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Items: 1 to 50 of 91

1.

Codon-specific translation reprogramming promotes resistance to targeted therapy.

Rapino F, Delaunay S, Rambow F, Zhou Z, Tharun L, De Tullio P, Sin O, Shostak K, Schmitz S, Piepers J, Ghesquière B, Karim L, Charloteaux B, Jamart D, Florin A, Lambert C, Rorive A, Jerusalem G, Leucci E, Dewaele M, Vooijs M, Leidel SA, Georges M, Voz M, Peers B, Büttner R, Marine JC, Chariot A, Close P.

Nature. 2018 Jun;558(7711):605-609. doi: 10.1038/s41586-018-0243-7. Epub 2018 Jun 20.

PMID:
29925953
2.

PepsNMR for 1H NMR metabolomic data pre-processing.

Martin M, Legat B, Leenders J, Vanwinsberghe J, Rousseau R, Boulanger B, Eilers PHC, De Tullio P, Govaerts B.

Anal Chim Acta. 2018 Aug 17;1019:1-13. doi: 10.1016/j.aca.2018.02.067. Epub 2018 Mar 12.

PMID:
29625674
3.

"NOTA-PRGD2 and NODAGA-PRGD2 : Bioconjugation, characterization, radiolabelling, and design space".

Salvé M, Avohou HT, Monbaliu JM, Lebrun P, Lemaire C, Damblon C, de Tullio P, Hubert P, Hustinx R, Luxen A.

J Labelled Comp Radiopharm. 2018 May 30;61(6):487-500. doi: 10.1002/jlcr.3613. Epub 2018 Apr 25.

PMID:
29430693
4.

Radiotherapy-Activated Cancer-Associated Fibroblasts Promote Tumor Progression through Paracrine IGF1R Activation.

Tommelein J, De Vlieghere E, Verset L, Melsens E, Leenders J, Descamps B, Debucquoy A, Vanhove C, Pauwels P, Gespach CP, Vral A, De Boeck A, Haustermans K, de Tullio P, Ceelen W, Demetter P, Boterberg T, Bracke M, De Wever O.

Cancer Res. 2018 Feb 1;78(3):659-670. doi: 10.1158/0008-5472.CAN-17-0524. Epub 2017 Dec 7.

PMID:
29217764
5.

31ièmes Journées Franco-Belges de Pharmacochimie: Meeting Report.

Frédérick R, Pochet L, De Tullio P, Dufrasne F.

Pharmaceuticals (Basel). 2017 Dec 4;10(4). pii: E94. doi: 10.3390/ph10040094.

6.

Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines.

Schnekenburger M, Goffin E, Lee JY, Jang JY, Mazumder A, Ji S, Rogister B, Bouider N, Lefranc F, Miklos W, Mathieu V, de Tullio P, Kim KW, Dicato M, Berger W, Han BW, Kiss R, Pirotte B, Diederich M.

J Med Chem. 2017 Jun 8;60(11):4714-4733. doi: 10.1021/acs.jmedchem.7b00533. Epub 2017 May 25.

7.

Metabolic inhibitors accentuate the anti-tumoral effect of HDAC5 inhibition.

Hendrick E, Peixoto P, Blomme A, Polese C, Matheus N, Cimino J, Frère A, Mouithys-Mickalad A, Serteyn D, Bettendorff L, Elmoualij B, De Tullio P, Eppe G, Dequiedt F, Castronovo V, Mottet D.

Oncogene. 2017 Aug 24;36(34):4859-4874. doi: 10.1038/onc.2017.103. Epub 2017 Apr 17.

8.

Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis.

Nokin MJ, Durieux F, Peixoto P, Chiavarina B, Peulen O, Blomme A, Turtoi A, Costanza B, Smargiasso N, Baiwir D, Scheijen JL, Schalkwijk CG, Leenders J, De Tullio P, Bianchi E, Thiry M, Uchida K, Spiegel DA, Cochrane JR, Hutton CA, De Pauw E, Delvenne P, Belpomme D, Castronovo V, Bellahcène A.

Elife. 2016 Oct 19;5. pii: e19375. doi: 10.7554/eLife.19375.

9.

Myoferlin regulates cellular lipid metabolism and promotes metastases in triple-negative breast cancer.

Blomme A, Costanza B, de Tullio P, Thiry M, Van Simaeys G, Boutry S, Doumont G, Di Valentin E, Hirano T, Yokobori T, Gofflot S, Peulen O, Bellahcène A, Sherer F, Le Goff C, Cavalier E, Mouithys-Mickalad A, Jouret F, Cusumano PG, Lifrange E, Muller RN, Goldman S, Delvenne P, De Pauw E, Nishiyama M, Castronovo V, Turtoi A.

Oncogene. 2017 Apr;36(15):2116-2130. doi: 10.1038/onc.2016.369. Epub 2016 Oct 24.

PMID:
27775075
10.

Nuclear Magnetic Resonance Metabolomic Profiling of Mouse Kidney, Urine and Serum Following Renal Ischemia/Reperfusion Injury.

Jouret F, Leenders J, Poma L, Defraigne JO, Krzesinski JM, de Tullio P.

PLoS One. 2016 Sep 22;11(9):e0163021. doi: 10.1371/journal.pone.0163021. eCollection 2016.

11.

Metabolomics as a Challenging Approach for Medicinal Chemistry and Personalized Medicine.

Frédérich M, Pirotte B, Fillet M, de Tullio P.

J Med Chem. 2016 Oct 13;59(19):8649-8666. Epub 2016 Jun 27.

PMID:
27295417
12.

4-Phenylureido/thioureido-substituted 2,2-dimethylchroman analogs of cromakalim bearing a bulky 'carbamate' moiety at the 6-position as potent inhibitors of glucose-sensitive insulin secretion.

Pirotte B, Florence X, Goffin E, Medeiros MB, de Tullio P, Lebrun P.

Eur J Med Chem. 2016 Oct 4;121:338-351. doi: 10.1016/j.ejmech.2016.05.042. Epub 2016 May 24.

PMID:
27267004
13.

Synthesis, characterization and biological evaluation of benzothiazoles and tetrahydrobenzothiazoles bearing urea or thiourea moieties as vasorelaxants and inhibitors of the insulin releasing process.

Harrouche K, Renard JF, Bouider N, de Tullio P, Goffin E, Lebrun P, Faury G, Pirotte B, Khelili S.

Eur J Med Chem. 2016 Jun 10;115:352-60. doi: 10.1016/j.ejmech.2016.03.028. Epub 2016 Mar 12.

PMID:
27031211
14.

Interest of cyclodextrins in spray-dried microparticles formulation for sustained pulmonary delivery of budesonide.

Dufour G, Bigazzi W, Wong N, Boschini F, de Tullio P, Piel G, Cataldo D, Evrard B.

Int J Pharm. 2015 Nov 30;495(2):869-78. doi: 10.1016/j.ijpharm.2015.09.052. Epub 2015 Sep 26.

PMID:
26410753
15.

2D-Cosy NMR Spectroscopy as a Quantitative Tool in Biological Matrix: Application to Cyclodextrins.

Dufour G, Evrard B, de Tullio P.

AAPS J. 2015 Nov;17(6):1501-10. doi: 10.1208/s12248-015-9806-9. Epub 2015 Aug 25.

16.

Data in support of metabolic reprogramming in transformed mouse cortical astrocytes: A proteomic study.

Bentaib A, De Tullio P, Chneiweiss H, Hermans E, Junier MP, Leprince P.

Data Brief. 2014 Nov 7;2:1-5. doi: 10.1016/j.dib.2014.09.004. eCollection 2015 Mar.

17.

Nuclear magnetic resonance: a key metabolomics platform in the drug discovery process.

Leenders J, Frédérich M, de Tullio P.

Drug Discov Today Technol. 2015 Jun;13:39-46. doi: 10.1016/j.ddtec.2015.06.005. Epub 2015 Jul 14. Review.

PMID:
26190682
18.

Metabolomics in drug discovery.

de Tullio P.

Drug Discov Today Technol. 2015 Jun;13:1-2. doi: 10.1016/j.ddtec.2015.01.001. Epub 2015 Jan 29. No abstract available.

PMID:
26190676
19.

Rapid quantification of 2-hydroxypropyl-β-cyclodextrin in liquid pharmaceutical formulations by (1)H nuclear magnetic resonance spectroscopy.

Dufour G, Evrard B, de Tullio P.

Eur J Pharm Sci. 2015 Jun 20;73:20-8. doi: 10.1016/j.ejps.2015.03.005. Epub 2015 Mar 20.

20.

Activation of the calcium-sensing receptor before renal ischemia/reperfusion exacerbates kidney injury.

Weekers L, de Tullio P, Bovy C, Poma L, Marée R, Bonvoisin C, Defraigne JO, Krzesinski JM, Jouret F.

Am J Transl Res. 2015 Jan 19;7(1):128-38. eCollection 2015.

21.

Positive allosteric modulators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors belonging to 4-cyclopropyl-3,4-dihydro-2h-1,2,4-pyridothiadiazine dioxides and diversely chloro-substituted 4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides.

Francotte P, Nørholm AB, Deva T, Olsen L, Frydenvang K, Goffin E, Fraikin P, de Tullio P, Challal S, Thomas JY, Iop F, Louis C, Botez-Pop I, Lestage P, Danober L, Kastrup JS, Pirotte B.

J Med Chem. 2014 Nov 26;57(22):9539-53. doi: 10.1021/jm501268r. Epub 2014 Nov 17.

PMID:
25375781
22.

Metabolic reprogramming in transformed mouse cortical astrocytes: A proteomic study.

Bentaib A, De Tullio P, Chneiweiss H, Hermans E, Junier MP, Leprince P.

J Proteomics. 2014 Oct 23;113C:292-314. doi: 10.1016/j.jprot.2014.09.019. [Epub ahead of print]

PMID:
25305589
23.

Blocking lipid synthesis overcomes tumor regrowth and metastasis after antiangiogenic therapy withdrawal.

Sounni NE, Cimino J, Blacher S, Primac I, Truong A, Mazzucchelli G, Paye A, Calligaris D, Debois D, De Tullio P, Mari B, De Pauw E, Noel A.

Cell Metab. 2014 Aug 5;20(2):280-94. doi: 10.1016/j.cmet.2014.05.022. Epub 2014 Jul 10.

24.

Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: from potassium channel openers to calcium entry blockers?

Florence X, Desvaux V, Goffin E, de Tullio P, Pirotte B, Lebrun P.

Eur J Med Chem. 2014 Jun 10;80:36-46. doi: 10.1016/j.ejmech.2014.04.024. Epub 2014 Apr 13.

PMID:
24763361
25.

An easy, convenient cell and tissue extraction protocol for nuclear magnetic resonance metabolomics.

Matheus N, Hansen S, Rozet E, Peixoto P, Maquoi E, Lambert V, Noël A, Frédérich M, Mottet D, de Tullio P.

Phytochem Anal. 2014 Jul-Aug;25(4):342-9. doi: 10.1002/pca.2498. Epub 2014 Jan 23.

PMID:
24453161
26.

Laser-induced choroidal neovascularization model to study age-related macular degeneration in mice.

Lambert V, Lecomte J, Hansen S, Blacher S, Gonzalez ML, Struman I, Sounni NE, Rozet E, de Tullio P, Foidart JM, Rakic JM, Noel A.

Nat Protoc. 2013 Nov;8(11):2197-211. doi: 10.1038/nprot.2013.135. Epub 2013 Oct 17.

27.

Development of thiophenic analogues of benzothiadiazine dioxides as new powerful potentiators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors.

Francotte P, Goffin E, Fraikin P, Graindorge E, Lestage P, Danober L, Challal S, Rogez N, Nosjean O, Caignard DH, Pirotte B, de Tullio P.

J Med Chem. 2013 Oct 24;56(20):7838-50. doi: 10.1021/jm400676g. Epub 2013 Oct 3.

PMID:
24090223
28.

Triphenylphosphonium salts of 1,2,4-benzothiadiazine 1,1-dioxides related to diazoxide targeting mitochondrial ATP-sensitive potassium channels.

Constant-Urban C, Charif M, Goffin E, Van Heugen JC, Elmoualij B, Chiap P, Mouithys-Mickalad A, Serteyn D, Lebrun P, Pirotte B, De Tullio P.

Bioorg Med Chem Lett. 2013 Nov 1;23(21):5878-81. doi: 10.1016/j.bmcl.2013.08.091. Epub 2013 Sep 6.

PMID:
24055044
29.

Identification of methylenecyclopropyl acetic acid in serum of European horses with atypical myopathy.

Votion DM, van Galen G, Sweetman L, Boemer F, de Tullio P, Dopagne C, Lefère L, Mouithys-Mickalad A, Patarin F, Rouxhet S, van Loon G, Serteyn D, Sponseller BT, Valberg SJ.

Equine Vet J. 2014 Mar;46(2):146-9. doi: 10.1111/evj.12117. Epub 2013 Sep 3.

PMID:
23773055
30.

1,4,2-Benzo/pyridodithiazine 1,1-dioxides structurally related to the ATP-sensitive potassium channel openers 1,2,4-Benzo/pyridothiadiazine 1,1-dioxides exert a myorelaxant activity linked to a distinct mechanism of action.

Pirotte B, de Tullio P, Florence X, Goffin E, Somers F, Boverie S, Lebrun P.

J Med Chem. 2013 Apr 25;56(8):3247-56. doi: 10.1021/jm301743b. Epub 2013 Apr 4.

PMID:
23517501
31.

AMPA receptor positive allosteric modulators: a patent review.

Pirotte B, Francotte P, Goffin E, de Tullio P.

Expert Opin Ther Pat. 2013 May;23(5):615-28. doi: 10.1517/13543776.2013.770840. Epub 2013 Feb 13. Review.

PMID:
23405869
32.

Identification and structural elucidation of four cannabimimetic compounds (RCS-4, AM-2201, JWH-203 and JWH-210) in seized products.

Denooz R, Vanheugen JC, Frederich M, de Tullio P, Charlier C.

J Anal Toxicol. 2013 Mar;37(2):56-63. doi: 10.1093/jat/bks095. Epub 2013 Jan 20.

PMID:
23339188
33.

N-Aryl-N'-(chroman-4-yl)ureas and thioureas display in vitro anticancer activity and selectivity on apoptosis-resistant glioblastoma cells: screening, synthesis of simplified derivatives, and structure-activity relationship analysis.

Goffin E, Lamoral-Theys D, Tajeddine N, de Tullio P, Mondin L, Lefranc F, Gailly P, Rogister B, Kiss R, Pirotte B.

Eur J Med Chem. 2012 Aug;54:834-44. doi: 10.1016/j.ejmech.2012.06.050. Epub 2012 Jul 4.

34.

Synthesis and pharmacological activity of N-(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)-4H-1,2,4-benzothiadiazine-3-carboxamides 1,1-dioxides on rat uterus, rat aorta and rat pancreatic β-cells.

Khelili S, Kihal N, Yekhlef M, de Tullio P, Lebrun P, Pirotte B.

Eur J Med Chem. 2012 Aug;54:873-8. doi: 10.1016/j.ejmech.2012.05.011. Epub 2012 May 15.

PMID:
22647221
35.
36.

Modulation of the 6-position of benzopyran derivatives and inhibitory effects on the insulin releasing process.

Florence X, Dilly S, de Tullio P, Pirotte B, Lebrun P.

Bioorg Med Chem. 2011 Jul 1;19(13):3919-28. doi: 10.1016/j.bmc.2011.05.040. Epub 2011 May 24.

PMID:
21664825
37.

Impact of the nature of the substituent at the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides on their opening activity toward ATP-sensitive potassium channels.

Pirotte B, de Tullio P, Boverie S, Michaux C, Lebrun P.

J Med Chem. 2011 May 12;54(9):3188-99. doi: 10.1021/jm200100c. Epub 2011 Apr 8.

PMID:
21428460
38.

Ring-fused thiadiazines as core structures for the development of potent AMPA receptor potentiators.

Pirotte B, Francotte P, Goffin E, Fraikin P, Danober L, Lesur B, Botez I, Caignard DH, Lestage P, de Tullio P.

Curr Med Chem. 2010;17(30):3575-82. Review.

PMID:
20738245
39.

Quality assessment of Polygonum cuspidatum and Polygonum multiflorum by 1H NMR metabolite fingerprinting and profiling analysis.

Frédérich M, Wauters JN, Tits M, Jason C, de Tullio P, Van der Heyden Y, Fan G, Angenot L.

Planta Med. 2011 Jan;77(1):81-6. doi: 10.1055/s-0030-1250132. Epub 2010 Jul 19.

PMID:
20645247
40.

New fluorinated 1,2,4-benzothiadiazine 1,1-dioxides: discovery of an orally active cognitive enhancer acting through potentiation of the 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors.

Francotte P, Goffin E, Fraikin P, Lestage P, Van Heugen JC, Gillotin F, Danober L, Thomas JY, Chiap P, Caignard DH, Pirotte B, de Tullio P.

J Med Chem. 2010 Feb 25;53(4):1700-11. doi: 10.1021/jm901495t.

PMID:
20108934
41.

Chloro-substituted 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel activators: impact of the position of the chlorine atom on the aromatic ring on activity and tissue selectivity.

Pirotte B, de Tullio P, Nguyen QA, Somers F, Fraikin P, Florence X, Wahl P, Hansen JB, Lebrun P.

J Med Chem. 2010 Jan 14;53(1):147-54. doi: 10.1021/jm9010093.

PMID:
19919106
42.

Coupling of liquid chromatography/tandem mass spectrometry and liquid chromatography/solid-phase extraction/NMR techniques for the structural identification of metabolites following in vitro biotransformation of SUR1-selective ATP-sensitive potassium channel openers.

Gillotin F, Chiap P, Frédérich M, Van Heugen JC, Francotte P, Lebrun P, Pirotte B, de Tullio P.

Drug Metab Dispos. 2010 Feb;38(2):232-40. doi: 10.1124/dmd.109.028928. Epub 2009 Oct 29.

43.

Metabolomic analysis of Echinacea spp. by 1H nuclear magnetic resonance spectrometry and multivariate data analysis technique.

Frédérich M, Jansen C, de Tullio P, Tits M, Demoulin V, Angenot L.

Phytochem Anal. 2010 Jan-Feb;21(1):61-5. doi: 10.1002/pca.1156.

PMID:
19743068
44.

Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators.

Francotte P, de Tullio P, Podona T, Diouf O, Fraikin P, Lestage P, Danober L, Thomas JY, Caignard DH, Pirotte B.

Bioorg Med Chem. 2008 Dec 1;16(23):9948-56. doi: 10.1016/j.bmc.2008.10.036. Epub 2008 Oct 17.

PMID:
18980844
45.

Synthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators.

Khelili S, Florence X, Bouhadja M, Abdelaziz S, Mechouch N, Mohamed Y, de Tullio P, Lebrun P, Pirotte B.

Bioorg Med Chem. 2008 Jun 1;16(11):6124-30. doi: 10.1016/j.bmc.2008.04.043. Epub 2008 Apr 25.

PMID:
18479927
46.

New R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylaminothiocarbonylamino)-2H-1-benzopyrans structurally related to (+/-)-cromakalim as tissue-selective pancreatic beta-cell K(ATP) channel openers.

Sebille S, de Tullio P, Florence X, Becker B, Antoine MH, Michaux C, Wouters J, Pirotte B, Lebrun P.

Bioorg Med Chem. 2008 May 15;16(10):5704-19. doi: 10.1016/j.bmc.2008.03.065. Epub 2008 Mar 30.

PMID:
18406154
47.

6-Substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives in a new approach of the treatment of cancer cell invasion and metastasis.

Kempen I, Hemmer M, Counerotte S, Pochet L, de Tullio P, Foidart JM, Blacher S, Noël A, Frankenne F, Pirotte B.

Eur J Med Chem. 2008 Dec;43(12):2735-50. doi: 10.1016/j.ejmech.2008.01.024. Epub 2008 Jan 31.

48.

In search of novel AMPA potentiators.

Francotte P, de Tullio P, Fraikin P, Counerotte S, Goffin E, Pirotte B.

Recent Pat CNS Drug Discov. 2006 Nov;1(3):239-46. Review.

PMID:
18221205
49.

KATP channel openers: tissue selectivity of original 3-alkylaminopyrido- and 3-alkylaminobenzothiadiazine 1,1-dioxides.

Lebrun P, Becker B, Morel N, Ghisdal P, Antoine MH, de Tullio P, Pirotte B.

Biochem Pharmacol. 2008 Jan 15;75(2):468-75. Epub 2007 Sep 1.

PMID:
17920043
50.

Development of a mass spectrometry method for the determination of a melanoma biomarker, 5-S-cysteinyldopa, in human plasma using solid phase extraction for sample clean-up.

Martin GB, Chiap P, Paquet P, Pierard G, de Tullio P, Martin Y, Rozet E, Hubert P, Crommen J, Fillet M.

J Chromatogr A. 2007 Jul 13;1156(1-2):141-8. Epub 2006 Dec 29.

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