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Items: 35

1.

Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02.

Tziotzios C, Petridis C, Dand N, Ainali C, Saklatvala JR, Pullabhatla V, Onoufriadis A, Pramanik R, Baudry D, Lee SH, Wood K, Liu L, Seegobin S, Michelotti GA, Lwin SM, Christou EAA, Curtis CJ, de Rinaldis E, Saxena A, Holmes S, Harries M, Palamaras I, Cunningham F, Parkins G, Kaur M, Farrant P, McDonagh A, Messenger A, Jones J, Jolliffe V, Ali I, Ardern-Jones M, Mitchell C, Burrows N, Atkar R, Banfield C, Alexandroff A, Champagne C, Cooper HL, Vañó-Galván S, Molina-Ruiz AM, Perez NO, Patel GK, Macbeth A, Page M, Bryden A, Mowbray M, Wahie S, Armstrong K, Cooke N, Goodfield M, Man I, de Berker D, Dunnill G, Takwale A, Rao A, Siah TW, Sinclair R, Wade MS, Dlova NC, Setterfield J, Lewis F, Bhargava K, Kirkpatrick N, Estivill X, Stefanato CM, Flohr C, Spector T, Watt FM, Smith CH, Barker JN, Fenton DA, Simpson MA, McGrath JA.

Nat Commun. 2019 Mar 8;10(1):1150. doi: 10.1038/s41467-019-09117-w.

2.

The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells.

Perucha E, Melchiotti R, Bibby JA, Wu W, Frederiksen KS, Roberts CA, Hall Z, LeFriec G, Robertson KA, Lavender P, Gerwien JG, Taams LS, Griffin JL, de Rinaldis E, van Baarsen LGM, Kemper C, Ghazal P, Cope AP.

Nat Commun. 2019 Jan 30;10(1):498. doi: 10.1038/s41467-019-08332-9.

3.

Time Series Integrative Analysis of RNA Sequencing and MicroRNA Expression Data Reveals Key Biologic Wound Healing Pathways in Keloid-Prone Individuals.

Onoufriadis A, Hsu CK, Ainali C, Ung CY, Rashidghamat E, Yang HS, Huang HY, Niazi U, Tziotzios C, Yang JC, Nuamah R, Tang MJ, Saxena A, de Rinaldis E, McGrath JA.

J Invest Dermatol. 2018 Dec;138(12):2690-2693. doi: 10.1016/j.jid.2018.05.017. Epub 2018 Jun 2. No abstract available.

PMID:
29870686
4.

Aurora kinase A (AURKA) interaction with Wnt and Ras-MAPK signalling pathways in colorectal cancer.

Jacobsen A, Bosch LJW, Martens-de Kemp SR, Carvalho B, Sillars-Hardebol AH, Dobson RJ, de Rinaldis E, Meijer GA, Abeln S, Heringa J, Fijneman RJA, Feenstra KA.

Sci Rep. 2018 May 14;8(1):7522. doi: 10.1038/s41598-018-24982-z.

5.

Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer.

Patel N, Weekes D, Drosopoulos K, Gazinska P, Noel E, Rashid M, Mirza H, Quist J, Brasó-Maristany F, Mathew S, Ferro R, Pereira AM, Prince C, Noor F, Francesch-Domenech E, Marlow R, de Rinaldis E, Grigoriadis A, Linardopoulos S, Marra P, Tutt ANJ.

Nat Commun. 2018 Mar 13;9(1):1044. doi: 10.1038/s41467-018-03283-z.

6.

De novo mutations implicate novel genes in systemic lupus erythematosus.

Pullabhatla V, Roberts AL, Lewis MJ, Mauro D, Morris DL, Odhams CA, Tombleson P, Liljedahl U, Vyse S, Simpson MA, Sauer S, de Rinaldis E, Syvänen AC, Vyse TJ.

Hum Mol Genet. 2018 Feb 1;27(3):421-429. doi: 10.1093/hmg/ddx407.

7.

Splicing imbalances in basal-like breast cancer underpin perturbation of cell surface and oncogenic pathways and are associated with patients' survival.

Gracio F, Burford B, Gazinska P, Mera A, Mohd Noor A, Marra P, Gillett C, Grigoriadis A, Pinder S, Tutt A, de Rinaldis E.

Sci Rep. 2017 Jan 6;7:40177. doi: 10.1038/srep40177.

8.

Cluster stability in the analysis of mass cytometry data.

Melchiotti R, Gracio F, Kordasti S, Todd AK, de Rinaldis E.

Cytometry A. 2017 Jan;91(1):73-84. doi: 10.1002/cyto.a.23001. Epub 2016 Oct 18.

9.

Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment.

Kordasti S, Costantini B, Seidl T, Perez Abellan P, Martinez Llordella M, McLornan D, Diggins KE, Kulasekararaj A, Benfatto C, Feng X, Smith A, Mian SA, Melchiotti R, de Rinaldis E, Ellis R, Petrov N, Povoleri GA, Chung SS, Thomas NS, Farzaneh F, Irish JM, Heck S, Young NS, Marsh JC, Mufti GJ.

Blood. 2016 Sep 1;128(9):1193-205. doi: 10.1182/blood-2016-03-703702. Epub 2016 Jun 8.

10.

Candidate driver genes involved in genome maintenance and DNA repair in Sézary syndrome.

Woollard WJ, Pullabhatla V, Lorenc A, Patel VM, Butler RM, Bayega A, Begum N, Bakr F, Dedhia K, Fisher J, Aguilar-Duran S, Flanagan C, Ghasemi AA, Hoffmann RM, Castillo-Mosquera N, Nuttall EA, Paul A, Roberts CA, Solomonidis EG, Tarrant R, Yoxall A, Beyers CZ, Ferreira S, Tosi I, Simpson MA, de Rinaldis E, Mitchell TJ, Whittaker SJ.

Blood. 2016 Jun 30;127(26):3387-97. doi: 10.1182/blood-2016-02-699843. Epub 2016 Apr 27.

11.

Bayesian clinical classification from high-dimensional data: Signatures versus variability.

Shalabi A, Inoue M, Watkins J, De Rinaldis E, Coolen AC.

Stat Methods Med Res. 2018 Feb;27(2):336-351. doi: 10.1177/0962280216628901. Epub 2016 Mar 16.

PMID:
26984907
12.

Association of MicroRNAs and YRNAs With Platelet Function.

Kaudewitz D, Skroblin P, Bender LH, Barwari T, Willeit P, Pechlaner R, Sunderland NP, Willeit K, Morton AC, Armstrong PC, Chan MV, Lu R, Yin X, Gracio F, Dudek K, Langley SR, Zampetaki A, de Rinaldis E, Ye S, Warner TD, Saxena A, Kiechl S, Storey RF, Mayr M.

Circ Res. 2016 Feb 5;118(3):420-432. doi: 10.1161/CIRCRESAHA.114.305663. Epub 2015 Dec 8.

13.

Role of retinoic acid in the stability of the T-helper-type 1 lineage and implications for autoimmunity.

Brown C, Esterhazy D, Sarde A, Pullabhatla V, London M, Arno M, de Rinaldis E, Mucida D, Lord G, Noelle R.

Lancet. 2015 Feb 26;385 Suppl 1:S25. doi: 10.1016/S0140-6736(15)60340-3.

PMID:
26312847
14.

Erratum. Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes. Diabetes 2014;63:3835-3845.

Arif S, Leete P, Nguyen V, Marks K, Nor NM, Estorninho M, Kronenberg-Versteeg D, Bingley PJ, Todd JA, Guy C, Dunger DB, Powrie J, Willcox A, Foulis AK, Richardson SJ, de Rinaldis E, Morgan NG, Lorenc A, Peakman M.

Diabetes. 2015 Sep;64(9):3334. doi: 10.2337/db15-er09a. No abstract available.

15.

Phenotypic Complexity of the Human Regulatory T Cell Compartment Revealed by Mass Cytometry.

Mason GM, Lowe K, Melchiotti R, Ellis R, de Rinaldis E, Peakman M, Heck S, Lombardi G, Tree TI.

J Immunol. 2015 Sep 1;195(5):2030-7. doi: 10.4049/jimmunol.1500703. Epub 2015 Jul 29.

16.

Correction: Pathway-Based Analysis of Genome-Wide siRNA Screens Reveals the Regulatory Landscape of App Processing.

Camargo LM, Zhang XD, Loerch P, Caceres RM, Marine SD, Uva P, Ferrer M, de Rinaldis E, Stone DJ, Majercak J, Ray WJ, Yi-An C, Shearman MS, Mizuguchi K.

PLoS One. 2015 Jun 1;10(6):e0129641. doi: 10.1371/journal.pone.0129641. eCollection 2015. No abstract available.

17.

Retinoic acid is essential for Th1 cell lineage stability and prevents transition to a Th17 cell program.

Brown CC, Esterhazy D, Sarde A, London M, Pullabhatla V, Osma-Garcia I, Al-Bader R, Ortiz C, Elgueta R, Arno M, de Rinaldis E, Mucida D, Lord GM, Noelle RJ.

Immunity. 2015 Mar 17;42(3):499-511. doi: 10.1016/j.immuni.2015.02.003. Epub 2015 Mar 10.

18.

Pathway-based analysis of genome-wide siRNA screens reveals the regulatory landscape of APP processing.

Camargo LM, Zhang XD, Loerch P, Caceres RM, Marine SD, Uva P, Ferrer M, de Rinaldis E, Stone DJ, Majercak J, Ray WJ, Yi-An C, Shearman MS, Mizuguchi K.

PLoS One. 2015 Feb 27;10(2):e0115369. doi: 10.1371/journal.pone.0115369. eCollection 2015. Erratum in: PLoS One. 2015;10(6):e0129641.

19.

The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility.

Kiuchi T, Ortiz-Zapater E, Monypenny J, Matthews DR, Nguyen LK, Barbeau J, Coban O, Lawler K, Burford B, Rolfe DJ, de Rinaldis E, Dafou D, Simpson MA, Woodman N, Pinder S, Gillett CE, Devauges V, Poland SP, Fruhwirth G, Marra P, Boersma YL, Plückthun A, Gullick WJ, Yarden Y, Santis G, Winn M, Kholodenko BN, Martin-Fernandez ML, Parker P, Tutt A, Ameer-Beg SM, Ng T.

Sci Signal. 2014 Aug 19;7(339):ra78. doi: 10.1126/scisignal.2005157.

PMID:
25140053
20.

IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers.

Marra P, Mathew S, Grigoriadis A, Wu Y, Kyle-Cezar F, Watkins J, Rashid M, De Rinaldis E, Hessey S, Gazinska P, Hayday A, Tutt A.

Cancer Res. 2014 Sep 1;74(17):4908-21. doi: 10.1158/0008-5472.CAN-14-0637. Epub 2014 Jun 30.

21.

Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes.

Arif S, Leete P, Nguyen V, Marks K, Nor NM, Estorninho M, Kronenberg-Versteeg D, Bingley PJ, Todd JA, Guy C, Dunger DB, Powrie J, Willcox A, Foulis AK, Richardson SJ, de Rinaldis E, Morgan NG, Lorenc A, Peakman M.

Diabetes. 2014 Nov;63(11):3835-45. doi: 10.2337/db14-0365. Epub 2014 Jun 17. Erratum in: Diabetes. 2015 Sep;64(9):3334.

22.

Integrated genomic analysis of triple-negative breast cancers reveals novel microRNAs associated with clinical and molecular phenotypes and sheds light on the pathways they control.

de Rinaldis E, Gazinska P, Mera A, Modrusan Z, Fedorowicz GM, Burford B, Gillett C, Marra P, Grigoriadis A, Dornan D, Holmberg L, Pinder S, Tutt A.

BMC Genomics. 2013 Sep 23;14:643. doi: 10.1186/1471-2164-14-643.

23.

Comparative Membranome expression analysis in primary tumors and derived cell lines.

Uva P, Lahm A, Sbardellati A, Grigoriadis A, Tutt A, de Rinaldis E.

PLoS One. 2010 Jul 23;5(7):e11742. doi: 10.1371/journal.pone.0011742.

24.

Growth delay of human bladder cancer cells by Prostate Stem Cell Antigen downregulation is associated with activation of immune signaling pathways.

Marra E, Uva P, Viti V, Simonelli V, Dogliotti E, De Rinaldis E, Lahm A, La Monica N, Nicosia A, Ciliberto G, Palombo F.

BMC Cancer. 2010 Apr 7;10:129. doi: 10.1186/1471-2407-10-129.

25.

MicroRNAs: shortcuts in dealing with molecular complexity?

Dontu G, de Rinaldis E.

Breast Cancer Res. 2010;12(1):301. doi: 10.1186/bcr2455.

26.

Loss of histone deacetylase 4 causes segregation defects during mitosis of p53-deficient human tumor cells.

Cadot B, Brunetti M, Coppari S, Fedeli S, de Rinaldis E, Dello Russo C, Gallinari P, De Francesco R, Steinkühler C, Filocamo G.

Cancer Res. 2009 Aug 1;69(15):6074-82. doi: 10.1158/0008-5472.CAN-08-2796. Epub 2009 Jul 21.

27.

MMP11: a novel target antigen for cancer immunotherapy.

Peruzzi D, Mori F, Conforti A, Lazzaro D, De Rinaldis E, Ciliberto G, La Monica N, Aurisicchio L.

Clin Cancer Res. 2009 Jun 15;15(12):4104-13. doi: 10.1158/1078-0432.CCR-08-3226. Epub 2009 Jun 9.

28.

Comparative expression pathway analysis of human and canine mammary tumors.

Uva P, Aurisicchio L, Watters J, Loboda A, Kulkarni A, Castle J, Palombo F, Viti V, Mesiti G, Zappulli V, Marconato L, Abramo F, Ciliberto G, Lahm A, La Monica N, de Rinaldis E.

BMC Genomics. 2009 Mar 27;10:135. doi: 10.1186/1471-2164-10-135.

29.

Genome-wide expression profile of sporadic gastric cancers with microsatellite instability.

D'Errico M, de Rinaldis E, Blasi MF, Viti V, Falchetti M, Calcagnile A, Sera F, Saieva C, Ottini L, Palli D, Palombo F, Giuliani A, Dogliotti E.

Eur J Cancer. 2009 Feb;45(3):461-9. doi: 10.1016/j.ejca.2008.10.032. Epub 2008 Dec 8.

PMID:
19081245
30.

CrossHybDetector: detection of cross-hybridization events in DNA microarray experiments.

Uva P, de Rinaldis E.

BMC Bioinformatics. 2008 Nov 17;9:485. doi: 10.1186/1471-2105-9-485.

31.

Differential screening of phage-ab libraries by oligonucleotide microarray technology.

Monaci P, Luzzago A, Santini C, De Pra A, Arcuri M, Magistri F, Bellini A, Ansuini H, Ambrosio M, Ammendola V, Bigotti MG, Cirillo A, Nuzzo M, Nasti AA, Neuner P, Orsatti L, Pezzanera M, Sbardellati A, Silvestre G, Uva P, Viti V, Barbato G, Colloca S, Demartis A, De Rinaldis E, Giampaoli S, Lahm A, Palombo F, Talamo F, Vitelli A, Nicosia A, Cortese R.

PLoS One. 2008 Jan 30;3(1):e1508. doi: 10.1371/journal.pone.0001508.

32.
33.

3dLOGO: a web server for the identification, analysis and use of conserved protein substructures.

Via A, Peluso D, Gherardini PF, de Rinaldis E, Colombo T, Ausiello G, Helmer-Citterich M.

Nucleic Acids Res. 2007 Jul;35(Web Server issue):W416-9. Epub 2007 May 8.

34.

Dissecting the biological functions of Drosophila histone deacetylases by RNA interference and transcriptional profiling.

Foglietti C, Filocamo G, Cundari E, De Rinaldis E, Lahm A, Cortese R, Steinkühler C.

J Biol Chem. 2006 Jun 30;281(26):17968-76. Epub 2006 Apr 21.

35.

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