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Items: 1 to 50 of 165

1.

Chronic high-dose testosterone treatment: impact on rat cardiac contractile biology.

Wadthaisong M, Witayavanitkul N, Bupha-Intr T, Wattanapermpool J, de Tombe PP.

Physiol Rep. 2019 Jul;7(14):e14192. doi: 10.14814/phy2.14192.

2.

Sarcomeric mutations in cardiac diseases.

Harris SP, de Tombe PP.

Pflugers Arch. 2019 May;471(5):659-660. doi: 10.1007/s00424-019-02275-2. Epub 2019 Apr 11. No abstract available.

PMID:
30976925
3.

Toward an understanding of the regulation of myofibrillar function.

Moss RL, de Tombe PP, Solaro RJ.

J Gen Physiol. 2019 Jan 7;151(1):1-2. doi: 10.1085/jgp.201812288. Epub 2018 Dec 21. No abstract available.

4.

Estrogen but not testosterone preserves myofilament function from doxorubicin-induced cardiotoxicity by reducing oxidative modifications.

Rattanasopa C, Kirk JA, Bupha-Intr T, Papadaki M, de Tombe PP, Wattanapermpool J.

Am J Physiol Heart Circ Physiol. 2019 Feb 1;316(2):H360-H370. doi: 10.1152/ajpheart.00428.2018. Epub 2018 Nov 30.

PMID:
30499711
5.

Frank's law of the heart: Found in translation.

de Tombe PP, Tyberg JV.

J Mol Cell Cardiol. 2018 Aug;121:33-35. doi: 10.1016/j.yjmcc.2018.06.003. Epub 2018 Jun 15. No abstract available.

PMID:
29908919
6.

Phenotyping cardiomyopathy in adult zebrafish.

Dvornikov AV, de Tombe PP, Xu X.

Prog Biophys Mol Biol. 2018 Oct;138:116-125. doi: 10.1016/j.pbiomolbio.2018.05.013. Epub 2018 May 30. Review.

7.

Altered myofilament structure and function in dogs with Duchenne muscular dystrophy cardiomyopathy.

Ait Mou Y, Lacampagne A, Irving T, Scheuermann V, Blot S, Ghaleh B, de Tombe PP, Cazorla O.

J Mol Cell Cardiol. 2018 Jan;114:345-353. doi: 10.1016/j.yjmcc.2017.12.008. Epub 2017 Dec 22.

8.

The naked mole-rat exhibits an unusual cardiac myofilament protein profile providing new insights into heart function of this naturally subterranean rodent.

Grimes KM, Barefield DY, Kumar M, McNamara JW, Weintraub ST, de Tombe PP, Sadayappan S, Buffenstein R.

Pflugers Arch. 2017 Dec;469(12):1603-1613. doi: 10.1007/s00424-017-2046-3. Epub 2017 Aug 5.

9.

Pathogenesis of Hypertrophic Cardiomyopathy is Mutation Rather Than Disease Specific: A Comparison of the Cardiac Troponin T E163R and R92Q Mouse Models.

Ferrantini C, Coppini R, Pioner JM, Gentile F, Tosi B, Mazzoni L, Scellini B, Piroddi N, Laurino A, Santini L, Spinelli V, Sacconi L, De Tombe P, Moore R, Tardiff J, Mugelli A, Olivotto I, Cerbai E, Tesi C, Poggesi C.

J Am Heart Assoc. 2017 Jul 22;6(7). pii: e005407. doi: 10.1161/JAHA.116.005407.

10.

Impact of titin strain on the cardiac slow force response.

Ait-Mou Y, Zhang M, Martin JL, Greaser ML, de Tombe PP.

Prog Biophys Mol Biol. 2017 Nov;130(Pt B):281-287. doi: 10.1016/j.pbiomolbio.2017.06.009. Epub 2017 Jun 22.

11.

Acute inhibitory effect of alpha-mangostin on sarcoplasmic reticulum calcium-ATPase and myocardial relaxation.

Phungphong S, Kijtawornrat A, de Tombe PP, Wattanapermpool J, Bupha-Intr T, Suksamrarn S.

J Biochem Mol Toxicol. 2017 Oct;31(10). doi: 10.1002/jbt.21942. Epub 2017 Jun 7.

PMID:
28590578
12.

Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I.

Siddiqui JK, Tikunova SB, Walton SD, Liu B, Meyer M, de Tombe PP, Neilson N, Kekenes-Huskey PM, Salhi HE, Janssen PM, Biesiadecki BJ, Davis JP.

Front Physiol. 2016 Dec 21;7:632. doi: 10.3389/fphys.2016.00632. eCollection 2016.

13.

Restrictive Cardiomyopathy Troponin I R145W Mutation Does Not Perturb Myofilament Length-dependent Activation in Human Cardiac Sarcomeres.

Dvornikov AV, Smolin N, Zhang M, Martin JL, Robia SL, de Tombe PP.

J Biol Chem. 2016 Oct 7;291(41):21817-21828. Epub 2016 Aug 24.

14.

Which way to grow? Force over time may be the heart's Dao de jing.

de Tombe PP, Kohl P.

Glob Cardiol Sci Pract. 2016 Jun 30;2016(2):e201621. doi: 10.21542/gcsp.2016.21. No abstract available.

15.

R-CEPIA1er as a new tool to directly measure sarcoplasmic reticulum [Ca] in ventricular myocytes.

Bovo E, Martin JL, Tyryfter J, de Tombe PP, Zima AV.

Am J Physiol Heart Circ Physiol. 2016 Jul 1;311(1):H268-75. doi: 10.1152/ajpheart.00175.2016. Epub 2016 May 27.

16.

Myosin light chain phosphorylation, novel targets to repair a broken heart?

Szczesna-Cordary D, de Tombe PP.

Cardiovasc Res. 2016 Jul 1;111(1):5-7. doi: 10.1093/cvr/cvw098. Epub 2016 May 17. No abstract available.

17.

Titin strain contributes to the Frank-Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins.

Ait-Mou Y, Hsu K, Farman GP, Kumar M, Greaser ML, Irving TC, de Tombe PP.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2306-11. doi: 10.1073/pnas.1516732113. Epub 2016 Feb 8.

18.

Nuclear accumulation of myocyte muscle LIM protein is regulated by heme oxygenase 1 and correlates with cardiac function in the transition to failure.

Paudyal A, Dewan S, Ikie C, Whalley BJ, de Tombe PP, Boateng SY.

J Physiol. 2016 Jun 15;594(12):3287-305. doi: 10.1113/JP271809. Epub 2016 May 5.

19.

Exploring cardiac biophysical properties.

Ait Mou Y, Bollensdorff C, Cazorla O, Magdi Y, de Tombe PP.

Glob Cardiol Sci Pract. 2015 Apr 10;2015:10. doi: 10.5339/gcsp.2015.10. eCollection 2015.

20.

Pacemaker-induced transient asynchrony suppresses heart failure progression.

Kirk JA, Chakir K, Lee KH, Karst E, Holewinski RJ, Pironti G, Tunin RS, Pozios I, Abraham TP, de Tombe P, Rockman HA, Van Eyk JE, Craig R, Farazi TG, Kass DA.

Sci Transl Med. 2015 Dec 23;7(319):319ra207. doi: 10.1126/scitranslmed.aad2899.

21.

Cardiac muscle mechanics: Sarcomere length matters.

de Tombe PP, ter Keurs HE.

J Mol Cell Cardiol. 2016 Feb;91:148-50. doi: 10.1016/j.yjmcc.2015.12.006. Epub 2015 Dec 8. No abstract available.

22.

Green Tea Catechin Normalizes the Enhanced Ca2+ Sensitivity of Myofilaments Regulated by a Hypertrophic Cardiomyopathy-Associated Mutation in Human Cardiac Troponin I (K206I).

Warren CM, Karam CN, Wolska BM, Kobayashi T, de Tombe PP, Arteaga GM, Bos JM, Ackerman MJ, Solaro RJ.

Circ Cardiovasc Genet. 2015 Dec;8(6):765-73. doi: 10.1161/CIRCGENETICS.115.001234. Epub 2015 Nov 9.

23.

Increased Energy Demand during Adrenergic Receptor Stimulation Contributes to Ca(2+) Wave Generation.

Bovo E, Mazurek SR, de Tombe PP, Zima AV.

Biophys J. 2015 Oct 20;109(8):1583-91. doi: 10.1016/j.bpj.2015.09.002.

24.

Cardiac Myosin-binding Protein C and Troponin-I Phosphorylation Independently Modulate Myofilament Length-dependent Activation.

Kumar M, Govindan S, Zhang M, Khairallah RJ, Martin JL, Sadayappan S, de Tombe PP.

J Biol Chem. 2015 Dec 4;290(49):29241-9. doi: 10.1074/jbc.M115.686790. Epub 2015 Oct 9.

25.

Rapid large-scale purification of myofilament proteins using a cleavable His6-tag.

Zhang M, Martin JL, Kumar M, Khairallah RJ, de Tombe PP.

Am J Physiol Heart Circ Physiol. 2015 Nov;309(9):H1509-15. doi: 10.1152/ajpheart.00598.2015. Epub 2015 Sep 18.

26.

Myosin light chain phosphorylation to the rescue.

Granzier HL, de Tombe PP.

Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):9148-9. doi: 10.1073/pnas.1511455112. Epub 2015 Jul 8. No abstract available.

27.

Acute inotropic and lusitropic effects of cardiomyopathic R9C mutation of phospholamban.

Abrol N, de Tombe PP, Robia SL.

J Biol Chem. 2015 Mar 13;290(11):7130-40. doi: 10.1074/jbc.M114.630319. Epub 2015 Jan 15.

28.

Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice.

Barefield D, Kumar M, Gorham J, Seidman JG, Seidman CE, de Tombe PP, Sadayappan S.

J Mol Cell Cardiol. 2015 Feb;79:234-43. doi: 10.1016/j.yjmcc.2014.11.018. Epub 2014 Nov 25.

29.

Effects of a myofilament calcium sensitizer on left ventricular systolic and diastolic function in rats with volume overload heart failure.

Wilson K, Guggilam A, West TA, Zhang X, Trask AJ, Cismowski MJ, de Tombe P, Sadayappan S, Lucchesi PA.

Am J Physiol Heart Circ Physiol. 2014 Dec 1;307(11):H1605-17. doi: 10.1152/ajpheart.00423.2014. Epub 2014 Sep 26.

30.

Cardiac troponin I tyrosine 26 phosphorylation decreases myofilament Ca2+ sensitivity and accelerates deactivation.

Salhi HE, Walton SD, Hassel NC, Brundage EA, de Tombe PP, Janssen PM, Davis JP, Biesiadecki BJ.

J Mol Cell Cardiol. 2014 Nov;76:257-64. doi: 10.1016/j.yjmcc.2014.09.013. Epub 2014 Sep 22.

31.

Heart failure: a special issue.

van der Velden J, de Tombe PP.

Pflugers Arch. 2014 Jun;466(6):1023. doi: 10.1007/s00424-014-1531-1. Epub 2014 May 14. No abstract available.

32.

The role of dyadic organization in regulation of sarcoplasmic reticulum Ca(2+) handling during rest in rabbit ventricular myocytes.

Bovo E, de Tombe PP, Zima AV.

Biophys J. 2014 May 6;106(9):1902-9. doi: 10.1016/j.bpj.2014.03.032.

33.

Cardiomyocyte-specific expression of CRNK, the C-terminal domain of PYK2, maintains ventricular function and slows ventricular remodeling in a mouse model of dilated cardiomyopathy.

Koshman YE, Chu M, Kim T, Kalmanson O, Farjah M, Kumar M, Lewis W, Geenen DL, de Tombe P, Goldspink PH, Solaro RJ, Samarel AM.

J Mol Cell Cardiol. 2014 Jul;72:281-91. doi: 10.1016/j.yjmcc.2014.03.021. Epub 2014 Apr 5.

34.

Novel approaches to determine contractile function of the isolated adult zebrafish ventricular cardiac myocyte.

Dvornikov AV, Dewan S, Alekhina OV, Pickett FB, de Tombe PP.

J Physiol. 2014 May 1;592(9):1949-56. doi: 10.1113/jphysiol.2014.270678. Epub 2014 Mar 3.

35.

Myocardial infarction-induced N-terminal fragment of cardiac myosin-binding protein C (cMyBP-C) impairs myofilament function in human myocardium.

Witayavanitkul N, Ait Mou Y, Kuster DW, Khairallah RJ, Sarkey J, Govindan S, Chen X, Ge Y, Rajan S, Wieczorek DF, Irving T, Westfall MV, de Tombe PP, Sadayappan S.

J Biol Chem. 2014 Mar 28;289(13):8818-27. doi: 10.1074/jbc.M113.541128. Epub 2014 Feb 7.

36.

Contractile dysfunction in a mouse model expressing a heterozygous MYBPC3 mutation associated with hypertrophic cardiomyopathy.

Barefield D, Kumar M, de Tombe PP, Sadayappan S.

Am J Physiol Heart Circ Physiol. 2014 Mar;306(6):H807-15. doi: 10.1152/ajpheart.00913.2013. Epub 2014 Jan 24.

37.

Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3β.

Kirk JA, Holewinski RJ, Kooij V, Agnetti G, Tunin RS, Witayavanitkul N, de Tombe PP, Gao WD, Van Eyk J, Kass DA.

J Clin Invest. 2014 Jan;124(1):129-38.

38.

Cardiac myosin binding protein-C as a central target of cardiac sarcomere signaling: a special mini review series.

Sadayappan S, de Tombe PP.

Pflugers Arch. 2014 Feb;466(2):195-200. doi: 10.1007/s00424-013-1396-8. Epub 2013 Nov 7. Review.

39.

Mechanisms of Ca²+ handling in zebrafish ventricular myocytes.

Bovo E, Dvornikov AV, Mazurek SR, de Tombe PP, Zima AV.

Pflugers Arch. 2013 Dec;465(12):1775-84. doi: 10.1007/s00424-013-1312-2. Epub 2013 Jul 3.

40.

Sex differences in health and disease: brain and heart connections--a special issue.

Wattanapermpool J, de Tombe PP, Pak TR.

Pflugers Arch. 2013 May;465(5):555-6. doi: 10.1007/s00424-013-1279-z. Epub 2013 Apr 16. No abstract available.

PMID:
23588381
41.

Impact of titin isoform on length dependent activation and cross-bridge cycling kinetics in rat skeletal muscle.

Mateja RD, Greaser ML, de Tombe PP.

Biochim Biophys Acta. 2013 Apr;1833(4):804-11. doi: 10.1016/j.bbamcr.2012.08.011. Epub 2012 Aug 23.

42.

New insights into the functional significance of the acidic region of the unique N-terminal extension of cardiac troponin I.

Henze M, Patrick SE, Hinken A, Scruggs SB, Goldspink P, de Tombe PP, Kobayashi M, Ping P, Kobayashi T, Solaro RJ.

Biochim Biophys Acta. 2013 Apr;1833(4):823-32. doi: 10.1016/j.bbamcr.2012.08.012. Epub 2012 Aug 25.

43.

Myofilament length-dependent activation develops within 5 ms in guinea-pig myocardium.

Mateja RD, de Tombe PP.

Biophys J. 2012 Jul 3;103(1):L13-5. doi: 10.1016/j.bpj.2012.05.034.

44.

The velocity of cardiac sarcomere shortening: mechanisms and implications.

de Tombe PP, ter Keurs HE.

J Muscle Res Cell Motil. 2012 Dec;33(6):431-7. doi: 10.1007/s10974-012-9310-0. Epub 2012 Jun 30. Review.

45.

Cardiac myosin binding protein-C: redefining its structure and function.

Sadayappan S, de Tombe PP.

Biophys Rev. 2012 Jun 1;4(2):93-106.

46.

Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitro.

Govindan S, Sarkey J, Ji X, Sundaresan NR, Gupta MP, de Tombe PP, Sadayappan S.

J Muscle Res Cell Motil. 2012 May;33(1):17-30. doi: 10.1007/s10974-012-9292-y. Epub 2012 Apr 17.

47.

Equal force recovery in dysferlin-deficient and wild-type muscles following saponin exposure.

Zhao P, Xu L, Ait-Mou Y, de Tombe PP, Han R.

J Biomed Biotechnol. 2011;2011:235216. doi: 10.1155/2011/235216. Epub 2011 Sep 18.

48.

Interventricular differences in myofilament function in experimental congestive heart failure.

Belin RJ, Sumandea MP, Sievert GA, Harvey LA, Geenen DL, Solaro RJ, de Tombe PP.

Pflugers Arch. 2011 Dec;462(6):795-809. doi: 10.1007/s00424-011-1024-4. Epub 2011 Sep 17.

49.

The cytoskeleton and the cellular transduction of mechanical strain in the heart: a special issue.

de Tombe PP, Granzier HL.

Pflugers Arch. 2011 Jul;462(1):1-2. doi: 10.1007/s00424-011-0976-8. Epub 2011 May 19. No abstract available.

PMID:
21594569
50.

Protein kinase A changes calcium sensitivity but not crossbridge kinetics in human cardiac myofibrils.

Walker JS, Walker LA, Margulies K, Buttrick P, de Tombe P.

Am J Physiol Heart Circ Physiol. 2011 Jul;301(1):H138-46. doi: 10.1152/ajpheart.00838.2010. Epub 2011 Apr 15.

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