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Items: 1 to 50 of 146

1.

Involve Children and Parents in Clinical Studies.

Vermeulen E, Karsenberg K, van der Lee JH, de Wildt SN.

Clin Transl Sci. 2019 Oct 24. doi: 10.1111/cts.12696. [Epub ahead of print] No abstract available.

PMID:
31647179
2.

Enteral Acetaminophen Bioavailability in Pediatric Intensive Care Patients Determined With an Oral Microtracer and Pharmacokinetic Modeling to Optimize Dosing.

Kleiber N, Calvier E, Mooij MG, Krekels EHJ, Vaes WHJ, Tibboel D, Knibbe CAJ, de Wildt SN.

Crit Care Med. 2019 Oct 14. doi: 10.1097/CCM.0000000000004032. [Epub ahead of print]

PMID:
31609773
3.

Incorporating Ontogeny in Physiologically Based Pharmacokinetic Modeling to Improve Pediatric Drug Development: What We Know About Developmental Changes in Membrane Transporters.

Cheung KWK, van Groen BD, Burckart GJ, Zhang L, de Wildt SN, Huang SM.

J Clin Pharmacol. 2019 Sep;59 Suppl 1:S56-S69. doi: 10.1002/jcph.1489.

PMID:
31502692
4.

Population Pharmacokinetics of Intravenous Salbutamol in Children with Refractory Status Asthmaticus.

Vet NJ, de Winter BCM, Koninckx M, Boeschoten SA, Boehmer ALM, Verhallen JT, Plötz FB, Vaessen-Verberne AA, van der Nagel BCH, Knibbe CAJ, Buysse CMP, de Wildt SN, Koch BCP, de Hoog M.

Clin Pharmacokinet. 2019 Aug 21. doi: 10.1007/s40262-019-00811-y. [Epub ahead of print]

PMID:
31432470
5.

Pharmacokinetics and Target Attainment of Antibiotics in Critically Ill Children: A Systematic Review of Current Literature.

Hartman SJF, Brüggemann RJ, Orriëns L, Dia N, Schreuder MF, de Wildt SN.

Clin Pharmacokinet. 2019 Aug 20. doi: 10.1007/s40262-019-00813-w. [Epub ahead of print] Review.

PMID:
31432468
6.

Pharmacokinetics in children with chronic kidney disease.

Schijvens AM, de Wildt SN, Schreuder MF.

Pediatr Nephrol. 2019 Aug 2. doi: 10.1007/s00467-019-04304-9. [Epub ahead of print] Review.

PMID:
31375913
7.

Dose-linearity of the pharmacokinetics of an intravenous [14 C]midazolam microdose in children.

van Groen BD, Vaes WH, Park BK, Krekels EHJ, van Duijn E, Kõrgvee LT, Maruszak W, Grynkiewicz G, Garner RC, Knibbe CAJ, Tibboel D, de Wildt SN, Turner MA.

Br J Clin Pharmacol. 2019 Oct;85(10):2332-2340. doi: 10.1111/bcp.14047. Epub 2019 Jul 30.

8.

A Pediatric Covariate Function for CYP3A-Mediated Midazolam Clearance Can Scale Clearance of Selected CYP3A Substrates in Children.

Brussee JM, Krekels EHJ, Calvier EAM, Palić S, Rostami-Hodjegan A, Danhof M, Barrett JS, de Wildt SN, Knibbe CAJ.

AAPS J. 2019 Jun 27;21(5):81. doi: 10.1208/s12248-019-0351-9.

9.

Orodispersible minitablets of enalapril for use in children with heart failure (LENA): Rationale and protocol for a multicentre pharmacokinetic bridging study and follow-up safety study.

Bajcetic M, de Wildt SN, Dalinghaus M, Breitkreutz J, Klingmann I, Lagler FB, Keatley-Clarke A, Breur JM, Male C, Jovanovic I, Szatmári A, Ablonczy L, Burckhardt BB, Cawello W, Kleine K, Obarcanin E, Spatenkova L, Swoboda V, van der Meulen M, Wagner P, Walsh J, Läer S.

Contemp Clin Trials Commun. 2019 Jun 8;15:100393. doi: 10.1016/j.conctc.2019.100393. eCollection 2019 Sep.

10.

Pharmacotherapy in paediatric heart failure: a Delphi process.

Díez CC, Khalil F, Makowski N, Schwender H, Jovanovic I, Dalinghaus M, Walsh J, van der Meulen M, Bajcetic M, de Wildt SN, Läer S.

Cardiol Young. 2019 Jul;29(7):869-876. doi: 10.1017/S1047951119000660. Epub 2019 Jun 24.

PMID:
31230601
11.

Correction to: Gabapentin as add-on to morphine for severe neuropathic or mixed pain in children from age 3 months to 18 years - evaluation of the safety, pharmacokinetics, and efficacy of a new gabapentin liquid formulation: study protocol for a randomized controlled trial.

de Leeuw TG, Mangiarini L, Lundin R, Kaguelidou F, van der Zanden T, Della Pasqua O, Tibboel D, Ceci A, de Wildt SN; GAPP consortium.

Trials. 2019 Jun 20;20(1):368. doi: 10.1186/s13063-019-3519-9.

12.

Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis.

Verscheijden LFM, Koenderink JB, de Wildt SN, Russel FGM.

PLoS Comput Biol. 2019 Jun 13;15(6):e1007117. doi: 10.1371/journal.pcbi.1007117. eCollection 2019 Jun.

13.

A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization.

Cheung KWK, van Groen BD, Spaans E, van Borselen MD, de Bruijn ACJM, Simons-Oosterhuis Y, Tibboel D, Samsom JN, Verdijk RM, Smeets B, Zhang L, Huang SM, Giacomini KM, de Wildt SN.

Clin Pharmacol Ther. 2019 Nov;106(5):1083-1092. doi: 10.1002/cpt.1516. Epub 2019 Jul 3.

PMID:
31127606
14.

Target attainment of cefotaxime in critically ill children with meningococcal septic shock as a model for cefotaxime dosing in severe pediatric sepsis.

Hartman SJF, Boeddha NP, Ekinci E, Koch BCP, Donders R, Hazelzet JA, Driessen GJ, de Wildt SN.

Eur J Clin Microbiol Infect Dis. 2019 Jul;38(7):1255-1260. doi: 10.1007/s10096-019-03535-w. Epub 2019 Apr 9.

15.

Pharmacotherapeutic management of paediatric heart failure and ACE-I use patterns: a European survey.

Castro Díez C, Khalil F, Schwender H, Dalinghaus M, Jovanovic I, Makowski N, Male C, Bajcetic M, van der Meulen M, de Wildt SN, Ablonczy L, Szatmári A, Klingmann I, Walsh J, Läer S.

BMJ Paediatr Open. 2019 Jan 31;3(1):e000365. doi: 10.1136/bmjpo-2018-000365. eCollection 2019.

16.

Non-inferiority double-blind randomised controlled trial comparing gabapentin versus tramadol for the treatment of chronic neuropathic or mixed pain in children and adolescents: the GABA-1 trial-a study protocol.

Kaguelidou F, Le Roux E, Mangiarini L, Lundin R, de Leeuw TG, Della Pasqua O, Felisi M, Bonifazi D, Tibboel D, Ceci A, de Wildt SN, Alberti C; GAPP consortium.

BMJ Open. 2019 Feb 20;9(2):e023296. doi: 10.1136/bmjopen-2018-023296.

17.

Macrolide prescription in Dutch children: compliance with guidelines.

Bandell RAM, Dekkers T, Semmekrot BA, de Wildt SN, Fleuren HWHA, Warlé-van Herwaarden MF, Füssenich P, Gerrits GP, Kramers C.

Eur J Clin Microbiol Infect Dis. 2019 Apr;38(4):675-681. doi: 10.1007/s10096-019-03473-7. Epub 2019 Jan 24.

PMID:
30680574
18.

Gabapentin as add-on to morphine for severe neuropathic or mixed pain in children from age 3 months to 18 years - evaluation of the safety, pharmacokinetics, and efficacy of a new gabapentin liquid formulation: study protocol for a randomized controlled trial.

de Leeuw TG, Mangiarini L, Lundin R, Kaguelidou F, van der Zanden T, Pasqua OD, Tibboel D, Ceci A, de Wildt SN; GAPP consortium.

Trials. 2019 Jan 15;20(1):49. doi: 10.1186/s13063-018-3169-3. Erratum in: Trials. 2019 Jun 20;20(1):368.

19.

Reply to Stamer, Ulrike; Stüber, Frank, regarding their comment 'Analgesic efficacy of dipyrone children - Still an absence of evidence'.

de Leeuw TG, de Wildt SN.

Paediatr Anaesth. 2018 Dec;28(12):1156. doi: 10.1111/pan.13484. No abstract available.

PMID:
30511794
20.

The potential impact of hematocrit correction on evaluation of tacrolimus target exposure in pediatric kidney transplant patients.

Schijvens AM, van Hesteren FHS, Cornelissen EAM, Bootsma-Robroeks CMHHT, Brüggemann RJM, Burger DM, de Wildt SN, Schreuder MF, Ter Heine R.

Pediatr Nephrol. 2019 Mar;34(3):507-515. doi: 10.1007/s00467-018-4117-x. Epub 2018 Oct 30.

21.

Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants.

van Groen BD, van de Steeg E, Mooij MG, van Lipzig MMH, de Koning BAE, Verdijk RM, Wortelboer HM, Gaedigk R, Bi C, Leeder JS, van Schaik RHN, van Rosmalen J, Tibboel D, Vaes WH, de Wildt SN.

Eur J Pharm Sci. 2018 Nov 1;124:217-227. doi: 10.1016/j.ejps.2018.08.042. Epub 2018 Aug 30.

22.

Characterization of Intestinal and Hepatic CYP3A-Mediated Metabolism of Midazolam in Children Using a Physiological Population Pharmacokinetic Modelling Approach.

Brussee JM, Yu H, Krekels EHJ, Palić S, Brill MJE, Barrett JS, Rostami-Hodjegan A, de Wildt SN, Knibbe CAJ.

Pharm Res. 2018 Jul 30;35(9):182. doi: 10.1007/s11095-018-2458-6.

23.

Combining Brain Microdialysis and Translational Pharmacokinetic Modeling to Predict Drug Concentrations in Pediatric Severe Traumatic Brain Injury: The Next Step Toward Evidence-Based Pharmacotherapy?

Ketharanathan N, Yamamoto Y, Rohlwink UK, Wildschut ED, Mathôt RAA, de Lange ECM, de Wildt SN, Argent AC, Tibboel D, Figaji AA.

J Neurotrauma. 2019 Jan 1;36(1):111-117. doi: 10.1089/neu.2017.5588. Epub 2018 Sep 6.

PMID:
30019622
24.

Clinically effective implementation of intravenous paracetamol as primary analgesia after major surgery in neonates and young infants.

Baarslag MA, Ista E, de Leeuw T, van Rosmalen J, Tibboel D, van Dijk M, de Wildt SN.

Arch Dis Child. 2018 Dec;103(12):1168-1169. doi: 10.1136/archdischild-2018-315379. Epub 2018 Jul 10. No abstract available.

PMID:
29991471
25.

Hemodynamic Tolerance to IV Clonidine Infusion in the PICU.

Kleiber N, van Rosmalen J, Tibboel D, de Wildt SN.

Pediatr Crit Care Med. 2018 Aug;19(8):e409-e416. doi: 10.1097/PCC.0000000000001602.

PMID:
29912068
26.

The Ontogeny of UDP-glucuronosyltransferase Enzymes, Recommendations for Future Profiling Studies and Application Through Physiologically Based Pharmacokinetic Modelling.

Badée J, Fowler S, de Wildt SN, Collier AC, Schmidt S, Parrott N.

Clin Pharmacokinet. 2019 Feb;58(2):189-211. doi: 10.1007/s40262-018-0681-2. Review.

PMID:
29862468
27.

Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium.

Evers R, Piquette-Miller M, Polli JW, Russel FGM, Sprowl JA, Tohyama K, Ware JA, de Wildt SN, Xie W, Brouwer KLR; International Transporter Consortium.

Clin Pharmacol Ther. 2018 Nov;104(5):900-915. doi: 10.1002/cpt.1115. Epub 2018 Jul 12.

28.

First-Pass CYP3A-Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates.

Brussee JM, Yu H, Krekels EHJ, de Roos B, Brill MJE, van den Anker JN, Rostami-Hodjegan A, de Wildt SN, Knibbe CAJ.

CPT Pharmacometrics Syst Pharmacol. 2018 Jun;7(6):374-383. doi: 10.1002/psp4.12295. Epub 2018 May 10.

29.

Pharmacokinetic studies in children: recommendations for practice and research.

Barker CIS, Standing JF, Kelly LE, Hanly Faught L, Needham AC, Rieder MJ, de Wildt SN, Offringa M.

Arch Dis Child. 2018 Jul;103(7):695-702. doi: 10.1136/archdischild-2017-314506. Epub 2018 Apr 19. Review.

30.

Perspectives of adolescents on decision making about participation in a biobank study: a pilot study.

Grootens-Wiegers P, Visser EG, van Rossum AMC, van Waardhuizen CN, de Wildt SN, Sweep B, van den Broek JM, de Vries MC.

BMJ Paediatr Open. 2017 Aug 23;1(1):e000111. doi: 10.1136/bmjpo-2017-000111. eCollection 2017.

31.

Oral lorazepam can be substituted for intravenous midazolam when weaning paediatric intensive care patients off sedation.

van der Vossen AC, van Nuland M, Ista EG, de Wildt SN, Hanff LM.

Acta Paediatr. 2018 Mar 23. doi: 10.1111/apa.14327. [Epub ahead of print]

32.

Pharmacology and pharmacogenetics of prednisone and prednisolone in patients with nephrotic syndrome.

Schijvens AM, Ter Heine R, de Wildt SN, Schreuder MF.

Pediatr Nephrol. 2019 Mar;34(3):389-403. doi: 10.1007/s00467-018-3929-z. Epub 2018 Mar 16.

33.

Reply to Ziesenitz, Victoria; Erb Thomas; Trachsel, Daniel; van den Anker Johannes, regarding their comment "Safety of dipryone (metamizole) in children-what's the risk of agranulocytosis?"

de Leeuw TG, Dirckx M, de Wildt SN.

Paediatr Anaesth. 2018 Mar;28(3):305-306. doi: 10.1111/pan.13326. No abstract available.

PMID:
29436141
34.

The use of dipyrone (metamizol) as an analgesic in children: what is the evidence? A review.

de Leeuw TG, Dirckx M, Gonzalez Candel A, Scoones GP, Huygen FJPM, de Wildt SN.

Paediatr Anaesth. 2018 Mar;28(3):309. doi: 10.1111/pan.13341. No abstract available.

PMID:
29436132
35.

Monitoring Haloperidol Plasma Concentration and Associated Adverse Events in Critically Ill Children With Delirium: First Results of a Clinical Protocol Aimed to Monitor Efficacy and Safety.

Slooff VD, van den Dungen DK, van Beusekom BS, Jessurun N, Ista E, Tibboel D, de Wildt SN.

Pediatr Crit Care Med. 2018 Feb;19(2):e112-e119. doi: 10.1097/PCC.0000000000001414.

PMID:
29239979
36.

Question 1: How safe are ACE inhibitors for heart failure in children?

van der Meulen M, Dalinghaus M, Burch M, Szatmari A, Castro Diez C, Khalil F, Swoboda V, Breur J, Bajcetic M, Jovanovic I, Lagler FB, Klingmann I, Laeer S, de Wildt SN.

Arch Dis Child. 2018 Jan;103(1):106-109. doi: 10.1136/archdischild-2017-312774. Epub 2017 Oct 26. No abstract available.

PMID:
29074732
37.

Predicting CYP3A-mediated midazolam metabolism in critically ill neonates, infants, children and adults with inflammation and organ failure.

Brussee JM, Vet NJ, Krekels EHJ, Valkenburg AJ, Jacqz-Aigrain E, van Gerven JMA, Swart EL, van den Anker JN, Tibboel D, de Hoog M, de Wildt SN, Knibbe CAJ.

Br J Clin Pharmacol. 2018 Feb;84(2):358-368. doi: 10.1111/bcp.13459. Epub 2017 Nov 29.

38.

The use of dipyrone (metamizol) as an analgesic in children: What is the evidence? A review.

de Leeuw TG, Dirckx M, Gonzalez Candel A, Scoones GP, Huygen FJPM, de Wildt SN.

Paediatr Anaesth. 2017 Dec;27(12):1193-1201. doi: 10.1111/pan.13257. Epub 2017 Oct 12. Review. Erratum in: Paediatr Anaesth. 2018 Mar;28(3):309.

PMID:
29024184
39.

Roles of Clinical Research Networks in Pediatric Drug Development.

Turner MA, Attar S, de Wildt SN, Vassal G, Mangiarini L, Giaquinto C.

Clin Ther. 2017 Oct;39(10):1939-1948. doi: 10.1016/j.clinthera.2017.09.001. Epub 2017 Sep 22. Review.

PMID:
28943118
40.

Advanced cancer pain: the search for genetic factors correlated with interindividual variability in opioid requirement.

Matic M, Jongen JL, Elens L, de Wildt SN, Tibboel D, Sillevis Smitt PA, van Schaik RH.

Pharmacogenomics. 2017 Aug;18(12):1133-1142. doi: 10.2217/pgs-2017-0060. Epub 2017 Jul 26.

PMID:
28745577
41.

Reply.

Matic M, van den Bosch GE, de Wildt SN, Tibboel D, van Schaik RHN.

Pain. 2017 Aug;158(8):1623. doi: 10.1097/j.pain.0000000000000945. No abstract available.

PMID:
28715358
42.

A Population Pharmacokinetic Model to Predict the Individual Starting Dose of Tacrolimus Following Pediatric Renal Transplantation.

Andrews LM, Hesselink DA, van Gelder T, Koch BCP, Cornelissen EAM, Brüggemann RJM, van Schaik RHN, de Wildt SN, Cransberg K, de Winter BCM.

Clin Pharmacokinet. 2018 Apr;57(4):475-489. doi: 10.1007/s40262-017-0567-8.

43.

Analgesia and Opioids: A Pharmacogenetics Shortlist for Implementation in Clinical Practice.

Matic M, de Wildt SN, Tibboel D, van Schaik RHN.

Clin Chem. 2017 Jul;63(7):1204-1213. doi: 10.1373/clinchem.2016.264986. Review.

44.

Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future.

Darwich AS, Ogungbenro K, Vinks AA, Powell JR, Reny JL, Marsousi N, Daali Y, Fairman D, Cook J, Lesko LJ, McCune JS, Knibbe C, de Wildt SN, Leeder JS, Neely M, Zuppa AF, Vicini P, Aarons L, Johnson TN, Boiani J, Rostami-Hodjegan A.

Clin Pharmacol Ther. 2017 May;101(5):646-656. doi: 10.1002/cpt.659. Epub 2017 Apr 4. Review.

PMID:
28182269
45.

Successful Use of [14C]Paracetamol Microdosing to Elucidate Developmental Changes in Drug Metabolism.

Mooij MG, van Duijn E, Knibbe CAJ, Allegaert K, Windhorst AD, van Rosmalen J, Hendrikse NH, Tibboel D, Vaes WHJ, de Wildt SN.

Clin Pharmacokinet. 2017 Oct;56(10):1185-1195. doi: 10.1007/s40262-017-0508-6.

46.

Population pharmacokinetics of intravenous clonidine for sedation during paediatric extracorporeal membrane oxygenation and continuous venovenous hemofiltration.

Kleiber N, Mathôt RAA, Ahsman MJ, Wildschut ED, Tibboel D, de Wildt SN.

Br J Clin Pharmacol. 2017 Jun;83(6):1227-1239. doi: 10.1111/bcp.13235. Epub 2017 Feb 27.

47.

Developing a paediatric drug formulary for the Netherlands.

van der Zanden TM, de Wildt SN, Liem Y, Offringa M, de Hoog M; Dutch Paediatric Pharmacotherapy Expertise Network NKFK (Nederlands Kenniscentrum voor Farmacotherapie bij Kinderen).

Arch Dis Child. 2017 Apr;102(4):357-361. doi: 10.1136/archdischild-2016-311674. Epub 2016 Oct 31. Review.

PMID:
27799154
48.

Genetic variants associated with thermal pain sensitivity in a paediatric population.

Matic M, van den Bosch GE, de Wildt SN, Tibboel D, van Schaik RH.

Pain. 2016 Nov;157(11):2476-2482.

PMID:
27541715
49.

Short-Term Health-Related Quality of Life of Critically Ill Children Following Daily Sedation Interruption.

Vet NJ, de Wildt SN, Verlaat CW, Mooij MG, Tibboel D, de Hoog M, Buysse CM; Stichting Kinder Intensive Care (Dutch collaborative PICU research network).

Pediatr Crit Care Med. 2016 Nov;17(11):e513-e520.

PMID:
27662565
50.

Sedation in Critically Ill Children with Respiratory Failure.

Vet NJ, Kleiber N, Ista E, de Hoog M, de Wildt SN.

Front Pediatr. 2016 Aug 24;4:89. doi: 10.3389/fped.2016.00089. eCollection 2016. Review.

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