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Items: 12


Adaptive mutations in replicase transmembrane subunits can counteract inhibition of equine arteritis virus RNA synthesis by cyclophilin inhibitors.

de Wilde AH, Boomaars-van der Zanden AL, de Jong AWM, Barcéna M, Snijder EJ, Posthuma CC.

J Virol. 2019 Jun 26. pii: JVI.00490-19. doi: 10.1128/JVI.00490-19. [Epub ahead of print]


Cyclophilins and cyclophilin inhibitors in nidovirus replication.

de Wilde AH, Pham U, Posthuma CC, Snijder EJ.

Virology. 2018 Sep;522:46-55. doi: 10.1016/j.virol.2018.06.011. Epub 2018 Jul 12. Review.


Coronaviruses and arteriviruses display striking differences in their cyclophilin A-dependence during replication in cell culture.

de Wilde AH, Zevenhoven-Dobbe JC, Beugeling C, Chatterji U, de Jong D, Gallay P, Szuhai K, Posthuma CC, Snijder EJ.

Virology. 2018 Apr;517:148-156. doi: 10.1016/j.virol.2017.11.022. Epub 2017 Dec 15.


Host Factors in Coronavirus Replication.

de Wilde AH, Snijder EJ, Kikkert M, van Hemert MJ.

Curr Top Microbiol Immunol. 2018;419:1-42. doi: 10.1007/82_2017_25. Review.


Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model.

de Wilde AH, Falzarano D, Zevenhoven-Dobbe JC, Beugeling C, Fett C, Martellaro C, Posthuma CC, Feldmann H, Perlman S, Snijder EJ.

Virus Res. 2017 Jan 15;228:7-13. doi: 10.1016/j.virusres.2016.11.011. Epub 2016 Nov 10.


Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity.

Peters HL, Jochmans D, de Wilde AH, Posthuma CC, Snijder EJ, Neyts J, Seley-Radtke KL.

Bioorg Med Chem Lett. 2015 Aug 1;25(15):2923-6. doi: 10.1016/j.bmcl.2015.05.039. Epub 2015 May 23.


A Kinome-Wide Small Interfering RNA Screen Identifies Proviral and Antiviral Host Factors in Severe Acute Respiratory Syndrome Coronavirus Replication, Including Double-Stranded RNA-Activated Protein Kinase and Early Secretory Pathway Proteins.

de Wilde AH, Wannee KF, Scholte FE, Goeman JJ, Ten Dijke P, Snijder EJ, Kikkert M, van Hemert MJ.

J Virol. 2015 Aug;89(16):8318-33. doi: 10.1128/JVI.01029-15. Epub 2015 Jun 3.


Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture.

de Wilde AH, Jochmans D, Posthuma CC, Zevenhoven-Dobbe JC, van Nieuwkoop S, Bestebroer TM, van den Hoogen BG, Neyts J, Snijder EJ.

Antimicrob Agents Chemother. 2014 Aug;58(8):4875-84. doi: 10.1128/AAC.03011-14. Epub 2014 May 19.


MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment.

de Wilde AH, Raj VS, Oudshoorn D, Bestebroer TM, van Nieuwkoop S, Limpens RW, Posthuma CC, van der Meer Y, Bárcena M, Haagmans BL, Snijder EJ, van den Hoogen BG.

J Gen Virol. 2013 Aug;94(Pt 8):1749-60. doi: 10.1099/vir.0.052910-0. Epub 2013 Apr 25.


Cyclophilin inhibitors block arterivirus replication by interfering with viral RNA synthesis.

de Wilde AH, Li Y, van der Meer Y, Vuagniaux G, Lysek R, Fang Y, Snijder EJ, van Hemert MJ.

J Virol. 2013 Feb;87(3):1454-64. doi: 10.1128/JVI.02078-12. Epub 2012 Nov 14.


Cyclosporin A inhibits the replication of diverse coronaviruses.

de Wilde AH, Zevenhoven-Dobbe JC, van der Meer Y, Thiel V, Narayanan K, Makino S, Snijder EJ, van Hemert MJ.

J Gen Virol. 2011 Nov;92(Pt 11):2542-8. doi: 10.1099/vir.0.034983-0. Epub 2011 Jul 13.


The in vitro RNA synthesizing activity of the isolated arterivirus replication/transcription complex is dependent on a host factor.

van Hemert MJ, de Wilde AH, Gorbalenya AE, Snijder EJ.

J Biol Chem. 2008 Jun 13;283(24):16525-36. doi: 10.1074/jbc.M708136200. Epub 2008 Apr 14.

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