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Items: 26

1.

The Zinc Transporter SLC39A7 (ZIP7) Is Essential for Regulation of Cytosolic Zinc Levels.

Woodruff G, Bouwkamp CG, de Vrij FM, Lovenberg T, Bonaventure P, Kushner SA, Harrington AW.

Mol Pharmacol. 2018 Sep;94(3):1092-1100. doi: 10.1124/mol.118.112557. Epub 2018 Jul 6.

PMID:
29980658
2.

Employed family-based genetic discovery combining linkage analysis and exome sequencing to identify RCL1 as a novel candidate gene for depression, with independent replication in a population-based cohort.

Amin N, de Vrij FMS, Baghdadi M, Brouwer RWW, van Rooij JGJ, Jovanova O, Uitterlinden AG, Hofman A, Janssen HLA, Murad SD, Kraaij R, Stedehouder J, van den Hout MCGN, Kros JM, van IJcken WFJ, Tiemeier H, Kushner SA, van Duijn CM.

Mol Psychiatry. 2018 May;23(5):1093. doi: 10.1038/mp.2018.6. No abstract available.

PMID:
29731510
3.

ACO2 homozygous missense mutation associated with complicated hereditary spastic paraplegia.

Bouwkamp CG, Afawi Z, Fattal-Valevski A, Krabbendam IE, Rivetti S, Masalha R, Quadri M, Breedveld GJ, Mandel H, Tailakh MA, Beverloo HB, Stevanin G, Brice A, van IJcken WFJ, Vernooij MW, Dolga AM, de Vrij FMS, Bonifati V, Kushner SA.

Neurol Genet. 2018 Mar 21;4(2):e223. doi: 10.1212/NXG.0000000000000223. eCollection 2018 Apr.

4.

Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia.

de Vrij FM, Bouwkamp CG, Gunhanlar N, Shpak G, Lendemeijer B, Baghdadi M, Gopalakrishna S, Ghazvini M, Li TM, Quadri M, Olgiati S, Breedveld GJ, Coesmans M, Mientjes E, de Wit T, Verheijen FW, Beverloo HB, Cohen D, Kok RM, Bakker PR, Nijburg A, Spijker AT, Haffmans PMJ, Hoencamp E, Bergink V; GROUP Study Consortium, Vorstman JA, Wu T, Olde Loohuis LM, Amin N, Langen CD, Hofman A, Hoogendijk WJ, van Duijn CM, Ikram MA, Vernooij MW, Tiemeier H, Uitterlinden AG, Elgersma Y, Distel B, Gribnau J, White T, Bonifati V, Kushner SA.

Mol Psychiatry. 2018 Jan 4. doi: 10.1038/s41380-017-0004-2. [Epub ahead of print]

PMID:
29302076
5.

An expandable embryonic stem cell-derived Purkinje neuron progenitor population that exhibits in vivo maturation in the adult mouse cerebellum.

Higuera GA, Iaffaldano G, Bedar M, Shpak G, Broersen R, Munshi ST, Dupont C, Gribnau J, de Vrij FMS, Kushner SA, De Zeeuw CI.

Sci Rep. 2017 Aug 18;7(1):8863. doi: 10.1038/s41598-017-09348-1.

6.

Phenotypic Differences between Asian and African Lineage Zika Viruses in Human Neural Progenitor Cells.

Anfasa F, Siegers JY, van der Kroeg M, Mumtaz N, Stalin Raj V, de Vrij FMS, Widagdo W, Gabriel G, Salinas S, Simonin Y, Reusken C, Kushner SA, Koopmans MPG, Haagmans B, Martina BEE, van Riel D.

mSphere. 2017 Jul 26;2(4). pii: e00292-17. doi: 10.1128/mSphere.00292-17. eCollection 2017 Jul-Aug.

7.

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474.

van Esbroeck ACM, Janssen APA, Cognetta AB 3rd, Ogasawara D, Shpak G, van der Kroeg M, Kantae V, Baggelaar MP, de Vrij FMS, Deng H, Allarà M, Fezza F, Lin Z, van der Wel T, Soethoudt M, Mock ED, den Dulk H, Baak IL, Florea BI, Hendriks G, De Petrocellis L, Overkleeft HS, Hankemeier T, De Zeeuw CI, Di Marzo V, Maccarrone M, Cravatt BF, Kushner SA, van der Stelt M.

Science. 2017 Jun 9;356(6342):1084-1087. doi: 10.1126/science.aaf7497.

8.

A simplified protocol for differentiation of electrophysiologically mature neuronal networks from human induced pluripotent stem cells.

Gunhanlar N, Shpak G, van der Kroeg M, Gouty-Colomer LA, Munshi ST, Lendemeijer B, Ghazvini M, Dupont C, Hoogendijk WJG, Gribnau J, de Vrij FMS, Kushner SA.

Mol Psychiatry. 2018 May;23(5):1336-1344. doi: 10.1038/mp.2017.56. Epub 2017 Apr 18.

9.

The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals.

Vanhauwaert R, Kuenen S, Masius R, Bademosi A, Manetsberger J, Schoovaerts N, Bounti L, Gontcharenko S, Swerts J, Vilain S, Picillo M, Barone P, Munshi ST, de Vrij FM, Kushner SA, Gounko NV, Mandemakers W, Bonifati V, Meunier FA, Soukup SF, Verstreken P.

EMBO J. 2017 May 15;36(10):1392-1411. doi: 10.15252/embj.201695773. Epub 2017 Mar 22.

10.

A rare missense variant in RCL1 segregates with depression in extended families.

Amin N, de Vrij FMS, Baghdadi M, Brouwer RWW, van Rooij JGJ, Jovanova O, Uitterlinden AG, Hofman A, Janssen HLA, Darwish Murad S, Kraaij R, Stedehouder J, van den Hout MCGN, Kros JM, van IJcken WFJ, Tiemeier H, Kushner SA, van Duijn CM.

Mol Psychiatry. 2018 May;23(5):1120-1126. doi: 10.1038/mp.2017.49. Epub 2017 Mar 21.

11.

Hepatitis E Virus Infects Neurons and Brains.

Zhou X, Huang F, Xu L, Lin Z, de Vrij FMS, Ayo-Martin AC, van der Kroeg M, Zhao M, Yin Y, Wang W, Cao W, Wang Y, Kushner SA, Marie Peron J, Alric L, de Man RA, Jacobs BC, van Eijk JJ, Aronica EMA, Sprengers D, Metselaar HJ, de Zeeuw CI, Dalton HR, Kamar N, Peppelenbosch MP, Pan Q.

J Infect Dis. 2017 Apr 15;215(8):1197-1206. doi: 10.1093/infdis/jix079.

PMID:
28199701
12.

Exome-sequencing in a large population-based study reveals a rare Asn396Ser variant in the LIPG gene associated with depressive symptoms.

Amin N, Jovanova O, Adams HH, Dehghan A, Kavousi M, Vernooij MW, Peeters RP, de Vrij FM, van der Lee SJ, van Rooij JG, van Leeuwen EM, Chaker L, Demirkan A, Hofman A, Brouwer RW, Kraaij R, Willems van Dijk K, Hankemeier T, van Ijcken WF, Uitterlinden AG, Niessen WJ, Franco OH, Kushner SA, Ikram MA, Tiemeier H, van Duijn CM.

Mol Psychiatry. 2017 Apr;22(4):634. doi: 10.1038/mp.2016.141. Epub 2016 Aug 9. No abstract available.

PMID:
27502476
13.

Exome-sequencing in a large population-based study reveals a rare Asn396Ser variant in the LIPG gene associated with depressive symptoms.

Amin N, Jovanova O, Adams HH, Dehghan A, Kavousi M, Vernooij MW, Peeters RP, de Vrij FM, van der Lee SJ, van Rooij JG, van Leeuwen EM, Chaker L, Demirkan A, Hofman A, Brouwer RW, Kraaij R, Willems van Dijk K, Hankemeier T, van Ijcken WF, Uitterlinden AG, Niessen WJ, Franco OH, Kushner SA, Ikram MA, Tiemeier H, van Duijn CM.

Mol Psychiatry. 2017 Apr;22(4):537-543. doi: 10.1038/mp.2016.101. Epub 2016 Jul 19. Erratum in: Mol Psychiatry. 2017 Apr;22(4):634.

PMID:
27431295
14.

A novel fragile X syndrome mutation reveals a conserved role for the carboxy-terminus in FMRP localization and function.

Okray Z, de Esch CE, Van Esch H, Devriendt K, Claeys A, Yan J, Verbeeck J, Froyen G, Willemsen R, de Vrij FM, Hassan BA.

EMBO Mol Med. 2015 Apr;7(4):423-37. doi: 10.15252/emmm.201404576.

15.

Epigenetic characterization of the FMR1 promoter in induced pluripotent stem cells from human fibroblasts carrying an unmethylated full mutation.

de Esch CE, Ghazvini M, Loos F, Schelling-Kazaryan N, Widagdo W, Munshi ST, van der Wal E, Douben H, Gunhanlar N, Kushner SA, Pijnappel WW, de Vrij FM, Geijsen N, Gribnau J, Willemsen R.

Stem Cell Reports. 2014 Oct 14;3(4):548-55. doi: 10.1016/j.stemcr.2014.07.013. Epub 2014 Sep 11.

16.

Subregion-specific dendritic spine abnormalities in the hippocampus of Fmr1 KO mice.

Levenga J, de Vrij FM, Buijsen RA, Li T, Nieuwenhuizen IM, Pop A, Oostra BA, Willemsen R.

Neurobiol Learn Mem. 2011 May;95(4):467-72. doi: 10.1016/j.nlm.2011.02.009. Epub 2011 Mar 1.

PMID:
21371563
17.

AFQ056, a new mGluR5 antagonist for treatment of fragile X syndrome.

Levenga J, Hayashi S, de Vrij FM, Koekkoek SK, van der Linde HC, Nieuwenhuizen I, Song C, Buijsen RA, Pop AS, Gomezmancilla B, Nelson DL, Willemsen R, Gasparini F, Oostra BA.

Neurobiol Dis. 2011 Jun;42(3):311-7. doi: 10.1016/j.nbd.2011.01.022. Epub 2011 Feb 21.

PMID:
21316452
18.

Potential therapeutic interventions for fragile X syndrome.

Levenga J, de Vrij FM, Oostra BA, Willemsen R.

Trends Mol Med. 2010 Nov;16(11):516-27. doi: 10.1016/j.molmed.2010.08.005. Epub 2010 Sep 21. Review.

19.

Ultrastructural analysis of the functional domains in FMRP using primary hippocampal mouse neurons.

Levenga J, Buijsen RA, Rifé M, Moine H, Nelson DL, Oostra BA, Willemsen R, de Vrij FM.

Neurobiol Dis. 2009 Aug;35(2):241-50. doi: 10.1016/j.nbd.2009.05.004. Epub 2009 May 21.

20.

Genes and pathways differentially expressed in the brains of Fxr2 knockout mice.

Cavallaro S, Paratore S, Fradale F, de Vrij FM, Willemsen R, Oostra BA.

Neurobiol Dis. 2008 Dec;32(3):510-20. doi: 10.1016/j.nbd.2008.09.008. Epub 2008 Sep 30.

PMID:
18930145
21.

Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice.

de Vrij FM, Levenga J, van der Linde HC, Koekkoek SK, De Zeeuw CI, Nelson DL, Oostra BA, Willemsen R.

Neurobiol Dis. 2008 Jul;31(1):127-32. doi: 10.1016/j.nbd.2008.04.002. Epub 2008 Apr 25.

22.

Dose-dependent inhibition of proteasome activity by a mutant ubiquitin associated with neurodegenerative disease.

van Tijn P, de Vrij FM, Schuurman KG, Dantuma NP, Fischer DF, van Leeuwen FW, Hol EM.

J Cell Sci. 2007 May 1;120(Pt 9):1615-23. Epub 2007 Apr 3.

23.

Protein quality control in Alzheimer's disease by the ubiquitin proteasome system.

de Vrij FM, Fischer DF, van Leeuwen FW, Hol EM.

Prog Neurobiol. 2004 Dec;74(5):249-70. Review.

PMID:
15582222
24.

Disease-specific accumulation of mutant ubiquitin as a marker for proteasomal dysfunction in the brain.

Fischer DF, De Vos RA, Van Dijk R, De Vrij FM, Proper EA, Sonnemans MA, Verhage MC, Sluijs JA, Hobo B, Zouambia M, Steur EN, Kamphorst W, Hol EM, Van Leeuwen FW.

FASEB J. 2003 Nov;17(14):2014-24.

PMID:
14597671
25.

Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation.

Lindsten K, de Vrij FM, Verhoef LG, Fischer DF, van Leeuwen FW, Hol EM, Masucci MG, Dantuma NP.

J Cell Biol. 2002 Apr 29;157(3):417-27. Epub 2002 Apr 29.

26.

Mutant ubiquitin expressed in Alzheimer's disease causes neuronal death.

De Vrij FM, Sluijs JA, Gregori L, Fischer DF, Hermens WT, Goldgaber D, Verhaagen J, Van Leeuwen FW, Hol EM.

FASEB J. 2001 Dec;15(14):2680-8.

PMID:
11726544

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