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Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses In Vitro and in Humanized Mice.

Amblard F, Boucle S, Bassit L, Cox B, Sari O, Tao S, Chen Z, Ozturk T, Verma K, Russell O, Rat V, de Rocquigny H, Fiquet O, Boussand M, Di Santo J, Strick-Marchand H, Schinazi RF.

Antimicrob Agents Chemother. 2020 Jan 27;64(2). pii: e01701-19. doi: 10.1128/AAC.01701-19. Print 2020 Jan 27.


Direct interaction between the hepatitis B virus core and envelope proteins analyzed in a cellular context.

Pastor F, Herrscher C, Patient R, Eymieux S, Moreau A, Burlaud-Gaillard J, Seigneuret F, de Rocquigny H, Roingeard P, Hourioux C.

Sci Rep. 2019 Nov 7;9(1):16178. doi: 10.1038/s41598-019-52824-z.


BAY 41-4109-mediated aggregation of assembled and misassembled HBV capsids in cells revealed by electron microscopy.

Rat V, Seigneuret F, Burlaud-Gaillard J, Lemoine R, Hourioux C, Zoulim F, Testoni B, Meunier JC, Tauber C, Roingeard P, de Rocquigny H.

Antiviral Res. 2019 Sep;169:104557. doi: 10.1016/j.antiviral.2019.104557. Epub 2019 Jul 11.


HIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry.

Pham VV, Salguero C, Khan SN, Meagher JL, Brown WC, Humbert N, de Rocquigny H, Smith JL, D'Souza VM.

Nat Commun. 2018 Oct 15;9(1):4266. doi: 10.1038/s41467-018-06591-6.


The NC domain of HIV-1 Gag contributes to the interaction of Gag with TSG101.

El Meshri SE, Boutant E, Mouhand A, Thomas A, Larue V, Richert L, Vivet-Boudou V, Mély Y, Tisné C, Muriaux D, de Rocquigny H.

Biochim Biophys Acta Gen Subj. 2018 Jun;1862(6):1421-1431. doi: 10.1016/j.bbagen.2018.03.020. Epub 2018 Mar 20.


The multiple roles of the nucleocapsid in retroviral RNA conversion into proviral DNA by reverse transcriptase.

Darlix JL, de Rocquigny H, Mély Y.

Biochem Soc Trans. 2016 Oct 15;44(5):1427-1440. Review.


Characterization of the interaction between the HIV-1 Gag structural polyprotein and the cellular ribosomal protein L7 and its implication in viral nucleic acid remodeling.

Mekdad HE, Boutant E, Karnib H, Biedma ME, Sharma KK, Malytska I, Laumond G, Roy M, Réal E, Paillart JC, Moog C, Darlix JL, Mély Y, de Rocquigny H.

Retrovirology. 2016 Aug 11;13(1):54. doi: 10.1186/s12977-016-0287-4.


Requirements for nucleocapsid-mediated regulation of reverse transcription during the late steps of HIV-1 assembly.

Racine PJ, Chamontin C, de Rocquigny H, Bernacchi S, Paillart JC, Mougel M.

Sci Rep. 2016 Jun 7;6:27536. doi: 10.1038/srep27536.


Convenient Access to Fluorescent Probes by Chemoselective Acylation of Hydrazinopeptides: Application to the Synthesis of the First Far-Red Ligand for Apelin Receptor Imaging.

Margathe JF, Iturrioz X, Regenass P, Karpenko IA, Humbert N, de Rocquigny H, Hibert M, Llorens-Cortes C, Bonnet D.

Chemistry. 2016 Jan 22;22(4):1399-405. doi: 10.1002/chem.201503630. Epub 2015 Dec 18.


Investigating the cellular distribution and interactions of HIV-1 nucleocapsid protein by quantitative fluorescence microscopy.

Anton H, Taha N, Boutant E, Richert L, Khatter H, Klaholz B, Rondé P, Réal E, de Rocquigny H, Mély Y.

PLoS One. 2015 Feb 27;10(2):e0116921. doi: 10.1371/journal.pone.0116921. eCollection 2015.


Role of the nucleocapsid domain in HIV-1 Gag oligomerization and trafficking to the plasma membrane: a fluorescence lifetime imaging microscopy investigation.

El Meshri SE, Dujardin D, Godet J, Richert L, Boudier C, Darlix JL, Didier P, Mély Y, de Rocquigny H.

J Mol Biol. 2015 Mar 27;427(6 Pt B):1480-1494. doi: 10.1016/j.jmb.2015.01.015. Epub 2015 Jan 30.


The HIV-1 nucleocapsid protein recruits negatively charged lipids to ensure its optimal binding to lipid membranes.

Kempf N, Postupalenko V, Bora S, Didier P, Arntz Y, de Rocquigny H, Mély Y.

J Virol. 2015 Feb;89(3):1756-67. doi: 10.1128/JVI.02931-14. Epub 2014 Nov 19.


Role of the nucleocapsid region in HIV-1 Gag assembly as investigated by quantitative fluorescence-based microscopy.

de Rocquigny H, El Meshri SE, Richert L, Didier P, Darlix JL, Mély Y.

Virus Res. 2014 Nov 26;193:78-88. doi: 10.1016/j.virusres.2014.06.009. Epub 2014 Jul 9. Review.


Retrospective on the all-in-one retroviral nucleocapsid protein.

Darlix JL, de Rocquigny H, Mauffret O, Mély Y.

Virus Res. 2014 Nov 26;193:2-15. doi: 10.1016/j.virusres.2014.05.011. Epub 2014 Jun 4. Review.


Direct, reagentless electrochemical detection of the BIR3 domain of X-linked inhibitor of apoptosis protein using a peptide-based conducting polymer sensor.

Wang X, Piro B, Reisberg S, Anquetin G, de Rocquigny H, Jiang P, Wang Q, Wu W, Pham MC, Dong CZ.

Biosens Bioelectron. 2014 Nov 15;61:57-62. doi: 10.1016/j.bios.2014.04.047. Epub 2014 May 9.


Dynamic interactions of the HIV-1 Tat with nucleic acids are critical for Tat activity in reverse transcription.

Boudier C, Humbert N, Chaminade F, Chen Y, de Rocquigny H, Godet J, Mauffret O, Fossé P, Mély Y.

Nucleic Acids Res. 2014 Jan;42(2):1065-78. doi: 10.1093/nar/gkt934. Epub 2013 Oct 22.


Functionalized two-photon absorbing diketopyrrolopyrrole-based fluorophores for living cells fluorescent microscopy.

Ftouni H, Bolze F, de Rocquigny H, Nicoud JF.

Bioconjug Chem. 2013 Jun 19;24(6):942-50. doi: 10.1021/bc300623q. Epub 2013 May 13.


APOBEC3G impairs the multimerization of the HIV-1 Vif protein in living cells.

Batisse J, Guerrero SX, Bernacchi S, Richert L, Godet J, Goldschmidt V, Mély Y, Marquet R, de Rocquigny H, Paillart JC.

J Virol. 2013 Jun;87(11):6492-506. doi: 10.1128/JVI.03494-12. Epub 2013 Apr 10.


Intrinsic nucleic acid dynamics modulates HIV-1 nucleocapsid protein binding to its targets.

Bazzi A, Zargarian L, Chaminade F, De Rocquigny H, René B, Mély Y, Fossé P, Mauffret O.

PLoS One. 2012;7(6):e38905. doi: 10.1371/journal.pone.0038905. Epub 2012 Jun 20.


Analysis of the RNA chaperoning activity of the hepatitis C virus core protein on the conserved 3'X region of the viral genome.

Sharma KK, de Rocquigny H, Darlix JL, Lavergne JP, Pénin F, Lessinger JM, Mély Y.

Nucleic Acids Res. 2012 Mar;40(6):2540-53. doi: 10.1093/nar/gkr1140. Epub 2011 Nov 29.


Characterization of the mechanisms of HIV-1 Vpr(52-96) internalization in cells.

Greiner VJ, Shvadchak V, Fritz J, Arntz Y, Didier P, Frisch B, Boudier C, Mély Y, de Rocquigny H.

Biochimie. 2011 Oct;93(10):1647-58. doi: 10.1016/j.biochi.2011.05.033. Epub 2011 Jun 21.


Specific implications of the HIV-1 nucleocapsid zinc fingers in the annealing of the primer binding site complementary sequences during the obligatory plus strand transfer.

Godet J, Ramalanjaona N, Sharma KK, Richert L, de Rocquigny H, Darlix JL, Duportail G, Mély Y.

Nucleic Acids Res. 2011 Aug;39(15):6633-45. doi: 10.1093/nar/gkr274. Epub 2011 May 4.


Structural insights into the cTAR DNA recognition by the HIV-1 nucleocapsid protein: role of sugar deoxyriboses in the binding polarity of NC.

Bazzi A, Zargarian L, Chaminade F, Boudier C, De Rocquigny H, René B, Mély Y, Fossé P, Mauffret O.

Nucleic Acids Res. 2011 May;39(9):3903-16. doi: 10.1093/nar/gkq1290. Epub 2011 Jan 11.


Kinetic analysis of the nucleic acid chaperone activity of the hepatitis C virus core protein.

Sharma Kk, Didier P, Darlix JL, de Rocquigny H, Bensikaddour H, Lavergne JP, Pénin F, Lessinger JM, Mély Y.

Nucleic Acids Res. 2010 Jun;38(11):3632-42. doi: 10.1093/nar/gkq094. Epub 2010 Feb 18.


HIV-1 Vpr oligomerization but not that of Gag directs the interaction between Vpr and Gag.

Fritz JV, Dujardin D, Godet J, Didier P, De Mey J, Darlix JL, Mély Y, de Rocquigny H.

J Virol. 2010 Feb;84(3):1585-96. doi: 10.1128/JVI.01691-09. Epub 2009 Nov 18.


Identification by high throughput screening of small compounds inhibiting the nucleic acid destabilization activity of the HIV-1 nucleocapsid protein.

Shvadchak V, Sanglier S, Rocle S, Villa P, Haiech J, Hibert M, Van Dorsselaer A, Mély Y, de Rocquigny H.

Biochimie. 2009 Jul;91(7):916-23. doi: 10.1016/j.biochi.2009.04.014. Epub 2009 May 4.


Sensing peptide-oligonucleotide interactions by a two-color fluorescence label: application to the HIV-1 nucleocapsid protein.

Shvadchak VV, Klymchenko AS, de Rocquigny H, Mély Y.

Nucleic Acids Res. 2009 Feb;37(3):e25. doi: 10.1093/nar/gkn1083. Epub 2009 Jan 16.


Direct Vpr-Vpr interaction in cells monitored by two photon fluorescence correlation spectroscopy and fluorescence lifetime imaging.

Fritz JV, Didier P, Clamme JP, Schaub E, Muriaux D, Cabanne C, Morellet N, Bouaziz S, Darlix JL, Mély Y, de Rocquigny H.

Retrovirology. 2008 Sep 22;5:87. doi: 10.1186/1742-4690-5-87.


Targeting the viral nucleocapsid protein in anti-HIV-1 therapy.

de Rocquigny H, Shvadchak V, Avilov S, Dong CZ, Dietrich U, Darlix JL, Mély Y.

Mini Rev Med Chem. 2008 Jan;8(1):24-35. Review.


Probing dynamics of HIV-1 nucleocapsid protein/target hexanucleotide complexes by 2-aminopurine.

Avilov SV, Piemont E, Shvadchak V, de Rocquigny H, Mély Y.

Nucleic Acids Res. 2008 Feb;36(3):885-96. Epub 2007 Dec 17.


Investigating the mechanism of the nucleocapsid protein chaperoning of the second strand transfer during HIV-1 DNA synthesis.

Ramalanjaona N, de Rocquigny H, Millet A, Ficheux D, Darlix JL, Mély Y.

J Mol Biol. 2007 Dec 7;374(4):1041-53. Epub 2007 Oct 5.


The single-finger nucleocapsid protein of moloney murine leukemia virus binds and destabilizes the TAR sequences of HIV-1 but does not promote efficiently their annealing.

Egelé C, Piémont E, Didier P, Ficheux D, Roques B, Darlix JL, de Rocquigny H, Mély Y.

Biochemistry. 2007 Dec 18;46(50):14650-62. Epub 2007 Nov 21.


Properties, functions, and drug targeting of the multifunctional nucleocapsid protein of the human immunodeficiency virus.

Darlix JL, Garrido JL, Morellet N, Mély Y, de Rocquigny H.

Adv Pharmacol. 2007;55:299-346. Review. No abstract available.


A tryptophan-rich hexapeptide inhibits nucleic acid destabilization chaperoned by the HIV-1 nucleocapsid protein.

Raja C, Ferner J, Dietrich U, Avilov S, Ficheux D, Darlix JL, de Rocquigny H, Schwalbe H, Mély Y.

Biochemistry. 2006 Aug 1;45(30):9254-65.


During the early phase of HIV-1 DNA synthesis, nucleocapsid protein directs hybridization of the TAR complementary sequences via the ends of their double-stranded stem.

Godet J, de Rocquigny H, Raja C, Glasser N, Ficheux D, Darlix JL, Mély Y.

J Mol Biol. 2006 Mar 10;356(5):1180-92. Epub 2005 Dec 27.


Investigation by fluorescence correlation spectroscopy of the chaperoning interactions of HIV-1 nucleocapsid protein with the viral DNA initiation sequences.

Egelé C, Schaub E, Piémont E, de Rocquigny H, Mély Y.

C R Biol. 2005 Dec;328(12):1041-51. Epub 2005 Oct 24.


Structural determinants of HIV-1 nucleocapsid protein for cTAR DNA binding and destabilization, and correlation with inhibition of self-primed DNA synthesis.

Beltz H, Clauss C, Piémont E, Ficheux D, Gorelick RJ, Roques B, Gabus C, Darlix JL, de Rocquigny H, Mély Y.

J Mol Biol. 2005 May 20;348(5):1113-26. Epub 2005 Apr 1.


The (52-96) C-terminal domain of Vpr stimulates HIV-1 IN-mediated homologous strand transfer of mini-viral DNA.

Bischerour J, Tauc P, Leh H, de Rocquigny H, Roques B, Mouscadet JF.

Nucleic Acids Res. 2003 May 15;31(10):2694-702.


Production and neurotropism of lentivirus vectors pseudotyped with lyssavirus envelope glycoproteins.

Desmaris N, Bosch A, Salaün C, Petit C, Prévost MC, Tordo N, Perrin P, Schwartz O, de Rocquigny H, Heard JM.

Mol Ther. 2001 Aug;4(2):149-56.


Highly sensitive and selective fluorescence assays for rapid screening of endothelin-converting enzyme inhibitors.

Luciani N, de Rocquigny H, Turcaud S, Romieu A, Roques BP.

Biochem J. 2001 Jun 15;356(Pt 3):813-9.


Generation of monoclonal antibodies specifically directed against the proximal zinc finger of HIV type 1 NCp7.

De Rocquigny H, Caneparo A, Dong CZ, Delaunay T, Roques BP.

AIDS Res Hum Retroviruses. 2000 Sep 1;16(13):1259-67.


Interactions of the C-terminus of viral protein R with nucleic acids are modulated by its N-terminus.

de Rocquigny H, Caneparo A, Delaunay T, Bischerour J, Mouscadet JF, Roques BP.

Eur J Biochem. 2000 Jun;267(12):3654-60.


The effect of mutations in the HIV-1 nucleocapsid protein on strand transfer in cell-free reverse transcription reactions.

Hsu M, Rong L, de Rocquigny H, Roques BP, Wainberg MA.

Nucleic Acids Res. 2000 Apr 15;28(8):1724-9.


Evidence of interactions between the nucleocapsid protein NCp7 and the reverse transcriptase of HIV-1.

Druillennec S, Caneparo A, de Rocquigny H, Roques BP.

J Biol Chem. 1999 Apr 16;274(16):11283-8.


Cleavage of L-leucine-containing dipeptides by Clostridium butyricum.

Khelifa N, Brik M, Tessedre AC, De Rocquigny H, Roques BP, Courtieu J, Rimbault A.

Bioorg Med Chem Lett. 1999 Jan 4;9(1):109-12.


NMR structure of the (52-96) C-terminal domain of the HIV-1 regulatory protein Vpr: molecular insights into its biological functions.

Schüler W, Wecker K, de Rocquigny H, Baudat Y, Sire J, Roques BP.

J Mol Biol. 1999 Feb 5;285(5):2105-17.


Structure of the complex between the HIV-1 nucleocapsid protein NCp7 and the single-stranded pentanucleotide d(ACGCC).

Morellet N, Déméné H, Teilleux V, Huynh-Dinh T, de Rocquigny H, Fournié-Zaluski MC, Roques BP.

J Mol Biol. 1998 Oct 23;283(2):419-34.


The annealing of tRNA3Lys to human immunodeficiency virus type 1 primer binding site is critically dependent on the NCp7 zinc fingers structure.

Remy E, de Rocquigny H, Petitjean P, Muriaux D, Theilleux V, Paoletti J, Roques BP.

J Biol Chem. 1998 Feb 27;273(9):4819-22.

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