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Items: 1 to 50 of 147

1.

Patients experiences of self-management and strategies for dealing with chronic conditions in rural Malawi.

Angwenyi V, Aantjes C, Kajumi M, De Man J, Criel B, Bunders-Aelen J.

PLoS One. 2018 Jul 2;13(7):e0199977. doi: 10.1371/journal.pone.0199977. eCollection 2018.

2.

Newly developed serine protease inhibitors decrease visceral hypersensitivity in a post-inflammatory rat model for irritable bowel syndrome.

Ceuleers H, Hanning N, Heirbaut J, Van Remoortel S, De Bruyn M, Joossens J, van der Veken P, Lambeir AM, Francque SM, De Man JG, Timmermans JP, Augustyns K, De Meester I, De Winter BY.

Br J Pharmacol. 2018 Jun 17. doi: 10.1111/bph.14396. [Epub ahead of print]

PMID:
29911328
3.

Huntington's Disease Outpatient Clinic for Functional Diagnosis and Treatment: Coming to Consensus: How Long Term Care Facility Procedures Complement Specialist Diagnosis and Treatment.

Veenhuizen R, Nijsten H, van Roosmalen P, Lammertsen K, Stor T, de Jager L, de Man J, van der Doelen R, Landa K, Grond V, Heffels J, Groenewoud R, Rovers L, Bakker C, Leiwakabessy S, van der Wedden D, van Blitterswijk J, van den Bosch D.

J Huntingtons Dis. 2018;7(2):189-191. doi: 10.3233/JHD-180298.

4.

Severe steatosis induces portal hypertension by systemic arterial hyporeactivity and hepatic vasoconstrictor hyperreactivity in rats.

Van der Graaff D, Kwanten WJ, Couturier FJ, Govaerts JS, Verlinden W, Brosius I, D'Hondt M, Driessen A, De Winter BY, De Man JG, Michielsen PP, Francque SM.

Lab Invest. 2018 Jan 11. doi: 10.1038/s41374-017-0018-z. [Epub ahead of print]

PMID:
29326427
5.

The effect of text message support on diabetes self-management in developing countries - A randomised trial.

Van Olmen J, Kegels G, Korachais C, de Man J, Van Acker K, Kalobu JC, van Pelt M, Ku GM, Hen H, Kanda D, Malombo B, Darras C, Schellevis F.

J Clin Transl Endocrinol. 2017 Jan 3;7:33-41. doi: 10.1016/j.jcte.2016.12.005. eCollection 2017 Mar.

6.

TTK Inhibitors as a Targeted Therapy for CTNNB1 (β-catenin) Mutant Cancers.

Zaman GJR, de Roos JADM, Libouban MAA, Prinsen MBW, de Man J, Buijsman RC, Uitdehaag JCM.

Mol Cancer Ther. 2017 Nov;16(11):2609-2617. doi: 10.1158/1535-7163.MCT-17-0342. Epub 2017 Jul 27.

PMID:
28751540
7.

Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.

Uitdehaag JCM, de Man J, Willemsen-Seegers N, Prinsen MBW, Libouban MAA, Sterrenburg JG, de Wit JJP, de Vetter JRF, de Roos JADM, Buijsman RC, Zaman GJR.

J Mol Biol. 2017 Jul 7;429(14):2211-2230. doi: 10.1016/j.jmb.2017.05.014. Epub 2017 May 21.

PMID:
28539250
8.

Stable aneuploid tumors cells are more sensitive to TTK inhibition than chromosomally unstable cell lines.

Libouban MAA, de Roos JADM, Uitdehaag JCM, Willemsen-Seegers N, Mainardi S, Dylus J, de Man J, Tops B, Meijerink JPP, Storchová Z, Buijsman RC, Medema RH, Zaman GJR.

Oncotarget. 2017 Jun 13;8(24):38309-38325. doi: 10.18632/oncotarget.16213.

9.

Regulation of intestinal permeability: The role of proteases.

Van Spaendonk H, Ceuleers H, Witters L, Patteet E, Joossens J, Augustyns K, Lambeir AM, De Meester I, De Man JG, De Winter BY.

World J Gastroenterol. 2017 Mar 28;23(12):2106-2123. doi: 10.3748/wjg.v23.i12.2106. Review.

10.

Visceral hypersensitivity in inflammatory bowel diseases and irritable bowel syndrome: The role of proteases.

Ceuleers H, Van Spaendonk H, Hanning N, Heirbaut J, Lambeir AM, Joossens J, Augustyns K, De Man JG, De Meester I, De Winter BY.

World J Gastroenterol. 2016 Dec 21;22(47):10275-10286. doi: 10.3748/wjg.v22.i47.10275. Review.

11.

Compound Selectivity and Target Residence Time of Kinase Inhibitors Studied with Surface Plasmon Resonance.

Willemsen-Seegers N, Uitdehaag JCM, Prinsen MBW, de Vetter JRF, de Man J, Sawa M, Kawase Y, Buijsman RC, Zaman GJR.

J Mol Biol. 2017 Feb 17;429(4):574-586. doi: 10.1016/j.jmb.2016.12.019. Epub 2016 Dec 30.

PMID:
28043854
12.

In Vitro Recording of Mesenteric Afferent Nerve Activity in Mouse Jejunal and Colonic Segments.

Nullens S, Deiteren A, Jiang W, Keating C, Ceuleers H, Francque S, Grundy D, De Man JG, De Winter BY.

J Vis Exp. 2016 Oct 25;(116). doi: 10.3791/54576.

PMID:
27805592
13.

Cell Panel Profiling Reveals Conserved Therapeutic Clusters and Differentiates the Mechanism of Action of Different PI3K/mTOR, Aurora Kinase and EZH2 Inhibitors.

Uitdehaag JC, de Roos JA, Prinsen MB, Willemsen-Seegers N, de Vetter JR, Dylus J, van Doornmalen AM, Kooijman J, Sawa M, van Gerwen SJ, de Man J, Buijsman RC, Zaman GJ.

Mol Cancer Ther. 2016 Dec;15(12):3097-3109. Epub 2016 Sep 1.

14.

Beneficial Effects of Anti-Interleukin-6 Antibodies on Impaired Gastrointestinal Motility, Inflammation and Increased Colonic Permeability in a Murine Model of Sepsis Are Most Pronounced When Administered in a Preventive Setup.

Nullens S, Staessens M, Peleman C, Plaeke P, Malhotra-Kumar S, Francque S, De Man JG, De Winter BY.

PLoS One. 2016 Apr 4;11(4):e0152914. doi: 10.1371/journal.pone.0152914. eCollection 2016.

15.

Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis.

Liu J, Guiadeen D, Krikorian A, Gao X, Wang J, Boga SB, Alhassan AB, Yu Y, Vaccaro H, Liu S, Yang C, Wu H, Cooper A, de Man J, Kaptein A, Maloney K, Hornak V, Gao YD, Fischmann TO, Raaijmakers H, Vu-Pham D, Presland J, Mansueto M, Xu Z, Leccese E, Zhang-Hoover J, Knemeyer I, Garlisi CG, Bays N, Stivers P, Brandish PE, Hicks A, Kim R, Kozlowski JA.

ACS Med Chem Lett. 2015 Dec 19;7(2):198-203. doi: 10.1021/acsmedchemlett.5b00463. eCollection 2016 Feb 11.

16.

Novel nervous system mechanisms in visceral pain.

De Winter BY, Deiteren A, De Man JG.

Neurogastroenterol Motil. 2016 Mar;28(3):309-15. doi: 10.1111/nmo.12785. Review.

PMID:
26891060
17.

EVALUATION OF A COMMERCIAL RAPID TEST KIT FOR DETECTION OF ACUTE DENGUE INFECTION.

Krishnananthasivam S, Fernando AN, Tippalagama R, Tennekoon R, De Man J, Seneviratne D, Premawansa S, Premawansa G, De Silva AD.

Southeast Asian J Trop Med Public Health. 2015 Jul;46(4):602-10.

PMID:
26867379
18.

Irritable bowel syndrome and visceral hypersensitivity : risk factors and pathophysiological mechanisms.

Deiteren A, de Wit A, van der Linden L, De Man JG, Pelckmans PA, De Winter BY.

Acta Gastroenterol Belg. 2016 Mar;79(1):29-38. Review.

PMID:
26852761
19.

Patient-centred innovation to ensure access to diabetes care in Cambodia: the case of MoPoTsyo.

van Olmen J, Eggermont N, van Pelt M, Hen H, de Man J, Schellevis F, Peters DH, Bigdeli M.

J Pharm Policy Pract. 2016 Jan 21;9:1. doi: 10.1186/s40545-016-0050-1. eCollection 2016.

20.

EFFECT OF GTS-21, AN ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONIST, ON CLP-INDUCED INFLAMMATORY, GASTROINTESTINAL MOTILITY, AND COLONIC PERMEABILITY CHANGES IN MICE.

Nullens S, Staessens M, Peleman C, Schrijvers DM, Malhotra-Kumar S, Francque S, Matteoli G, Boeckxstaens GE, De Man JG, De Winter BY.

Shock. 2016 Apr;45(4):450-9. doi: 10.1097/SHK.0000000000000519.

PMID:
26618987
21.

Mechanisms contributing to visceral hypersensitivity: focus on splanchnic afferent nerve signaling.

Deiteren A, De Man JG, Keating C, Jiang W, De Schepper HU, Pelckmans PA, Francque SM, De Winter BY.

Neurogastroenterol Motil. 2015 Dec;27(12):1709-20. doi: 10.1111/nmo.12667. Epub 2015 Sep 4.

PMID:
26337498
22.

Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model.

Maia AR, de Man J, Boon U, Janssen A, Song JY, Omerzu M, Sterrenburg JG, Prinsen MB, Willemsen-Seegers N, de Roos JA, van Doornmalen AM, Uitdehaag JC, Kops GJ, Jonkers J, Buijsman RC, Zaman GJ, Medema RH.

Ann Oncol. 2015 Oct;26(10):2180-92. doi: 10.1093/annonc/mdv293. Epub 2015 Jul 7.

PMID:
26153498
23.

Selective Targeting of CTNBB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs.

Uitdehaag JC, de Roos JA, van Doornmalen AM, Prinsen MB, Spijkers-Hagelstein JA, de Vetter JR, de Man J, Buijsman RC, Zaman GJ.

PLoS One. 2015 May 27;10(5):e0125021. doi: 10.1371/journal.pone.0125021. eCollection 2015. Erratum in: PLoS One. 2015;10(6):e0132230.

24.

P2X3 receptors mediate visceral hypersensitivity during acute chemically-induced colitis and in the post-inflammatory phase via different mechanisms of sensitization.

Deiteren A, van der Linden L, de Wit A, Ceuleers H, Buckinx R, Timmermans JP, Moreels TG, Pelckmans PA, De Man JG, De Winter BY.

PLoS One. 2015 Apr 17;10(4):e0123810. doi: 10.1371/journal.pone.0123810. eCollection 2015.

25.

Treatment with egg antigens of Schistosoma mansoni ameliorates experimental colitis in mice through a colonic T-cell-dependent mechanism.

Heylen M, Ruyssers NE, Nullens S, Schramm G, Pelckmans PA, Moreels TG, De Man JG, De Winter BY.

Inflamm Bowel Dis. 2015 Jan;21(1):48-59. doi: 10.1097/MIB.0000000000000246.

PMID:
25437821
26.

Towards virtual training of emotion regulation.

Bosse T, Gerritsen C, de Man J, Treur J.

Brain Inform. 2014 Dec;1(1-4):27-37. Epub 2014 Sep 26.

27.

Histamine H₄ receptors in the gastrointestinal tract.

Deiteren A, De Man JG, Pelckmans PA, De Winter BY.

Br J Pharmacol. 2015 Mar;172(5):1165-78. doi: 10.1111/bph.12989. Epub 2015 Jan 12. Review.

28.

Worm proteins of Schistosoma mansoni reduce the severity of experimental chronic colitis in mice by suppressing colonic proinflammatory immune responses.

Heylen M, Ruyssers NE, De Man JG, Timmermans JP, Pelckmans PA, Moreels TG, De Winter BY.

PLoS One. 2014 Oct 14;9(10):e110002. doi: 10.1371/journal.pone.0110002. eCollection 2014.

29.

The effect of chemically induced colitis, psychological stress and their combination on visceral pain in female Wistar rats.

Deiteren A, Vermeulen W, Moreels TG, Pelckmans PA, De Man JG, De Winter BY.

Stress. 2014 Sep;17(5):431-44. doi: 10.3109/10253890.2014.951034.

PMID:
25089934
30.

High-throughput fluorescence-based screening assays for tryptophan-catabolizing enzymes.

Seegers N, van Doornmalen AM, Uitdehaag JC, de Man J, Buijsman RC, Zaman GJ.

J Biomol Screen. 2014 Oct;19(9):1266-74. doi: 10.1177/1087057114536616. Epub 2014 May 27.

PMID:
24870017
31.

Continuous flushing of the bladder in rodents reduces artifacts and improves quantification in molecular imaging.

Deleye S, Heylen M, Deiteren A, De Man J, Stroobants S, De Winter B, Staelens S.

Mol Imaging. 2014;13. doi: 10.2310/7290.2014.00013.

PMID:
24825484
32.

Comparison of the cancer gene targeting and biochemical selectivities of all targeted kinase inhibitors approved for clinical use.

Uitdehaag JC, de Roos JA, van Doornmalen AM, Prinsen MB, de Man J, Tanizawa Y, Kawase Y, Yoshino K, Buijsman RC, Zaman GJ.

PLoS One. 2014 Mar 20;9(3):e92146. doi: 10.1371/journal.pone.0092146. eCollection 2014.

33.

Of worms, mice and man: an overview of experimental and clinical helminth-based therapy for inflammatory bowel disease.

Heylen M, Ruyssers NE, Gielis EM, Vanhomwegen E, Pelckmans PA, Moreels TG, De Man JG, De Winter BY.

Pharmacol Ther. 2014 Aug;143(2):153-67. doi: 10.1016/j.pharmthera.2014.02.011. Epub 2014 Mar 3. Review.

PMID:
24603369
34.

Neuroanatomy of lower gastrointestinal pain disorders.

Vermeulen W, De Man JG, Pelckmans PA, De Winter BY.

World J Gastroenterol. 2014 Jan 28;20(4):1005-20. doi: 10.3748/wjg.v20.i4.1005. Review.

35.

Histamine H4 and H1 receptors contribute to postinflammatory visceral hypersensitivity.

Deiteren A, De Man JG, Ruyssers NE, Moreels TG, Pelckmans PA, De Winter BY.

Gut. 2014 Dec;63(12):1873-82. doi: 10.1136/gutjnl-2013-305870. Epub 2014 Feb 21.

PMID:
24561612
36.

What is the place of pre-exposure prophylaxis in HIV prevention?

De Man J, Colebunders R, Florence E, Laga M, Kenyon C.

AIDS Rev. 2013 Apr-Jun;15(2):102-11. Review.

PMID:
23685443
37.

Mechanisms of pelvic organ crosstalk: 1. Peripheral modulation of bladder inhibition by colorectal distention in rats.

Wyndaele M, De Wachter S, De Man J, Minagawa T, Wyndaele JJ, Pelckmans PA, De Winter BY.

J Urol. 2013 Aug;190(2):765-71. doi: 10.1016/j.juro.2013.03.045. Epub 2013 Mar 21.

PMID:
23524199
38.

Colonoscopy and µPET/CT are valid techniques to monitor inflammation in the adoptive transfer colitis model in mice.

Heylen M, Deleye S, De Man JG, Ruyssers NE, Vermeulen W, Stroobants S, Pelckmans PA, Moreels TG, Staelens S, De Winter BY.

Inflamm Bowel Dis. 2013 Apr;19(5):967-76. doi: 10.1097/MIB.0b013e3182802c7c.

PMID:
23407045
39.

Role of TRPV1 and TRPA1 in visceral hypersensitivity to colorectal distension during experimental colitis in rats.

Vermeulen W, De Man JG, De Schepper HU, Bult H, Moreels TG, Pelckmans PA, De Winter BY.

Eur J Pharmacol. 2013 Jan 5;698(1-3):404-12. doi: 10.1016/j.ejphar.2012.10.014. Epub 2012 Oct 23.

PMID:
23099257
40.

A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets.

Uitdehaag JC, Verkaar F, Alwan H, de Man J, Buijsman RC, Zaman GJ.

Br J Pharmacol. 2012 Jun;166(3):858-76. doi: 10.1111/j.1476-5381.2012.01859.x. Review.

41.

Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis.

De Filippis D, Esposito G, Cirillo C, Cipriano M, De Winter BY, Scuderi C, Sarnelli G, Cuomo R, Steardo L, De Man JG, Iuvone T.

PLoS One. 2011;6(12):e28159. doi: 10.1371/journal.pone.0028159. Epub 2011 Dec 6.

42.

The use of colonoscopy to follow the inflammatory time course of TNBS colitis in rats.

Vermeulen W, De Man JG, Nullens S, Pelckmans PA, De Winter BY, Moreels TG.

Acta Gastroenterol Belg. 2011 Jun;74(2):304-11.

PMID:
21861315
43.

Role of tachykinin receptors in the modulation of colonic peristaltic activity in mice.

Deiteren A, De Winter BY, Nullens S, Pelckmans PA, De Man JG.

Eur J Pharmacol. 2011 Sep 30;667(1-3):339-47. doi: 10.1016/j.ejphar.2011.05.044. Epub 2011 Jun 1.

PMID:
21645508
44.

Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.

Ray P, Wright J, Adam J, Boucharens S, Black D, Brown AR, Epemolu O, Fletcher D, Huggett M, Jones P, Laats S, Lyons A, de Man J, Morphy R, Sherborne B, Sherry L, Straten Nv, Westwood P, York M.

Bioorg Med Chem Lett. 2011 Feb 15;21(4):1084-8. doi: 10.1016/j.bmcl.2010.12.104. Epub 2010 Dec 28.

PMID:
21251828
45.

Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.

Ray P, Wright J, Adam J, Bennett J, Boucharens S, Black D, Cook A, Brown AR, Epemolu O, Fletcher D, Haunso A, Huggett M, Jones P, Laats S, Lyons A, Mestres J, de Man J, Morphy R, Rankovic Z, Sherborne B, Sherry L, van Straten N, Westwood P, Zaman GZ.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):97-101. doi: 10.1016/j.bmcl.2010.11.060. Epub 2010 Nov 19.

PMID:
21145740
46.

Interplay between inflammation, immune system and neuronal pathways: effect on gastrointestinal motility.

De Winter BY, De Man JG.

World J Gastroenterol. 2010 Nov 28;16(44):5523-35. Review.

47.

Chronic alcohol consumption affects gastrointestinal motility and reduces the proportion of neuronal NOS-immunoreactive myenteric neurons in the murine jejunum.

Bagyánszki M, Krecsmarik M, De Winter BY, De Man JG, Fekete E, Pelckmans PA, Adriaensen D, Kroese AB, Van Nassauw L, Timmermans JP.

Anat Rec (Hoboken). 2010 Sep;293(9):1536-42. doi: 10.1002/ar.21192.

48.

Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice.

Ruyssers NE, De Winter BY, De Man JG, Ruyssers ND, Van Gils AJ, Loukas A, Pearson MS, Weinstock JV, Pelckmans PA, Moreels TG.

World J Gastroenterol. 2010 Feb 14;16(6):703-12.

49.

Involvement of afferent neurons in the pathogenesis of endotoxin-induced ileus in mice: role of CGRP and TRPV1 receptors.

De Winter BY, Bredenoord AJ, Van Nassauw L, De Man JG, De Schepper HU, Timmermans JP, Pelckmans PA.

Eur J Pharmacol. 2009 Aug 1;615(1-3):177-84. doi: 10.1016/j.ejphar.2009.04.055. Epub 2009 May 13.

PMID:
19445917
50.

Effect of genetic SSTR4 ablation on inflammatory peptide and receptor expression in the non-inflamed and inflamed murine intestine.

Van Op den Bosch J, Torfs P, De Winter BY, De Man JG, Pelckmans PA, Van Marck E, Grundy D, Van Nassauw L, Timmermans JP.

J Cell Mol Med. 2009 Sep;13(9B):3283-95. doi: 10.1111/j.1582-4934.2009.00760.x. Epub 2009 May 1.

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