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Emergence of a Novel Coronavirus (COVID-19): Protocol for Extending Surveillance Used by the Royal College of General Practitioners Research and Surveillance Centre and Public Health England.

de Lusignan S, Lopez Bernal J, Zambon M, Akinyemi O, Amirthalingam G, Andrews N, Borrow R, Byford R, Charlett A, Dabrera G, Ellis J, Elliot AJ, Feher M, Ferreira F, Krajenbrink E, Leach J, Linley E, Liyanage H, Okusi C, Ramsay M, Smith G, Sherlock J, Thomas N, Tripathy M, Williams J, Howsam G, Joy M, Hobbs R.

JMIR Public Health Surveill. 2020 Apr 2;6(2):e18606. doi: 10.2196/18606.


Assessing data protection and governance in health information systems: a novel methodology of Privacy and Ethics Impact and Performance Assessment (PEIPA).

Di Iorio CT, Carinci F, Oderkirk J, Smith D, Siano M, de Marco DA, de Lusignan S, Hamalainen P, Benedetti MM.

J Med Ethics. 2020 Mar 27. pii: medethics-2019-105948. doi: 10.1136/medethics-2019-105948. [Epub ahead of print]


Cardiovascular risk factors and outcomes in early rheumatoid arthritis: a population-based study.

Nikiphorou E, de Lusignan S, Mallen CD, Khavandi K, Bedarida G, Buckley CD, Galloway J, Raza K.

Heart. 2020 Mar 24. pii: heartjnl-2019-316193. doi: 10.1136/heartjnl-2019-316193. [Epub ahead of print]


Sodium-glucose co-transporter-2 inhibitor cardiovascular outcome trials and generalizability to English primary care.

Hinton W, Feher M, Munro N, Joy M, de Lusignan S.

Diabet Med. 2020 Mar 3. doi: 10.1111/dme.14290. [Epub ahead of print]


Brand-specific enhanced safety surveillance of GSK's Fluarix Tetra seasonal influenza vaccine in England: 2017/2018 season.

de Lusignan S, Damaso S, Ferreira F, Byford R, McGee C, Pathirannehelage S, Shende V, Yonova I, Schmidt A, Schuind A, Dos Santos G.

Hum Vaccin Immunother. 2020 Mar 2:1-10. doi: 10.1080/21645515.2019.1705112. [Epub ahead of print]


ADVANCE database characterisation and fit for purpose assessment for multi-country studies on the coverage, benefits and risks of pertussis vaccinations.

Sturkenboom M, Braeye T, van der Aa L, Danieli G, Dodd C, Duarte-Salles T, Emborg HD, Gheorghe M, Kahlert J, Gini R, Huerta C, Martín-Merino E, McGee C, de Lusignan S, Picelli G, Roberto G, Tramontan L, Villa M, Weibel D, Titievsky L.

Vaccine. 2020 Feb 12. pii: S0264-410X(20)30153-5. doi: 10.1016/j.vaccine.2020.01.100. [Epub ahead of print]


Investigating regional variation of respiratory infections in a general practice syndromic surveillance system.

Smith S, Morbey R, de Lusignan S, Pebody RG, Smith GE, Elliot AJ.

J Public Health (Oxf). 2020 Feb 2. pii: fdaa014. doi: 10.1093/pubmed/fdaa014. [Epub ahead of print]


Clinical Ontologies Improve Case Finding of Primary Biliary Cholangitis in UK Primary and Secondary Care.

Pericleous M, Kelly C, Odin JA, Kallis Y, McGee C, Sherlock J, Yonova I, de Lusignan S, Ala A.

Dig Dis Sci. 2020 Jan 17. doi: 10.1007/s10620-019-06039-x. [Epub ahead of print]


The association between colorectal cancer and prior antibiotic prescriptions: case control study.

Armstrong D, Dregan A, Ashworth M, White P, McGee C, de Lusignan S.

Br J Cancer. 2020 Mar;122(6):912-917. doi: 10.1038/s41416-019-0701-5. Epub 2020 Jan 13.


Electronic Consultation in Primary Care Between Providers and Patients: Systematic Review.

Mold F, Hendy J, Lai YL, de Lusignan S.

JMIR Med Inform. 2019 Dec 3;7(4):e13042. doi: 10.2196/13042. Review.


Enhanced Safety Surveillance of Influenza Vaccines in General Practice, Winter 2015-16: Feasibility Study.

de Lusignan S, Correa A, Dos Santos G, Meyer N, Haguinet F, Webb R, McGee C, Byford R, Yonova I, Pathirannehelage S, Ferreira FM, Jones S.

JMIR Public Health Surveill. 2019 Nov 14;5(4):e12016. doi: 10.2196/12016.


Feasibility of Point-of-Care Testing for Influenza Within a National Primary Care Sentinel Surveillance Network in England: Protocol for a Mixed Methods Study.

de Lusignan S, Hoang U, Liyanage H, Yonova I, Ferreira F, Diez-Domingo J, Clark T.

JMIR Res Protoc. 2019 Nov 11;8(11):e14186. doi: 10.2196/14186.


ADVANCE system testing: Can coverage of pertussis vaccination be estimated in European countries using electronic healthcare databases: An example.

Emborg HD, Kahlert J, Braeye T, Bauwens J, Bollaerts K, Danieli G, Duarte-Salles T, Glismann S, Huerta C, de Lusignan S, Martin E, McGee C, Correa A, Tramontan L, Weibel D, Sturkenboom M.

Vaccine. 2019 Oct 31. pii: S0264-410X(19)30930-2. doi: 10.1016/j.vaccine.2019.07.039. [Epub ahead of print]


Why we need more collaboration in Europe to enhance post-marketing surveillance of vaccines.

Sturkenboom M, Bahri P, Chiucchiuini A, Grove Krause T, Hahné S, Khromava A, Kokki M, Kramarz P, Kurz X, Larson HJ, de Lusignan S, Mahy P, Torcel-Pagnon L, Titievsky L, Bauchau V; ADVANCE consortium.

Vaccine. 2019 Oct 31. pii: S0264-410X(19)31002-3. doi: 10.1016/j.vaccine.2019.07.081. [Epub ahead of print]


ADVANCE: Towards near real-time monitoring of vaccination coverage, benefits and risks using European electronic health record databases.

Bollaerts K, de Smedt T, McGee C, Emborg HD, Villa M, Alexandridou M, Duarte-Salles T, Gini R, Bartolini C, de Lusignan S, Tin Tin Htar M, Titievsky L, Sturkenboom M, Bauchau V.

Vaccine. 2019 Oct 31. pii: S0264-410X(19)31051-5. doi: 10.1016/j.vaccine.2019.08.012. [Epub ahead of print]


Advance system testing: Vaccine benefit studies using multi-country electronic health data - The example of pertussis vaccination.

Tin Tin Htar M, de Ridder M, Braeye T, Correa A, McGee C, de Lusignan S, Duarte-Salles T, Huerta C, Martín-Merino E, Tramontan L, Danieli G, Picelli G, van der Maas N, Berencsi K, Arnheim-Dahlström L, Heininger U, Emborg HD, Weibel D, Bollaerts K, Sturkenboom M.

Vaccine. 2019 Oct 31. pii: S0264-410X(19)31167-3. doi: 10.1016/j.vaccine.2019.08.078. [Epub ahead of print]


The nexus between air pollution, green infrastructure and human health.

Kumar P, Druckman A, Gallagher J, Gatersleben B, Allison S, Eisenman TS, Hoang U, Hama S, Tiwari A, Sharma A, Abhijith KV, Adlakha D, McNabola A, Astell-Burt T, Feng X, Skeldon AC, de Lusignan S, Morawska L.

Environ Int. 2019 Dec;133(Pt A):105181. doi: 10.1016/j.envint.2019.105181. Epub 2019 Oct 29. Review.


Seasonal influenza: Modelling approaches to capture immunity propagation.

Hill EM, Petrou S, de Lusignan S, Yonova I, Keeling MJ.

PLoS Comput Biol. 2019 Oct 28;15(10):e1007096. doi: 10.1371/journal.pcbi.1007096. eCollection 2019 Oct.


Disparities in glycaemic control, monitoring, and treatment of type 2 diabetes in England: A retrospective cohort analysis.

Whyte MB, Hinton W, McGovern A, van Vlymen J, Ferreira F, Calderara S, Mount J, Munro N, de Lusignan S.

PLoS Med. 2019 Oct 7;16(10):e1002942. doi: 10.1371/journal.pmed.1002942. eCollection 2019 Oct.


Influence of prior antibiotic use on risk of rheumatoid arthritis: case control study in general practice.

Armstrong D, Dregan A, Ashworth M, White P, McGee C, de Lusignan S.

Rheumatology (Oxford). 2019 Oct 3. pii: kez452. doi: 10.1093/rheumatology/kez452. [Epub ahead of print]


Prognostic value of comorbidity indices and lung diseases in early rheumatoid arthritis: a UK population-based study.

Nikiphorou E, de Lusignan S, Mallen C, Roberts J, Khavandi K, Bedarida G, Buckley CD, Galloway J, Raza K.

Rheumatology (Oxford). 2019 Oct 3. pii: kez409. doi: 10.1093/rheumatology/kez409. [Epub ahead of print]


A Fully Integrated Real-Time Detection, Diagnosis, and Control of Community Diarrheal Disease Clusters and Outbreaks (the INTEGRATE Project): Protocol for an Enhanced Surveillance System.

McIntyre KM, Bolton FJ, Christley RM, Cleary P, Deja E, Durie AE, Diggle PJ, Hughes DA, de Lusignan S, Orton L, Radford AD, Elliot AJ, Smith GE, Snape DA, Stanistreet D, Vivancos R, Winstanley C, O'Brien SJ.

JMIR Res Protoc. 2019 Sep 26;8(9):e13941. doi: 10.2196/13941.


Haematological abnormalities in new-onset rheumatoid arthritis and risk of common infections: a population-based study.

Nikiphorou E, de Lusignan S, Mallen C, Khavandi K, Roberts J, Buckley CD, Galloway J, Raza K.

Rheumatology (Oxford). 2019 Sep 9. pii: kez344. doi: 10.1093/rheumatology/kez344. [Epub ahead of print]


Near-Real Time Monitoring of Vaccine Uptake of Pregnant Women in a Primary Care Sentinel Network: Ontological Case Definition Across Heterogeneous Data Sources.

Liyanage H, Williams J, Byford R, Pathirannehelage S, de Lusignan S.

Stud Health Technol Inform. 2019 Aug 21;264:1855-1856. doi: 10.3233/SHTI190682.


End of season influenza vaccine effectiveness in adults and children in the United Kingdom in 2017/18.

Pebody R, Djennad A, Ellis J, Andrews N, Marques DFP, Cottrell S, Reynolds AJ, Gunson R, Galiano M, Hoschler K, Lackenby A, Robertson C, O'Doherty M, Sinnathamby M, Panagiotopoulos N, Yonova I, Webb R, Moore C, Donati M, Sartaj M, Shepherd SJ, McMenamin J, de Lusignan S, Zambon M.

Euro Surveill. 2019 Aug;24(31). doi: 10.2807/1560-7917.ES.2019.24.31.1800488.


Ontology to identify pregnant women in electronic health records: primary care sentinel network database study.

Liyanage H, Williams J, Byford R, de Lusignan S.

BMJ Health Care Inform. 2019 Jul;26(1). pii: e100013. doi: 10.1136/bmjhci-2019-100013. Epub 2019 Jul 4.


Monitoring epidemiological trends in back to school asthma among preschool and school-aged children using real-time syndromic surveillance in England, 2012-2016.

Bundle N, Verlander NQ, Morbey R, Edeghere O, Balasegaram S, de Lusignan S, Smith G, Elliot AJ.

J Epidemiol Community Health. 2019 Sep;73(9):825-831. doi: 10.1136/jech-2018-211936. Epub 2019 Jul 1.


Estimating age-stratified influenza-associated invasive pneumococcal disease in England: A time-series model based on population surveillance data.

Chiavenna C, Presanis AM, Charlett A, de Lusignan S, Ladhani S, Pebody RG, De Angelis D.

PLoS Med. 2019 Jun 27;16(6):e1002829. doi: 10.1371/journal.pmed.1002829. eCollection 2019 Jun.


Saving bones without risking brain-bisphosphonates and risk of stroke: matched case-control study.

Asghar ZB, Godoy Caballero A, Pathirannehelage S, Williams J, McKay S, Grassby P, de Lusignan S, Niroshan Siriwardena A.

Osteoporos Int. 2019 Sep;30(9):1845-1854. doi: 10.1007/s00198-019-05045-z. Epub 2019 Jun 17.


The role of physician associates in secondary care: the PA-SCER mixed-methods study.

Drennan VM, Halter M, Wheeler C, Nice L, Brearley S, Ennis J, Gabe J, Gage H, Levenson R, de Lusignan S, Begg P, Parle J.

Southampton (UK): NIHR Journals Library; 2019 May.


Preconception health in England: a proposal for annual reporting with core metrics.

Stephenson J, Vogel C, Hall J, Hutchinson J, Mann S, Duncan H, Woods-Townsend K, de Lusignan S, Poston L, Cade J, Godfrey K, Hanson M, Barrett G, Barker M, Conti G, Shannon G, Colbourn T; Preconception Partnership.

Lancet. 2019 Jun 1;393(10187):2262-2271. doi: 10.1016/S0140-6736(19)30954-7.


Intensification to injectable therapy in type 2 diabetes: mixed methods study (protocol).

de Lusignan S, Hinton W, Konstantara E, Munro N, Whyte M, Mount J, Feher M.

BMC Health Serv Res. 2019 May 3;19(1):284. doi: 10.1186/s12913-019-4112-3.


How Generalizable Are Cardiovascular Outcome Trials of Sodium-Glucose Co-Transporter-2 Inhibitors? A National Database Study: Study Protocol.

Hinton W, Feher MD, Munro N, de Lusignan S.

Diabetes Ther. 2019 Jun;10(3):1163-1170. doi: 10.1007/s13300-019-0620-8. Epub 2019 Apr 30.


Artificial Intelligence in Primary Health Care: Perceptions, Issues, and Challenges.

Liyanage H, Liaw ST, Jonnagaddala J, Schreiber R, Kuziemsky C, Terry AL, de Lusignan S.

Yearb Med Inform. 2019 Aug;28(1):41-46. doi: 10.1055/s-0039-1677901. Epub 2019 Apr 25.


Obstructive sleep apnoea in Type 2 diabetes mellitus: increased risk for overweight as well as obese people included in a national primary care database analysis.

Feher M, Hinton W, Munro N, de Lusignan S.

Diabet Med. 2019 Oct;36(10):1304-1311. doi: 10.1111/dme.13968. Epub 2019 May 6.


Analysis of Primary Care Computerised Medical Records with Deep Learning.

de Lusignan S, Smith N, Livina V, Yonova I, Webb R, Thomas SA.

Stud Health Technol Inform. 2019;258:249-250.


Real-world prevalence of the inclusion criteria for the LEADER trial: Data from a national general practice network.

Hinton W, Feher M, Munro N, Walker M, de Lusignan S.

Diabetes Obes Metab. 2019 Jul;21(7):1661-1667. doi: 10.1111/dom.13710. Epub 2019 Apr 11.


Serological surveillance of influenza in an English sentinel network: pilot study protocol.

de Lusignan S, Borrow R, Tripathy M, Linley E, Zambon M, Hoschler K, Ferreira F, Andrews N, Yonova I, Hriskova M, Rafi I, Pebody R.

BMJ Open. 2019 Mar 8;9(3):e024285. doi: 10.1136/bmjopen-2018-024285.


A basic model for assessing primary health care electronic medical record data quality.

Terry AL, Stewart M, Cejic S, Marshall JN, de Lusignan S, Chesworth BM, Chevendra V, Maddocks H, Shadd J, Burge F, Thind A.

BMC Med Inform Decis Mak. 2019 Feb 12;19(1):30. doi: 10.1186/s12911-019-0740-0.


What is the contribution of physician associates in hospital care in England? A mixed methods, multiple case study.

Drennan VM, Halter M, Wheeler C, Nice L, Brearley S, Ennis J, Gabe J, Gage H, Levenson R, de Lusignan S, Begg P, Parle J.

BMJ Open. 2019 Jan 30;9(1):e027012. doi: 10.1136/bmjopen-2018-027012.


Trends in end digit preference for blood pressure and associations with cardiovascular outcomes in Canadian and UK primary care: a retrospective observational study.

Greiver M, Kalia S, Voruganti T, Aliarzadeh B, Moineddin R, Hinton W, Dawes M, Sullivan F, Syed S, Williams J, de Lusignan S.

BMJ Open. 2019 Jan 24;9(1):e024970. doi: 10.1136/bmjopen-2018-024970.


Determinants of inter-practice variation in childhood asthma and respiratory infections: cross-sectional study of a national sentinel network.

Hoang U, Liyanage H, Coyle R, Godden C, Jones S, Blair M, Rigby M, de Lusignan S.

BMJ Open. 2019 Jan 24;9(1):e024372. doi: 10.1136/bmjopen-2018-024372.


An instrument to identify computerised primary care research networks, genetic and disease registries prepared to conduct linked research: TRANSFoRm International Research Readiness (TIRRE) survey.

Jennings E, De Lusignan S, Michalakidis G, Krause P, Sullivan F, Liyanage H, Delaney B.

J Innov Health Inform. 2018 Dec 31;25(4):207-220. doi: 10.14236/jhi.v25i4.964.


Time to mandate collaborative working is part of computerised medical record systems, at a time of general practitioner shortage.

De Lusignan S.

J Innov Health Inform. 2018 Dec 31;25(4):260-262. doi: 10.14236/jhi.v25i4.1140. No abstract available.


In this issue - Assumptions, openness, apps, collaborative working and a new editor.

De Lusignan S.

J Innov Health Inform. 2018 Dec 30;25(4):1167. doi: 10.14236/jhi.v25i4.1167.


Enhanced passive surveillance of influenza vaccination in England, 2016-2017- an observational study using an adverse events reporting card.

de Lusignan S, Ferreira F, Damaso S, Byford R, Pathirannehelage S, Yeakey A, Yonova I, Schuind A, Dos Santos G.

Hum Vaccin Immunother. 2019;15(5):1048-1059. doi: 10.1080/21645515.2019.1565258. Epub 2019 Mar 20.


Variation in the diagnosis and control of hypertension is not explained by conventional variables: Cross-sectional database study in English general practice.

Coyle R, Feher M, Jones S, Hamilton M, de Lusignan S.

PLoS One. 2019 Jan 10;14(1):e0210657. doi: 10.1371/journal.pone.0210657. eCollection 2019.


Capturing complexity in clinician case-mix: classification system development using GP and physician associate data.

Halter M, Joly L, de Lusignan S, Grant RL, Gage H, Drennan VM.

BJGP Open. 2018 Apr 10;2(1):bjgpopen18X101277. doi: 10.3399/bjgpopen18X101277. eCollection 2018 Apr.


Conurbation, Urban, and Rural Living as Determinants of Allergies and Infectious Diseases: Royal College of General Practitioners Research and Surveillance Centre Annual Report 2016-2017.

de Lusignan S, McGee C, Webb R, Joy M, Byford R, Yonova I, Hriskova M, Matos Ferreira F, Elliot AJ, Smith G, Rafi I.

JMIR Public Health Surveill. 2018 Nov 26;4(4):e11354. doi: 10.2196/11354.


Granular Jamming Based Controllable Organ Design for Abdominal Palpation.

He L, Herzig N, de Lusignan S, Nanayakkara T.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:2154-2157. doi: 10.1109/EMBC.2018.8512709.

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