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Items: 1 to 50 of 69

1.

Hepatic Intra-arterial Delivery of a "Trojan-horses" Gene Therapy: A Pilot Study on Rabbit VX2 Hepatic Tumor Model.

Pellerin O, Amara I, Sapoval M, Méachi T, Déan C, Beaune P, de Waziers I.

Cardiovasc Intervent Radiol. 2018 Jan;41(1):153-162. doi: 10.1007/s00270-017-1833-8. Epub 2017 Oct 31.

PMID:
29090347
2.

Engineered mesenchymal stem cells as vectors in a suicide gene therapy against preclinical murine models for solid tumors.

Amara I, Pramil E, Senamaud-Beaufort C, Devillers A, Macedo R, Lescaille G, Seguin J, Tartour E, Lemoine FM, Beaune P, de Waziers I.

J Control Release. 2016 Oct 10;239:82-91. doi: 10.1016/j.jconrel.2016.08.019. Epub 2016 Aug 23.

PMID:
27565211
3.

Knocking Down TMPRSS2-ERG Fusion Oncogene by siRNA Could be an Alternative Treatment to Flutamide.

Urbinati G, de Waziers I, Slamiç M, Foussignière T, Ali HM, Desmaële D, Couvreur P, Massaad-Massade L.

Mol Ther Nucleic Acids. 2016 Mar 29;5:e301. doi: 10.1038/mtna.2016.16.

4.

Gene expression profiling of cytochromes P450, ABC transporters and their principal transcription factors in the amygdala and prefrontal cortex of alcoholics, smokers and drug-free controls by qRT-PCR.

Toselli F, de Waziers I, Dutheil M, Vincent M, Wilce PA, Dodd PR, Beaune P, Loriot MA, Gillam EM.

Xenobiotica. 2015;45(12):1129-37. doi: 10.3109/00498254.2015.1040102. Epub 2015 Jun 22.

PMID:
26095139
5.

Mesenchymal stem cells as cellular vehicles for prodrug gene therapy against tumors.

Amara I, Touati W, Beaune P, de Waziers I.

Biochimie. 2014 Oct;105:4-11. doi: 10.1016/j.biochi.2014.06.016. Epub 2014 Jun 27. Review.

PMID:
24977933
6.

Optimization and validation of a label-free MRM method for the quantification of cytochrome P450 isoforms in biological samples.

Al Ali A, Touboul D, Le Caër JP, Schmitz-Afonso I, Flinois JP, Marchetti C, De Waziers I, Brunelle A, Laprévote O, Beaune P.

Anal Bioanal Chem. 2014 Aug;406(20):4861-74. doi: 10.1007/s00216-014-7928-z. Epub 2014 Jun 22.

PMID:
24952904
7.

Important role of CYP2J2 in protein kinase inhibitor degradation: a possible role in intratumor drug disposition and resistance.

Narjoz C, Favre A, McMullen J, Kiehl P, Montemurro M, Figg WD, Beaune P, de Waziers I, Rochat B.

PLoS One. 2014 May 12;9(5):e95532. doi: 10.1371/journal.pone.0095532. eCollection 2014.

8.

A suicide gene therapy combining the improvement of cyclophosphamide tumor cytotoxicity and the development of an anti-tumor immune response.

Touati W, Tran T, Seguin J, Diry M, Flinois JP, Baillou C, Lescaille G, Andre F, Tartour E, Lemoine FM, Beaune P, de Waziers I.

Curr Gene Ther. 2014;14(3):236-46.

PMID:
24766134
9.

Combined transcriptomic-(1)H NMR metabonomic study reveals that monoethylhexyl phthalate stimulates adipogenesis and glyceroneogenesis in human adipocytes.

Ellero-Simatos S, Claus SP, Benelli C, Forest C, Letourneur F, Cagnard N, Beaune PH, de Waziers I.

J Proteome Res. 2011 Dec 2;10(12):5493-502. doi: 10.1021/pr200765v. Epub 2011 Nov 9.

10.

Colonization-induced host-gut microbial metabolic interaction.

Claus SP, Ellero SL, Berger B, Krause L, Bruttin A, Molina J, Paris A, Want EJ, de Waziers I, Cloarec O, Richards SE, Wang Y, Dumas ME, Ross A, Rezzi S, Kochhar S, Van Bladeren P, Lindon JC, Holmes E, Nicholson JK.

MBio. 2011 Mar 1;2(2):e00271-10. doi: 10.1128/mBio.00271-10. Print 2011.

11.

[Could idiosyncratic thinking fit with << omics >>?].

Narjoz C, Beaune P, de Waziers I.

Med Sci (Paris). 2010 Jun-Jul;26(6-7):641-6. doi: 10.1051/medsci/2010266-7641. Review. French.

12.

Xenobiotic-metabolizing cytochromes p450 in human white adipose tissue: expression and induction.

Ellero S, Chakhtoura G, Barreau C, Langouët S, Benelli C, Penicaud L, Beaune P, de Waziers I.

Drug Metab Dispos. 2010 Apr;38(4):679-86. doi: 10.1124/dmd.109.029249. Epub 2009 Dec 24.

PMID:
20035023
13.

Genomic consequences of cytochrome P450 2C9 overexpression in human hepatoma cells.

Narjoz C, Marisa L, Imbeaud S, Paris A, Delacroix H, Beaune P, De Waziers I.

Chem Res Toxicol. 2009 May;22(5):779-87. doi: 10.1021/tx800417u.

PMID:
19445531
14.

Xenobiotic-metabolizing enzymes and transporters in the normal human brain: regional and cellular mapping as a basis for putative roles in cerebral function.

Dutheil F, Dauchy S, Diry M, Sazdovitch V, Cloarec O, Mellottée L, Bièche I, Ingelman-Sundberg M, Flinois JP, de Waziers I, Beaune P, Declèves X, Duyckaerts C, Loriot MA.

Drug Metab Dispos. 2009 Jul;37(7):1528-38. doi: 10.1124/dmd.109.027011. Epub 2009 Apr 9.

PMID:
19359404
15.

ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier.

Dauchy S, Dutheil F, Weaver RJ, Chassoux F, Daumas-Duport C, Couraud PO, Scherrmann JM, De Waziers I, Declèves X.

J Neurochem. 2008 Dec;107(6):1518-28. doi: 10.1111/j.1471-4159.2008.05720.x.

16.

Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells.

Dauchy S, Miller F, Couraud PO, Weaver RJ, Weksler B, Romero IA, Scherrmann JM, De Waziers I, Declèves X.

Biochem Pharmacol. 2009 Mar 1;77(5):897-909. doi: 10.1016/j.bcp.2008.11.001. Epub 2008 Nov 12.

PMID:
19041851
17.

Improvement of cyclophosphamide activation by CYP2B6 mutants: from in silico to ex vivo.

Nguyen TA, Tychopoulos M, Bichat F, Zimmermann C, Flinois JP, Diry M, Ahlberg E, Delaforge M, Corcos L, Beaune P, Dansette P, André F, de Waziers I.

Mol Pharmacol. 2008 Apr;73(4):1122-33. doi: 10.1124/mol.107.042861. Epub 2008 Jan 22. Erratum in: Mol Pharmacol. 2008 Jun;73(6):1866.

PMID:
18212249
18.

Induction of glucokinase mRNA by dietary phenolic compounds in rat liver cells in vitro.

Valentová K, Truong NT, Moncion A, de Waziers I, Ulrichová J.

J Agric Food Chem. 2007 Sep 19;55(19):7726-31. Epub 2007 Aug 23.

PMID:
17715892
19.

Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP)1, CYP2 and CYP3 families in 22 different human tissues.

Bièche I, Narjoz C, Asselah T, Vacher S, Marcellin P, Lidereau R, Beaune P, de Waziers I.

Pharmacogenet Genomics. 2007 Sep;17(9):731-42.

PMID:
17700362
20.

Simultaneous measurement of 23 isoforms from the human cytochrome P450 families 1 to 3 by quantitative reverse transcriptase-polymerase chain reaction.

Girault I, Rougier N, Chesné C, Lidereau R, Beaune P, Bieche I, de Waziers I.

Drug Metab Dispos. 2005 Dec;33(12):1803-10. Epub 2005 Aug 31.

PMID:
16135659
21.

A virus-directed enzyme prodrug therapy (VDEPT) strategy for lung cancer using a CYP2B6/NADPH-cytochrome P450 reductase fusion protein.

Tychopoulos M, Corcos L, Genne P, Beaune P, de Waziers I.

Cancer Gene Ther. 2005 May;12(5):497-508.

PMID:
15746946
22.

Regulatory sequence responsible for insulin destabilization of cytochrome P450 2B1 (CYP2B1) mRNA.

Truong NT, Moncion A, Barouki R, Beaune P, de Waziers I.

Biochem J. 2005 May 15;388(Pt 1):227-35.

23.

The activities of several detoxication enzymes are differentially induced by juices of garden cress, water cress and mustard in human HepG2 cells.

Lhoste EF, Gloux K, De Waziers I, Garrido S, Lory S, Philippe C, Rabot S, Knasmüller S.

Chem Biol Interact. 2004 Dec 7;150(3):211-9.

PMID:
15560888
24.

The effect of Smallanthus sonchifolius leaf extracts on rat hepatic metabolism.

Valentová K, Moncion A, de Waziers I, Ulrichová J.

Cell Biol Toxicol. 2004 Mar;20(2):109-20.

PMID:
15242186
25.

Induction of cytochrome P450 2B6 and 3A4 expression by phenobarbital and cyclophosphamide in cultured human liver slices.

Martin H, Sarsat JP, de Waziers I, Housset C, Balladur P, Beaune P, Albaladejo V, Lerche-Langrand C.

Pharm Res. 2003 Apr;20(4):557-68.

PMID:
12739762
26.

Identification of a 16-nucleotide sequence that mediates post-transcriptional regulation of rat CYP2E1 by insulin.

Moncion A, Truong NT, Garrone A, Beaune P, Barouki R, De Waziers I.

J Biol Chem. 2002 Nov 29;277(48):45904-10. Epub 2002 Sep 20.

27.

Genetic polymorphisms of glutathione S-transferases as modulators of lung cancer susceptibility.

Stücker I, Hirvonen A, de Waziers I, Cabelguenne A, Mitrunen K, Cénée S, Koum-Besson E, Hémon D, Beaune P, Loriot MA.

Carcinogenesis. 2002 Sep;23(9):1475-81.

PMID:
12189190
28.

Glutathione-associated enzymes in head and neck squamous cell carcinoma and response to cisplatin-based neoadjuvant chemotherapy.

Cabelguenne A, Loriot MA, Stucker I, Blons H, Koum-Besson E, Brasnu D, Beaune P, Laccourreye O, Laurent-Puig P, De Waziers I.

Int J Cancer. 2001 Sep 1;93(5):725-30.

29.

Relation between inducibility of CYP1A1, GSTM1 and lung cancer in a French population.

Stücker I, Jacquet M, de Waziers I, Cénée S, Beaune P, Kremers P, Hémon D.

Pharmacogenetics. 2000 Oct;10(7):617-27.

PMID:
11037803
30.
31.

Combined glutathione-S-transferase M1 and T1 genetic polymorphism and tacrine hepatotoxicity.

Simon T, Becquemont L, Mary-Krause M, de Waziers I, Beaune P, Funck-Brentano C, Jaillon P.

Clin Pharmacol Ther. 2000 Apr;67(4):432-7.

PMID:
10801254
32.

p53 alterations predict tumor response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma: a prospective series.

Cabelguenne A, Blons H, de Waziers I, Carnot F, Houllier AM, Soussi T, Brasnu D, Beaune P, Laccourreye O, Laurent-Puig P.

J Clin Oncol. 2000 Apr;18(7):1465-73.

PMID:
10735894
33.

GSTM1, smoking and lung cancer: a case-control study.

Stücker I, de Waziers I, Cenée S, Bignon J, Depierre A, Milleron B, Beaune P, Hémon D.

Int J Epidemiol. 1999 Oct;28(5):829-35.

PMID:
10597978
34.

Human CYP2B6: expression, inducibility and catalytic activities.

Gervot L, Rochat B, Gautier JC, Bohnenstengel F, Kroemer H, de Berardinis V, Martin H, Beaune P, de Waziers I.

Pharmacogenetics. 1999 Jun;9(3):295-306.

PMID:
10471061
35.

Microsatellite analysis and response to chemotherapy in head-and-neck squamous-cell carcinoma.

Blons H, Cabelguenne A, Carnot F, Laccourreye O, de Waziers I, Hamelin R, Brasnu D, Beaune P, Laurent-Puig P.

Int J Cancer. 1999 Aug 20;84(4):410-5.

36.

Detection and characterization of novel polymorphisms in the CYP2E1 gene.

Fairbrother KS, Grove J, de Waziers I, Steimel DT, Day CP, Crespi CL, Daly AK.

Pharmacogenetics. 1998 Dec;8(6):543-52.

PMID:
9918138
37.

Interindividual variability in P450-dependent generation of neoantigens in halothane hepatitis.

Eliasson E, Gardner I, Hume-Smith H, de Waziers I, Beaune P, Kenna JG.

Chem Biol Interact. 1998 Nov 6;116(1-2):123-41.

PMID:
9877205
38.

Cytochrome P450 mediated bioactivation of methyleugenol to 1'-hydroxymethyleugenol in Fischer 344 rat and human liver microsomes.

Gardner I, Wakazono H, Bergin P, de Waziers I, Beaune P, Kenna JG, Caldwell J.

Carcinogenesis. 1997 Sep;18(9):1775-83.

PMID:
9328175
39.

The use of human in vitro metabolic parameters to explore the risk assessment of hazardous compounds: the case of ethylene dibromide.

Ploemen JP, Wormhoudt LW, Haenen GR, Oudshoorn MJ, Commandeur JN, Vermeulen NP, de Waziers I, Beaune PH, Watabe T, van Bladeren PJ.

Toxicol Appl Pharmacol. 1997 Mar;143(1):56-69.

PMID:
9073592
40.

CYP3A5 is the major cytochrome P450 3A expressed in human colon and colonic cell lines.

Gervot L, Carrière V, Costet P, Cugnenc PH, Berger A, Beaune PH, de Waziers I.

Environ Toxicol Pharmacol. 1996 Dec 20;2(4):381-8.

PMID:
21781746
41.

Inter-individual variability in the oxidation of 1,2-dibromoethane: use of heterologously expressed human cytochrome P450 and human liver microsomes.

Wormhoudt LW, Ploemen JH, de Waziers I, Commandeur JN, Beaune PH, van Bladeren PJ, Vermeulen NP.

Chem Biol Interact. 1996 Sep 6;101(3):175-92.

PMID:
8870687
42.

Selective induction of the CYP3A family by endosulfan and DNA-adduct formation in different hepatic and hepatoma cells.

Dubois M, Pfohl-Leszkowicz A, De Waziers I, Kremers P.

Environ Toxicol Pharmacol. 1996 Jul 15;1(4):249-56. doi: 10.1016/1382-6689(96)00018-X.

PMID:
21781690
43.

Human cytochrome P450 2E1 (CYP2E1): from genotype to phenotype.

Carrière V, Berthou F, Baird S, Belloc C, Beaune P, de Waziers I.

Pharmacogenetics. 1996 Jun;6(3):203-11.

PMID:
8807659
44.

Regulation of sucrase-isomaltase and hexose transporters in Caco-2 cells: a role for cytochrome P-4501A1?

Carrière V, Barbat A, Rousset M, Brot-Laroche E, Dussaulx E, Cambier D, De Waziers ID, Beaune P, Zweibaum A.

Am J Physiol. 1996 Jun;270(6 Pt 1):G976-86.

PMID:
8764205
45.

Rat liver epithelial cells express functional cytochrome P450 2E1.

Lerche C, Le Jossic C, Fautrel A, de Waziers I, Ballet F, Guillouzo A, Corcos L.

Carcinogenesis. 1996 May;17(5):1101-6.

PMID:
8640919
46.

Human cytochromes P450 expressed in Escherichia coli: production of specific antibodies.

Belloc C, Baird S, Cosme J, Lecoeur S, Gautier JC, Challine D, de Waziers I, Flinois JP, Beaune PH.

Toxicology. 1996 Jan 8;106(1-3):207-19.

PMID:
8571393
47.

P450 induction by Aroclor 1254 and 3,3',4,4'-tetrachlorobiphenyl in cultured hepatocytes from rat, quail and man: interspecies comparison.

Dubois M, De Waziers I, Thome JP, Kremers P.

Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1996 Jan;113(1):51-9.

PMID:
8665401
48.

High levels of DNA adducts in human colon are associated with colorectal cancer.

Pfohl-Leszkowicz A, Grosse Y, Carrière V, Cugnenc PH, Berger A, Carnot F, Beaune P, de Waziers I.

Cancer Res. 1995 Dec 1;55(23):5611-6.

49.

Insulin down-regulates cytochrome P450 2B and 2E expression at the post-transcriptional level in the rat hepatoma cell line.

De Waziers I, Garlatti M, Bouguet J, Beaune PH, Barouki R.

Mol Pharmacol. 1995 Mar;47(3):474-9.

PMID:
7700245
50.

Expression of cytochrome P-450 3A in HT29-MTX cells and Caco-2 clone TC7.

Carrière V, Lesuffleur T, Barbat A, Rousset M, Dussaulx E, Costet P, de Waziers I, Beaune P, Zweibaum A.

FEBS Lett. 1994 Dec 5;355(3):247-50. Erratum in: FEBS Lett 1995 Mar 27;362(1):99.

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