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Items: 1 to 50 of 91

1.

Effect of sequence context on Polζ-dependent error-prone extension past (6-4) photoproducts.

Akagi JI, Hashimoto K, Suzuki K, Yokoi M, de Wind N, Iwai S, Ohmori H, Moriya M, Hanaoka F.

DNA Repair (Amst). 2019 Dec 14;87:102771. doi: 10.1016/j.dnarep.2019.102771. [Epub ahead of print]

PMID:
31911268
2.

Mutagenic replication: target for tumor therapy?

Jansen JG, de Wind N.

Cell Res. 2019 Oct;29(10):783-784. doi: 10.1038/s41422-019-0218-8. No abstract available.

PMID:
31434995
3.

A functional assay-based procedure to classify mismatch repair gene variants in Lynch syndrome.

Drost M, Tiersma Y, Thompson BA, Frederiksen JH, Keijzers G, Glubb D, Kathe S, Osinga J, Westers H, Pappas L, Boucher KM, Molenkamp S, Zonneveld JB, van Asperen CJ, Goldgar DE, Wallace SS, Sijmons RH, Spurdle AB, Rasmussen LJ, Greenblatt MS, de Wind N, Tavtigian SV.

Genet Med. 2019 Jul;21(7):1486-1496. doi: 10.1038/s41436-018-0372-2. Epub 2018 Dec 3.

PMID:
30504929
4.

Adjuvant Treatment for POLE Proofreading Domain-Mutant Cancers: Sensitivity to Radiotherapy, Chemotherapy, and Nucleoside Analogues.

Van Gool IC, Rayner E, Osse EM, Nout RA, Creutzberg CL, Tomlinson IPM, Church DN, Smit VTHBM, de Wind N, Bosse T, Drost M.

Clin Cancer Res. 2018 Jul 1;24(13):3197-3203. doi: 10.1158/1078-0432.CCR-18-0266. Epub 2018 Mar 20.

5.

Author Correction: Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis.

Fakouri NB, Durhuus JA, Regnell CE, Angleys M, Desler C, Hasan-Olive MM, Martín-Pardillos A, Tsaalbi-Shtylik A, Thomsen K, Lauritzen M, Bohr VA, de Wind N, Bergersen LH, Rasmussen LJ.

Sci Rep. 2018 Mar 6;8(1):4245. doi: 10.1038/s41598-018-20586-9.

6.

Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis.

Fakouri NB, Durhuus JA, Regnell CE, Angleys M, Desler C, Hasan-Olive MM, Martín-Pardillos A, Tsaalbi-Shtylik A, Thomsen K, Lauritzen M, Bohr VA, de Wind N, Bergersen LH, Rasmussen LJ.

Sci Rep. 2017 Oct 2;7(1):12480. doi: 10.1038/s41598-017-12662-3. Erratum in: Sci Rep. 2018 Mar 6;8(1):4245.

7.

Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions.

Martín-Pardillos A, Tsaalbi-Shtylik A, Chen S, Lazare S, van Os RP, Dethmers-Ausema A, Fakouri NB, Bosshard M, Aprigliano R, van Loon B, Salvatori DCF, Hashimoto K, Dingemanse-van der Spek C, Moriya M, Rasmussen LJ, de Haan G, Raaijmakers MHGP, de Wind N.

Blood. 2017 Sep 28;130(13):1523-1534. doi: 10.1182/blood-2017-01-764274. Epub 2017 Aug 21. Erratum in: Blood. 2018 Feb 8;131(6):710.

8.

Comprehensive Mutation Analysis of PMS2 in a Large Cohort of Probands Suspected of Lynch Syndrome or Constitutional Mismatch Repair Deficiency Syndrome.

van der Klift HM, Mensenkamp AR, Drost M, Bik EC, Vos YJ, Gille HJ, Redeker BE, Tiersma Y, Zonneveld JB, García EG, Letteboer TG, Olderode-Berends MJ, van Hest LP, van Os TA, Verhoef S, Wagner A, van Asperen CJ, Ten Broeke SW, Hes FJ, de Wind N, Nielsen M, Devilee P, Ligtenberg MJ, Wijnen JT, Tops CM.

Hum Mutat. 2016 Nov;37(11):1162-1179. doi: 10.1002/humu.23052. Epub 2016 Aug 21.

PMID:
27435373
9.

DNA mismatch repair: from biophysics to bedside.

Lebbink JH, Drost M, de Wind N.

DNA Repair (Amst). 2016 Feb;38:1-2. doi: 10.1016/j.dnarep.2015.11.007. Epub 2015 Dec 8. No abstract available.

PMID:
26777339
10.

Post-translesion synthesis repair.

Jansen JG, Tsaalbi-Shtylik A, de Wind N.

Oncotarget. 2015 Aug 14;6(23):19342-3. No abstract available.

11.

FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress.

Yang Y, Liu Z, Wang F, Temviriyanukul P, Ma X, Tu Y, Lv L, Lin YF, Huang M, Zhang T, Pei H, Chen BP, Jansen JG, de Wind N, Fischhaber PL, Friedberg EC, Tang TS, Guo C.

Nucleic Acids Res. 2015 Sep 30;43(17):8325-39. doi: 10.1093/nar/gkv737. Epub 2015 Jul 17.

12.

When mismatch repair met translesion synthesis.

Tsaalbi-Shtylik A, Jansen JG, de Wind N.

Cell Cycle. 2015 Aug 3;14(15):2377-8. doi: 10.1080/15384101.2015.1063288. Epub 2015 Jun 23. No abstract available.

13.

De novo mutations in PLXND1 and REV3L cause Möbius syndrome.

Tomas-Roca L, Tsaalbi-Shtylik A, Jansen JG, Singh MK, Epstein JA, Altunoglu U, Verzijl H, Soria L, van Beusekom E, Roscioli T, Iqbal Z, Gilissen C, Hoischen A, de Brouwer APM, Erasmus C, Schubert D, Brunner H, Pérez Aytés A, Marin F, Aroca P, Kayserili H, Carta A, de Wind N, Padberg GW, van Bokhoven H.

Nat Commun. 2015 Jun 12;6:7199. doi: 10.1038/ncomms8199.

14.

Excision of translesion synthesis errors orchestrates responses to helix-distorting DNA lesions.

Tsaalbi-Shtylik A, Ferrás C, Pauw B, Hendriks G, Temviriyanukul P, Carlée L, Calléja F, van Hees S, Akagi J, Iwai S, Hanaoka F, Jansen JG, de Wind N.

J Cell Biol. 2015 Apr 13;209(1):33-46. doi: 10.1083/jcb.201408017.

15.

Roles of mutagenic translesion synthesis in mammalian genome stability, health and disease.

Jansen JG, Tsaalbi-Shtylik A, de Wind N.

DNA Repair (Amst). 2015 May;29:56-64. doi: 10.1016/j.dnarep.2015.01.001. Epub 2015 Jan 21. Review.

PMID:
25655219
16.

DNA lesion identity drives choice of damage tolerance pathway in murine cell chromosomes.

Cohen IS, Bar C, Paz-Elizur T, Ainbinder E, Leopold K, de Wind N, Geacintov N, Livneh Z.

Nucleic Acids Res. 2015 Feb 18;43(3):1637-45.

17.

Roles of PCNA ubiquitination and TLS polymerases κ and η in the bypass of methyl methanesulfonate-induced DNA damage.

Wit N, Buoninfante OA, van den Berk PC, Jansen JG, Hogenbirk MA, de Wind N, Jacobs H.

Nucleic Acids Res. 2015 Jan;43(1):282-94. doi: 10.1093/nar/gku1301. Epub 2014 Dec 10.

18.

Redundancy of mammalian Y family DNA polymerases in cellular responses to genomic DNA lesions induced by ultraviolet light.

Jansen JG, Temviriyanukul P, Wit N, Delbos F, Reynaud CA, Jacobs H, de Wind N.

Nucleic Acids Res. 2014;42(17):11071-82. doi: 10.1093/nar/gku779. Epub 2014 Aug 28.

19.

Maternal aldehyde elimination during pregnancy preserves the fetal genome.

Oberbeck N, Langevin F, King G, de Wind N, Crossan GP, Patel KJ.

Mol Cell. 2014 Sep 18;55(6):807-817. doi: 10.1016/j.molcel.2014.07.010. Epub 2014 Aug 21.

20.

Functional implications of the p.Cys680Arg mutation in the MLH1 mismatch repair protein.

Dominguez-Valentin M, Drost M, Therkildsen C, Rambech E, Ehrencrona H, Angleys M, Lau Hansen T, de Wind N, Nilbert M, Juel Rasmussen L.

Mol Genet Genomic Med. 2014 Jul;2(4):352-5. doi: 10.1002/mgg3.80. Epub 2014 May 6.

21.

In memory of John Bruce Hays (1937-2014).

de Wind N, Buermeyer AB, Hanawalt PC.

DNA Repair (Amst). 2014 Apr;16:vi-vii. doi: 10.1016/S1568-7864(14)00071-8. No abstract available.

PMID:
24674631
22.

Persistently stalled replication forks inhibit nucleotide excision repair in trans by sequestering Replication protein A.

Tsaalbi-Shtylik A, Moser J, Mullenders LH, Jansen JG, de Wind N.

Nucleic Acids Res. 2014 Apr;42(7):4406-13. doi: 10.1093/nar/gkt1412. Epub 2014 Jan 23.

23.

Consequences of germline variation disrupting the constitutional translational initiation codon start sites of MLH1 and BRCA2: Use of potential alternative start sites and implications for predicting variant pathogenicity.

Parsons MT, Whiley PJ, Beesley J, Drost M, de Wind N, Thompson BA, Marquart L, Hopper JL, Jenkins MA; Australasian Colorectal Cancer Family Registry, Brown MA, Tucker K, Warwick L, Buchanan DD, Spurdle AB.

Mol Carcinog. 2015 Jul;54(7):513-22. doi: 10.1002/mc.22116. Epub 2013 Dec 2.

24.

Inactivation of DNA mismatch repair by variants of uncertain significance in the PMS2 gene.

Drost M, Koppejan H, de Wind N.

Hum Mutat. 2013 Nov;34(11):1477-80. doi: 10.1002/humu.22426. Epub 2013 Sep 11.

25.

Rev1 is essential in generating G to C transversions downstream of the Ung2 pathway but not the Msh2+Ung2 hybrid pathway.

Krijger PH, Tsaalbi-Shtylik A, Wit N, van den Berk PC, de Wind N, Jacobs H.

Eur J Immunol. 2013 Oct;43(10):2765-70. doi: 10.1002/eji.201243191. Epub 2013 Aug 5.

26.

Multivariate analysis of MLH1 c.1664T>C (p.Leu555Pro) mismatch repair gene variant demonstrates its pathogenicity.

Farrell MP, Hughes DJ, Drost M, Wallace AJ, Cummins RJ, Fletcher TA, Meany MA, Kay EW, de Wind N, Power DG, Andrews EJ, Green AJ, Gallagher DJ.

Fam Cancer. 2013 Dec;12(4):741-7. doi: 10.1007/s10689-013-9652-9.

PMID:
23712482
27.

Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome.

Drost M, Lützen A, van Hees S, Ferreira D, Calléja F, Zonneveld JB, Nielsen FC, Rasmussen LJ, de Wind N.

Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9403-8. doi: 10.1073/pnas.1220537110. Epub 2013 May 20.

28.

Response to: Design of a core classification process for DNA mismatch repair variations of a priori unknown functional significance.

Rasmussen LJ, Heinen CD, Royer-Pokora B, Drost M, Tavtigian S, Hofstra RM, de Wind N.

Hum Mutat. 2013 Jun;34(6):923-4. doi: 10.1002/humu.22310. Epub 2013 Mar 28. No abstract available.

PMID:
23554108
29.

Pathological assessment of mismatch repair gene variants in Lynch syndrome: past, present, and future.

Rasmussen LJ, Heinen CD, Royer-Pokora B, Drost M, Tavtigian S, Hofstra RM, de Wind N.

Hum Mutat. 2012 Dec;33(12):1617-25. doi: 10.1002/humu.22168. Epub 2012 Aug 13. Review.

PMID:
22833534
30.

Functional characterization of MLH1 missense variants identified in Lynch syndrome patients.

Andersen SD, Liberti SE, Lützen A, Drost M, Bernstein I, Nilbert M, Dominguez M, Nyström M, Hansen TV, Christoffersen JW, Jäger AC, de Wind N, Nielsen FC, Tørring PM, Rasmussen LJ.

Hum Mutat. 2012 Dec;33(12):1647-55. doi: 10.1002/humu.22153. Epub 2012 Jul 23.

PMID:
22753075
31.

Temporally distinct translesion synthesis pathways for ultraviolet light-induced photoproducts in the mammalian genome.

Temviriyanukul P, van Hees-Stuivenberg S, Delbos F, Jacobs H, de Wind N, Jansen JG.

DNA Repair (Amst). 2012 Jun 1;11(6):550-8. doi: 10.1016/j.dnarep.2012.03.007. Epub 2012 Apr 20.

PMID:
22521143
32.

Different sets of translesion synthesis DNA polymerases protect from genome instability induced by distinct food-derived genotoxins.

Temviriyanukul P, Meijers M, van Hees-Stuivenberg S, Boei JJ, Delbos F, Ohmori H, de Wind N, Jansen JG.

Toxicol Sci. 2012 May;127(1):130-8. doi: 10.1093/toxsci/kfs074. Epub 2012 Feb 13.

PMID:
22331492
33.

The vital role of polymerase ζ and REV1 in mutagenic, but not correct, DNA synthesis across benzo[a]pyrene-dG and recruitment of polymerase ζ by REV1 to replication-stalled site.

Hashimoto K, Cho Y, Yang IY, Akagi J, Ohashi E, Tateishi S, de Wind N, Hanaoka F, Ohmori H, Moriya M.

J Biol Chem. 2012 Mar 16;287(12):9613-22. doi: 10.1074/jbc.M111.331728. Epub 2012 Feb 2.

34.

A rapid and cell-free assay to test the activity of lynch syndrome-associated MSH2 and MSH6 missense variants.

Drost M, Zonneveld JB, van Hees S, Rasmussen LJ, Hofstra RM, de Wind N.

Hum Mutat. 2012 Mar;33(3):488-94. doi: 10.1002/humu.22000. Epub 2011 Dec 29.

PMID:
22102614
35.

DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity.

Diamant N, Hendel A, Vered I, Carell T, Reissner T, de Wind N, Geacinov N, Livneh Z.

Nucleic Acids Res. 2012 Jan;40(1):170-80. doi: 10.1093/nar/gkr596. Epub 2011 Sep 9.

36.

PCNA ubiquitination-independent activation of polymerase η during somatic hypermutation and DNA damage tolerance.

Krijger PH, van den Berk PC, Wit N, Langerak P, Jansen JG, Reynaud CA, de Wind N, Jacobs H.

DNA Repair (Amst). 2011 Oct 10;10(10):1051-9. doi: 10.1016/j.dnarep.2011.08.005. Epub 2011 Sep 1.

PMID:
21889916
37.

Transient suppression of MLH1 allows effective single-nucleotide substitution by single-stranded DNA oligonucleotides.

Dekker M, de Vries S, Aarts M, Dekker R, Brouwers C, Wiebenga O, de Wind N, Cantelli E, Tonelli R, Te Riele H.

Mutat Res. 2011 Oct 1;715(1-2):52-60. doi: 10.1016/j.mrfmmm.2011.07.008. Epub 2011 Jul 27.

PMID:
21801734
38.

The Rev1 translesion synthesis polymerase has multiple distinct DNA binding modes.

de Groote FH, Jansen JG, Masuda Y, Shah DM, Kamiya K, de Wind N, Siegal G.

DNA Repair (Amst). 2011 Sep 5;10(9):915-25. doi: 10.1016/j.dnarep.2011.04.033. Epub 2011 Jul 12.

PMID:
21752727
39.

Deciphering the colon cancer genes--report of the InSiGHT-Human Variome Project Workshop, UNESCO, Paris 2010.

Kohonen-Corish MR, Macrae F, Genuardi M, Aretz S, Bapat B, Bernstein IT, Burn J, Cotton RG, den Dunnen JT, Frebourg T, Greenblatt MS, Hofstra R, Holinski-Feder E, Lappalainen I, Lindblom A, Maglott D, Møller P, Morreau H, Möslein G, Sijmons R, Spurdle AB, Tavtigian S, Tops CM, Weber TK, de Wind N, Woods MO; Contributors to the InSiGHT-HVP Workshop.

Hum Mutat. 2011 Apr;32(4):491-4. doi: 10.1002/humu.21450. Epub 2011 Mar 8.

PMID:
21387463
40.

Transcription-coupled repair and apoptosis provide specific protection against transcription-associated mutagenesis by ultraviolet light.

Hendriks G, Jansen JG, Mullenders LH, de Wind N.

Transcription. 2010 Sep-Oct;1(2):95-8. doi: 10.4161/trns.1.2.12788.

41.

Transcription and replication: far relatives make uneasy bedfellows.

Hendriks G, Jansen JG, Mullenders LH, de Wind N.

Cell Cycle. 2010 Jun 15;9(12):2300-4. Epub 2010 Jun 15.

PMID:
20519944
42.

Transcription-dependent cytosine deamination is a novel mechanism in ultraviolet light-induced mutagenesis.

Hendriks G, Calléja F, Besaratinia A, Vrieling H, Pfeifer GP, Mullenders LH, Jansen JG, de Wind N.

Curr Biol. 2010 Jan 26;20(2):170-5. doi: 10.1016/j.cub.2009.11.061. Epub 2009 Dec 31.

43.

A cell-free assay for the functional analysis of variants of the mismatch repair protein MLH1.

Drost M, Zonneveld Je, van Dijk L, Morreau H, Tops CM, Vasen HF, Wijnen JT, de Wind N.

Hum Mutat. 2010 Mar;31(3):247-53. doi: 10.1002/humu.21180.

PMID:
20020535
44.

Error-prone translesion replication of damaged DNA suppresses skin carcinogenesis by controlling inflammatory hyperplasia.

Tsaalbi-Shtylik A, Verspuy JW, Jansen JG, Rebel H, Carlée LM, van der Valk MA, Jonkers J, de Gruijl FR, de Wind N.

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21836-41. doi: 10.1073/pnas.0909507106. Epub 2009 Dec 10.

45.

Mammalian polymerase zeta is essential for post-replication repair of UV-induced DNA lesions.

Jansen JG, Tsaalbi-Shtylik A, Hendriks G, Verspuy J, Gali H, Haracska L, de Wind N.

DNA Repair (Amst). 2009 Dec 3;8(12):1444-51. doi: 10.1016/j.dnarep.2009.09.006. Epub 2009 Sep 27.

PMID:
19783229
46.

Functional interactions between DNA damage signaling and mutagenic translesion synthesis at post-replicative gaps.

Jansen JG, Tsaalbi-Shtylik A, de Wind N.

Cell Cycle. 2009 Sep 15;8(18):2857-8. Epub 2009 Sep 1. No abstract available.

PMID:
19729992
47.

The translesion polymerase Rev3L in the tolerance of alkylating anticancer drugs.

Roos WP, Tsaalbi-Shtylik A, Tsaryk R, Güvercin F, de Wind N, Kaina B.

Mol Pharmacol. 2009 Oct;76(4):927-34. doi: 10.1124/mol.109.058131. Epub 2009 Jul 29.

PMID:
19641035
48.

Abrogation of microsatellite-instable tumors using a highly selective suicide gene/prodrug combination.

Ferrás C, Oude Vrielink JA, Verspuy JW, te Riele H, Tsaalbi-Shtylik A, de Wind N.

Mol Ther. 2009 Aug;17(8):1373-80. doi: 10.1038/mt.2009.114. Epub 2009 May 26.

49.

Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells.

Jansen JG, Tsaalbi-Shtylik A, Hendriks G, Gali H, Hendel A, Johansson F, Erixon K, Livneh Z, Mullenders LH, Haracska L, de Wind N.

Mol Cell Biol. 2009 Jun;29(11):3113-23. doi: 10.1128/MCB.00071-09. Epub 2009 Mar 30.

50.

Two distinct translesion synthesis pathways across a lipid peroxidation-derived DNA adduct in mammalian cells.

Yang IY, Hashimoto K, de Wind N, Blair IA, Moriya M.

J Biol Chem. 2009 Jan 2;284(1):191-8. doi: 10.1074/jbc.M806414200. Epub 2008 Nov 3.

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