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Ultra-micronized palmitoylethanolamide rescues the cognitive decline-associated loss of neural plasticity in the neuropathic mouse entorhinal cortex-dentate gyrus pathway.

Boccella S, Cristiano C, Romano R, Iannotta M, Belardo C, Farina A, Guida F, Piscitelli F, Palazzo E, Mazzitelli M, Imperatore R, Tunisi L, de Novellis V, Cristino L, Di Marzo V, Calignano A, Maione S, Luongo L.

Neurobiol Dis. 2019 Jan;121:106-119. doi: 10.1016/j.nbd.2018.09.023. Epub 2018 Sep 25.


Ketones and pain: unexplored role of hydroxyl carboxylic acid receptor type 2 in the pathophysiology of neuropathic pain.

Boccella S, Guida F, De Logu F, De Gregorio D, Mazzitelli M, Belardo C, Iannotta M, Serra N, Nassini R, de Novellis V, Geppetti P, Maione S, Luongo L.

FASEB J. 2019 Jan;33(1):1062-1073. doi: 10.1096/fj.201801033R. Epub 2018 Aug 7.


Metabotropic glutamate receptor subtype 7 in the dorsal striatum oppositely modulates pain in sham and neuropathic rats.

Marabese I, Boccella S, Iannotta M, Luongo L, de Novellis V, Guida F, Serra N, Farina A, Maione S, Palazzo E.

Neuropharmacology. 2018 Jun;135:86-99. doi: 10.1016/j.neuropharm.2018.03.003. Epub 2018 Mar 2.


Spared Nerve Injury as a Long-Lasting Model of Neuropathic Pain.

Boccella S, Guida F, Palazzo E, Marabese I, de Novellis V, Maione S, Luongo L.

Methods Mol Biol. 2018;1727:373-378. doi: 10.1007/978-1-4939-7571-6_28.


Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice.

Guida F, Turco F, Iannotta M, De Gregorio D, Palumbo I, Sarnelli G, Furiano A, Napolitano F, Boccella S, Luongo L, Mazzitelli M, Usiello A, De Filippis F, Iannotti FA, Piscitelli F, Ercolini D, de Novellis V, Di Marzo V, Cuomo R, Maione S.

Brain Behav Immun. 2018 Jan;67:230-245. doi: 10.1016/j.bbi.2017.09.001. Epub 2017 Sep 7.


d-Aspartic acid ameliorates painful and neuropsychiatric changes and reduces β-amyloid Aβ1-42 peptide in a long lasting model of neuropathic pain.

D'Aniello A, Luongo L, Romano R, Iannotta M, Marabese I, Boccella S, Belardo C, de Novellis V, Arra C, Barbieri A, D'Aniello B, Scandurra A, Magliozzi L, Fisher G, Guida F, Maione S.

Neurosci Lett. 2017 Jun 9;651:151-158. doi: 10.1016/j.neulet.2017.04.041. Epub 2017 May 6.


Preclinical evaluation of the urokinase receptor-derived peptide UPARANT as an anti-inflammatory drug.

Boccella S, Panza E, Lista L, Belardo C, Ianaro A, De Rosa M, de Novellis V, Pavone V.

Inflamm Res. 2017 Aug;66(8):701-709. doi: 10.1007/s00011-017-1051-5. Epub 2017 Apr 29.


Palmitoylethanolamide induces microglia changes associated with increased migration and phagocytic activity: involvement of the CB2 receptor.

Guida F, Luongo L, Boccella S, Giordano ME, Romano R, Bellini G, Manzo I, Furiano A, Rizzo A, Imperatore R, Iannotti FA, D'Aniello E, Piscitelli F, Sca Rossi F, Cristino L, Di Marzo V, de Novellis V, Maione S.

Sci Rep. 2017 Mar 23;7(1):375. doi: 10.1038/s41598-017-00342-1.


Palmitoylethanolamide Reduces Neuropsychiatric Behaviors by Restoring Cortical Electrophysiological Activity in a Mouse Model of Mild Traumatic Brain Injury.

Guida F, Boccella S, Iannotta M, De Gregorio D, Giordano C, Belardo C, Romano R, Palazzo E, Scafuro MA, Serra N, de Novellis V, Rossi F, Maione S, Luongo L.

Front Pharmacol. 2017 Mar 6;8:95. doi: 10.3389/fphar.2017.00095. eCollection 2017.


Nociception modulation by supraspinal group III metabotropic glutamate receptors.

Palazzo E, Marabese I, Luongo L, Guida F, de Novellis V, Maione S.

J Neurochem. 2017 May;141(4):507-519. doi: 10.1111/jnc.13725. Epub 2017 Feb 22. Review.


Metabotropic Glutamate Receptor 7: From Synaptic Function to Therapeutic Implications.

Palazzo E, Marabese I, de Novellis V, Rossi F, Maione S.

Curr Neuropharmacol. 2016;14(5):504-13. Review.


D-Aspartate drinking solution alleviates pain and cognitive impairment in neuropathic mice.

Palazzo E, Luongo L, Guida F, Marabese I, Romano R, Iannotta M, Rossi F, D'Aniello A, Stella L, Marmo F, Usiello A, de Bartolomeis A, Maione S, de Novellis V.

Amino Acids. 2016 Jul;48(7):1553-67. doi: 10.1007/s00726-016-2205-4. Epub 2016 Apr 26.


Age-Related Changes in D-Aspartate Oxidase Promoter Methylation Control Extracellular D-Aspartate Levels and Prevent Precocious Cell Death during Brain Aging.

Punzo D, Errico F, Cristino L, Sacchi S, Keller S, Belardo C, Luongo L, Nuzzo T, Imperatore R, Florio E, De Novellis V, Affinito O, Migliarini S, Maddaloni G, Sisalli MJ, Pasqualetti M, Pollegioni L, Maione S, Chiariotti L, Usiello A.

J Neurosci. 2016 Mar 9;36(10):3064-78. doi: 10.1523/JNEUROSCI.3881-15.2016.


Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction.

Rinaldi B, Guida F, Furiano A, Donniacuo M, Luongo L, Gritti G, Urbanek K, Messina G, Maione S, Rossi F, de Novellis V.

Neural Plast. 2015;2015:265967. doi: 10.1155/2015/265967. Epub 2015 Jul 22.


Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice.

Guida F, Luongo L, Marmo F, Romano R, Iannotta M, Napolitano F, Belardo C, Marabese I, D'Aniello A, De Gregorio D, Rossi F, Piscitelli F, Lattanzi R, de Bartolomeis A, Usiello A, Di Marzo V, de Novellis V, Maione S.

Mol Brain. 2015 Aug 12;8:47. doi: 10.1186/s13041-015-0139-5.


Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS.

Spaziano G, Luongo L, Guida F, Petrosino S, Matteis M, Palazzo E, Sullo N, de Novellis V, Di Marzo V, Rossi F, Maione S, D'Agostino B.

Biomed Res Int. 2015;2015:980983. doi: 10.1155/2015/980983. Epub 2015 Mar 19.


MMPIP, an mGluR7-selective negative allosteric modulator, alleviates pain and normalizes affective and cognitive behavior in neuropathic mice.

Palazzo E, Romano R, Luongo L, Boccella S, De Gregorio D, Giordano ME, Rossi F, Marabese I, Scafuro MA, de Novellis V, Maione S.

Pain. 2015 Jun;156(6):1060-73. doi: 10.1097/j.pain.0000000000000150.


D-aspartate modulates nociceptive-specific neuron activity and pain threshold in inflammatory and neuropathic pain condition in mice.

Boccella S, Vacca V, Errico F, Marinelli S, Squillace M, Guida F, Di Maio A, Vitucci D, Palazzo E, De Novellis V, Maione S, Pavone F, Usiello A.

Biomed Res Int. 2015;2015:905906. doi: 10.1155/2015/905906. Epub 2015 Jan 5.


PC1, a non-peptide PKR1-preferring antagonist, reduces pain behavior and spinal neuronal sensitization in neuropathic mice.

Guida F, Lattanzi R, Boccella S, Maftei D, Romano R, Marconi V, Balboni G, Salvadori S, Scafuro MA, de Novellis V, Negri L, Maione S, Luongo L.

Pharmacol Res. 2015 Jan;91:36-46. doi: 10.1016/j.phrs.2014.11.004. Epub 2014 Nov 27.


Supraspinal metabotropic glutamate receptor subtype 8: a switch to turn off pain.

Palazzo E, de Novellis V, Rossi F, Maione S.

Amino Acids. 2014 Jun;46(6):1441-8. doi: 10.1007/s00726-014-1703-5. Epub 2014 Mar 13. Review.


Supraspinal metabotropic glutamate receptors: a target for pain relief and beyond.

Palazzo E, Marabese I, de Novellis V, Rossi F, Maione S.

Eur J Neurosci. 2014 Feb;39(3):444-54. doi: 10.1111/ejn.12398. Review.


Dorsal striatum metabotropic glutamate receptor 8 affects nocifensive responses and rostral ventromedial medulla cell activity in neuropathic pain conditions.

Rossi F, Marabese I, De Chiaro M, Boccella S, Luongo L, Guida F, De Gregorio D, Giordano C, de Novellis V, Palazzo E, Maione S.

J Neurophysiol. 2014 Jun 1;111(11):2196-209. doi: 10.1152/jn.00212.2013. Epub 2013 Dec 4.


The A1 adenosine receptor as a new player in microglia physiology.

Luongo L, Guida F, Imperatore R, Napolitano F, Gatta L, Cristino L, Giordano C, Siniscalco D, Di Marzo V, Bellini G, Petrelli R, Cappellacci L, Usiello A, de Novellis V, Rossi F, Maione S.

Glia. 2014 Jan;62(1):122-32. doi: 10.1002/glia.22592.


Endogenous modulators of TRP channels.

Palazzo E, Rossi F, de Novellis V, Maione S.

Curr Top Med Chem. 2013;13(3):398-407. Review.


Palmitoylethanolamide reduces formalin-induced neuropathic-like behaviour through spinal glial/microglial phenotypical changes in mice.

Luongo L, Guida F, Boccella S, Bellini G, Gatta L, Rossi F, de Novellis V, Maione S.

CNS Neurol Disord Drug Targets. 2013 Feb 1;12(1):45-54.


Stealth liposomes encapsulating zoledronic acid: a new opportunity to treat neuropathic pain.

Caraglia M, Luongo L, Salzano G, Zappavigna S, Marra M, Guida F, Lusa S, Giordano C, De Novellis V, Rossi F, Abbruzzese Saccardi A, De Rosa G, Maione S.

Mol Pharm. 2013 Mar 4;10(3):1111-8. doi: 10.1021/mp3006215. Epub 2013 Feb 14.


5'-Chloro-5'-deoxy-(±)-ENBA, a potent and selective adenosine A(1) receptor agonist, alleviates neuropathic pain in mice through functional glial and microglial changes without affecting motor or cardiovascular functions.

Luongo L, Petrelli R, Gatta L, Giordano C, Guida F, Vita P, Franchetti P, Grifantini M, de Novellis V, Cappellacci L, Maione S.

Molecules. 2012 Nov 22;17(12):13712-26. doi: 10.3390/molecules171213712.


The 17-β-oestradiol inhibits osteoclast activity by increasing the cannabinoid CB2 receptor expression.

Rossi F, Bellini G, Luongo L, Mancusi S, Torella M, Tortora C, Manzo I, Guida F, Nobili B, de Novellis V, Maione S.

Pharmacol Res. 2013 Feb;68(1):7-15. doi: 10.1016/j.phrs.2012.10.017. Epub 2012 Nov 6.


Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection.

Guida F, Luongo L, Aviello G, Palazzo E, De Chiaro M, Gatta L, Boccella S, Marabese I, Zjawiony JK, Capasso R, Izzo AA, de Novellis V, Maione S.

Mol Pain. 2012 Aug 23;8:60. doi: 10.1186/1744-8069-8-60.


Role of metabotropic glutamate receptor 1 in the basolateral amygdala-driven prefrontal cortical deactivation in inflammatory pain in the rat.

Luongo L, de Novellis V, Gatta L, Palazzo E, Vita D, Guida F, Giordano C, Siniscalco D, Marabese I, De Chiaro M, Boccella S, Rossi F, Maione S.

Neuropharmacology. 2013 Mar;66:317-29. doi: 10.1016/j.neuropharm.2012.05.047. Epub 2012 Jul 13.


Role of neurotrophins in neuropathic pain.

Siniscalco D, Giordano C, Rossi F, Maione S, de Novellis V.

Curr Neuropharmacol. 2011 Dec;9(4):523-9. doi: 10.2174/157015911798376208.


Palvanil, a non-pungent capsaicin analogue, inhibits inflammatory and neuropathic pain with little effects on bronchopulmonary function and body temperature.

Luongo L, Costa B, D'Agostino B, Guida F, Comelli F, Gatta L, Matteis M, Sullo N, De Petrocellis L, de Novellis V, Maione S, Di Marzo V.

Pharmacol Res. 2012 Sep;66(3):243-50. doi: 10.1016/j.phrs.2012.05.005. Epub 2012 May 24.


Changes in cannabinoid receptor subtype 1 activity and interaction with metabotropic glutamate subtype 5 receptors in the periaqueductal gray-rostral ventromedial medulla pathway in a rodent neuropathic pain model.

Palazzo E, Luongo L, Bellini G, Guida F, Marabese I, Boccella S, Rossi F, Maione S, de Novellis V.

CNS Neurol Disord Drug Targets. 2012 Mar;11(2):148-61.


Effects of intra-ventrolateral periaqueductal grey palmitoylethanolamide on thermoceptive threshold and rostral ventromedial medulla cell activity.

de Novellis V, Luongo L, Guida F, Cristino L, Palazzo E, Russo R, Marabese I, D'Agostino G, Calignano A, Rossi F, Di Marzo V, Maione S.

Eur J Pharmacol. 2012 Feb 15;676(1-3):41-50. doi: 10.1016/j.ejphar.2011.11.034. Epub 2011 Dec 3.


Long-lasting effects of human mesenchymal stem cell systemic administration on pain-like behaviors, cellular, and biomolecular modifications in neuropathic mice.

Siniscalco D, Giordano C, Galderisi U, Luongo L, de Novellis V, Rossi F, Maione S.

Front Integr Neurosci. 2011 Dec 1;5:79. doi: 10.3389/fnint.2011.00079. eCollection 2011.


TRPV1-dependent and -independent alterations in the limbic cortex of neuropathic mice: impact on glial caspases and pain perception.

Giordano C, Cristino L, Luongo L, Siniscalco D, Petrosino S, Piscitelli F, Marabese I, Gatta L, Rossi F, Imperatore R, Palazzo E, de Novellis V, Di Marzo V, Maione S.

Cereb Cortex. 2012 Nov;22(11):2495-518. doi: 10.1093/cercor/bhr328. Epub 2011 Dec 1.


Pharmacological activity of a Bv8 analogue modified in position 24.

Lattanzi R, Sacerdote P, Franchi S, Canestrelli M, Miele R, Barra D, Visentin S, DeNuccio C, Porreca F, De Felice M, Guida F, Luongo L, de Novellis V, Maione S, Negri L.

Br J Pharmacol. 2012 Jun;166(3):950-63. doi: 10.1111/j.1476-5381.2011.01797.x.


Transient receptor potential vanilloid type 1 and pain development.

Palazzo E, Luongo L, de Novellis V, Rossi F, Marabese I, Maione S.

Curr Opin Pharmacol. 2012 Feb;12(1):9-17. doi: 10.1016/j.coph.2011.10.022. Epub 2011 Nov 20. Review.


EP1 receptor within the ventrolateral periaqueductal grey controls thermonociception and rostral ventromedial medulla cell activity in healthy and neuropathic rat.

Palazzo E, Guida F, Gatta L, Luongo L, Boccella S, Bellini G, Marabese I, de Novellis V, Rossi F, Maione S.

Mol Pain. 2011 Oct 24;7:82. doi: 10.1186/1744-8069-7-82.


The expression of caspases is enhanced in peripheral blood mononuclear cells of autism spectrum disorder patients.

Siniscalco D, Sapone A, Giordano C, Cirillo A, de Novellis V, de Magistris L, Rossi F, Fasano A, Maione S, Antonucci N.

J Autism Dev Disord. 2012 Jul;42(7):1403-10. doi: 10.1007/s10803-011-1373-z.


Metabotropic glutamate receptor subtype 8 in the amygdala modulates thermal threshold, neurotransmitter release, and rostral ventromedial medulla cell activity in inflammatory pain.

Palazzo E, Marabese I, Soukupova M, Luongo L, Boccella S, Giordano C, de Novellis V, Rossi F, Maione S.

J Neurosci. 2011 Mar 23;31(12):4687-97. doi: 10.1523/JNEUROSCI.2938-10.2011.


Datura stramonium intake: a report on three cases.

Stella L, Vitelli MR, Palazzo E, Oliva P, De Novellis V, Capuano A, Scafuro MA, Berrino L, Rossi F, Maione S.

J Psychoactive Drugs. 2010 Dec;42(4):507-12.


The galactosylation of N(ω)-nitro-L-arginine enhances its anti-nocifensive or anti-allodynic effects by targeting glia in healthy and neuropathic mice.

Giordano C, Siniscalco D, Melisi D, Luongo L, Curcio A, Soukupova M, Palazzo E, Marabese I, De Chiaro M, Rimoli MG, Rossi F, Maione S, de Novellis V.

Eur J Pharmacol. 2011 Apr 10;656(1-3):52-62. doi: 10.1016/j.ejphar.2011.01.045. Epub 2011 Feb 4.


The blockade of the transient receptor potential vanilloid type 1 and fatty acid amide hydrolase decreases symptoms and central sequelae in the medial prefrontal cortex of neuropathic rats.

de Novellis V, Vita D, Gatta L, Luongo L, Bellini G, De Chiaro M, Marabese I, Siniscalco D, Boccella S, Piscitelli F, Di Marzo V, Palazzo E, Rossi F, Maione S.

Mol Pain. 2011 Jan 17;7:7. doi: 10.1186/1744-8069-7-7.


Palmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in rats.

De Filippis D, Luongo L, Cipriano M, Palazzo E, Cinelli MP, de Novellis V, Maione S, Iuvone T.

Mol Pain. 2011 Jan 10;7:3. doi: 10.1186/1744-8069-7-3.


N-palmitoyl-vanillamide (palvanil) is a non-pungent analogue of capsaicin with stronger desensitizing capability against the TRPV1 receptor and anti-hyperalgesic activity.

De Petrocellis L, Guida F, Moriello AS, De Chiaro M, Piscitelli F, de Novellis V, Maione S, Di Marzo V.

Pharmacol Res. 2011 Apr;63(4):294-9. doi: 10.1016/j.phrs.2010.12.019. Epub 2011 Jan 5.


Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action.

Maione S, Piscitelli F, Gatta L, Vita D, De Petrocellis L, Palazzo E, de Novellis V, Di Marzo V.

Br J Pharmacol. 2011 Feb;162(3):584-96. doi: 10.1111/j.1476-5381.2010.01063.x.


Moving towards supraspinal TRPV1 receptors for chronic pain relief.

Palazzo E, Luongo L, de Novellis V, Berrino L, Rossi F, Maione S.

Mol Pain. 2010 Oct 11;6:66. doi: 10.1186/1744-8069-6-66. Review.


Effects of URB597, an inhibitor of fatty acid amide hydrolase (FAAH), on analgesic activity of paracetamol.

Soukupová M, Palazzo E, De Chiaro M, Gatta L, Migliozzi AL, Guida F, Luongo L, Giordano C, Siniscalco D, De Novellis V, Marabese I, Krsiak M, Maione S.

Neuro Endocrinol Lett. 2010;31(4):507-11.


Human mesenchymal stem cells as novel neuropathic pain tool.

Siniscalco D, Giordano C, Galderisi U, Luongo L, Alessio N, Di Bernardo G, de Novellis V, Rossi F, Maione S.

J Stem Cells Regen Med. 2010 Oct 23;6(2):127. eCollection 2010. No abstract available.


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