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Haematological abnormalities in new-onset rheumatoid arthritis and risk of common infections: a population-based study.

Nikiphorou E, de Lusignan S, Mallen C, Khavandi K, Roberts J, Buckley CD, Galloway J, Raza K.

Rheumatology (Oxford). 2019 Sep 9. pii: kez344. doi: 10.1093/rheumatology/kez344. [Epub ahead of print]


Near-Real Time Monitoring of Vaccine Uptake of Pregnant Women in a Primary Care Sentinel Network: Ontological Case Definition Across Heterogeneous Data Sources.

Liyanage H, Williams J, Byford R, Pathirannehelage S, de Lusignan S.

Stud Health Technol Inform. 2019 Aug 21;264:1855-1856. doi: 10.3233/SHTI190682.


End of season influenza vaccine effectiveness in adults and children in the United Kingdom in 2017/18.

Pebody R, Djennad A, Ellis J, Andrews N, Marques DFP, Cottrell S, Reynolds AJ, Gunson R, Galiano M, Hoschler K, Lackenby A, Robertson C, O'Doherty M, Sinnathamby M, Panagiotopoulos N, Yonova I, Webb R, Moore C, Donati M, Sartaj M, Shepherd SJ, McMenamin J, de Lusignan S, Zambon M.

Euro Surveill. 2019 Aug;24(31). doi: 10.2807/1560-7917.ES.2019.24.31.1800488.


Ontology to identify pregnant women in electronic health records: primary care sentinel network database study.

Liyanage H, Williams J, Byford R, de Lusignan S.

BMJ Health Care Inform. 2019 Jul;26(1). pii: e100013. doi: 10.1136/bmjhci-2019-100013. Epub 2019 Jul 4.


Monitoring epidemiological trends in back to school asthma among preschool and school-aged children using real-time syndromic surveillance in England, 2012-2016.

Bundle N, Verlander NQ, Morbey R, Edeghere O, Balasegaram S, de Lusignan S, Smith G, Elliot AJ.

J Epidemiol Community Health. 2019 Sep;73(9):825-831. doi: 10.1136/jech-2018-211936. Epub 2019 Jul 1.


Estimating age-stratified influenza-associated invasive pneumococcal disease in England: A time-series model based on population surveillance data.

Chiavenna C, Presanis AM, Charlett A, de Lusignan S, Ladhani S, Pebody RG, De Angelis D.

PLoS Med. 2019 Jun 27;16(6):e1002829. doi: 10.1371/journal.pmed.1002829. eCollection 2019 Jun.


Saving bones without risking brain-bisphosphonates and risk of stroke: matched case-control study.

Asghar ZB, Godoy Caballero A, Pathirannehelage S, Williams J, McKay S, Grassby P, de Lusignan S, Niroshan Siriwardena A.

Osteoporos Int. 2019 Sep;30(9):1845-1854. doi: 10.1007/s00198-019-05045-z. Epub 2019 Jun 17.


The role of physician associates in secondary care: the PA-SCER mixed-methods study.

Drennan VM, Halter M, Wheeler C, Nice L, Brearley S, Ennis J, Gabe J, Gage H, Levenson R, de Lusignan S, Begg P, Parle J.

Southampton (UK): NIHR Journals Library; 2019 May.


Preconception health in England: a proposal for annual reporting with core metrics.

Stephenson J, Vogel C, Hall J, Hutchinson J, Mann S, Duncan H, Woods-Townsend K, de Lusignan S, Poston L, Cade J, Godfrey K, Hanson M, Barrett G, Barker M, Conti G, Shannon G, Colbourn T; Preconception Partnership.

Lancet. 2019 Jun 1;393(10187):2262-2271. doi: 10.1016/S0140-6736(19)30954-7.


Intensification to injectable therapy in type 2 diabetes: mixed methods study (protocol).

de Lusignan S, Hinton W, Konstantara E, Munro N, Whyte M, Mount J, Feher M.

BMC Health Serv Res. 2019 May 3;19(1):284. doi: 10.1186/s12913-019-4112-3.


How Generalizable Are Cardiovascular Outcome Trials of Sodium-Glucose Co-Transporter-2 Inhibitors? A National Database Study: Study Protocol.

Hinton W, Feher MD, Munro N, de Lusignan S.

Diabetes Ther. 2019 Jun;10(3):1163-1170. doi: 10.1007/s13300-019-0620-8. Epub 2019 Apr 30.


Artificial Intelligence in Primary Health Care: Perceptions, Issues, and Challenges.

Liyanage H, Liaw ST, Jonnagaddala J, Schreiber R, Kuziemsky C, Terry AL, de Lusignan S.

Yearb Med Inform. 2019 Aug;28(1):41-46. doi: 10.1055/s-0039-1677901. Epub 2019 Apr 25.


Obstructive sleep apnoea in Type 2 diabetes mellitus: increased risk for overweight as well as obese people included in a national primary care database analysis.

Feher M, Hinton W, Munro N, de Lusignan S.

Diabet Med. 2019 Apr 18. doi: 10.1111/dme.13968. [Epub ahead of print]


Analysis of Primary Care Computerised Medical Records with Deep Learning.

de Lusignan S, Smith N, Livina V, Yonova I, Webb R, Thomas SA.

Stud Health Technol Inform. 2019;258:249-250.


Real-world prevalence of the inclusion criteria for the LEADER trial: Data from a national general practice network.

Hinton W, Feher M, Munro N, Walker M, de Lusignan S.

Diabetes Obes Metab. 2019 Jul;21(7):1661-1667. doi: 10.1111/dom.13710. Epub 2019 Apr 11.


Serological surveillance of influenza in an English sentinel network: pilot study protocol.

de Lusignan S, Borrow R, Tripathy M, Linley E, Zambon M, Hoschler K, Ferreira F, Andrews N, Yonova I, Hriskova M, Rafi I, Pebody R.

BMJ Open. 2019 Mar 8;9(3):e024285. doi: 10.1136/bmjopen-2018-024285.


A basic model for assessing primary health care electronic medical record data quality.

Terry AL, Stewart M, Cejic S, Marshall JN, de Lusignan S, Chesworth BM, Chevendra V, Maddocks H, Shadd J, Burge F, Thind A.

BMC Med Inform Decis Mak. 2019 Feb 12;19(1):30. doi: 10.1186/s12911-019-0740-0.


What is the contribution of physician associates in hospital care in England? A mixed methods, multiple case study.

Drennan VM, Halter M, Wheeler C, Nice L, Brearley S, Ennis J, Gabe J, Gage H, Levenson R, de Lusignan S, Begg P, Parle J.

BMJ Open. 2019 Jan 30;9(1):e027012. doi: 10.1136/bmjopen-2018-027012.


Trends in end digit preference for blood pressure and associations with cardiovascular outcomes in Canadian and UK primary care: a retrospective observational study.

Greiver M, Kalia S, Voruganti T, Aliarzadeh B, Moineddin R, Hinton W, Dawes M, Sullivan F, Syed S, Williams J, de Lusignan S.

BMJ Open. 2019 Jan 24;9(1):e024970. doi: 10.1136/bmjopen-2018-024970.


Determinants of inter-practice variation in childhood asthma and respiratory infections: cross-sectional study of a national sentinel network.

Hoang U, Liyanage H, Coyle R, Godden C, Jones S, Blair M, Rigby M, de Lusignan S.

BMJ Open. 2019 Jan 24;9(1):e024372. doi: 10.1136/bmjopen-2018-024372.


An instrument to identify computerised primary care research networks, genetic and disease registries prepared to conduct linked research: TRANSFoRm International Research Readiness (TIRRE) survey.

Jennings E, De Lusignan S, Michalakidis G, Krause P, Sullivan F, Liyanage H, Delaney B.

J Innov Health Inform. 2018 Dec 31;25(4):207-220. doi: 10.14236/jhi.v25i4.964.


Time to mandate collaborative working is part of computerised medical record systems, at a time of general practitioner shortage.

De Lusignan S.

J Innov Health Inform. 2018 Dec 31;25(4):260-262. doi: 10.14236/jhi.v25i4.1140. No abstract available.


In this issue - Assumptions, openness, apps, collaborative working and a new editor.

De Lusignan S.

J Innov Health Inform. 2018 Dec 30;25(4):1167. doi: 10.14236/jhi.v25i4.1167.


Enhanced passive surveillance of influenza vaccination in England, 2016-2017- an observational study using an adverse events reporting card.

de Lusignan S, Ferreira F, Damaso S, Byford R, Pathirannehelage S, Yeakey A, Yonova I, Schuind A, Dos Santos G.

Hum Vaccin Immunother. 2019;15(5):1048-1059. doi: 10.1080/21645515.2019.1565258. Epub 2019 Mar 20.


Variation in the diagnosis and control of hypertension is not explained by conventional variables: Cross-sectional database study in English general practice.

Coyle R, Feher M, Jones S, Hamilton M, de Lusignan S.

PLoS One. 2019 Jan 10;14(1):e0210657. doi: 10.1371/journal.pone.0210657. eCollection 2019.


Capturing complexity in clinician case-mix: classification system development using GP and physician associate data.

Halter M, Joly L, de Lusignan S, Grant RL, Gage H, Drennan VM.

BJGP Open. 2018 Apr 10;2(1):bjgpopen18X101277. doi: 10.3399/bjgpopen18X101277. eCollection 2018 Apr.


Conurbation, Urban, and Rural Living as Determinants of Allergies and Infectious Diseases: Royal College of General Practitioners Research and Surveillance Centre Annual Report 2016-2017.

de Lusignan S, McGee C, Webb R, Joy M, Byford R, Yonova I, Hriskova M, Matos Ferreira F, Elliot AJ, Smith G, Rafi I.

JMIR Public Health Surveill. 2018 Nov 26;4(4):e11354. doi: 10.2196/11354.


Granular Jamming Based Controllable Organ Design for Abdominal Palpation.

He L, Herzig N, de Lusignan S, Nanayakkara T.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:2154-2157. doi: 10.1109/EMBC.2018.8512709.


In this issue: Digital disparities, complexity and patient safety.

De Lusignan S.

J Innov Health Inform. 2018 Oct 31;25(3):1129. doi: 10.14236/jhi.v25i3.1129.


Ontologies in Big Health Data Analytics: Application to Routine Clinical Data.

Liyanage H, Williams J, Byford R, Stergioulas L, de Lusignan S.

Stud Health Technol Inform. 2018;255:65-69.


Common Data Models (CDMs) to Enhance International Big Data Analytics: A Diabetes Use Case to Compare Three CDMs.

Liyanage H, Liaw ST, Jonnagaddala J, Hinton W, de Lusignan S.

Stud Health Technol Inform. 2018;255:60-64. Review.


Uptake and effectiveness of influenza vaccine in those aged 65 years and older in the United Kingdom, influenza seasons 2010/11 to 2016/17.

Pebody RG, Warburton F, Andrews N, Sinnathamby M, Yonova I, Reynolds A, Robertson C, Cottrell S, Sartaj M, Gunson R, Donati M, Moore C, Ellis J, de Lusignan S, McMenamin J, Zambon M.

Euro Surveill. 2018 Sep;23(39). doi: 10.2807/1560-7917.ES.2018.23.39.1800092.


The association between serum sodium concentration, hypertension and primary cardiovascular events: a retrospective cohort study.

Cole NI, Suckling RJ, Swift PA, He FJ, MacGregor GA, Hinton W, van Vlymen J, Hayward N, Jones S, de Lusignan S.

J Hum Hypertens. 2019 Jan;33(1):69-77. doi: 10.1038/s41371-018-0115-5. Epub 2018 Sep 24.


Incidence of household transmission of acute gastroenteritis (AGE) in a primary care sentinel network (1992-2017): cross-sectional and retrospective cohort study protocol.

de Lusignan S, Konstantara E, Joy M, Sherlock J, Hoang U, Coyle R, Ferreira F, Jones S, O'Brien SJ.

BMJ Open. 2018 Aug 23;8(8):e022524. doi: 10.1136/bmjopen-2018-022524.


Incidence and prevalence of cardiovascular disease in English primary care: a cross-sectional and follow-up study of the Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC).

Hinton W, McGovern A, Coyle R, Han TS, Sharma P, Correa A, Ferreira F, de Lusignan S.

BMJ Open. 2018 Aug 20;8(8):e020282. doi: 10.1136/bmjopen-2017-020282.


Enhanced Safety Surveillance of Seasonal Quadrivalent Influenza Vaccines in English Primary Care: Interim Analysis.

de Lusignan S, Dos Santos G, Byford R, Schuind A, Damaso S, Shende V, McGee C, Yonova I, Ferreira F.

Adv Ther. 2018 Aug;35(8):1199-1214. doi: 10.1007/s12325-018-0747-4. Epub 2018 Jul 11.


Type 2 Diabetes and Asthma: Systematic Review of the Bidirectional Relationship.

Rayner L, McGovern A, Creagh-Brown B, Woodmansey C, de Lusignan S.

Curr Diabetes Rev. 2019;15(2):118-126. doi: 10.2174/1573399814666180711114859.


The Impact of Patient Online Access to Computerized Medical Records and Services on Type 2 Diabetes: Systematic Review.

Mold F, Raleigh M, Alharbi NS, de Lusignan S.

J Med Internet Res. 2018 Jul 6;20(7):e235. doi: 10.2196/jmir.7858.


The role of the chronic care model in promoting the management of the patient with rare liver disease.

Pericleous M, Kelly C, Ala A, De Lusignan S.

Expert Rev Gastroenterol Hepatol. 2018 Aug;12(8):829-841. doi: 10.1080/17474124.2018.1497483. Epub 2018 Jul 13. Review.


Estimating the burden on general practitioner services in England from increases in respiratory disease associated with seasonal respiratory pathogen activity.

Morbey RA, Elliot AJ, Harcourt S, Smith S, de Lusignan S, Pebody R, Yeates A, Zambon M, Smith GE.

Epidemiol Infect. 2018 Aug;146(11):1389-1396. doi: 10.1017/S0950268818000262. Epub 2018 Jul 4.


Uptake and impact of vaccinating primary school-age children against influenza: experiences of a live attenuated influenza vaccine programme, England, 2015/16.

Pebody RG, Sinnathamby MA, Warburton F, Andrews N, Boddington NL, Zhao H, Yonova I, Ellis J, Tessier E, Donati M, Elliot AJ, Hughes HE, Pathirannehelage S, Byford R, Smith GE, de Lusignan S, Zambon M.

Euro Surveill. 2018 Jun;23(25). doi: 10.2807/1560-7917.ES.2018.23.25.1700496.


Contribution of physician assistants/associates to secondary care: a systematic review.

Halter M, Wheeler C, Pelone F, Gage H, de Lusignan S, Parle J, Grant R, Gabe J, Nice L, Drennan VM.

BMJ Open. 2018 Jun 19;8(6):e019573. doi: 10.1136/bmjopen-2017-019573.


Interventions to improve the uptake of screening across a range of conditions in Ethnic Minority Groups: a systematic review.

Kelly C, Pericleous M, Hendy J, de Lusignan S, Ahmed A, Vandrevala T, Ala A.

Int J Clin Pract. 2018 Jun 19:e13202. doi: 10.1111/ijcp.13202. [Epub ahead of print] Review.


Type 2 diabetes: A protective factor for COPD?

Rayner LH, McGovern AP, Sherlock J, Gatenby P, Correa A, Creagh-Brown B, de Lusignan S.

Prim Care Diabetes. 2018 Oct;12(5):438-444. doi: 10.1016/j.pcd.2018.05.002. Epub 2018 May 26.


Novel diabetes subgroups.

Feher MD, Munro N, Russell-Jones D, de Lusignan S, Khunti K.

Lancet Diabetes Endocrinol. 2018 Jun;6(6):439. doi: 10.1016/S2213-8587(18)30126-8. No abstract available.


Significant spike in excess mortality in England in winter 2014/15 - influenza the likely culprit.

Pebody RG, Green HK, Warburton F, Sinnathamby M, Ellis J, Mølbak K, Nielsen J, de Lusignan S, Andrews N.

Epidemiol Infect. 2018 Jul;146(9):1106-1113. doi: 10.1017/S0950268818001152. Epub 2018 May 10.


Computerised medical record systems that guide and protect - reflections on the Bawa-Garba case.

De Lusignan S, Liyanage H, Scott P.

J Innov Health Inform. 2018 Apr 10;25(1):58-59. doi: 10.14236/jhi.v25i1.1040.


In this issue - Patient risks are ignored at organisation level.

De Lusignan S.

J Innov Health Inform. 2018 Apr 10;25(1):1041. doi: 10.14236/jhi.v25i1.1041. No abstract available.


Incidence of Lower Respiratory Tract Infections and Atopic Conditions in Boys and Young Male Adults: Royal College of General Practitioners Research and Surveillance Centre Annual Report 2015-2016.

de Lusignan S, Correa A, Pebody R, Yonova I, Smith G, Byford R, Pathirannehelage SR, McGee C, Elliot AJ, Hriskova M, Ferreira FI, Rafi I, Jones S.

JMIR Public Health Surveill. 2018 Apr 30;4(2):e49. doi: 10.2196/publichealth.9307.


Benefit-risk of Patients' Online Access to their Medical Records: Consensus Exercise of an International Expert Group.

Liyanage H, Liaw ST, Konstantara E, Mold F, Schreiber R, Kuziemsky C, Terry AL, de Lusignan S.

Yearb Med Inform. 2018 Aug;27(1):156-162. doi: 10.1055/s-0038-1641202. Epub 2018 Apr 22.

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