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Ontologies in Big Health Data Analytics: Application to Routine Clinical Data.

Liyanage H, Williams J, Byford R, Stergioulas L, de Lusignan S.

Stud Health Technol Inform. 2018;255:65-69.


Common Data Models (CDMs) to Enhance International Big Data Analytics: A Diabetes Use Case to Compare Three CDMs.

Liyanage H, Liaw ST, Jonnagaddala J, Hinton W, de Lusignan S.

Stud Health Technol Inform. 2018;255:60-64.


Uptake and effectiveness of influenza vaccine in those aged 65 years and older in the United Kingdom, influenza seasons 2010/11 to 2016/17.

Pebody RG, Warburton F, Andrews N, Sinnathamby M, Yonova I, Reynolds A, Robertson C, Cottrell S, Sartaj M, Gunson R, Donati M, Moore C, Ellis J, de Lusignan S, McMenamin J, Zambon M.

Euro Surveill. 2018 Sep;23(39). doi: 10.2807/1560-7917.ES.2018.23.39.1800092.


The association between serum sodium concentration, hypertension and primary cardiovascular events: a retrospective cohort study.

Cole NI, Suckling RJ, Swift PA, He FJ, MacGregor GA, Hinton W, van Vlymen J, Hayward N, Jones S, de Lusignan S.

J Hum Hypertens. 2018 Sep 24. doi: 10.1038/s41371-018-0115-5. [Epub ahead of print]


Incidence of household transmission of acute gastroenteritis (AGE) in a primary care sentinel network (1992-2017): cross-sectional and retrospective cohort study protocol.

de Lusignan S, Konstantara E, Joy M, Sherlock J, Hoang U, Coyle R, Ferreira F, Jones S, O'Brien SJ.

BMJ Open. 2018 Aug 23;8(8):e022524. doi: 10.1136/bmjopen-2018-022524.


Incidence and prevalence of cardiovascular disease in English primary care: a cross-sectional and follow-up study of the Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC).

Hinton W, McGovern A, Coyle R, Han TS, Sharma P, Correa A, Ferreira F, de Lusignan S.

BMJ Open. 2018 Aug 20;8(8):e020282. doi: 10.1136/bmjopen-2017-020282.


Enhanced Safety Surveillance of Seasonal Quadrivalent Influenza Vaccines in English Primary Care: Interim Analysis.

de Lusignan S, Dos Santos G, Byford R, Schuind A, Damaso S, Shende V, McGee C, Yonova I, Ferreira F.

Adv Ther. 2018 Jul 11. doi: 10.1007/s12325-018-0747-4. [Epub ahead of print]


Type 2 Diabetes And Asthma: Systematic Review.

Rayner L, McGovern A, Creagh-Brown B, Woodmansey C, de Lusignan S.

Curr Diabetes Rev. 2018 Jul 10. doi: 10.2174/1573399814666180711114859. [Epub ahead of print]


The Impact of Patient Online Access to Computerized Medical Records and Services on Type 2 Diabetes: Systematic Review.

Mold F, Raleigh M, Alharbi NS, de Lusignan S.

J Med Internet Res. 2018 Jul 6;20(7):e235. doi: 10.2196/jmir.7858. Review.


The role of the chronic care model in promoting the management of the patient with rare liver disease.

Pericleous M, Kelly C, Ala A, De Lusignan S.

Expert Rev Gastroenterol Hepatol. 2018 Aug;12(8):829-841. doi: 10.1080/17474124.2018.1497483. Epub 2018 Jul 13.


Estimating the burden on general practitioner services in England from increases in respiratory disease associated with seasonal respiratory pathogen activity.

Morbey RA, Elliot AJ, Harcourt S, Smith S, de Lusignan S, Pebody R, Yeates A, Zambon M, Smith GE.

Epidemiol Infect. 2018 Aug;146(11):1389-1396. doi: 10.1017/S0950268818000262. Epub 2018 Jul 4.


Uptake and impact of vaccinating primary school-age children against influenza: experiences of a live attenuated influenza vaccine programme, England, 2015/16.

Pebody RG, Sinnathamby MA, Warburton F, Andrews N, Boddington NL, Zhao H, Yonova I, Ellis J, Tessier E, Donati M, Elliot AJ, Hughes HE, Pathirannehelage S, Byford R, Smith GE, de Lusignan S, Zambon M.

Euro Surveill. 2018 Jun;23(25). doi: 10.2807/1560-7917.ES.2018.23.25.1700496.


Contribution of physician assistants/associates to secondary care: a systematic review.

Halter M, Wheeler C, Pelone F, Gage H, de Lusignan S, Parle J, Grant R, Gabe J, Nice L, Drennan VM.

BMJ Open. 2018 Jun 19;8(6):e019573. doi: 10.1136/bmjopen-2017-019573.


Interventions to improve the uptake of screening across a range of conditions in Ethnic Minority Groups: a systematic review.

Kelly C, Pericleous M, Hendy J, de Lusignan S, Ahmed A, Vandrevala T, Ala A.

Int J Clin Pract. 2018 Jun 19:e13202. doi: 10.1111/ijcp.13202. [Epub ahead of print] Review.


Type 2 diabetes: A protective factor for COPD?

Rayner LH, McGovern AP, Sherlock J, Gatenby P, Correa A, Creagh-Brown B, de Lusignan S.

Prim Care Diabetes. 2018 Oct;12(5):438-444. doi: 10.1016/j.pcd.2018.05.002. Epub 2018 May 26.


Novel diabetes subgroups.

Feher MD, Munro N, Russell-Jones D, de Lusignan S, Khunti K.

Lancet Diabetes Endocrinol. 2018 Jun;6(6):439. doi: 10.1016/S2213-8587(18)30126-8. No abstract available.


Significant spike in excess mortality in England in winter 2014/15 - influenza the likely culprit.

Pebody RG, Green HK, Warburton F, Sinnathamby M, Ellis J, Mølbak K, Nielsen J, de Lusignan S, Andrews N.

Epidemiol Infect. 2018 Jul;146(9):1106-1113. doi: 10.1017/S0950268818001152. Epub 2018 May 10.


Computerised medical record systems that guide and protect - reflections on the Bawa-Garba case.

De Lusignan S, Liyanage H, Scott P.

J Innov Health Inform. 2018 Apr 10;25(1):58-59. doi: 10.14236/jhi.v25i1.1040.


In this issue - Patient risks are ignored at organisation level.

De Lusignan S.

J Innov Health Inform. 2018 Apr 10;25(1):1041. doi: 10.14236/jhi.v25i1.1041. No abstract available.


Incidence of Lower Respiratory Tract Infections and Atopic Conditions in Boys and Young Male Adults: Royal College of General Practitioners Research and Surveillance Centre Annual Report 2015-2016.

de Lusignan S, Correa A, Pebody R, Yonova I, Smith G, Byford R, Pathirannehelage SR, McGee C, Elliot AJ, Hriskova M, Ferreira FI, Rafi I, Jones S.

JMIR Public Health Surveill. 2018 Apr 30;4(2):e49. doi: 10.2196/publichealth.9307.


Benefit-risk of Patients' Online Access to their Medical Records: Consensus Exercise of an International Expert Group.

Liyanage H, Liaw ST, Konstantara E, Mold F, Schreiber R, Kuziemsky C, Terry AL, de Lusignan S.

Yearb Med Inform. 2018 Aug;27(1):156-162. doi: 10.1055/s-0038-1641202. Epub 2018 Apr 22.


Uptake of a Dashboard Designed to Give Realtime Feedback to a Sentinel Network About Key Data Required for Influenza Vaccine Effectiveness Studies.

Pathirannehelage S, Kumarapeli P, Byford R, Yonova I, Ferreira F, de Lusignan S.

Stud Health Technol Inform. 2018;247:161-165.


Automated Differentiation of Incident and Prevalent Cases in Primary Care Computerised Medical Records (CMR).

Smith N, Livina V, Byford R, Ferreira F, Yonova I, de Lusignan S.

Stud Health Technol Inform. 2018;247:151-155.


Profiling Databases to Facilitate Comparison of Child Health Systems Across Europe Using Standardised Quality Markers.

Liyanage H, Shinneman S, Hoang U, Ferreira F, Alexander D, Rigby M, Blair M, de Lusignan S.

Stud Health Technol Inform. 2018;247:61-65.


Glycemic control is an important modifiable risk factor for uveitis in patients with diabetes: A retrospective cohort study establishing clinical risk and ophthalmic disease burden.

Ansari AS, de Lusignan S, Hinton W, Munro N, Taylor S, McGovern A.

J Diabetes Complications. 2018 Jun;32(6):602-608. doi: 10.1016/j.jdiacomp.2018.03.008. Epub 2018 Mar 23.


An ontological approach to identifying cases of chronic kidney disease from routine primary care data: a cross-sectional study.

Cole NI, Liyanage H, Suckling RJ, Swift PA, Gallagher H, Byford R, Williams J, Kumar S, de Lusignan S.

BMC Nephrol. 2018 Apr 10;19(1):85. doi: 10.1186/s12882-018-0882-9.


Does Real World Use of Liraglutide Match its Use in the LEADER Cardiovascular Outcome Trial? Study Protocol.

Hinton W, Feher M, Munro N, de Lusignan S.

Diabetes Ther. 2018 Jun;9(3):1397-1402. doi: 10.1007/s13300-018-0390-8. Epub 2018 Mar 31.


Ischaemic stroke, haemorrhage, and mortality in older patients with chronic kidney disease newly started on anticoagulation for atrial fibrillation: a population based study from UK primary care.

Kumar S, de Lusignan S, McGovern A, Correa A, Hriskova M, Gatenby P, Jones S, Goldsmith D, Camm AJ.

BMJ. 2018 Feb 14;360:k342. doi: 10.1136/bmj.k342.


Building an evidence base for the primary care workforce.

Drennan VM, de Lusignan S, Gage H, Gabe J, Halter M.

BMJ. 2018 Jan 25;360:k248. doi: 10.1136/bmj.k248. No abstract available.


Real World Evidence to an eHealth tool: The 2017 top ten papers from Journal of Innovation in Health Informatics.

De Lusignan S.

J Innov Health Inform. 2018 Jan 12;24(4):347-349. doi: 10.14236/jhi.v24i4.1004.


Genesis of a UK Faculty of Clinical Informatics at a time of anticipation for some, and ruby, golden and diamond celebrations for others.

De Lusignan S, Barlow J, Scott PJ.

J Innov Health Inform. 2018 Jan 12;24(4):344-346. doi: 10.14236/jhi.v24i4.1003.


In this issue: Prerequisites for precision medicine are genomics, computerised medical record systems, and big data analytics.

De Lusignan S.

J Innov Health Inform. 2018 Jan 12;24(4):1009. doi: 10.14236/jhi.v24i4.1009. No abstract available.


A Class Comparison of Medication Persistence in People with Type 2 Diabetes: A Retrospective Observational Study.

McGovern A, Hinton W, Calderara S, Munro N, Whyte M, de Lusignan S.

Diabetes Ther. 2018 Feb;9(1):229-242. doi: 10.1007/s13300-017-0361-5. Epub 2018 Jan 4.


Evaluation of the effect of the herpes zoster vaccination programme 3 years after its introduction in England: a population-based study.

Amirthalingam G, Andrews N, Keel P, Mullett D, Correa A, de Lusignan S, Ramsay M.

Lancet Public Health. 2018 Feb;3(2):e82-e90. doi: 10.1016/S2468-2667(17)30234-7. Epub 2017 Dec 22.


Estimating primary care attendance rates for fever in infants after meningococcal B vaccination in England using national syndromic surveillance data.

Harcourt S, Morbey RA, Bates C, Carter H, Ladhani SN, de Lusignan S, Smith GE, Elliot AJ.

Vaccine. 2018 Jan 25;36(4):565-571. doi: 10.1016/j.vaccine.2017.11.076. Epub 2017 Dec 13.


Disease burden and costs from excess alcohol consumption, obesity, and viral hepatitis: fourth report of the Lancet Standing Commission on Liver Disease in the UK.

Williams R, Alexander G, Armstrong I, Baker A, Bhala N, Camps-Walsh G, Cramp ME, de Lusignan S, Day N, Dhawan A, Dillon J, Drummond C, Dyson J, Foster G, Gilmore I, Hudson M, Kelly D, Langford A, McDougall N, Meier P, Moriarty K, Newsome P, O'Grady J, Pryke R, Rolfe L, Rice P, Rutter H, Sheron N, Taylor A, Thompson J, Thorburn D, Verne J, Wass J, Yeoman A.

Lancet. 2018 Mar 17;391(10125):1097-1107. doi: 10.1016/S0140-6736(17)32866-0. Epub 2017 Nov 29. Erratum in: Lancet. 2017 Dec 7;:.


Comparison of medication adherence and persistence in type 2 diabetes: A systematic review and meta-analysis.

McGovern A, Tippu Z, Hinton W, Munro N, Whyte M, de Lusignan S.

Diabetes Obes Metab. 2018 Apr;20(4):1040-1043. doi: 10.1111/dom.13160. Epub 2017 Dec 12.


Flu vaccination by pharmacists leads to suboptimal medical records.

de Lusignan S, Hoghton M, Rafi I.

BMJ. 2017 Nov 9;359:j5084. doi: 10.1136/bmj.j5084. No abstract available.


In this issue: tools and processes that translate knowledge into practice.

De Lusignan S.

J Innov Health Inform. 2017 Oct 31;24(3):980. doi: 10.14236/jhi.v24i3.980.


U-shaped relationship between serum phosphate and cardiovascular risk: A retrospective cohort study.

Hayward N, McGovern A, de Lusignan S, Cole N, Hinton W, Jones S.

PLoS One. 2017 Nov 8;12(11):e0184774. doi: 10.1371/journal.pone.0184774. eCollection 2017.


End-of-season influenza vaccine effectiveness in adults and children, United Kingdom, 2016/17.

Pebody R, Warburton F, Ellis J, Andrews N, Potts A, Cottrell S, Reynolds A, Gunson R, Thompson C, Galiano M, Robertson C, Gallagher N, Sinnathamby M, Yonova I, Correa A, Moore C, Sartaj M, de Lusignan S, McMenamin J, Zambon M.

Euro Surveill. 2017 Nov;22(44). doi: 10.2807/1560-7917.ES.2017.22.44.17-00306.


Using a genetic/clinical risk score to stop smoking (GeTSS): randomised controlled trial.

Nichols JAA, Grob P, Kite W, Williams P, de Lusignan S.

BMC Res Notes. 2017 Oct 23;10(1):507. doi: 10.1186/s13104-017-2831-2.


Retrospective Observational Study of Atypical Winter Respiratory Illness Season Using Real-Time Syndromic Surveillance, England, 2014-15.

Smith S, Morbey R, Pebody RG, Hughes TC, de Lusignan S, Yeates FA, Thomas H, O'Brien SJ, Smith GE, Elliot AJ.

Emerg Infect Dis. 2017 Nov;23(11):1834-1842. doi: 10.3201/eid2311.161632.


Probabilistic broken-stick model: A regression algorithm for irregularly sampled data with application to eGFR.

Poh N, Tirunagari S, Cole N, de Lusignan S.

J Biomed Inform. 2017 Dec;76:69-77. doi: 10.1016/j.jbi.2017.10.006. Epub 2017 Oct 16.


Availability of Computerised Medical Record System Data to Compare Models of Child Health Care in Primary Care Across Europe.

Liyanage H, Hoang U, Ferreira F, Alexander D, Rigby M, Blair M, De Lusignan S.

Stud Health Technol Inform. 2017;244:8-12.


RCGP Research and Surveillance Centre: 50 years' surveillance of influenza, infections, and respiratory conditions.

de Lusignan S, Correa A, Smith GE, Yonova I, Pebody R, Ferreira F, Elliot AJ, Fleming D.

Br J Gen Pract. 2017 Oct;67(663):440-441. doi: 10.3399/bjgp17X692645. No abstract available.


An Ontology to Improve Transparency in Case Definition and Increase Case Finding of Infectious Intestinal Disease: Database Study in English General Practice.

de Lusignan S, Shinneman S, Yonova I, van Vlymen J, Elliot AJ, Bolton F, Smith GE, O'Brien S.

JMIR Med Inform. 2017 Sep 28;5(3):e34. doi: 10.2196/medinform.7641.


Physician associates working in secondary care teams in England: Interprofessional implications from a national survey.

Wheeler C, Halter M, Drennan VM, de Lusignan S, Grant R, Gabe J, Gage H, Begg P, Ennis J, Parle J.

J Interprof Care. 2017 Nov;31(6):774-776. doi: 10.1080/13561820.2017.1341390. Epub 2017 Sep 6.


Incidence, Demographics, and Clinical Characteristics of Diabetes of the Exocrine Pancreas (Type 3c): A Retrospective Cohort Study.

Woodmansey C, McGovern AP, McCullough KA, Whyte MB, Munro NM, Correa AC, Gatenby PAC, Jones SA, de Lusignan S.

Diabetes Care. 2017 Nov;40(11):1486-1493. doi: 10.2337/dc17-0542. Epub 2017 Aug 31.


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