper J, Pasterkamp G, Hoefer IE, de Jager SCA; Queen of Hearts Consortium.

J Mol Cell Cardiol. 2019 Feb;127:260-269. doi: 10.1016/j.yjmcc.2019.01.002. Epub 2019 Jan 7.

14.

Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?

van Beek AA, Van den Bossche J, Mastroberardino PG, de Winther MPJ, Leenen PJM.

Trends Immunol. 2019 Feb;40(2):113-127. doi: 10.1016/j.it.2018.12.007. Epub 2019 Jan 6. Review.

PMID:
30626541
15.

A Proinflammatory Gut Microbiota Increases Systemic Inflammation and Accelerates Atherosclerosis.

Brandsma E, Kloosterhuis NJ, Koster M, Dekker DC, Gijbels MJJ, van der Velden S, Ríos-Morales M, van Faassen MJR, Loreti MG, de Bruin A, Fu J, Kuipers F, Bakker BM, Westerterp M, de Winther MPJ, Hofker MH, van de Sluis B, Koonen DPY.

Circ Res. 2019 Jan 4;124(1):94-100. doi: 10.1161/CIRCRESAHA.118.313234.

16.

Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis.

Aarts SA, Seijkens TT, Kusters PJ, van Tiel CM, Reiche ME, den Toom M, Beckers L, van Roomen CP, de Winther MP, Kooij G, Lutgens E.

J Pathol. 2019 Apr;247(4):471-480. doi: 10.1002/path.5205. Epub 2019 Jan 30.

17.

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia.

Baardman J, Verberk SGS, Prange KHM, van Weeghel M, van der Velden S, Ryan DG, Wüst RCI, Neele AE, Speijer D, Denis SW, Witte ME, Houtkooper RH, O'neill LA, Knatko EV, Dinkova-Kostova AT, Lutgens E, de Winther MPJ, Van den Bossche J.

Cell Rep. 2018 Nov 20;25(8):2044-2052.e5. doi: 10.1016/j.celrep.2018.10.092.

18.

Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8+ T cell-mediated macrophage death.

Seijkens TTP, Poels K, Meiler S, van Tiel CM, Kusters PJH, Reiche M, Atzler D, Winkels H, Tjwa M, Poelman H, Slütter B, Kuiper J, Gijbels M, Kuivenhoven JA, Matic LP, Paulsson-Berne G, Hedin U, Hansson GK, Nicolaes GAF, Daemen MJAP, Weber C, Gerdes N, de Winther MPJ, Lutgens E.

Eur Heart J. 2019 Jan 21;40(4):372-382. doi: 10.1093/eurheartj/ehy714.

19.

Potential epigenetic therapeutics for atherosclerosis treatment.

Nicorescu I, Dallinga GM, de Winther MPJ, Stroes ESG, Bahjat M.

Atherosclerosis. 2019 Feb;281:189-197. doi: 10.1016/j.atherosclerosis.2018.10.006. Epub 2018 Oct 8. Review.

PMID:
30340764
20.

Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction.

Aarts SABM, Reiche ME, den Toom M, Beckers L, Gijbels MJJ, Gerdes N, de Winther MPJ, Lutgens E.

PLoS One. 2018 Aug 10;13(8):e0202150. doi: 10.1371/journal.pone.0202150. eCollection 2018.

21.

Myeloid Kdm6b deficiency results in advanced atherosclerosis.

Neele AE, Gijbels MJJ, van der Velden S, Hoeksema MA, Boshuizen MCS, Prange KHM, Chen HJ, Van den Bossche J, van Roomen CPPA, Shami A, Levels JHM, Kroon J, Lucas T, Dimmeler S, Lutgens E, de Winther MPJ.

Atherosclerosis. 2018 Aug;275:156-165. doi: 10.1016/j.atherosclerosis.2018.05.052. Epub 2018 Jun 1.

22.

Repressing the repressor: Ezh2 mediates macrophage activation.

Neele AE, de Winther MPJ.

J Exp Med. 2018 May 7;215(5):1269-1271. doi: 10.1084/jem.20180479. Epub 2018 Apr 24.

23.

Lipopolysaccharide Lowers Cholesteryl Ester Transfer Protein by Activating F4/80+Clec4f+Vsig4+Ly6C- Kupffer Cell Subsets.

van der Tuin SJL, Li Z, Berbée JFP, Verkouter I, Ringnalda LE, Neele AE, van Klinken JB, Rensen SS, Fu J, de Winther MPJ, Groen AK, Rensen PCN, Willems van Dijk K, Wang Y.

J Am Heart Assoc. 2018 Mar 10;7(6). pii: e008105. doi: 10.1161/JAHA.117.008105.

24.

Noncanonical NF-κB signaling in microvessels of atherosclerotic lesions is associated with inflammation, atheromatous plaque morphology and myocardial infarction.

Maracle CX, Agca R, Helder B, Meeuwsen JAL, Niessen HWM, Biessen EAL, de Winther MPJ, de Jager SCA, Nurmohamed MT, Tas SW.

Atherosclerosis. 2018 Mar;270:33-41. doi: 10.1016/j.atherosclerosis.2018.01.032. Epub 2018 Jan 31.

25.

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis.

Seijkens TTP, van Tiel CM, Kusters PJH, Atzler D, Soehnlein O, Zarzycka B, Aarts SABM, Lameijer M, Gijbels MJ, Beckers L, den Toom M, Slütter B, Kuiper J, Duchene J, Aslani M, Megens RTA, van 't Veer C, Kooij G, Schrijver R, Hoeksema MA, Boon L, Fay F, Tang J, Baxter S, Jongejan A, Moerland PD, Vriend G, Bleijlevens B, Fisher EA, Duivenvoorden R, Gerdes N, de Winther MPJ, Nicolaes GA, Mulder WJM, Weber C, Lutgens E.

J Am Coll Cardiol. 2018 Feb 6;71(5):527-542. doi: 10.1016/j.jacc.2017.11.055.

26.

DARC matter(s) for inflammatory cells.

Atzler D, de Winther MPJ.

Cardiovasc Res. 2018 Feb 1;114(2):e11-e13. doi: 10.1093/cvr/cvx230. No abstract available.

PMID:
29373721
27.

Monocyte and haematopoietic progenitor reprogramming as common mechanism underlying chronic inflammatory and cardiovascular diseases.

Hoogeveen RM, Nahrendorf M, Riksen NP, Netea MG, de Winther MPJ, Lutgens E, Nordestgaard BG, Neidhart M, Stroes ESG, Catapano AL, Bekkering S.

Eur Heart J. 2018 Oct 7;39(38):3521-3527. doi: 10.1093/eurheartj/ehx581. Review. Erratum in: Eur Heart J. 2018 Jun 14;39(23):2182.

28.

IgG is elevated in obese white adipose tissue but does not induce glucose intolerance via Fcγ-receptor or complement.

van Dam AD, van Beek L, Pronk ACM, van den Berg SM, Van den Bossche J, de Winther MPJ, Koning F, van Kooten C, Rensen PCN, Boon MR, Verbeek JS, van Dijk KW, van Harmelen V.

Int J Obes (Lond). 2018 Feb;42(2):260-269. doi: 10.1038/ijo.2017.209. Epub 2017 Aug 30.

PMID:
28852207
29.

Helminth antigens counteract a rapid high-fat diet-induced decrease in adipose tissue eosinophils.

van den Berg SM, van Dam AD, Kusters PJH, Beckers L, den Toom M, van der Velden S, Van den Bossche J, van Die I, Boon MR, Rensen PCN, Lutgens E, de Winther MPJ.

J Mol Endocrinol. 2017 Oct;59(3):245-255. doi: 10.1530/JME-17-0112. Epub 2017 Jul 10.

PMID:
28694301
30.

Hyaluronan Nanoparticles Selectively Target Plaque-Associated Macrophages and Improve Plaque Stability in Atherosclerosis.

Beldman TJ, Senders ML, Alaarg A, Pérez-Medina C, Tang J, Zhao Y, Fay F, Deichmöller J, Born B, Desclos E, van der Wel NN, Hoebe RA, Kohen F, Kartvelishvily E, Neeman M, Reiner T, Calcagno C, Fayad ZA, de Winther MPJ, Lutgens E, Mulder WJM, Kluza E.

ACS Nano. 2017 Jun 27;11(6):5785-5799. doi: 10.1021/acsnano.7b01385. Epub 2017 May 15.

31.

High miR-124-3p expression identifies smoking individuals susceptible to atherosclerosis.

de Ronde MWJ, Kok MGM, Moerland PD, Van den Bossche J, Neele AE, Halliani A, van der Made I, de Winther MPJ, Meijers JCM, Creemers EE, Pinto-Sietsma SJ.

Atherosclerosis. 2017 Aug;263:377-384. doi: 10.1016/j.atherosclerosis.2017.03.045. Epub 2017 Apr 5.

32.

PCSK9 monoclonal antibodies reverse the pro-inflammatory profile of monocytes in familial hypercholesterolaemia.

Bernelot Moens SJ, Neele AE, Kroon J, van der Valk FM, Van den Bossche J, Hoeksema MA, Hoogeveen RM, Schnitzler JG, Baccara-Dinet MT, Manvelian G, de Winther MPJ, Stroes ESG.

Eur Heart J. 2017 May 21;38(20):1584-1593. doi: 10.1093/eurheartj/ehx002.

PMID:
28329114
33.

Macrophage Kdm6b controls the pro-fibrotic transcriptome signature of foam cells.

Neele AE, Prange KH, Hoeksema MA, van der Velden S, Lucas T, Dimmeler S, Lutgens E, Van den Bossche J, de Winther MP.

Epigenomics. 2017 Apr;9(4):383-391. doi: 10.2217/epi-2016-0152. Epub 2017 Mar 21.

PMID:
28322580
34.

Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo.

Asare Y, Ommer M, Azombo FA, Alampour-Rajabi S, Sternkopf M, Sanati M, Gijbels MJ, Schmitz C, Sinitski D, Tilstam PV, Lue H, Gessner A, Lange D, Schmid JA, Weber C, Dichgans M, Jankowski J, Pardi R, de Winther MP, Noels H, Bernhagen J.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2766-E2775. doi: 10.1073/pnas.1618411114. Epub 2017 Mar 14.

35.

High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling.

van der Vorst EPC, Theodorou K, Wu Y, Hoeksema MA, Goossens P, Bursill CA, Aliyev T, Huitema LFA, Tas SW, Wolfs IMJ, Kuijpers MJE, Gijbels MJ, Schalkwijk CG, Koonen DPY, Abdollahi-Roodsaz S, McDaniels K, Wang CC, Leitges M, Lawrence T, Plat J, Van Eck M, Rye KA, Touqui L, de Winther MPJ, Biessen EAL, Donners MMPC.

Cell Metab. 2017 Jan 10;25(1):197-207. doi: 10.1016/j.cmet.2016.10.013. Epub 2016 Nov 17.

36.

Immune Modulation of Brown(ing) Adipose Tissue in Obesity.

van den Berg SM, van Dam AD, Rensen PC, de Winther MP, Lutgens E.

Endocr Rev. 2017 Feb 1;38(1):46-68. doi: 10.1210/er.2016-1066. Review.

PMID:
27849358
37.

Epigenetic Regulation of Monocyte and Macrophage Function.

Hoeksema MA, de Winther MP.

Antioxid Redox Signal. 2016 Nov 10;25(14):758-774. Epub 2016 Apr 25. Review.

38.

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages.

Van den Bossche J, Baardman J, Otto NA, van der Velden S, Neele AE, van den Berg SM, Luque-Martin R, Chen HJ, Boshuizen MC, Ahmed M, Hoeksema MA, de Vos AF, de Winther MP.

Cell Rep. 2016 Oct 11;17(3):684-696. doi: 10.1016/j.celrep.2016.09.008.

39.

Epigenetic mechanisms of macrophage activation in type 2 diabetes.

Ahmed M, de Winther MPJ, Van den Bossche J.

Immunobiology. 2017 Oct;222(10):937-943. doi: 10.1016/j.imbio.2016.08.011. Epub 2016 Sep 3. Review.

40.

Deleting myeloid IL-10 receptor signalling attenuates atherosclerosis in LDLR-/- mice by altering intestinal cholesterol fluxes.

Stöger JL, Boshuizen MC, Brufau G, Gijbels MJ, Wolfs IM, van der Velden S, Pöttgens CC, Vergouwe MN, Wijnands E, Beckers L, Goossens P, Kerksiek A, Havinga R, Müller W, Lütjohann D, Groen AK, de Winther MP.

Thromb Haemost. 2016 Aug 30;116(3):565-77. doi: 10.1160/TH16-01-0043. Epub 2016 Jun 30.

PMID:
27358035
41.

BCG lowers plasma cholesterol levels and delays atherosclerotic lesion progression in mice.

van Dam AD, Bekkering S, Crasborn M, van Beek L, van den Berg SM, Vrieling F, Joosten SA, van Harmelen V, de Winther MPJ, Lütjohann D, Lutgens E, Boon MR, Riksen NP, Rensen PCN, Berbée JFP.

Atherosclerosis. 2016 Aug;251:6-14. doi: 10.1016/j.atherosclerosis.2016.05.031. Epub 2016 May 19.

42.

Head-to-Head Comparison of Anti-Inflammatory Performance of Known Natural Products In Vitro.

Allijn IE, Vaessen SF, Quarles van Ufford LC, Beukelman KJ, de Winther MP, Storm G, Schiffelers RM.

PLoS One. 2016 May 10;11(5):e0155325. doi: 10.1371/journal.pone.0155325. eCollection 2016.

43.

Treatment with Trichuris suis soluble products during monocyte-to-macrophage differentiation reduces inflammatory responses through epigenetic remodeling.

Hoeksema MA, Laan LC, Postma JJ, Cummings RD, de Winther MP, Dijkstra CD, van Die I, Kooij G.

FASEB J. 2016 Aug;30(8):2826-36. doi: 10.1096/fj.201600343R. Epub 2016 Apr 19.

44.

Myeloid interferon-γ receptor deficiency does not affect atherosclerosis in LDLR(-/-) mice.

Boshuizen MC, Neele AE, Gijbels MJ, van der Velden S, Hoeksema MA, Forman RA, Muller W, Van den Bossche J, de Winther MP.

Atherosclerosis. 2016 Mar;246:325-33. doi: 10.1016/j.atherosclerosis.2016.01.026. Epub 2016 Jan 19.

PMID:
26828750
45.

The Plot Thickens Further for Type I Interferons in Atherosclerotic Disease.

de Winther MP.

Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):217-8. doi: 10.1161/ATVBAHA.115.306907. No abstract available.

PMID:
26819462
46.

Diet-induced obesity in mice diminishes hematopoietic stem and progenitor cells in the bone marrow.

van den Berg SM, Seijkens TT, Kusters PJ, Beckers L, den Toom M, Smeets E, Levels J, de Winther MP, Lutgens E.

FASEB J. 2016 May;30(5):1779-88. doi: 10.1096/fj.201500175. Epub 2016 Jan 26.

PMID:
26813974
47.

Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis.

Van den Bossche J, Baardman J, de Winther MP.

J Vis Exp. 2015 Nov 28;(105). doi: 10.3791/53424.

48.

Metabolic-epigenetic crosstalk in macrophage activation.

Baardman J, Licht I, de Winther MP, Van den Bossche J.

Epigenomics. 2015 Oct;7(7):1155-64. doi: 10.2217/epi.15.71. Epub 2015 Nov 20.

49.

Interferon-β promotes macrophage foam cell formation by altering both cholesterol influx and efflux mechanisms.

Boshuizen MC, Hoeksema MA, Neele AE, van der Velden S, Hamers AA, Van den Bossche J, Lutgens E, de Winther MP.

Cytokine. 2016 Jan;77:220-6. doi: 10.1016/j.cyto.2015.09.016. Epub 2015 Oct 1.

PMID:
26427927
50.

Impaired microbial killing by neutrophils from patients with protein kinase C delta deficiency.

Szilagyi K, Gazendam RP, van Hamme JL, Tool AT, van Houdt M, Vos WA, Verkuijlen P, Janssen H, Belot A, Juillard L, Förster-Waldl E, Boztug K, Kraal G, de Winther MP, Kuijpers TW, van den Berg TK.

J Allergy Clin Immunol. 2015 Nov;136(5):1404-7.e1-10. doi: 10.1016/j.jaci.2015.06.016. Epub 2015 Jul 30. No abstract available.

PMID:
26233929

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