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Items: 1 to 50 of 157

1.

On the role of toll-like receptor 5 (TLR5) in experimental melioidosis.

Birnie E, Weehuizen TAF, Lankelma JM, de Jong HK, Koh GCKW, van Lieshout MHP, Roelofs JJTH, Budding AE, de Vos AF, van der Poll T, Wiersinga WJ.

Infect Immun. 2019 May 20. pii: IAI.00409-18. doi: 10.1128/IAI.00409-18. [Epub ahead of print]

PMID:
31109950
2.

Human Adipose-Derived Mesenchymal Stem Cells Modify Lung Immunity and Improve Antibacterial Defense in Pneumosepsis Caused by Klebsiella pneumoniae.

Perlee D, de Vos AF, Scicluna BP, Mancheño P, de la Rosa O, Dalemans W, Nürnberg P, Lombardo E, van der Poll T.

Stem Cells Transl Med. 2019 Apr 29. doi: 10.1002/sctm.18-0260. [Epub ahead of print]

3.

Platelet Btk is Required for Maintaining Lung Vascular Integrity during Murine Pneumococcal Pneumosepsis.

de Porto APNA, Claushuis TAM, van der Donk LEH, de Beer R, de Boer OJ, Florquin S, Roelofs JJTH, Hendriks RW, van der Poll T, Van't Veer C, de Vos AF.

Thromb Haemost. 2019 Jun;119(6):930-940. doi: 10.1055/s-0039-1681046. Epub 2019 Mar 14.

PMID:
30873567
4.

Btk inhibitor ibrutinib reduces inflammatory myeloid cell responses in the lung during murine pneumococcal pneumonia.

de Porto AP, Liu Z, de Beer R, Florquin S, de Boer OJ, Hendriks RW, van der Poll T, de Vos AF.

Mol Med. 2019 Jan 15;25(1):3. doi: 10.1186/s10020-018-0069-7.

5.

Platelet-Dense Granules Worsen Pre-Infection Thrombocytopenia during Gram-Negative Pneumonia-Derived Sepsis.

Claushuis TAM, de Vos AF, Roelofs JJTH, de Boer OJ, van 't Veer C, van der Poll T.

J Innate Immun. 2019;11(2):168-180. doi: 10.1159/000494147. Epub 2018 Dec 17.

6.

Kinase activity is impaired in neutrophils of sepsis patients.

Hoogendijk AJ, van Vught LA, Wiewel MA, Fuhler GM, Belkasim-Bohoudi H, Horn J, Schultz MJ, Scicluna BP, Peppelenbosch MP, van 't Veer C, de Vos AF, van der Poll T.

Haematologica. 2019 Jun;104(6):e233-e235. doi: 10.3324/haematol.2018.201913. Epub 2018 Dec 4. No abstract available.

7.

Neutrophils mitigate the systemic host response during endotoxemia in mice.

van der Meer AJ, Ding C, Hoogendijk AJ, de Vos AF, Boon L, Zeerleder SS, van der Poll T.

Immunology. 2019 Mar;156(3):277-281. doi: 10.1111/imm.13026. Epub 2018 Dec 18.

8.

Kininogen deficiency or depletion reduces enhanced pause independent of pulmonary inflammation in a house dust mite-induced murine asthma model.

Yang J, van 't Veer C, Roelofs JJTH, van Heijst JWJ, de Vos AF, McCrae KR, Revenko AS, Crosby J, van der Poll T.

Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1;316(1):L187-L196. doi: 10.1152/ajplung.00162.2018. Epub 2018 Oct 25.

PMID:
30358441
9.

Thrombocytopenia Impairs Host Defense Against Burkholderia pseudomallei (Melioidosis).

Birnie E, Claushuis TAM, Koh GCKW, Limmathurotsakul D, Day NPJ, Roelofs JJTH, Ware J, Hou B, de Vos AF, van der Poll T, van 't Veer C, Wiersinga WJ.

J Infect Dis. 2019 Jan 29;219(4):648-659. doi: 10.1093/infdis/jiy541.

10.

Intravenous Infusion of Human Adipose Mesenchymal Stem Cells Modifies the Host Response to Lipopolysaccharide in Humans: A Randomized, Single-Blind, Parallel Group, Placebo Controlled Trial.

Perlee D, van Vught LA, Scicluna BP, Maag A, Lutter R, Kemper EM, van 't Veer C, Punchard MA, González J, Richard MP, Dalemans W, Lombardo E, de Vos AF, van der Poll T.

Stem Cells. 2018 Nov;36(11):1778-1788. doi: 10.1002/stem.2891. Epub 2018 Aug 20.

PMID:
30063804
11.

LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells.

Lino AC, Dang VD, Lampropoulou V, Welle A, Joedicke J, Pohar J, Simon Q, Thalmensi J, Baures A, Flühler V, Sakwa I, Stervbo U, Ries S, Jouneau L, Boudinot P, Tsubata T, Adachi T, Hutloff A, Dörner T, Zimber-Strobl U, de Vos AF, Dahlke K, Loh G, Korniotis S, Goosmann C, Weill JC, Reynaud CA, Kaufmann SHE, Walter J, Fillatreau S.

Immunity. 2018 Jul 17;49(1):120-133.e9. doi: 10.1016/j.immuni.2018.06.007. Epub 2018 Jul 10.

12.

Role of Peptidylarginine Deiminase 4 in Neutrophil Extracellular Trap Formation and Host Defense during Klebsiella pneumoniae-Induced Pneumonia-Derived Sepsis.

Claushuis TAM, van der Donk LEH, Luitse AL, van Veen HA, van der Wel NN, van Vught LA, Roelofs JJTH, de Boer OJ, Lankelma JM, Boon L, de Vos AF, van 't Veer C, van der Poll T.

J Immunol. 2018 Aug 15;201(4):1241-1252. doi: 10.4049/jimmunol.1800314. Epub 2018 Jul 9.

PMID:
29987161
13.

Nbeal2 Deficiency Increases Organ Damage but Does Not Affect Host Defense During Gram-Negative Pneumonia-Derived Sepsis.

Claushuis TAM, de Stoppelaar SF, de Vos AF, Grootemaat AE, van der Wel NN, Roelofs JJTH, Ware J, Van't Veer C, van der Poll T.

Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1772-1784. doi: 10.1161/ATVBAHA.118.311332.

PMID:
29930006
14.

Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria.

Claushuis TAM, de Vos AF, Nieswandt B, Boon L, Roelofs JJTH, de Boer OJ, van 't Veer C, van der Poll T.

Blood. 2018 Feb 22;131(8):864-876. doi: 10.1182/blood-2017-06-788067. Epub 2017 Nov 29.

15.

ASC and NLRP3 impair host defense during lethal pneumonia caused by serotype 3 Streptococcus pneumoniae in mice.

van Lieshout MHP, de Vos AF, Dessing MC, de Porto APNA, de Boer OJ, de Beer R, Terpstra S, Florquin S, Van't Veer C, van der Poll T.

Eur J Immunol. 2018 Jan;48(1):66-79. doi: 10.1002/eji.201646554. Epub 2017 Nov 3.

16.

Differences in Inflammation Patterns Induced by African and Asian Burkholderia pseudomallei Isolates in Mice.

Weehuizen TAF, Birnie E, Ferwerda B, Roelofs JJTH, de Vos AF, Grobusch MP, Wiersinga WJ.

Am J Trop Med Hyg. 2017 Jun;96(6):1365-1369. doi: 10.4269/ajtmh.16-0121.

17.

Expression and Function of Granzymes A and B in Escherichia coli Peritonitis and Sepsis.

García-Laorden MI, Stroo I, Terpstra S, Florquin S, Medema JP, van T Veer C, de Vos AF, van der Poll T.

Mediators Inflamm. 2017;2017:4137563. doi: 10.1155/2017/4137563. Epub 2017 Jun 12.

18.

The gut microbiota as a modulator of innate immunity during melioidosis.

Lankelma JM, Birnie E, Weehuizen TAF, Scicluna BP, Belzer C, Houtkooper RH, Roelofs JJTH, de Vos AF, van der Poll T, Budding AE, Wiersinga WJ.

PLoS Negl Trop Dis. 2017 Apr 19;11(4):e0005548. doi: 10.1371/journal.pntd.0005548. eCollection 2017 Apr.

19.

Sepsis Patients Display a Reduced Capacity to Activate Nuclear Factor-κB in Multiple Cell Types.

Hoogendijk AJ, Garcia-Laorden MI, van Vught LA, Wiewel MA, Belkasim-Bohoudi H, Duitman J, Horn J, Schultz MJ, Scicluna BP, van 't Veer C, de Vos AF, van der Poll T.

Crit Care Med. 2017 May;45(5):e524-e531. doi: 10.1097/CCM.0000000000002294.

PMID:
28240686
20.

Epithelial Myeloid-Differentiation Factor 88 Is Dispensable during Klebsiella Pneumonia.

Anas AA, Claushuis TAM, Mohan RA, Christoffels VM, Aidinis V, Florquin S, Van't Veer C, Hou B, de Vos AF, van der Poll T.

Am J Respir Cell Mol Biol. 2017 May;56(5):648-656. doi: 10.1165/rcmb.2016-0190OC.

PMID:
28187270
21.

Therapeutic Administration of a Monoclonal Anti-Il-1β Antibody Protects Against Experimental Melioidosis.

Weehuizen TA, Lankelma JM, De Jong HK, De Boer OJ, Roelofs JJ, Day NP, Gram H, De Vos AF, Wiersinga WJ.

Shock. 2016 Nov;46(5):566-574.

22.

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages.

Van den Bossche J, Baardman J, Otto NA, van der Velden S, Neele AE, van den Berg SM, Luque-Martin R, Chen HJ, Boshuizen MC, Ahmed M, Hoeksema MA, de Vos AF, de Winther MP.

Cell Rep. 2016 Oct 11;17(3):684-696. doi: 10.1016/j.celrep.2016.09.008.

23.

General, but not myeloid or type II lung epithelial cell, myeloid differentiation factor 88 deficiency abrogates house dust mite induced allergic lung inflammation.

Anas AA, Yang J, Daan de Boer J, Roelofs JJ, Hou B, de Vos AF, van der Poll T.

Clin Exp Immunol. 2017 Feb;187(2):204-212. doi: 10.1111/cei.12867. Epub 2016 Oct 13.

24.

Antibiotic-Induced Gut Microbiota Disruption Decreases TNF-α Release by Mononuclear Cells in Healthy Adults.

Lankelma JM, Belzer C, Hoogendijk AJ, de Vos AF, de Vos WM, van der Poll T, Wiersinga WJ.

Clin Transl Gastroenterol. 2016 Aug 4;7(8):e186. doi: 10.1038/ctg.2016.43.

25.

Granzyme A impairs host defense during Streptococcus pneumoniae pneumonia.

van den Boogaard FE, van Gisbergen KP, Vernooy JH, Medema JP, Roelofs JJ, van Zoelen MA, Endeman H, Biesma DH, Boon L, Van't Veer C, de Vos AF, van der Poll T.

Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L507-16. doi: 10.1152/ajplung.00116.2016. Epub 2016 Jun 24.

26.

Antibiotic-induced gut microbiota disruption during human endotoxemia: a randomised controlled study.

Lankelma JM, Cranendonk DR, Belzer C, de Vos AF, de Vos WM, van der Poll T, Wiersinga WJ.

Gut. 2017 Sep;66(9):1623-1630. doi: 10.1136/gutjnl-2016-312132. Epub 2016 Jun 15.

PMID:
27307305
27.

Lung epithelial MyD88 drives early pulmonary clearance of Pseudomonas aeruginosa by a flagellin dependent mechanism.

Anas AA, van Lieshout MH, Claushuis TA, de Vos AF, Florquin S, de Boer OJ, Hou B, Van't Veer C, van der Poll T.

Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L219-28. doi: 10.1152/ajplung.00078.2016. Epub 2016 Jun 10.

28.

Triggering Receptor Expressed on Myeloid Cells (TREM)-2 Impairs Host Defense in Experimental Melioidosis.

Weehuizen TA, Hommes TJ, Lankelma JM, de Jong HK, Roelofs JJ, de Vos AF, Colonna M, van der Poll T, Wiersinga WJ.

PLoS Negl Trop Dis. 2016 Jun 2;10(6):e0004747. doi: 10.1371/journal.pntd.0004747. eCollection 2016 Jun.

29.

The impact of HIV infection on blood leukocyte responsiveness to bacterial stimulation in asymptomatic patients and patients with bloodstream infection.

Huson MA, Hoogendijk AJ, de Vos AF, Grobusch MP, van der Poll T.

J Int AIDS Soc. 2016 May 16;19(1):20759. doi: 10.7448/IAS.19.1.20759. eCollection 2016.

30.

Nur77-deficiency in bone marrow-derived macrophages modulates inflammatory responses, extracellular matrix homeostasis, phagocytosis and tolerance.

Hamers AA, Argmann C, Moerland PD, Koenis DS, Marinković G, Sokolović M, de Vos AF, de Vries CJ, van Tiel CM.

BMC Genomics. 2016 Mar 1;17:162. doi: 10.1186/s12864-016-2469-9.

31.

Granzymes A and B Regulate the Local Inflammatory Response during Klebsiella pneumoniae Pneumonia.

García-Laorden MI, Stroo I, Blok DC, Florquin S, Medema JP, de Vos AF, van der Poll T.

J Innate Immun. 2016;8(3):258-68. doi: 10.1159/000443401. Epub 2016 Feb 20.

32.

Receptor for Advanced Glycation End Products (RAGE) Serves a Protective Role during Klebsiella pneumoniae - Induced Pneumonia.

Achouiti A, de Vos AF, van 't Veer C, Florquin S, Tanck MW, Nawroth PP, Bierhaus A, van der Poll T, van Zoelen MA.

PLoS One. 2016 Jan 29;11(1):e0141000. doi: 10.1371/journal.pone.0141000. eCollection 2016.

33.

Differential Toll-Like Receptor-Signalling of Burkholderia pseudomallei Lipopolysaccharide in Murine and Human Models.

Weehuizen TA, Prior JL, van der Vaart TW, Ngugi SA, Nepogodiev SA, Field RA, Kager LM, van 't Veer C, de Vos AF, Wiersinga WJ.

PLoS One. 2015 Dec 21;10(12):e0145397. doi: 10.1371/journal.pone.0145397. eCollection 2015.

34.

Role of Nucleotide-Binding Oligomerization Domain-Containing (NOD) 2 in Host Defense during Pneumococcal Pneumonia.

Hommes TJ, van Lieshout MH, van 't Veer C, Florquin S, Bootsma HJ, Hermans PW, de Vos AF, van der Poll T.

PLoS One. 2015 Dec 16;10(12):e0145138. doi: 10.1371/journal.pone.0145138. eCollection 2015.

35.

Soluble and cell-associated triggering receptor expressed on myeloid cells-1 and -2 in patients with pulmonary tuberculosis.

Hoogendijk AJ, Blok DC, Garcia Laorden MI, Kager LM, Lede IO, Rahman W, Afroz R, Bresser P, van der Zee JS, Ghose A, Visser CE, de Jong MD, Zahed AS, Husain MA, Alam KM, Barua PC, Hassan M, Hossain A, Tayab MA, Lutter R, Day N, Dondorp AM, Van't Veer C, de Vos AF, van der Poll T.

J Infect. 2015 Dec;71(6):706-9. doi: 10.1016/j.jinf.2015.09.002. Epub 2015 Sep 15. No abstract available.

PMID:
26384438
36.

Activated protein C inhibits neutrophil migration in allergic asthma: a randomised trial.

de Boer JD, Berger M, Majoor CJ, Kager LM, Meijers JC, Terpstra S, Nieuwland R, Boing AN, Lutter R, Wouters D, van Mierlo GJ, Zeerleder SS, Bel EH, van't Veer C, de Vos AF, van der Zee JS, van der Poll T.

Eur Respir J. 2015 Dec;46(6):1636-44. doi: 10.1183/13993003.00459-2015. Epub 2015 Sep 17.

37.

Endoplasmic reticulum chaperone gp96 in macrophages is essential for protective immunity during Gram-negative pneumonia.

Anas AA, de Vos AF, Hoogendijk AJ, van Lieshout MH, van Heijst JW, Florquin S, Li Z, van 't Veer C, van der Poll T.

J Pathol. 2016 Jan;238(1):74-84. doi: 10.1002/path.4637. Epub 2015 Oct 19.

38.

Increased intra- and extracellular granzyme expression in patients with tuberculosis.

Garcia-Laorden MI, Blok DC, Kager LM, Hoogendijk AJ, van Mierlo GJ, Lede IO, Rahman W, Afroz R, Ghose A, Visser CE, Md Zahed AS, Husain MA, Alam KM, Chandra Barua P, Hassan M, Hossain A, Tayab MA, Day N, Dondorp AM, de Vos AF, van der Poll T.

Tuberculosis (Edinb). 2015 Sep;95(5):575-80. doi: 10.1016/j.tube.2015.05.016. Epub 2015 Jun 20.

PMID:
26156785
39.

The receptor for advanced glycation end products promotes bacterial growth at distant body sites in Staphylococcus aureus skin infection.

Achouiti A, Van't Veer C, de Vos AF, van der Poll T.

Microbes Infect. 2015 Sep;17(9):622-7. doi: 10.1016/j.micinf.2015.06.002. Epub 2015 Jun 16.

PMID:
26086798
40.

TIR-Domain-Containing Adaptor-Inducing Interferon-β (TRIF) Mediates Antibacterial Defense during Gram-Negative Pneumonia by Inducing Interferon-x03B3.

van Lieshout MH, Florquin S, Vanʼt Veer C, de Vos AF, van der Poll T.

J Innate Immun. 2015;7(6):637-46. doi: 10.1159/000430913. Epub 2015 Jun 9.

41.

Expression of inhibitory regulators of innate immunity in patients with active tuberculosis.

Blok DC, Kager LM, Hoogendijk AJ, Lede IO, Rahman W, Afroz R, Bresser P, van der Zee JS, Ghose A, Visser CE, de Jong MD, Zahed AS, Husain MA, Alam KM, Barua PC, Hassan M, Hossain A, Tayab MA, Lutter R, Day N, Dondorp AM, de Vos AF, van 't Veer C, van der Poll T.

BMC Infect Dis. 2015 Feb 26;15:98. doi: 10.1186/s12879-015-0833-z.

42.

Expression and function of S100A8/A9 (calprotectin) in human typhoid fever and the murine Salmonella model.

De Jong HK, Achouiti A, Koh GC, Parry CM, Baker S, Faiz MA, van Dissel JT, Vollaard AM, van Leeuwen EM, Roelofs JJ, de Vos AF, Roth J, van der Poll T, Vogl T, Wiersinga WJ.

PLoS Negl Trop Dis. 2015 Apr 10;9(4):e0003663. doi: 10.1371/journal.pntd.0003663. eCollection 2015 Apr.

43.

Role of triggering receptor expressed on myeloid cells-1/3 in Klebsiella-derived pneumosepsis.

Hommes TJ, Dessing MC, Veer Cv, Florquin S, Colonna M, de Vos AF, van der Poll T.

Am J Respir Cell Mol Biol. 2015 Nov;53(5):647-55. doi: 10.1165/rcmb.2014-0485OC.

PMID:
25860078
44.

Myeloid-related protein-14 deficiency promotes inflammation in staphylococcal pneumonia.

Achouiti A, Vogl T, Van der Meer AJ, Stroo I, Florquin S, de Boer OJ, Roth J, Zeerleder S, van 't Veer C, de Vos AF, van der Poll T.

Eur Respir J. 2015 Aug;46(2):464-73. doi: 10.1183/09031936.00183814. Epub 2015 Mar 18.

45.

The polysaccharide capsule of Streptococcus pneumonia partially impedes MyD88-mediated immunity during pneumonia in mice.

de Vos AF, Dessing MC, Lammers AJ, de Porto AP, Florquin S, de Boer OJ, de Beer R, Terpstra S, Bootsma HJ, Hermans PW, van 't Veer C, van der Poll T.

PLoS One. 2015 Feb 20;10(2):e0118181. doi: 10.1371/journal.pone.0118181. eCollection 2015.

46.

DNAX-activating protein of 12 kDa impairs host defense in pneumococcal pneumonia.

Hommes TJ, Hoogendijk AJ, Dessing MC, Van't Veer C, Florquin S, de Vos AF, van der Poll T.

Crit Care Med. 2014 Dec;42(12):e783-90. doi: 10.1097/CCM.0000000000000686.

PMID:
25402298
47.

Hematopoietic but not endothelial cell MyD88 contributes to host defense during gram-negative pneumonia derived sepsis.

van Lieshout MH, Anas AA, Florquin S, Hou B, van't Veer C, de Vos AF, van der Poll T.

PLoS Pathog. 2014 Sep 25;10(9):e1004368. doi: 10.1371/journal.ppat.1004368. eCollection 2014 Sep.

48.

Myeloid-related protein-8/14 facilitates bacterial growth during pneumococcal pneumonia.

Achouiti A, Vogl T, Endeman H, Mortensen BL, Laterre PF, Wittebole X, van Zoelen MA, Zhang Y, Hoogerwerf JJ, Florquin S, Schultz MJ, Grutters JC, Biesma DH, Roth J, Skaar EP, van 't Veer C, de Vos AF, van der Poll T.

Thorax. 2014 Nov;69(11):1034-42. doi: 10.1136/thoraxjnl-2014-205668. Epub 2014 Sep 1.

PMID:
25179663
49.

Triggering receptor expressed on myeloid cells-1 (TREM-1) improves host defence in pneumococcal pneumonia.

Hommes TJ, Hoogendijk AJ, Dessing MC, Van't Veer C, Florquin S, Colonna M, de Vos AF, van der Poll T.

J Pathol. 2014 Aug;233(4):357-67. doi: 10.1002/path.4361. Epub 2014 Jun 3.

PMID:
24752755
50.

Single immunoglobulin interleukin-1 receptor-related molecule impairs host defense during pneumonia and sepsis caused by Streptococcus pneumoniae.

Blok DC, van Lieshout MH, Hoogendijk AJ, Florquin S, de Boer OJ, Garlanda C, Mantovani A, van't Veer C, de Vos AF, van der Poll T.

J Innate Immun. 2014;6(4):542-52. doi: 10.1159/000358239. Epub 2014 Feb 14.

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