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Items: 1 to 50 of 182

1.

Altered secretory and neuroprotective function of the choroid plexus in progressive multiple sclerosis.

Rodríguez-Lorenzo S, Ferreira Francisco DM, Vos R, van Het Hof B, Rijnsburger M, Schroten H, Ishikawa H, Beaino W, Bruggmann R, Kooij G, de Vries HE.

Acta Neuropathol Commun. 2020 Mar 19;8(1):35. doi: 10.1186/s40478-020-00903-y.

2.

Correction to: Inflammation of the choroid plexus in progressive multiple sclerosis: accumulation of granulocytes and T cells.

Rodríguez-Lorenzo S, Konings J, van der Pol S, Kamermans A, Amor S, van Horssen J, Witte ME, Kooij G, de Vries HE.

Acta Neuropathol Commun. 2020 Feb 26;8(1):24. doi: 10.1186/s40478-020-00899-5.

3.

Inflammation of the choroid plexus in progressive multiple sclerosis: accumulation of granulocytes and T cells.

Rodríguez-Lorenzo S, Konings J, van der Pol S, Kamermans A, Amor S, van Horssen J, Witte ME, Kooij G, de Vries HE.

Acta Neuropathol Commun. 2020 Feb 3;8(1):9. doi: 10.1186/s40478-020-0885-1. Erratum in: Acta Neuropathol Commun. 2020 Feb 26;8(1):24.

4.

Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model.

van Olst L, Verhaege D, Franssen M, Kamermans A, Roucourt B, Carmans S, Ytebrouck E, van der Pol SMA, Wever D, Popovic M, Vandenbroucke RE, Sobrino T, Schouten M, de Vries HE.

Neurobiol Aging. 2020 May;89:89-98. doi: 10.1016/j.neurobiolaging.2020.01.003. Epub 2020 Jan 10.

5.

Nonionotropic Action of Endothelial NMDA Receptors on Blood-Brain Barrier Permeability via Rho/ROCK-Mediated Phosphorylation of Myosin.

Mehra A, Guérit S, Macrez R, Gosselet F, Sevin E, Lebas H, Maubert E, De Vries HE, Bardou I, Vivien D, Docagne F.

J Neurosci. 2020 Feb 19;40(8):1778-1787. doi: 10.1523/JNEUROSCI.0969-19.2019. Epub 2020 Jan 17.

PMID:
31953371
6.

Sphingolipids in Alzheimer's disease, how can we target them?

Crivelli SM, Giovagnoni C, Visseren L, Scheithauer AL, de Wit N, den Hoedt S, Losen M, Mulder MT, Walter J, de Vries HE, Bieberich E, Martinez-Martinez P.

Adv Drug Deliv Rev. 2020 Jan 3. pii: S0169-409X(20)30002-8. doi: 10.1016/j.addr.2019.12.003. [Epub ahead of print]

PMID:
31911096
7.

Preclinical evaluation of binimetinib (MEK162) delivered via polymeric nanocarriers in combination with radiation and temozolomide in glioma.

Bikhezar F, de Kruijff RM, van der Meer AJGM, Torrelo Villa G, van der Pol SMA, Becerril Aragon G, Gasol Garcia A, Narayan RS, de Vries HE, Slotman BJ, Denkova AG, Sminia P.

J Neurooncol. 2020 Jan;146(2):239-246. doi: 10.1007/s11060-019-03365-y. Epub 2019 Dec 24.

8.

Specialized pro-resolving lipid mediators are differentially altered in peripheral blood of patients with multiple sclerosis and attenuate monocyte and blood-brain barrier dysfunction.

Kooij G, Derada Troletti C, Leuti A, Norris PC, Riley I, Albanese M, Ruggieri S, Libreros S, van der Pol SMA, van Het Hof B, Schell Y, Guerrera G, Buttari F, Mercuri NB, Centonze D, Gasperini C, Battistini L, de Vries HE, Serhan CN, Chiurchiù V.

Haematologica. 2019 Nov 28. pii: haematol.2019.219519. doi: 10.3324/haematol.2019.219519. [Epub ahead of print]

9.

The P2X7 receptor tracer [11C]SMW139 as an in vivo marker of neuroinflammation in multiple sclerosis: a first-in man study.

Hagens MHJ, Golla SSV, Janssen B, Vugts DJ, Beaino W, Windhorst AD, O'Brien-Brown J, Kassiou M, Schuit RC, Schwarte LA, de Vries HE, Killestein J, Barkhof F, van Berckel BNM, Lammertsma AA.

Eur J Nucl Med Mol Imaging. 2020 Feb;47(2):379-389. doi: 10.1007/s00259-019-04550-x. Epub 2019 Nov 8.

10.

Setmelanotide, a Novel, Selective Melanocortin Receptor-4 Agonist Exerts Anti-inflammatory Actions in Astrocytes and Promotes an Anti-inflammatory Macrophage Phenotype.

Kamermans A, Verhoeven T, van Het Hof B, Koning JJ, Borghuis L, Witte M, van Horssen J, de Vries HE, Rijnsburger M.

Front Immunol. 2019 Oct 4;10:2312. doi: 10.3389/fimmu.2019.02312. eCollection 2019.

11.

Profiling the unique protective properties of intracranial arterial endothelial cells.

Hermkens DMA, Stam OCG, de Wit NM, Fontijn RD, Jongejan A, Moerland PD, Mackaaij C, Waas ISE, Daemen MJAP, de Vries HE.

Acta Neuropathol Commun. 2019 Oct 14;7(1):151. doi: 10.1186/s40478-019-0805-4.

12.

Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function.

Wouters E, de Wit NM, Vanmol J, van der Pol SMA, van Het Hof B, Sommer D, Loix M, Geerts D, Gustafsson JA, Steffensen KR, Vanmierlo T, Bogie JFJ, Hendriks JJA, de Vries HE.

Front Immunol. 2019 Jul 31;10:1811. doi: 10.3389/fimmu.2019.01811. eCollection 2019.

13.

Macrophage galactose-type lectin (MGL) is induced on M2 microglia and participates in the resolution phase of autoimmune neuroinflammation.

Ilarregui JM, Kooij G, Rodríguez E, van der Pol SMA, Koning N, Kalay H, van der Horst JC, van Vliet SJ, García-Vallejo JJ, de Vries HE, van Kooyk Y.

J Neuroinflammation. 2019 Jun 27;16(1):130. doi: 10.1186/s12974-019-1522-4.

14.

Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain.

Schouten M, Bielefeld P, Garcia-Corzo L, Passchier EMJ, Gradari S, Jungenitz T, Pons-Espinal M, Gebara E, Martín-Suárez S, Lucassen PJ, De Vries HE, Trejo JL, Schwarzacher SW, De Pietri Tonelli D, Toni N, Mira H, Encinas JM, Fitzsimons CP.

Mol Psychiatry. 2019 Jun 20. doi: 10.1038/s41380-019-0440-2. [Epub ahead of print]

PMID:
31222184
15.

Increased matrix metalloproteinases expression in tuberous sclerosis complex: modulation by microRNA 146a and 147b in vitro.

Broekaart DWM, van Scheppingen J, Anink JJ, Wierts L, van Het Hof B, Jansen FE, Spliet WG, van Rijen PC, Kamphuis WW, de Vries HE, Aronica E, van Vliet EA.

Neuropathol Appl Neurobiol. 2019 Jun 10. doi: 10.1111/nan.12572. [Epub ahead of print]

PMID:
31183875
16.

Induction of brain-infiltrating T-bet-expressing B cells in multiple sclerosis.

van Langelaar J, Rijvers L, Janssen M, Wierenga-Wolf AF, Melief MJ, Siepman TA, de Vries HE, Unger PA, van Ham SM, Hintzen RQ, van Luijn MM.

Ann Neurol. 2019 Aug;86(2):264-278. doi: 10.1002/ana.25508. Epub 2019 Jun 19.

17.

Reduced Angiopoietin-Like 4 Expression in Multiple Sclerosis Lesions Facilitates Lipid Uptake by Phagocytes via Modulation of Lipoprotein-Lipase Activity.

Kamermans A, Rijnsburger M, Chakraborty A, van der Pol S, de Vries HE, van Horssen J.

Front Immunol. 2019 May 3;10:950. doi: 10.3389/fimmu.2019.00950. eCollection 2019.

18.

The P4-ATPase ATP9A is a novel determinant of exosome release.

Naik J, Hau CM, Ten Bloemendaal L, Mok KS, Hajji N, Wehman AM, Meisner S, Muncan V, Paauw NJ, de Vries HE, Nieuwland R, Paulusma CC, Bosma PJ.

PLoS One. 2019 Apr 4;14(4):e0213069. doi: 10.1371/journal.pone.0213069. eCollection 2019.

19.

Astrocytic ceramide as possible indicator of neuroinflammation.

de Wit NM, den Hoedt S, Martinez-Martinez P, Rozemuller AJ, Mulder MT, de Vries HE.

J Neuroinflammation. 2019 Feb 25;16(1):48. doi: 10.1186/s12974-019-1436-1.

20.

Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction and occurs during multiple sclerosis pathophysiology.

Derada Troletti C, Fontijn RD, Gowing E, Charabati M, van Het Hof B, Didouh I, van der Pol SMA, Geerts D, Prat A, van Horssen J, Kooij G, de Vries HE.

Cell Death Dis. 2019 Jan 18;10(2):45. doi: 10.1038/s41419-018-1294-2.

21.

Acid sphingomyelinase: No potential as a biomarker for multiple sclerosis.

Leurs CE, Lopes Pinheiro MA, Wierts L, den Hoedt S, Mulder MT, Eijlers AJC, Schoonheim MM, Balk LJ, Uitdehaag BMJ, Killestein J, de Vries HE.

Mult Scler Relat Disord. 2019 Feb;28:44-49. doi: 10.1016/j.msard.2018.11.024. Epub 2018 Nov 30.

PMID:
30553168
22.

Angiopoietin like-4 as a novel vascular mediator in capillary cerebral amyloid angiopathy.

Chakraborty A, Kamermans A, van Het Hof B, Castricum K, Aanhane E, van Horssen J, Thijssen VL, Scheltens P, Teunissen CE, Fontijn RD, van der Flier WM, de Vries HE.

Brain. 2018 Dec 1;141(12):3377-3388. doi: 10.1093/brain/awy274.

PMID:
30462206
23.

Reactive astrocytes in multiple sclerosis impair neuronal outgrowth through TRPM7-mediated chondroitin sulfate proteoglycan production.

Kamermans A, Planting KE, Jalink K, van Horssen J, de Vries HE.

Glia. 2019 Jan;67(1):68-77. doi: 10.1002/glia.23526. Epub 2018 Nov 19.

24.

Activation of the innate immune system is evident throughout epileptogenesis and is associated with blood-brain barrier dysfunction and seizure progression.

Broekaart DWM, Anink JJ, Baayen JC, Idema S, de Vries HE, Aronica E, Gorter JA, van Vliet EA.

Epilepsia. 2018 Oct;59(10):1931-1944. doi: 10.1111/epi.14550. Epub 2018 Sep 8.

25.

Vascular Endothelial Growth Factor remains unchanged in cerebrospinal fluid of patients with Alzheimer's disease and vascular dementia.

Chakraborty A, Chatterjee M, Twaalfhoven H, Del Campo Milan M, Teunissen CE, Scheltens P, Fontijn RD, van Der Flier WM, de Vries HE.

Alzheimers Res Ther. 2018 Jun 23;10(1):58. doi: 10.1186/s13195-018-0385-8.

26.

Glucocorticoid-mediated modulation of morphological changes associated with aging in microglia.

van Olst L, Bielefeld P, Fitzsimons CP, de Vries HE, Schouten M.

Aging Cell. 2018 Aug;17(4):e12790. doi: 10.1111/acel.12790. Epub 2018 Jun 7.

27.

Mycobacteria employ two different mechanisms to cross the blood-brain barrier.

van Leeuwen LM, Boot M, Kuijl C, Picavet DI, van Stempvoort G, van der Pol SMA, de Vries HE, van der Wel NN, van der Kuip M, van Furth AM, van der Sar AM, Bitter W.

Cell Microbiol. 2018 Sep;20(9):e12858. doi: 10.1111/cmi.12858. Epub 2018 May 30.

28.

T helper 17.1 cells associate with multiple sclerosis disease activity: perspectives for early intervention.

van Langelaar J, van der Vuurst de Vries RM, Janssen M, Wierenga-Wolf AF, Spilt IM, Siepman TA, Dankers W, Verjans GMGM, de Vries HE, Lubberts E, Hintzen RQ, van Luijn MM.

Brain. 2018 May 1;141(5):1334-1349. doi: 10.1093/brain/awy069.

PMID:
29659729
29.

Studying the blood-brain barrier will provide new insights into neurodegeneration - Yes.

Kamphuis WW, De Vries HE.

Mult Scler. 2018 Jul;24(8):1023-1024. doi: 10.1177/1352458518754367. Epub 2018 Mar 5. No abstract available.

30.

Notch signaling is impaired during inflammation in a Lunatic Fringe-dependent manner.

Derada Troletti C, Lopes Pinheiro MA, Charabati M, Gowing E, van Het Hof B, van der Pol SMA, Geerts D, Prat A, Fontijn RD, Unger WW, de Vries HE.

Brain Behav Immun. 2018 Mar;69:48-56. doi: 10.1016/j.bbi.2017.12.016. Epub 2017 Dec 28.

PMID:
29289661
31.

Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis.

Beaino W, Janssen B, Kooij G, van der Pol SMA, van Het Hof B, van Horssen J, Windhorst AD, de Vries HE.

J Neuroinflammation. 2017 Dec 22;14(1):259. doi: 10.1186/s12974-017-1034-z.

32.

Serotonin: A mediator of the gut-brain axis in multiple sclerosis.

Malinova TS, Dijkstra CD, de Vries HE.

Mult Scler. 2018 Aug;24(9):1144-1150. doi: 10.1177/1352458517739975. Epub 2017 Nov 9. Review.

33.

Synthesis, Radiosynthesis, and Preliminary in vitro and in vivo Evaluation of the Fluorinated Ceramide Trafficking Inhibitor (HPA-12) for Brain Applications.

Crivelli SM, Paulus A, Markus J, Bauwens M, Berkes D, De Vries HE, Mulder MT, Walter J, Mottaghy FM, Losen M, Martinez-Martinez P.

J Alzheimers Dis. 2017;60(3):783-794. doi: 10.3233/JAD-161231.

PMID:
28922150
34.

Optical clearing and fluorescence deep-tissue imaging for 3D quantitative analysis of the brain tumor microenvironment.

Lagerweij T, Dusoswa SA, Negrean A, Hendrikx EML, de Vries HE, Kole J, Garcia-Vallejo JJ, Mansvelder HD, Vandertop WP, Noske DP, Tannous BA, Musters RJP, van Kooyk Y, Wesseling P, Zhao XW, Wurdinger T.

Angiogenesis. 2017 Nov;20(4):533-546. doi: 10.1007/s10456-017-9565-6. Epub 2017 Jul 11.

35.

Brain endothelial cell expression of SPARCL-1 is specific to chronic multiple sclerosis lesions and is regulated by inflammatory mediators in vitro.

Bridel C, Koel-Simmelink MJA, Peferoen L, Derada Troletti C, Durieux S, Gorter R, Nutma E, Gami P, Iacobaeus E, Brundin L, Kuhle J, Vrenken H, Killestein J, Piersma SR, Pham TV, De Vries HE, Amor S, Jimenez CR, Teunissen CE.

Neuropathol Appl Neurobiol. 2018 Jun;44(4):404-416. doi: 10.1111/nan.12412. Epub 2017 Jun 28.

PMID:
28543098
36.

In Vivo Molecular MRI of ICAM-1 Expression on Endothelium and Leukocytes from Subacute to Chronic Stages After Experimental Stroke.

Deddens LH, van Tilborg GAF, van der Marel K, Hunt H, van der Toorn A, Viergever MA, de Vries HE, Dijkhuizen RM.

Transl Stroke Res. 2017 May 16. doi: 10.1007/s12975-017-0536-4. [Epub ahead of print]

37.

Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation.

Aarts SABM, Seijkens TTP, Kusters PJH, van der Pol SMA, Zarzycka B, Heijnen PDAM, Beckers L, den Toom M, Gijbels MJJ, Boon L, Weber C, de Vries HE, Nicolaes GAF, Dijkstra CD, Kooij G, Lutgens E.

J Neuroinflammation. 2017 May 12;14(1):105. doi: 10.1186/s12974-017-0875-9.

38.

MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion to human brain endothelium.

Cerutti C, Edwards LJ, de Vries HE, Sharrack B, Male DK, Romero IA.

Sci Rep. 2017 Mar 30;7:45284. doi: 10.1038/srep45284.

39.

Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels.

den Hoedt S, Janssen CIF, Astarita G, Piomelli D, Leijten FPJ, Crivelli SM, Verhoeven AJM, de Vries HE, Walter J, Martinez-Martinez P, Sijbrands EJG, Kiliaan AJ, Mulder MT.

J Alzheimers Dis. 2017;60(3):769-781. doi: 10.3233/JAD-160739.

PMID:
28035926
40.

Altered blood-brain barrier transport in neuro-inflammatory disorders.

Schenk GJ, de Vries HE.

Drug Discov Today Technol. 2016 Jun;20:5-11. doi: 10.1016/j.ddtec.2016.07.002. Epub 2016 Oct 17. Review.

PMID:
27986224
41.

The blood brain barrier in Alzheimer's disease.

Chakraborty A, de Wit NM, van der Flier WM, de Vries HE.

Vascul Pharmacol. 2017 Feb;89:12-18. doi: 10.1016/j.vph.2016.11.008. Epub 2016 Nov 25. Review.

PMID:
27894893
42.

Correction: Dissecting the Effects of Ischemia and Reperfusion on the Coronary Microcirculation in a Rat Model of Acute Myocardial Infarction.

Hollander MR, de Waard GA, Konijnenberg LS, Meijer-van Putten RM, van den Brom CE, Paauw N, de Vries HE, van de Ven PM, Aman J, Van Nieuw Amerongen GP, Hordijk PL, Niessen HW, Horrevoets AJ, Van Royen N.

PLoS One. 2016 Nov 15;11(11):e0166809. doi: 10.1371/journal.pone.0166809. eCollection 2016.

43.

Altered Sphingolipid Balance in Capillary Cerebral Amyloid Angiopathy.

de Wit NM, Snkhchyan H, den Hoedt S, Wattimena D, de Vos R, Mulder MT, Walter J, Martinez-Martinez P, Hoozemans JJ, Rozemuller AJ, de Vries HE.

J Alzheimers Dis. 2017;60(3):795-807. doi: 10.3233/JAD-160551.

PMID:
27662305
44.

Inflammation at the blood-brain barrier: The role of liver X receptors.

de Wit NM, Vanmol J, Kamermans A, Hendriks J, de Vries HE.

Neurobiol Dis. 2017 Nov;107:57-65. doi: 10.1016/j.nbd.2016.09.015. Epub 2016 Sep 20. Review.

PMID:
27659108
45.

Protandim Protects Oligodendrocytes against an Oxidative Insult.

Lim JL, van der Pol SM, Baron W, McCord JM, de Vries HE, van Horssen J.

Antioxidants (Basel). 2016 Sep 7;5(3). pii: E30. doi: 10.3390/antiox5030030.

46.

In Vitro and Ex Vivo Model Systems to Measure ABC Transporter Activity at the Blood-Brain Barrier.

de Wit NM, Kooij G, de Vries HE.

Curr Pharm Des. 2016;22(38):5768-5773. Review.

PMID:
27514708
47.

Neuroendothelial NMDA receptors as therapeutic targets in experimental autoimmune encephalomyelitis.

Macrez R, Ortega MC, Bardou I, Mehra A, Fournier A, Van der Pol SM, Haelewyn B, Maubert E, Lesept F, Chevilley A, de Castro F, De Vries HE, Vivien D, Clemente D, Docagne F.

Brain. 2016 Sep;139(Pt 9):2406-19. doi: 10.1093/brain/aww172. Epub 2016 Jul 19.

PMID:
27435092
48.

Dissecting the Effects of Ischemia and Reperfusion on the Coronary Microcirculation in a Rat Model of Acute Myocardial Infarction.

Hollander MR, de Waard GA, Konijnenberg LS, Meijer-van Putten RM, van den Brom CE, Paauw N, de Vries HE, van de Ven PM, Aman J, Van Nieuw-Amerongen GP, Hordijk PL, Niessen HW, Horrevoets AJ, Van Royen N.

PLoS One. 2016 Jul 8;11(7):e0157233. doi: 10.1371/journal.pone.0157233. eCollection 2016. Erratum in: PLoS One. 2016 Nov 15;11(11):e0166809.

49.

Internalization and presentation of myelin antigens by the brain endothelium guides antigen-specific T cell migration.

Lopes Pinheiro MA, Kamermans A, Garcia-Vallejo JJ, van Het Hof B, Wierts L, O'Toole T, Boeve D, Verstege M, van der Pol SM, van Kooyk Y, de Vries HE, Unger WW.

Elife. 2016 Jun 23;5. pii: e13149. doi: 10.7554/eLife.13149.

50.

Morphogens and blood-brain barrier function in health and disease.

Wevers NR, de Vries HE.

Tissue Barriers. 2015 Sep 11;4(1):e1090524. doi: 10.1080/21688370.2015.1090524. eCollection 2016 Jan-Mar. Review.

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