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Items: 1 to 50 of 55

1.

Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1.

Cyranka M, Veprik A, McKay EJ, van Loon N, Thijsse A, Cotter L, Hare N, Saibudeen A, Lingam S, Pires E, Larraufie P, Reimann F, Gribble F, Stewart M, Bentley E, Lear P, McCullagh J, Cantley J, Cox RD, de Wet H.

Obesity (Silver Spring). 2019 Aug;27(8):1292-1304. doi: 10.1002/oby.22521.

PMID:
31338999
2.

A Ketone Ester Drink Lowers Human Ghrelin and Appetite.

Stubbs BJ, Cox PJ, Evans RD, Cyranka M, Clarke K, de Wet H.

Obesity (Silver Spring). 2018 Feb;26(2):269-273. doi: 10.1002/oby.22051. Epub 2017 Nov 6.

3.

Perceived barriers and facilitators to HIV testing in South African communities.

De Wet H, Kagee A.

J Health Psychol. 2018 Oct;23(12):1635-1645. doi: 10.1177/1359105316664140. Epub 2016 Aug 30.

PMID:
27577040
4.

Plants used to treat skin diseases in northern Maputaland, South Africa: antimicrobial activity and in vitro permeability studies.

Nciki S, Vuuren S, van Eyk A, de Wet H.

Pharm Biol. 2016 Nov;54(11):2420-2436. Epub 2016 May 3.

PMID:
27137350
5.

Carpal tunnel syndrome: The role of collagen gene variants.

Dada S, Burger MC, Massij F, de Wet H, Collins M.

Gene. 2016 Aug 1;587(1):53-8. doi: 10.1016/j.gene.2016.04.030. Epub 2016 Apr 14.

PMID:
27090000
6.

Correction: Molecular action of sulphonylureas on KATP channels: a real partnership between drugs and nucleotides.

de Wet H, Proks P.

Biochem Soc Trans. 2015 Dec;43(6):1297. doi: 10.1042/BST0431297. Epub 2015 Nov 27. No abstract available.

PMID:
26614675
7.

Matrix metalloproteinase genes on chromosome 11q22 and risk of carpal tunnel syndrome.

Burger MC, De Wet H, Collins M.

Rheumatol Int. 2016 Mar;36(3):413-9. doi: 10.1007/s00296-015-3385-z. Epub 2015 Oct 31.

PMID:
26521080
8.

Molecular action of sulphonylureas on KATP channels: a real partnership between drugs and nucleotides.

de Wet H, Proks P.

Biochem Soc Trans. 2015 Oct;43(5):901-7. doi: 10.1042/BST20150096. Review. Erratum in: Biochem Soc Trans. 2015 Dec;43(6):1297.

9.

Antimicrobial evaluation of plants used for the treatment of diarrhoea in a rural community in northern Maputaland, KwaZulu-Natal, South Africa.

van Vuuren SF, Nkwanyana MN, de Wet H.

BMC Complement Altern Med. 2015 Mar 10;15:53. doi: 10.1186/s12906-015-0570-2.

10.

Interleukin and growth factor gene variants and risk of carpal tunnel syndrome.

Burger MC, de Wet H, Collins M.

Gene. 2015 Jun 10;564(1):67-72. doi: 10.1016/j.gene.2015.03.047. Epub 2015 Mar 24.

PMID:
25813875
11.

Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A KATP channels: a mechanistic study.

Proks P, de Wet H, Ashcroft FM.

J Gen Physiol. 2014 Nov;144(5):469-86. doi: 10.1085/jgp.201411222.

12.

The BGN and ACAN genes and carpal tunnel syndrome.

Burger MC, De Wet H, Collins M.

Gene. 2014 Nov 10;551(2):160-6. doi: 10.1016/j.gene.2014.08.051. Epub 2014 Aug 27.

PMID:
25173489
13.

The COL5A1 gene is associated with increased risk of carpal tunnel syndrome.

Burger M, de Wet H, Collins M.

Clin Rheumatol. 2015 Apr;34(4):767-74. doi: 10.1007/s10067-014-2727-7. Epub 2014 Jun 26.

PMID:
24966028
14.

Plants traditionally used individually and in combination to treat sexually transmitted infections in northern Maputaland, South Africa: antimicrobial activity and cytotoxicity.

Naidoo D, van Vuuren SF, van Zyl RL, de Wet H.

J Ethnopharmacol. 2013 Oct 7;149(3):656-67. doi: 10.1016/j.jep.2013.07.018. Epub 2013 Jul 20.

PMID:
23880127
15.

Medicinal plants used for the treatment of various skin disorders by a rural community in northern Maputaland, South Africa.

De Wet H, Nciki S, van Vuuren SF.

J Ethnobiol Ethnomed. 2013 Jul 19;9:51. doi: 10.1186/1746-4269-9-51.

16.

Molecular mechanism of sulphonylurea block of K(ATP) channels carrying mutations that impair ATP inhibition and cause neonatal diabetes.

Proks P, de Wet H, Ashcroft FM.

Diabetes. 2013 Nov;62(11):3909-19. doi: 10.2337/db13-0531. Epub 2013 Jul 8.

17.

Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles.

Fotinou C, Aittoniemi J, de Wet H, Polidori A, Pucci B, Sansom MS, Vénien-Bryan C, Ashcroft FM.

FEBS J. 2013 Feb;280(4):1051-63. doi: 10.1111/febs.12097. Epub 2013 Jan 27.

18.

An antimicrobial evaluation of plants used for the treatment of respiratory infections in rural Maputaland, KwaZulu-Natal, South Africa.

York T, van Vuuren SF, de Wet H.

J Ethnopharmacol. 2012 Oct 31;144(1):118-27. doi: 10.1016/j.jep.2012.08.038. Epub 2012 Sep 1.

PMID:
22960551
19.

A universally conserved residue in the SUR1 subunit of the KATP channel is essential for translating nucleotide binding at SUR1 into channel opening.

de Wet H, Shimomura K, Aittoniemi J, Ahmad N, Lafond M, Sansom MS, Ashcroft FM.

J Physiol. 2012 Oct 15;590(20):5025-36. doi: 10.1113/jphysiol.2012.236075. Epub 2012 Jul 16.

20.

Transvaginal posterior colporrhaphy combined with laparoscopic ventral mesh rectopexy for isolated Grade III rectocele: a prospective study of 27 patients.

van der Hagen SJ, van Gemert WG, Soeters PB, de Wet H, Baeten CG.

Colorectal Dis. 2012 Nov;14(11):1398-402. doi: 10.1111/j.1463-1318.2012.03023.x.

PMID:
22405411
21.

Polar compounds isolated from the leaves of Albertisia delagoensis (Menispermaceae).

Hawkes GE, de Wet H, Li J.

Molecules. 2011 Nov 2;16(11):9153-60. doi: 10.3390/molecules16119153.

22.

MKP-1 knockout does not prevent glucocorticoid-induced bone disease in mice.

Conradie MM, Cato AC, Ferris WF, de Wet H, Horsch K, Hough S.

Calcif Tissue Int. 2011 Sep;89(3):221-7. doi: 10.1007/s00223-011-9509-x. Epub 2011 Jun 23.

PMID:
21698455
23.

Plants used for treating respiratory infections in rural Maputaland, KwaZulu-Natal, South Africa.

York T, de Wet H, van Vuuren SF.

J Ethnopharmacol. 2011 Jun 1;135(3):696-710. doi: 10.1016/j.jep.2011.03.072. Epub 2011 Apr 8.

PMID:
21497646
24.

Alkaloidal variation in cissampelos capensis (Menispermaceae).

de Wet H, van Heerden FR, van Wyk BE.

Molecules. 2011 Apr 7;16(4):3001-9. doi: 10.3390/molecules16043001.

25.

Activation of the K(ATP) channel by Mg-nucleotide interaction with SUR1.

Proks P, de Wet H, Ashcroft FM.

J Gen Physiol. 2010 Oct;136(4):389-405. doi: 10.1085/jgp.201010475.

26.

Disease progression and search for monogenic diabetes among children with new onset type 1 diabetes negative for ICA, GAD- and IA-2 Antibodies.

Pörksen S, Laborie LB, Nielsen L, Louise Max Andersen M, Sandal T, de Wet H, Schwarcz E, Aman J, Swift P, Kocova M, Schönle EJ, de Beaufort C, Hougaard P, Ashcroft F, Molven A, Knip M, Mortensen HB, Hansen L, Njølstad PR; Hvidøre Study Group on Childhood Diabetes.

BMC Endocr Disord. 2010 Sep 23;10:16. doi: 10.1186/1472-6823-10-16.

27.

The ATPase activities of sulfonylurea receptor 2A and sulfonylurea receptor 2B are influenced by the C-terminal 42 amino acids.

de Wet H, Fotinou C, Amad N, Dreger M, Ashcroft FM.

FEBS J. 2010 Jun;277(12):2654-62. doi: 10.1111/j.1742-464X.2010.07675.x.

28.

Asymmetric switching in a homodimeric ABC transporter: a simulation study.

Aittoniemi J, de Wet H, Ashcroft FM, Sansom MS.

PLoS Comput Biol. 2010 Apr 29;6(4):e1000762. doi: 10.1371/journal.pcbi.1000762.

29.

Medicinal plants used for the treatment of diarrhoea in northern Maputaland, KwaZulu-Natal Province, South Africa.

de Wet H, Nkwanyana MN, van Vuuren SF.

J Ethnopharmacol. 2010 Jul 20;130(2):284-9. doi: 10.1016/j.jep.2010.05.004. Epub 2010 May 7.

PMID:
20452415
30.

Analysing steroid modulation of BK(Ca) channels reconstituted into planar lipid bilayers.

de Wet H, Lippiat JD, Allen M.

Methods Mol Biol. 2008;491:177-86. doi: 10.1007/978-1-59745-526-8_14.

PMID:
18998093
31.

Review. SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator.

Aittoniemi J, Fotinou C, Craig TJ, de Wet H, Proks P, Ashcroft FM.

Philos Trans R Soc Lond B Biol Sci. 2009 Jan 27;364(1514):257-67. doi: 10.1098/rstb.2008.0142. Review.

32.

A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes.

de Wet H, Proks P, Lafond M, Aittoniemi J, Sansom MS, Flanagan SE, Pearson ER, Hattersley AT, Ashcroft FM.

EMBO Rep. 2008 Jul;9(7):648-54. doi: 10.1038/embor.2008.71. Epub 2008 May 23.

33.
34.

Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes.

de Wet H, Rees MG, Shimomura K, Aittoniemi J, Patch AM, Flanagan SE, Ellard S, Hattersley AT, Sansom MS, Ashcroft FM.

Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):18988-92. Epub 2007 Nov 19.

35.

Vanadate prevents glucocorticoid-induced apoptosis of osteoblasts in vitro and osteocytes in vivo.

Conradie MM, de Wet H, Kotze DD, Burrin JM, Hough FS, Hulley PA.

J Endocrinol. 2007 Nov;195(2):229-40.

36.

Mitogen-activated protein kinase phosphatase 1/dual specificity phosphatase 1 mediates glucocorticoid inhibition of osteoblast proliferation.

Horsch K, de Wet H, Schuurmans MM, Allie-Reid F, Cato AC, Cunningham J, Burrin JM, Hough FS, Hulley PA.

Mol Endocrinol. 2007 Dec;21(12):2929-40. Epub 2007 Aug 30.

37.

A novel mutation causing DEND syndrome: a treatable channelopathy of pancreas and brain.

Shimomura K, Hörster F, de Wet H, Flanagan SE, Ellard S, Hattersley AT, Wolf NI, Ashcroft F, Ebinger F.

Neurology. 2007 Sep 25;69(13):1342-9. Epub 2007 Jul 25.

PMID:
17652641
38.

Antiplasmodial activity and cytotoxicity of Albertisia delagoensis.

De Wet H, Van Heerden FR, Van Wyk BE, Van Zyl RL.

Fitoterapia. 2007 Sep;78(6):420-2. Epub 2007 May 24.

PMID:
17570613
39.

Studies of the ATPase activity of the ABC protein SUR1.

de Wet H, Mikhailov MV, Fotinou C, Dreger M, Craig TJ, Vénien-Bryan C, Ashcroft FM.

FEBS J. 2007 Jul;274(14):3532-3544. doi: 10.1111/j.1742-4658.2007.05879.x. Epub 2007 Jun 11.

40.

Modulation of the BK channel by estrogens: examination at single channel level.

De Wet H, Allen M, Holmes C, Stobbart M, Lippiat JD, Callaghan R.

Mol Membr Biol. 2006 Sep-Oct;23(5):420-9.

PMID:
17060159
41.

3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1.

Mikhailov MV, Campbell JD, de Wet H, Shimomura K, Zadek B, Collins RF, Sansom MS, Ford RC, Ashcroft FM.

EMBO J. 2005 Dec 7;24(23):4166-75. Epub 2005 Nov 24.

43.

Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters.

Di Pietro A, Conseil G, Pérez-Victoria JM, Dayan G, Baubichon-Cortay H, Trompier D, Steinfels E, Jault JM, de Wet H, Maitrejean M, Comte G, Boumendjel A, Mariotte AM, Dumontet C, McIntosh DB, Goffeau A, Castanys S, Gamarro F, Barron D.

Cell Mol Life Sci. 2002 Feb;59(2):307-22. Review.

PMID:
11915946
44.

Sequence requirements of the ATP-binding site within the C-terminal nucleotide-binding domain of mouse P-glycoprotein: structure-activity relationships for flavonoid binding.

de Wet H, McIntosh DB, Conseil G, Baubichon-Cortay H, Krell T, Jault JM, Daskiewicz JB, Barron D, Di Pietro A.

Biochemistry. 2001 Aug 28;40(34):10382-91.

PMID:
11513617
45.

Images in infectious diseases in obstetrics and gynecology. Lethal sepsis due to traditional healing.

Donders GG, De Wet HG, De Jonghe E.

Infect Dis Obstet Gynecol. 2000;8(2):76. No abstract available.

46.

ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yor1p.

Decottignies A, Grant AM, Nichols JW, de Wet H, McIntosh DB, Goffeau A.

J Biol Chem. 1998 May 15;273(20):12612-22.

47.

Rapid antigen tests for Neisseria gonorrhoeae and Chlamydia trachomatis are not accurate for screening women with disturbed vaginal lactobacillary flora.

Donders GG, van Gerven V, de Wet HG, van Straten AM, de Boer F.

Scand J Infect Dis. 1996;28(6):559-62.

PMID:
9060056
48.

Practical application of data obtained from a Perinatal Problem Identification Programme.

Pattinson RC, de Jonge E, Pistorius LR, Howarth GR, de Wet H, Bremer P, Hay IT, Delport S.

S Afr Med J. 1995 Mar;85(3):131-2. No abstract available.

PMID:
7777952
49.

Lactobacilli in Papanicolaou smears, genital infections, and pregnancy.

Donders G, De Wet HG, Hooft P, Desmyter J.

Am J Perinatol. 1993 Sep;10(5):358-61.

PMID:
8240593
50.

Simultaneous dislocation of all five carpometacarpal joints.

Fayman M, Hugo B, de Wet H.

Plast Reconstr Surg. 1988 Jul;82(1):151-4.

PMID:
3380904

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