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Items: 1 to 50 of 158

1.

Vascular Endothelial Growth Factor remains unchanged in cerebrospinal fluid of patients with Alzheimer's disease and vascular dementia.

Chakraborty A, Chatterjee M, Twaalfhoven H, Del Campo Milan M, Teunissen CE, Scheltens P, Fontijn RD, van Der Flier WM, de Vries HE.

Alzheimers Res Ther. 2018 Jun 23;10(1):58. doi: 10.1186/s13195-018-0385-8.

2.

Glucocorticoid-mediated modulation of morphological changes associated with aging in microglia.

van Olst L, Bielefeld P, Fitzsimons CP, de Vries HE, Schouten M.

Aging Cell. 2018 Jun 7:e12790. doi: 10.1111/acel.12790. [Epub ahead of print]

3.

Mycobacteria employ two different mechanisms to cross the blood-brain barrier.

van Leeuwen LM, Boot M, Kuijl C, Picavet DI, van Stempvoort G, van der Pol SMA, de Vries HE, van der Wel NN, van der Kuip M, van Furth AM, van der Sar AM, Bitter W.

Cell Microbiol. 2018 May 10:e12858. doi: 10.1111/cmi.12858. [Epub ahead of print]

PMID:
29749044
4.

T helper 17.1 cells associate with multiple sclerosis disease activity: perspectives for early intervention.

van Langelaar J, van der Vuurst de Vries RM, Janssen M, Wierenga-Wolf AF, Spilt IM, Siepman TA, Dankers W, Verjans GMGM, de Vries HE, Lubberts E, Hintzen RQ, van Luijn MM.

Brain. 2018 May 1;141(5):1334-1349. doi: 10.1093/brain/awy069.

PMID:
29659729
5.

Studying the blood-brain barrier will provide new insights into neurodegeneration - Yes.

Kamphuis WW, De Vries HE.

Mult Scler. 2018 Jul;24(8):1023-1024. doi: 10.1177/1352458518754367. Epub 2018 Mar 5. No abstract available.

6.

Notch signaling is impaired during inflammation in a Lunatic Fringe-dependent manner.

Derada Troletti C, Lopes Pinheiro MA, Charabati M, Gowing E, van Het Hof B, van der Pol SMA, Geerts D, Prat A, Fontijn RD, Unger WW, de Vries HE.

Brain Behav Immun. 2018 Mar;69:48-56. doi: 10.1016/j.bbi.2017.12.016. Epub 2017 Dec 28.

PMID:
29289661
7.

Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis.

Beaino W, Janssen B, Kooij G, van der Pol SMA, van Het Hof B, van Horssen J, Windhorst AD, de Vries HE.

J Neuroinflammation. 2017 Dec 22;14(1):259. doi: 10.1186/s12974-017-1034-z.

8.

Serotonin: A mediator of the gut-brain axis in multiple sclerosis.

Malinova TS, Dijkstra CD, de Vries HE.

Mult Scler. 2018 Aug;24(9):1144-1150. doi: 10.1177/1352458517739975. Epub 2017 Nov 9.

9.

Synthesis, Radiosynthesis, and Preliminary in vitro and in vivo Evaluation of the Fluorinated Ceramide Trafficking Inhibitor (HPA-12) for Brain Applications.

Crivelli SM, Paulus A, Markus J, Bauwens M, Berkes D, De Vries HE, Mulder MT, Walter J, Mottaghy FM, Losen M, Martinez-Martinez P.

J Alzheimers Dis. 2017;60(3):783-794. doi: 10.3233/JAD-161231.

PMID:
28922150
10.

Optical clearing and fluorescence deep-tissue imaging for 3D quantitative analysis of the brain tumor microenvironment.

Lagerweij T, Dusoswa SA, Negrean A, Hendrikx EML, de Vries HE, Kole J, Garcia-Vallejo JJ, Mansvelder HD, Vandertop WP, Noske DP, Tannous BA, Musters RJP, van Kooyk Y, Wesseling P, Zhao XW, Wurdinger T.

Angiogenesis. 2017 Nov;20(4):533-546. doi: 10.1007/s10456-017-9565-6. Epub 2017 Jul 11.

11.

Brain endothelial cell expression of SPARCL-1 is specific to chronic multiple sclerosis lesions and is regulated by inflammatory mediators in vitro.

Bridel C, Koel-Simmelink MJA, Peferoen L, Derada Troletti C, Durieux S, Gorter R, Nutma E, Gami P, Iacobaeus E, Brundin L, Kuhle J, Vrenken H, Killestein J, Piersma SR, Pham TV, De Vries HE, Amor S, Jimenez CR, Teunissen CE.

Neuropathol Appl Neurobiol. 2018 Jun;44(4):404-416. doi: 10.1111/nan.12412. Epub 2017 Jun 28.

PMID:
28543098
12.

In Vivo Molecular MRI of ICAM-1 Expression on Endothelium and Leukocytes from Subacute to Chronic Stages After Experimental Stroke.

Deddens LH, van Tilborg GAF, van der Marel K, Hunt H, van der Toorn A, Viergever MA, de Vries HE, Dijkhuizen RM.

Transl Stroke Res. 2017 May 16. doi: 10.1007/s12975-017-0536-4. [Epub ahead of print]

13.

Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation.

Aarts SABM, Seijkens TTP, Kusters PJH, van der Pol SMA, Zarzycka B, Heijnen PDAM, Beckers L, den Toom M, Gijbels MJJ, Boon L, Weber C, de Vries HE, Nicolaes GAF, Dijkstra CD, Kooij G, Lutgens E.

J Neuroinflammation. 2017 May 12;14(1):105. doi: 10.1186/s12974-017-0875-9.

14.

MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion to human brain endothelium.

Cerutti C, Edwards LJ, de Vries HE, Sharrack B, Male DK, Romero IA.

Sci Rep. 2017 Mar 30;7:45284. doi: 10.1038/srep45284.

15.

Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels.

den Hoedt S, Janssen CIF, Astarita G, Piomelli D, Leijten FPJ, Crivelli SM, Verhoeven AJM, de Vries HE, Walter J, Martinez-Martinez P, Sijbrands EJG, Kiliaan AJ, Mulder MT.

J Alzheimers Dis. 2017;60(3):769-781. doi: 10.3233/JAD-160739.

PMID:
28035926
16.

Altered blood-brain barrier transport in neuro-inflammatory disorders.

Schenk GJ, de Vries HE.

Drug Discov Today Technol. 2016 Jun;20:5-11. doi: 10.1016/j.ddtec.2016.07.002. Epub 2016 Oct 17. Review.

PMID:
27986224
17.

The blood brain barrier in Alzheimer's disease.

Chakraborty A, de Wit NM, van der Flier WM, de Vries HE.

Vascul Pharmacol. 2017 Feb;89:12-18. doi: 10.1016/j.vph.2016.11.008. Epub 2016 Nov 25. Review.

PMID:
27894893
18.

Correction: Dissecting the Effects of Ischemia and Reperfusion on the Coronary Microcirculation in a Rat Model of Acute Myocardial Infarction.

Hollander MR, de Waard GA, Konijnenberg LS, Meijer-van Putten RM, van den Brom CE, Paauw N, de Vries HE, van de Ven PM, Aman J, Van Nieuw Amerongen GP, Hordijk PL, Niessen HW, Horrevoets AJ, Van Royen N.

PLoS One. 2016 Nov 15;11(11):e0166809. doi: 10.1371/journal.pone.0166809. eCollection 2016.

19.

Altered Sphingolipid Balance in Capillary Cerebral Amyloid Angiopathy.

de Wit NM, Snkhchyan H, den Hoedt S, Wattimena D, de Vos R, Mulder MT, Walter J, Martinez-Martinez P, Hoozemans JJ, Rozemuller AJ, de Vries HE.

J Alzheimers Dis. 2017;60(3):795-807. doi: 10.3233/JAD-160551.

PMID:
27662305
20.

Inflammation at the blood-brain barrier: The role of liver X receptors.

de Wit NM, Vanmol J, Kamermans A, Hendriks J, de Vries HE.

Neurobiol Dis. 2017 Nov;107:57-65. doi: 10.1016/j.nbd.2016.09.015. Epub 2016 Sep 20. Review.

PMID:
27659108
21.

Protandim Protects Oligodendrocytes against an Oxidative Insult.

Lim JL, van der Pol SM, Baron W, McCord JM, de Vries HE, van Horssen J.

Antioxidants (Basel). 2016 Sep 7;5(3). pii: E30. doi: 10.3390/antiox5030030.

22.

In Vitro and Ex Vivo Model Systems to Measure ABC Transporter Activity at the Blood-Brain Barrier.

de Wit NM, Kooij G, de Vries HE.

Curr Pharm Des. 2016;22(38):5768-5773. Review.

PMID:
27514708
23.

Neuroendothelial NMDA receptors as therapeutic targets in experimental autoimmune encephalomyelitis.

Macrez R, Ortega MC, Bardou I, Mehra A, Fournier A, Van der Pol SM, Haelewyn B, Maubert E, Lesept F, Chevilley A, de Castro F, De Vries HE, Vivien D, Clemente D, Docagne F.

Brain. 2016 Sep;139(Pt 9):2406-19. doi: 10.1093/brain/aww172. Epub 2016 Jul 19.

PMID:
27435092
24.

Dissecting the Effects of Ischemia and Reperfusion on the Coronary Microcirculation in a Rat Model of Acute Myocardial Infarction.

Hollander MR, de Waard GA, Konijnenberg LS, Meijer-van Putten RM, van den Brom CE, Paauw N, de Vries HE, van de Ven PM, Aman J, Van Nieuw-Amerongen GP, Hordijk PL, Niessen HW, Horrevoets AJ, Van Royen N.

PLoS One. 2016 Jul 8;11(7):e0157233. doi: 10.1371/journal.pone.0157233. eCollection 2016. Erratum in: PLoS One. 2016 Nov 15;11(11):e0166809.

25.

Internalization and presentation of myelin antigens by the brain endothelium guides antigen-specific T cell migration.

Lopes Pinheiro MA, Kamermans A, Garcia-Vallejo JJ, van Het Hof B, Wierts L, O'Toole T, Boeve D, Verstege M, van der Pol SM, van Kooyk Y, de Vries HE, Unger WW.

Elife. 2016 Jun 23;5. pii: e13149. doi: 10.7554/eLife.13149.

26.

Morphogens and blood-brain barrier function in health and disease.

Wevers NR, de Vries HE.

Tissue Barriers. 2015 Sep 11;4(1):e1090524. doi: 10.1080/21688370.2015.1090524. eCollection 2016 Jan-Mar. Review.

27.

Regulation of brain endothelial barrier function by microRNAs in health and neuroinflammation.

Lopez-Ramirez MA, Reijerkerk A, de Vries HE, Romero IA.

FASEB J. 2016 Aug;30(8):2662-72. doi: 10.1096/fj.201600435RR. Epub 2016 Apr 26. Review.

28.

Resuscitation with Valproic Acid Alters Inflammatory Genes in a Porcine Model of Combined Traumatic Brain Injury and Hemorrhagic Shock.

Bambakidis T, Dekker SE, Sillesen M, Liu B, Johnson CN, Jin G, de Vries HE, Li Y, Alam HB.

J Neurotrauma. 2016 Aug 15;33(16):1514-21. doi: 10.1089/neu.2015.4163. Epub 2016 Apr 8.

29.

Blood-brain barrier leakage after status epilepticus in rapamycin-treated rats I: Magnetic resonance imaging.

van Vliet EA, Otte WM, Wadman WJ, Aronica E, Kooij G, de Vries HE, Dijkhuizen RM, Gorter JA.

Epilepsia. 2016 Jan;57(1):59-69. doi: 10.1111/epi.13246. Epub 2015 Dec 22.

30.

Blood-brain barrier leakage after status epilepticus in rapamycin-treated rats II: Potential mechanisms.

van Vliet EA, Otte WM, Wadman WJ, Aronica E, Kooij G, de Vries HE, Dijkhuizen RM, Gorter JA.

Epilepsia. 2016 Jan;57(1):70-8. doi: 10.1111/epi.13245. Epub 2015 Dec 22.

31.

Protective effects of monomethyl fumarate at the inflamed blood-brain barrier.

Lim JL, van der Pol SM, Di Dio F, van Het Hof B, Kooij G, de Vries HE, van Horssen J.

Microvasc Res. 2016 May;105:61-9. doi: 10.1016/j.mvr.2015.12.003. Epub 2015 Dec 8.

PMID:
26679389
32.

Differential expression of glucose-metabolizing enzymes in multiple sclerosis lesions.

Nijland PG, Molenaar RJ, van der Pol SM, van der Valk P, van Noorden CJ, de Vries HE, van Horssen J.

Acta Neuropathol Commun. 2015 Dec 4;3:79. doi: 10.1186/s40478-015-0261-8.

33.

Acid Sphingomyelinase-Derived Ceramide Regulates ICAM-1 Function during T Cell Transmigration across Brain Endothelial Cells.

Lopes Pinheiro MA, Kroon J, Hoogenboezem M, Geerts D, van Het Hof B, van der Pol SM, van Buul JD, de Vries HE.

J Immunol. 2016 Jan 1;196(1):72-9. doi: 10.4049/jimmunol.1500702. Epub 2015 Nov 23.

34.

Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke.

Lopes Pinheiro MA, Kooij G, Mizee MR, Kamermans A, Enzmann G, Lyck R, Schwaninger M, Engelhardt B, de Vries HE.

Biochim Biophys Acta. 2016 Mar;1862(3):461-71. doi: 10.1016/j.bbadis.2015.10.018. Epub 2015 Oct 23. Review.

35.

Molecular alterations of the blood-brain barrier under inflammatory conditions: The role of endothelial to mesenchymal transition.

Derada Troletti C, de Goede P, Kamermans A, de Vries HE.

Biochim Biophys Acta. 2016 Mar;1862(3):452-60. doi: 10.1016/j.bbadis.2015.10.010. Epub 2015 Oct 19.

36.

Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening.

Raj DD, Moser J, van der Pol SM, van Os RP, Holtman IR, Brouwer N, Oeseburg H, Schaafsma W, Wesseling EM, den Dunnen W, Biber KP, de Vries HE, Eggen BJ, Boddeke HW.

Aging Cell. 2015 Dec;14(6):1003-13. doi: 10.1111/acel.12370. Epub 2015 Aug 3.

37.

Trichuris suis induces human non-classical patrolling monocytes via the mannose receptor and PKC: implications for multiple sclerosis.

Kooij G, Braster R, Koning JJ, Laan LC, van Vliet SJ, Los T, Eveleens AM, van der Pol SM, Förster-Waldl E, Boztug K, Belot A, Szilagyi K, van den Berg TK, van Buul JD, van Egmond M, de Vries HE, Cummings RD, Dijkstra CD, van Die I.

Acta Neuropathol Commun. 2015 Jul 25;3:45. doi: 10.1186/s40478-015-0223-1.

38.

Tissue Transglutaminase contributes to experimental multiple sclerosis pathogenesis and clinical outcome by promoting macrophage migration.

van Strien ME, de Vries HE, Chrobok NL, Bol JGJM, Breve JJP, van der Pol SMP, Kooij G, van Buul JD, Karpuj M, Steinman L, Wilhelmus MM, Sestito C, Drukarch B, Van Dam AM.

Brain Behav Immun. 2015 Nov;50:141-154. doi: 10.1016/j.bbi.2015.06.023. Epub 2015 Jun 29.

PMID:
26133787
39.

Neuronal and axonal loss in normal-appearing gray matter and subpial lesions in multiple sclerosis.

Klaver R, Popescu V, Voorn P, Galis-de Graaf Y, van der Valk P, de Vries HE, Schenk GJ, Geurts JJ.

J Neuropathol Exp Neurol. 2015 May;74(5):453-8. doi: 10.1097/NEN.0000000000000189.

PMID:
25853695
40.

Soluble VCAM-1 impairs human brain endothelial barrier integrity via integrin α-4-transduced outside-in signalling.

Haarmann A, Nowak E, Deiß A, van der Pol S, Monoranu CM, Kooij G, Müller N, van der Valk P, Stoll G, de Vries HE, Berberich-Siebelt F, Buttmann M.

Acta Neuropathol. 2015 May;129(5):639-52. doi: 10.1007/s00401-015-1417-0. Epub 2015 Mar 27.

41.

Overcoming the blood-brain tumor barrier for effective glioblastoma treatment.

van Tellingen O, Yetkin-Arik B, de Gooijer MC, Wesseling P, Wurdinger T, de Vries HE.

Drug Resist Updat. 2015 Mar;19:1-12. doi: 10.1016/j.drup.2015.02.002. Epub 2015 Mar 6. Review.

PMID:
25791797
42.

GM-CSF promotes migration of human monocytes across the blood brain barrier.

Vogel DY, Kooij G, Heijnen PD, Breur M, Peferoen LA, van der Valk P, de Vries HE, Amor S, Dijkstra CD.

Eur J Immunol. 2015 Jun;45(6):1808-19. doi: 10.1002/eji.201444960. Epub 2015 May 3.

43.

The best basic science paper in multiple sclerosis in 2014: important role for the choroid plexus in the central nervous system entry of leukocytes.

Kooij G, de Vries HE.

Mult Scler. 2015 Apr;21(4):372-3. doi: 10.1177/1352458515573095. Epub 2015 Feb 25. No abstract available.

PMID:
25716882
44.

Activation of endogenous neural stem cells for multiple sclerosis therapy.

Michailidou I, de Vries HE, Hol EM, van Strien ME.

Front Neurosci. 2015 Jan 20;8:454. doi: 10.3389/fnins.2014.00454. eCollection 2014.

45.

IL-15 amplifies the pathogenic properties of CD4+CD28- T cells in multiple sclerosis.

Broux B, Mizee MR, Vanheusden M, van der Pol S, van Horssen J, Van Wijmeersch B, Somers V, de Vries HE, Stinissen P, Hellings N.

J Immunol. 2015 Mar 1;194(5):2099-109. doi: 10.4049/jimmunol.1401547. Epub 2015 Jan 23.

46.

The blood-brain barrier in multiple sclerosis: microRNAs as key regulators.

Kamphuis WW, Derada Troletti C, Reijerkerk A, Romero IA, de Vries HE.

CNS Neurol Disord Drug Targets. 2015;14(2):157-67. Review.

PMID:
25613507
47.

What drives MRI-measured cortical atrophy in multiple sclerosis?

Popescu V, Klaver R, Voorn P, Galis-de Graaf Y, Knol DL, Twisk JW, Versteeg A, Schenk GJ, Van der Valk P, Barkhof F, De Vries HE, Vrenken H, Geurts JJ.

Mult Scler. 2015 Sep;21(10):1280-90. doi: 10.1177/1352458514562440. Epub 2015 Jan 12.

PMID:
25583833
48.

Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation.

Wu D, Cerutti C, Lopez-Ramirez MA, Pryce G, King-Robson J, Simpson JE, van der Pol SM, Hirst MC, de Vries HE, Sharrack B, Baker D, Male DK, Michael GJ, Romero IA.

J Cereb Blood Flow Metab. 2015 Mar;35(3):412-23. doi: 10.1038/jcbfm.2014.207. Epub 2014 Dec 17.

49.

Astroglial PGC-1alpha increases mitochondrial antioxidant capacity and suppresses inflammation: implications for multiple sclerosis.

Nijland PG, Witte ME, van het Hof B, van der Pol S, Bauer J, Lassmann H, van der Valk P, de Vries HE, van Horssen J.

Acta Neuropathol Commun. 2014 Dec 10;2:170. doi: 10.1186/s40478-014-0170-2.

50.

Antioxidative defense mechanisms controlled by Nrf2: state-of-the-art and clinical perspectives in neurodegenerative diseases.

Lim JL, Wilhelmus MM, de Vries HE, Drukarch B, Hoozemans JJ, van Horssen J.

Arch Toxicol. 2014 Oct;88(10):1773-86. doi: 10.1007/s00204-014-1338-z. Epub 2014 Aug 28. Review.

PMID:
25164826

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