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Items: 1 to 50 of 67

1.

No Inhibition of MATE1/2K-Mediated Renal Creatinine Secretion Predicted With Ritonavir or Cobicistat.

Kikuchi R, Chiou WJ, Kasai MA, de Morais SM, Bow DAJ.

J Pharm Sci. 2019 Apr 26. pii: S0022-3549(19)30289-8. doi: 10.1016/j.xphs.2019.04.023. [Epub ahead of print]

PMID:
31034908
2.

Chemical Composition and Antifungal In Vitro and In Silico, Antioxidant, and Anticholinesterase Activities of Extracts and Constituents of Ouratea fieldingiana (DC.) Baill.

do Nascimento JET, Rodrigues ALM, de Lisboa DS, Liberato HR, Falcão MJC, da Silva CR, Nobre Júnior HV, Braz Filho R, de Paula Junior VF, Alves DR, de Morais SM.

Evid Based Complement Alternat Med. 2018 Nov 7;2018:1748487. doi: 10.1155/2018/1748487. eCollection 2018.

3.

Photoprotective potential of medicinal plants from Cerrado biome (Brazil) in relation to phenolic content and antioxidant activity.

Nunes AR, Rodrigues ALM, de Queiróz DB, Vieira IGP, Neto JFC, Junior JTC, Tintino SR, de Morais SM, Coutinho HDM.

J Photochem Photobiol B. 2018 Dec;189:119-123. doi: 10.1016/j.jphotobiol.2018.10.013. Epub 2018 Oct 13.

PMID:
30342307
4.

The orofacial antinociceptive effect of Kaempferol-3-O-rutinoside, isolated from the plant Ouratea fieldingiana, on adult zebrafish (Danio rerio).

do Nascimento JET, de Morais SM, de Lisboa DS, de Oliveira Sousa M, Santos SAAR, Magalhães FEA, Campos AR.

Biomed Pharmacother. 2018 Nov;107:1030-1036. doi: 10.1016/j.biopha.2018.08.089. Epub 2018 Aug 24.

PMID:
30257314
5.

Caryocar coriaceum extracts exert leishmanicidal effect acting in promastigote forms by apoptosis-like mechanism and intracellular amastigotes by Nrf2/HO-1/ferritin dependent response and iron depletion: Leishmanicidal effect of Caryocar coriaceum leaf exracts.

Tomiotto-Pellissier F, Alves DR, Miranda-Sapla MM, de Morais SM, Assolini JP, da Silva Bortoleti BT, Gonçalves MD, Cataneo AHD, Kian D, Madeira TB, Yamauchi LM, Nixdorf SL, Costa IN, Conchon-Costa I, Pavanelli WR.

Biomed Pharmacother. 2018 Feb;98:662-672. doi: 10.1016/j.biopha.2017.12.083. Epub 2018 Jan 4.

PMID:
29294453
6.

Himatanthus drasticus (Apocynaceae) latex reduces oxidative stress and modulates CD4+, CD8+, FoxP3+ and HSP-60+ expressions in Sarcoma 180-bearing mice.

Santos GJL, Oliveira ES, Pinheiro ADN, da Costa PM, de Freitas JCC, de Araújo Santos FG, Maia FMM, de Morais SM, Nunes-Pinheiro DCS.

J Ethnopharmacol. 2018 Jun 28;220:159-168. doi: 10.1016/j.jep.2017.09.043. Epub 2017 Oct 24.

7.

Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective.

Ewart L, Fabre K, Chakilam A, Dragan Y, Duignan DB, Eswaraka J, Gan J, Guzzie-Peck P, Otieno M, Jeong CG, Keller DA, de Morais SM, Phillips JA, Proctor W, Sura R, Van Vleet T, Watson D, Will Y, Tagle D, Berridge B.

Exp Biol Med (Maywood). 2017 Oct;242(16):1579-1585. doi: 10.1177/1535370217715441. Epub 2017 Jun 16.

8.

Mechanisms and Predictions of Drug-Drug Interactions of the Hepatitis C Virus Three Direct-Acting Antiviral Regimen: Paritaprevir/Ritonavir, Ombitasvir, and Dasabuvir.

Shebley M, Liu J, Kavetskaia O, Sydor J, de Morais SM, Fischer V, Nijsen MJMA, Bow DAJ.

Drug Metab Dispos. 2017 Jul;45(7):755-764. doi: 10.1124/dmd.116.074518. Epub 2017 May 8.

PMID:
28483778
9.

Medicinal Plants from Northeastern Brazil against Alzheimer's Disease.

Penido AB, De Morais SM, Ribeiro AB, Alves DR, Rodrigues AL, Dos Santos LH, de Menezes JE.

Evid Based Complement Alternat Med. 2017;2017:1753673. doi: 10.1155/2017/1753673. Epub 2017 Feb 21.

10.

Metabolism and Disposition of a Novel B-Cell Lymphoma-2 Inhibitor Venetoclax in Humans and Characterization of Its Unusual Metabolites.

Liu H, Michmerhuizen MJ, Lao Y, Wan K, Salem AH, Sawicki J, Serby M, Vaidyanathan S, Wong SL, Agarwal S, Dunbar M, Sydor J, de Morais SM, Lee AJ.

Drug Metab Dispos. 2017 Mar;45(3):294-305. doi: 10.1124/dmd.116.071613. Epub 2016 Dec 19.

PMID:
27993930
11.

The Genus Luehea (Malvaceae-Tiliaceae): Review about Chemical and Pharmacological Aspects.

Calixto-Júnior JT, de Morais SM, Colares AV, Coutinho HD.

J Pharm (Cairo). 2016;2016:1368971. Epub 2016 Oct 13. Review.

12.

Validation of a total IC50 method which enables in vitro assessment of transporter inhibition under semi-physiological conditions.

Kikuchi R, Peterkin VC, Chiou WJ, de Morais SM, Bow DAJ.

Xenobiotica. 2017 Sep;47(9):825-832. doi: 10.1080/00498254.2016.1233372. Epub 2016 Oct 3.

PMID:
27609543
13.

Chemical composition and in vitro activity of Calotropis procera (Ait.) latex on Haemonchus contortus.

Cavalcante GS, de Morais SM, Andre WP, Ribeiro WL, Rodrigues AL, De Lira FC, Viana JM, Bevilaqua CM.

Vet Parasitol. 2016 Aug 15;226:22-5. doi: 10.1016/j.vetpar.2016.06.012. Epub 2016 Jun 8.

PMID:
27514877
14.

Screening of Bioactivities and Toxicity of Cnidoscolus quercifolius Pohl.

Paredes PF, Vasconcelos FR, Paim RT, Marques MM, De Morais SM, Lira SM, Braquehais ID, Vieira ÍG, Mendes FN, Guedes MI.

Evid Based Complement Alternat Med. 2016;2016:7930563. doi: 10.1155/2016/7930563. Epub 2016 May 12.

15.

Metabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in Humans.

Shen J, Serby M, Surber B, Lee AJ, Ma J, Badri P, Menon R, Kavetskaia O, de Morais SM, Sydor J, Fischer V.

Drug Metab Dispos. 2016 Aug;44(8):1148-57. doi: 10.1124/dmd.115.067496. Epub 2016 May 13.

PMID:
27179128
16.

Phenolic composition and antiparasitic activity of plants from the Brazilian Northeast "Cerrado".

Calixto Júnior JT, de Morais SM, Gomez CV, Molas CC, Rolon M, Boligon AA, Athayde ML, de Morais Oliveira CD, Tintino SR, Henrique Douglas MC.

Saudi J Biol Sci. 2016 May;23(3):434-40. doi: 10.1016/j.sjbs.2015.10.009. Epub 2015 Oct 23.

17.

Comparative efficacy and toxic effects of carvacryl acetate and carvacrol on sheep gastrointestinal nematodes and mice.

Andre WP, Ribeiro WL, Cavalcante GS, dos Santos JM, Macedo IT, de Paula HC, de Freitas RM, de Morais SM, de Melo JV, Bevilaqua CM.

Vet Parasitol. 2016 Mar 15;218:52-8. doi: 10.1016/j.vetpar.2016.01.001. Epub 2016 Jan 7.

18.

Antiviral and Antioxidant Activities of Sulfated Galactomannans from Plants of Caatinga Biome.

Marques MM, de Morais SM, da Silva AR, Barroso ND, Pontes Filho TR, Araújo FM, Vieira ÍG, Lima DM, Guedes MI.

Evid Based Complement Alternat Med. 2015;2015:591214. doi: 10.1155/2015/591214. Epub 2015 Jul 14.

19.

A High Throughput, 384-Well, Semi-Automated, Hepatocyte Intrinsic Clearance Assay for Screening New Molecular Entities in Drug Discovery.

Heinle L, Peterkin V, de Morais SM, Jenkins GJ, Badagnani I.

Comb Chem High Throughput Screen. 2015;18(5):442-52.

PMID:
25828461
20.

Thymol and eugenol derivatives as potential antileishmanial agents.

de Morais SM, Vila-Nova NS, Bevilaqua CM, Rondon FC, Lobo CH, de Alencar Araripe Noronha Moura A, Sales AD, Rodrigues AP, de Figuereido JR, Campello CC, Wilson ME, de Andrade HF Jr.

Bioorg Med Chem. 2014 Nov 1;22(21):6250-5. doi: 10.1016/j.bmc.2014.08.020. Epub 2014 Sep 6.

21.

In vitro and in vivo leishmanicidal activity of Astronium fraxinifolium (Schott) and Plectranthus amboinicus (Lour.) Spreng against Leishmania (Viannia) braziliensis.

de Lima SC, Teixeira MJ, Lopes JE Jr, de Morais SM, Torres AF, Braga MA, Rodrigues RO, Santiago GM, Martins AC, Nagao-Dias AT.

Biomed Res Int. 2014;2014:848293. doi: 10.1155/2014/848293. Epub 2014 Apr 16.

22.

In vitro effects of Coriandrum sativum, Tagetes minuta, Alpinia zerumbet and Lantana camara essential oils on Haemonchus contortus.

Macedo IT, de Oliveira LM, Camurça-Vasconcelos AL, Ribeiro WL, dos Santos JM, de Morais SM, de Paula HC, Bevilaqua CM.

Rev Bras Parasitol Vet. 2013 Oct-Dec;22(4):463-9. doi: 10.1590/S1984-29612013000400004.

23.

Prediction of clinical drug-drug interactions of veliparib (ABT-888) with human renal transporters (OAT1, OAT3, OCT2, MATE1, and MATE2K).

Kikuchi R, Lao Y, Bow DA, Chiou WJ, Andracki ME, Carr RA, Voorman RL, De Morais SM.

J Pharm Sci. 2013 Dec;102(12):4426-32. doi: 10.1002/jps.23737. Epub 2013 Oct 2.

PMID:
24122511
24.

In vitro P-glycoprotein efflux ratio can predict the in vivo brain penetration regardless of biopharmaceutics drug disposition classification system class.

Kikuchi R, de Morais SM, Kalvass JC.

Drug Metab Dispos. 2013 Dec;41(12):2012-7. doi: 10.1124/dmd.113.053868. Epub 2013 Sep 5. Review.

PMID:
24009309
25.

In vitro OATP1B1 and OATP1B3 inhibition is associated with observations of benign clinical unconjugated hyperbilirubinemia.

Chiou WJ, de Morais SM, Kikuchi R, Voorman RL, Li X, Bow DA.

Xenobiotica. 2014 Mar;44(3):276-82. doi: 10.3109/00498254.2013.820006. Epub 2013 Jul 25.

PMID:
23886114
26.

Further insecticidal activities of essential oils from Lippia sidoides and Croton species against Aedes aegypti L.

de Lima GP, de Souza TM, de Paula Freire G, Farias DF, Cunha AP, Ricardo NM, de Morais SM, Carvalho AF.

Parasitol Res. 2013 May;112(5):1953-8. doi: 10.1007/s00436-013-3351-1. Epub 2013 Feb 23.

PMID:
23435925
27.

Species-dependent metabolism of a novel selective α7 neuronal acetylcholine receptor agonist ABT-107.

Liu H, Deng X, Liu J, Liu N, Stuart P, Xu H, Guan Z, Marsh KC, De Morais SM.

Xenobiotica. 2013 Sep;43(9):803-16. doi: 10.3109/00498254.2012.760763. Epub 2013 Jan 18.

PMID:
23327533
28.

Different susceptibilities of Leishmania spp. promastigotes to the Annona muricata acetogenins annonacinone and corossolone, and the Platymiscium floribundum coumarin scoparone.

Vila-Nova NS, de Morais SM, Falcão MJ, Alcantara TT, Ferreira PA, Cavalcanti ES, Vieira IG, Campello CC, Wilson M.

Exp Parasitol. 2013 Mar;133(3):334-8. doi: 10.1016/j.exppara.2012.11.025. Epub 2012 Dec 8.

29.

In vitro efficacy of Coriandrum sativum, Lippia sidoides and Copaifera reticulata against Leishmania chagasi.

Rondon FC, Bevilaqua CM, Accioly MP, de Morais SM, de Andrade-Júnior HF, de Carvalho CA, Lima JC, Magalhães HC.

Rev Bras Parasitol Vet. 2012 Jul-Sep;21(3):185-91.

30.

Leishmanicidal activity in vitro of Musa paradisiaca L. and Spondias mombin L. fractions.

Accioly MP, Bevilaqua CM, Rondon FC, de Morais SM, Machado LK, Almeida CA, de Andrade HF Jr, Cardoso RP.

Vet Parasitol. 2012 Jun 8;187(1-2):79-84. doi: 10.1016/j.vetpar.2011.12.029. Epub 2011 Dec 29.

PMID:
22521971
31.

Chemical composition, antioxidant and antibacterial activities of two Spondias species from Northeastern Brazil.

da Silva AR, de Morais SM, Marques MM, de Oliveira DF, Barros CC, de Almeida RR, Vieira ÍG, Guedes MI.

Pharm Biol. 2012 Jun;50(6):740-6. doi: 10.3109/13880209.2011.627347. Epub 2012 Apr 10.

PMID:
22486631
32.

Phenolic content and antioxidant and antiacetylcholinesterase properties of honeys from different floral origins.

Liberato Mda C, de Morais SM, Siqueira SM, de Menezes JE, Ramos DN, Machado LK, Magalhães IL.

J Med Food. 2011 Jun;14(6):658-63. doi: 10.1089/jmf.2010.0097. Epub 2011 May 9.

PMID:
21554131
33.

Effects of Myracrodruon urundeuva extracts on egg hatching and larval exsheathment of Haemonchus contortus.

de Oliveira LM, Bevilaqua CM, Macedo IT, de Morais SM, Machado LK, Campello CC, de Aquino Mesquita M.

Parasitol Res. 2011 Sep;109(3):893-8. doi: 10.1007/s00436-011-2331-6. Epub 2011 Apr 5.

PMID:
21465262
34.

Disposition and drug-drug interaction potential of veliparib (ABT-888), a novel and potent inhibitor of poly(ADP-ribose) polymerase.

Li X, Delzer J, Voorman R, de Morais SM, Lao Y.

Drug Metab Dispos. 2011 Jul;39(7):1161-9. doi: 10.1124/dmd.110.037820. Epub 2011 Mar 24.

PMID:
21436403
35.

In vivo topical anti-inflammatory and wound healing activities of the fixed oil of Caryocar coriaceum Wittm. seeds.

de Oliveira ML, Nunes-Pinheiro DC, Tomé AR, Mota EF, Lima-Verde IA, Pinheiro FG, Campello CC, de Morais SM.

J Ethnopharmacol. 2010 May 27;129(2):214-9. doi: 10.1016/j.jep.2010.03.014. Epub 2010 Mar 21.

PMID:
20332017
36.

Croton sonderianus essential oil samples distinctly affect rat airway smooth muscle.

Pinho-da-Silva L, Mendes-Maia PV, do Nascimento Garcia TM, Cruz JS, de Morais SM, Coelho-de-Souza AN, Lahlou S, Leal-Cardoso JH.

Phytomedicine. 2010 Aug;17(10):721-5. doi: 10.1016/j.phymed.2010.01.015. Epub 2010 Feb 19.

PMID:
20171859
37.

Gastroprotective effect of barbatusin and 3-beta-hydroxy-3-deoxibarbatusin, quinonoid diterpenes isolated from Plectranthus grandis, in ethanol-induced gastric lesions in mice.

Rodrigues Pde A, de Morais SM, de Souza CM, Silva AR, de Andrade GM, Silva MG, Albuquerque RL, Rao VS, Santos FA.

J Ethnopharmacol. 2010 Feb 17;127(3):725-30. doi: 10.1016/j.jep.2009.11.031. Epub 2009 Dec 16.

PMID:
20025953
38.

Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human.

Warren MS, Zerangue N, Woodford K, Roberts LM, Tate EH, Feng B, Li C, Feuerstein TJ, Gibbs J, Smith B, de Morais SM, Dower WJ, Koller KJ.

Pharmacol Res. 2009 Jun;59(6):404-13. doi: 10.1016/j.phrs.2009.02.007. Epub 2009 Feb 24.

PMID:
19429473
39.

Utility of a novel Oatp1b2 knockout mouse model for evaluating the role of Oatp1b2 in the hepatic uptake of model compounds.

Chen C, Stock JL, Liu X, Shi J, Van Deusen JW, DiMattia DA, Dullea RG, de Morais SM.

Drug Metab Dispos. 2008 Sep;36(9):1840-5. doi: 10.1124/dmd.108.020594. Epub 2008 Jun 12.

PMID:
18556442
40.

Effect of human renal cationic transporter inhibition on the pharmacokinetics of varenicline, a new therapy for smoking cessation: an in vitro-in vivo study.

Feng B, Obach RS, Burstein AH, Clark DJ, de Morais SM, Faessel HM.

Clin Pharmacol Ther. 2008 Apr;83(4):567-76. Epub 2007 Oct 31.

PMID:
17971819
41.

In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system.

Feng B, Mills JB, Davidson RE, Mireles RJ, Janiszewski JS, Troutman MD, de Morais SM.

Drug Metab Dispos. 2008 Feb;36(2):268-75. Epub 2007 Oct 25.

PMID:
17962372
42.

The time to move cytochrome p450 induction into mainstream pharmacology is long overdue.

Smith DA, Dickins M, Fahmi OA, Iwasaki K, Lee C, Obach RS, Padbury G, De Morais SM, Ripp SL, Stevens J, Voorman R, Youdim K.

Drug Metab Dispos. 2007 Apr;35(4):697-8. No abstract available.

PMID:
17384203
43.

Topical anti-inflammatory, gastroprotective and antioxidant effects of the essential oil of Lippia sidoides Cham. leaves.

Monteiro MV, de Melo Leite AK, Bertini LM, de Morais SM, Nunes-Pinheiro DC.

J Ethnopharmacol. 2007 May 4;111(2):378-82. Epub 2006 Dec 12.

PMID:
17254726
44.

Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction.

Ripp SL, Mills JB, Fahmi OA, Trevena KA, Liras JL, Maurer TS, de Morais SM.

Drug Metab Dispos. 2006 Oct;34(10):1742-8. Epub 2006 Jul 12.

PMID:
16837568
45.

Metabolism and transporter-mediated drug-drug interactions of the endothelin-A receptor antagonist CI-1034.

Sahi J, Sinz MW, Campbell S, Mireles R, Zheng X, Rose KA, Raeissi S, Hashim MF, Ye Y, de Morais SM, Black C, Tugnait M, Keller LH.

Chem Biol Interact. 2006 Feb 1;159(2):156-68. Epub 2005 Dec 13.

PMID:
16356485
46.

Contact dermatitis associated with Astronium urundeuva (allemão) Engl., a traditional medicinal plant from Brazil.

Vilar Mdo L, Diógenes MJ, Vilar JL, Filho JG, D'arc Pereira Dantas J, De Souza JA, de Morais SM.

Contact Dermatitis. 2004 Nov-Dec;51(5-6):311. No abstract available.

PMID:
15606659
47.

Inhibition of human organic anion transporting polypeptide OATP 1B1 as a mechanism of drug-induced hyperbilirubinemia.

Campbell SD, de Morais SM, Xu JJ.

Chem Biol Interact. 2004 Nov 20;150(2):179-87.

PMID:
15535988
48.

Effects of essential oil of Alpinia zerumbet on the compound action potential of the rat sciatic nerve.

Leal-Cardoso JH, Moreira MR, da Cruz GM, de Morais SM, Lahlou MS, Coelho-de-Souza AN.

Phytomedicine. 2004 Sep;11(6):549-53.

PMID:
15500268
49.

Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line.

Mills JB, Rose KA, Sadagopan N, Sahi J, de Morais SM.

J Pharmacol Exp Ther. 2004 Apr;309(1):303-9. Epub 2004 Jan 13.

PMID:
14722322
50.

The role of absorption, distribution, metabolism, excretion and toxicity in drug discovery.

Lin J, Sahakian DC, de Morais SM, Xu JJ, Polzer RJ, Winter SM.

Curr Top Med Chem. 2003;3(10):1125-54. Review.

PMID:
12769713

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