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Items: 1 to 50 of 120

1.

Establishment of engineered cell-based assays mediating LAG3 and PD1 immune suppression enables potency measurement of blocking antibodies and assessment of signal transduction.

Bhagwat B, Cherwinski H, Sathe M, Seghezzi W, McClanahan TK, de Waal Malefyt R, Willingham A.

J Immunol Methods. 2018 May;456:7-14. doi: 10.1016/j.jim.2018.02.003. Epub 2018 Feb 8.

2.

IL-17A Produced by Innate Lymphoid Cells Is Essential for Intestinal Ischemia-Reperfusion Injury.

Geha M, Tsokos MG, Bosse RE, Sannikova T, Iwakura Y, Dalle Lucca JJ, De Waal Malefyt R, Tsokos GC.

J Immunol. 2017 Oct 15;199(8):2921-2929. doi: 10.4049/jimmunol.1700655. Epub 2017 Sep 6.

3.

IL-33 promotes innate IFN-γ production and modulates dendritic cell response in LCMV-induced hepatitis in mice.

Liang Y, Jie Z, Hou L, Yi P, Wang W, Kwota Z, Salvato M, de Waal Malefyt R, Soong L, Sun J.

Eur J Immunol. 2015 Nov;45(11):3052-63. doi: 10.1002/eji.201545696. Epub 2015 Aug 28.

4.

TSLP is differentially regulated by vitamin D3 and cytokines in human skin.

Landheer J, Giovannone B, Sadekova S, Tjabringa S, Hofstra C, Dechering K, Bruijnzeel-Koomen C, Chang C, Ying Y, de Waal Malefyt R, Hijnen D, Knol E.

Immun Inflamm Dis. 2015 Mar;3(1):32-43. doi: 10.1002/iid3.48. Epub 2015 Feb 16.

5.

A clinical biomarker assay to quantitate thymic stromal lymphopoietin in human plasma at sub-pg/ml level.

Zhao X, Ayanoglu G, Bilardello M, Fayadat-Dilman L, Zhang JH, Li HL, Bald L, Mcclanahan T, de Waal Malefyt R, Weiner R, Laterza OF.

Bioanalysis. 2015;7(5):573-82. doi: 10.4155/bio.14.297.

PMID:
25826139
6.

Nod/Ripk2 signaling in dendritic cells activates IL-17A-secreting innate lymphoid cells and drives colitis in T-bet-/-.Rag2-/- (TRUC) mice.

Ermann J, Staton T, Glickman JN, de Waal Malefyt R, Glimcher LH.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2559-66. doi: 10.1073/pnas.1408540111. Epub 2014 Jun 9.

7.

Aberrant tissue positioning of metallophilic macrophages in the thymus of XCL1-deficient mice.

Milićević NM, Lalić IM, Despotović SZ, Ćirić DN, Westermann J, De Waal Malefyt R, Milićević Ž.

Anat Rec (Hoboken). 2014 Aug;297(8):1472-7. doi: 10.1002/ar.22935. Epub 2014 Apr 29.

8.

IL-17A gene transfer induces bone loss and epidermal hyperplasia associated with psoriatic arthritis.

Adamopoulos IE, Suzuki E, Chao CC, Gorman D, Adda S, Maverakis E, Zarbalis K, Geissler R, Asio A, Blumenschein WM, Mcclanahan T, De Waal Malefyt R, Gershwin ME, Bowman EP.

Ann Rheum Dis. 2015 Jun;74(6):1284-92. doi: 10.1136/annrheumdis-2013-204782. Epub 2014 Feb 23.

9.

Glucocorticoid-Induced TNF Receptor Family-Related Protein Ligand is Requisite for Optimal Functioning of Regulatory CD4(+) T Cells.

Liao G, O'Keeffe MS, Wang G, van Driel B, de Waal Malefyt R, Reinecker HC, Herzog RW, Terhorst C.

Front Immunol. 2014 Feb 3;5:35. doi: 10.3389/fimmu.2014.00035. eCollection 2014.

10.

Epicutaneous application of house dust mite induces thymic stromal lymphopoietin in nonlesional skin of patients with atopic dermatitis.

Landheer J, Giovannone B, Mattson JD, Tjabringa S, Bruijnzeel-Koomen CA, McClanahan T, de Waal Malefyt R, Knol E, Hijnen D.

J Allergy Clin Immunol. 2013 Nov;132(5):1252-4. doi: 10.1016/j.jaci.2013.07.051. Epub 2013 Oct 8. No abstract available.

PMID:
24112829
11.

Glucocorticoid-induced TNF receptor family-related protein ligand regulates the migration of monocytes to the inflamed intestine.

Liao G, van Driel B, Magelky E, O'Keeffe MS, de Waal Malefyt R, Engel P, Herzog RW, Mizoguchi E, Bhan AK, Terhorst C.

FASEB J. 2014 Jan;28(1):474-84. doi: 10.1096/fj.13-236505. Epub 2013 Oct 9.

12.

Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis.

Noti M, Wojno ED, Kim BS, Siracusa MC, Giacomin PR, Nair MG, Benitez AJ, Ruymann KR, Muir AB, Hill DA, Chikwava KR, Moghaddam AE, Sattentau QJ, Alex A, Zhou C, Yearley JH, Menard-Katcher P, Kubo M, Obata-Ninomiya K, Karasuyama H, Comeau MR, Brown-Whitehorn T, de Waal Malefyt R, Sleiman PM, Hakonarson H, Cianferoni A, Falk GW, Wang ML, Spergel JM, Artis D.

Nat Med. 2013 Aug;19(8):1005-13. doi: 10.1038/nm.3281. Epub 2013 Jul 21.

13.

Signaling lymphocyte activation molecule regulates development of colitis in mice.

van Driel B, Liao G, Romero X, O'Keeffe MS, Wang G, Faubion WA, Berger SB, Magelky EM, Manocha M, Azcutia V, Grisham M, Luscinskas FW, Mizoguchi E, de Waal Malefyt R, Reinecker HC, Bhan AK, Wang N, Terhorst C.

Gastroenterology. 2012 Dec;143(6):1544-1554.e7. doi: 10.1053/j.gastro.2012.08.042. Epub 2012 Sep 6.

14.

Biomarkers of disease and treatment in murine and cynomolgus models of chronic asthma.

Louten J, Mattson JD, Malinao MC, Li Y, Emson C, Vega F, Wardle RL, Van Scott MR, Fick RB, McClanahan TK, de Waal Malefyt R, Beaumont M.

Biomark Insights. 2012;7:87-104. doi: 10.4137/BMI.S9776. Epub 2012 Jul 10.

15.

Glucocorticoid-induced tumor necrosis factor receptor family-related protein regulates CD4(+)T cell-mediated colitis in mice.

Liao G, Detre C, Berger SB, Engel P, de Waal Malefyt R, Herzog RW, Bhan AK, Terhorst C.

Gastroenterology. 2012 Mar;142(3):582-591.e8. doi: 10.1053/j.gastro.2011.11.031. Epub 2011 Dec 6.

16.

Interleukin-19: a constituent of the regulome that controls antigen presenting cells in the lungs and airway responses to microbial products.

Hoffman C, Park SH, Daley E, Emson C, Louten J, Sisco M, de Waal Malefyt R, Grunig G.

PLoS One. 2011;6(11):e27629. doi: 10.1371/journal.pone.0027629. Epub 2011 Nov 15.

17.

Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation.

Louten J, Rankin AL, Li Y, Murphy EE, Beaumont M, Moon C, Bourne P, McClanahan TK, Pflanz S, de Waal Malefyt R.

Int Immunol. 2011 May;23(5):307-15. doi: 10.1093/intimm/dxr006. Epub 2011 Mar 21.

PMID:
21422152
18.

Differential expression of monocyte/macrophage- selective markers in human idiopathic pulmonary fibrosis.

Desai B, Mattson J, Paintal H, Nathan M, Shen F, Beaumont M, Malinao MC, Li Y, Canfield J, Basham B, de Waal Malefyt R, McClanahan T, Krishna G, Fick R Jr.

Exp Lung Res. 2011 May;37(4):227-38. doi: 10.3109/01902148.2010.538132. Epub 2011 Feb 11.

PMID:
21309737
19.

Modelling asthma in macaques: longitudinal changes in cellular and molecular markers.

Ayanoglu G, Desai B, Fick RB Jr, Grein J, de Waal Malefyt R, Mattson J, McClanahan T, Olmstead S, Reece SP, Van Scott MR, Wardle RL.

Eur Respir J. 2011 Mar;37(3):541-52. doi: 10.1183/09031936.00047410. Epub 2010 Jul 22.

20.

Human Th17 cells comprise heterogeneous subsets including IFN-gamma-producing cells with distinct properties from the Th1 lineage.

Boniface K, Blumenschein WM, Brovont-Porth K, McGeachy MJ, Basham B, Desai B, Pierce R, McClanahan TK, Sadekova S, de Waal Malefyt R.

J Immunol. 2010 Jul 1;185(1):679-87. doi: 10.4049/jimmunol.1000366. Epub 2010 May 28.

21.

T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis.

Axtell RC, de Jong BA, Boniface K, van der Voort LF, Bhat R, De Sarno P, Naves R, Han M, Zhong F, Castellanos JG, Mair R, Christakos A, Kolkowitz I, Katz L, Killestein J, Polman CH, de Waal Malefyt R, Steinman L, Raman C.

Nat Med. 2010 Apr;16(4):406-12. doi: 10.1038/nm.2110. Epub 2010 Mar 28.

22.

GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells.

Liao G, Nayak S, Regueiro JR, Berger SB, Detre C, Romero X, de Waal Malefyt R, Chatila TA, Herzog RW, Terhorst C.

Int Immunol. 2010 Apr;22(4):259-70. doi: 10.1093/intimm/dxq001. Epub 2010 Feb 5.

23.

Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis.

Hillyer P, Larché MJ, Bowman EP, McClanahan TK, de Waal Malefyt R, Schewitz LP, Giddins G, Feldmann M, Kastelein RA, Brennan FM.

Rheumatology (Oxford). 2009 Dec;48(12):1581-9. doi: 10.1093/rheumatology/kep293. Epub 2009 Oct 8.

24.

Functional role of thymic stromal lymphopoietin in chronic allergic keratoconjunctivitis.

Matsuda A, Ebihara N, Yokoi N, Kawasaki S, Tanioka H, Inatomi T, de Waal Malefyt R, Hamuro J, Kinoshita S, Murakami A.

Invest Ophthalmol Vis Sci. 2010 Jan;51(1):151-5. doi: 10.1167/iovs.09-4183. Epub 2009 Sep 9.

PMID:
19741251
25.

Development and function of TH17 cells in health and disease.

Louten J, Boniface K, de Waal Malefyt R.

J Allergy Clin Immunol. 2009 May;123(5):1004-11. doi: 10.1016/j.jaci.2009.04.003. Review.

PMID:
19410689
26.

IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells.

Diveu C, McGeachy MJ, Boniface K, Stumhofer JS, Sathe M, Joyce-Shaikh B, Chen Y, Tato CM, McClanahan TK, de Waal Malefyt R, Hunter CA, Cua DJ, Kastelein RA.

J Immunol. 2009 May 1;182(9):5748-56. doi: 10.4049/jimmunol.0801162.

27.

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.

Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R.

J Exp Med. 2009 Mar 16;206(3):535-48. doi: 10.1084/jem.20082293. Epub 2009 Mar 9.

28.

Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation.

Kleinschek MA, Boniface K, Sadekova S, Grein J, Murphy EE, Turner SP, Raskin L, Desai B, Faubion WA, de Waal Malefyt R, Pierce RH, McClanahan T, Kastelein RA.

J Exp Med. 2009 Mar 16;206(3):525-34. doi: 10.1084/jem.20081712. Epub 2009 Mar 9.

29.

Early production of thymic stromal lymphopoietin precedes infiltration of dendritic cells expressing its receptor in allergen-induced late phase cutaneous responses in atopic subjects.

Corrigan CJ, Jayaratnam A, Wang Y, Liu Y, de Waal Malefyt R, Meng Q, Kay AB, Phipps S, Lee TH, Ying S.

Allergy. 2009 Jul;64(7):1014-22. doi: 10.1111/j.1398-9995.2009.01947.x. Epub 2009 Feb 2.

PMID:
19187393
30.

From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited.

Boniface K, Blom B, Liu YJ, de Waal Malefyt R.

Immunol Rev. 2008 Dec;226:132-46. doi: 10.1111/j.1600-065X.2008.00714.x. Review.

31.

Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice.

Beamer GL, Flaherty DK, Assogba BD, Stromberg P, Gonzalez-Juarrero M, de Waal Malefyt R, Vesosky B, Turner J.

J Immunol. 2008 Oct 15;181(8):5545-50.

32.

IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4.

Avery DT, Bryant VL, Ma CS, de Waal Malefyt R, Tangye SG.

J Immunol. 2008 Aug 1;181(3):1767-79.

33.

Pulmonary arterial remodeling induced by a Th2 immune response.

Daley E, Emson C, Guignabert C, de Waal Malefyt R, Louten J, Kurup VP, Hogaboam C, Taraseviciene-Stewart L, Voelkel NF, Rabinovitch M, Grunig E, Grunig G.

J Exp Med. 2008 Feb 18;205(2):361-72. doi: 10.1084/jem.20071008. Epub 2008 Jan 28.

34.

Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells.

Bryant VL, Ma CS, Avery DT, Li Y, Good KL, Corcoran LM, de Waal Malefyt R, Tangye SG.

J Immunol. 2007 Dec 15;179(12):8180-90.

35.

Development, cytokine profile and function of human interleukin 17-producing helper T cells.

Wilson NJ, Boniface K, Chan JR, McKenzie BS, Blumenschein WM, Mattson JD, Basham B, Smith K, Chen T, Morel F, Lecron JC, Kastelein RA, Cua DJ, McClanahan TK, Bowman EP, de Waal Malefyt R.

Nat Immunol. 2007 Sep;8(9):950-7. Epub 2007 Aug 5.

PMID:
17676044
36.

IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis.

Chan JR, Blumenschein W, Murphy E, Diveu C, Wiekowski M, Abbondanzo S, Lucian L, Geissler R, Brodie S, Kimball AB, Gorman DM, Smith K, de Waal Malefyt R, Kastelein RA, McClanahan TK, Bowman EP.

J Exp Med. 2006 Nov 27;203(12):2577-87. Epub 2006 Oct 30.

37.

Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells.

Hoeve MA, Savage ND, de Boer T, Langenberg DM, de Waal Malefyt R, Ottenhoff TH, Verreck FA.

Eur J Immunol. 2006 Mar;36(3):661-70.

38.

A canine model of cutaneous late-phase reactions: prednisolone inhibition of cellular and cytokine responses.

Pucheu-Haston CM, Shuster D, Olivry T, Brianceau P, Lockwood P, McClanahan T, de Waal Malefyt R, Mattson JD, Hammerberg B.

Immunology. 2006 Feb;117(2):177-87.

39.

Molecular regulation of Th2 immunity by dendritic cells.

Grunig G, Banz A, de Waal Malefyt R.

Pharmacol Ther. 2005 Apr;106(1):75-96. Epub 2004 Dec 20. Review.

PMID:
15781123
40.

IL-12 and IL-23: master regulators of innate and adaptive immunity.

Langrish CL, McKenzie BS, Wilson NJ, de Waal Malefyt R, Kastelein RA, Cua DJ.

Immunol Rev. 2004 Dec;202:96-105. Review.

PMID:
15546388
41.

Initiation of cellular organization in lymph nodes is regulated by non-B cell-derived signals and is not dependent on CXC chemokine ligand 13.

Cupedo T, Lund FE, Ngo VN, Randall TD, Jansen W, Greuter MJ, de Waal-Malefyt R, Kraal G, Cyster JG, Mebius RE.

J Immunol. 2004 Oct 15;173(8):4889-96.

42.

The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains.

Hör S, Pirzer H, Dumoutier L, Bauer F, Wittmann S, Sticht H, Renauld JC, de Waal Malefyt R, Fickenscher H.

J Biol Chem. 2004 Aug 6;279(32):33343-51. Epub 2004 Jun 3.

43.

Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells.

Nagalakshmi ML, Rascle A, Zurawski S, Menon S, de Waal Malefyt R.

Int Immunopharmacol. 2004 May;4(5):679-91.

PMID:
15120652
44.

Expression patterns of IL-10 ligand and receptor gene families provide leads for biological characterization.

Nagalakshmi ML, Murphy E, McClanahan T, de Waal Malefyt R.

Int Immunopharmacol. 2004 May;4(5):577-92. Review.

PMID:
15120644
45.

Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria.

Verreck FA, de Boer T, Langenberg DM, Hoeve MA, Kramer M, Vaisberg E, Kastelein R, Kolk A, de Waal-Malefyt R, Ottenhoff TH.

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4560-5. Epub 2004 Mar 19.

46.

Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion.

Watanabe N, Hanabuchi S, Soumelis V, Yuan W, Ho S, de Waal Malefyt R, Liu YJ.

Nat Immunol. 2004 Apr;5(4):426-34. Epub 2004 Feb 29.

PMID:
14991051
47.

WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27.

Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, Phillips JH, McClanahan TK, de Waal Malefyt R, Kastelein RA.

J Immunol. 2004 Feb 15;172(4):2225-31.

48.

IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells.

Hibbert L, Pflanz S, De Waal Malefyt R, Kastelein RA.

J Interferon Cytokine Res. 2003 Sep;23(9):513-22.

PMID:
14565860
49.

Human dendritic cells activated by TSLP and CD40L induce proallergic cytotoxic T cells.

Gilliet M, Soumelis V, Watanabe N, Hanabuchi S, Antonenko S, de Waal-Malefyt R, Liu YJ.

J Exp Med. 2003 Apr 21;197(8):1059-63.

50.

The role of interleukin-10 in autoimmune disease: systemic lupus erythematosus (SLE) and multiple sclerosis (MS).

Beebe AM, Cua DJ, de Waal Malefyt R.

Cytokine Growth Factor Rev. 2002 Aug-Oct;13(4-5):403-12. Review.

PMID:
12220553

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