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Items: 1 to 50 of 166


The hypocretin (orexin) system: from a neural circuitry perspective.

Li SB, de Lecea L.

Neuropharmacology. 2020 May 1;167:107993. doi: 10.1016/j.neuropharm.2020.107993. Epub 2020 Feb 6. Review.


Arousal State-Dependent Alterations in VTA-GABAergic Neuronal Activity.

Eban-Rothschild A, Borniger JC, Rothschild G, Giardino WJ, Morrow JG, de Lecea L.

eNeuro. 2020 Mar 30;7(2). pii: ENEURO.0356-19.2020. doi: 10.1523/ENEURO.0356-19.2020. Print 2020 Mar/Apr.


Multisensory modulation of body ownership in mice.

Buckmaster CL, Rathmann-Bloch JE, de Lecea L, Schatzberg AF, Lyons DM.

Neurosci Conscious. 2020 Jan 23;2020(1):niz019. doi: 10.1093/nc/niz019. eCollection 2020.


In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness.

Yamaguchi H, Hopf FW, Li SB, de Lecea L.

Nat Commun. 2018 Dec 6;9(1):5211. doi: 10.1038/s41467-018-07566-3.


In vivo cell type-specific CRISPR gene editing for sleep research.

Yamaguchi H, de Lecea L.

J Neurosci Methods. 2019 Mar 15;316:99-102. doi: 10.1016/j.jneumeth.2018.10.016. Epub 2018 Nov 12. Review.


Recent advances in understanding the roles of hypocretin/orexin in arousal, affect, and motivation.

Nevárez N, de Lecea L.

F1000Res. 2018 Sep 6;7. pii: F1000 Faculty Rev-1421. doi: 10.12688/f1000research.15097.1. eCollection 2018. Review.


Optical probing of orexin/hypocretin receptor antagonists.

Li SB, Nevárez N, Giardino WJ, de Lecea L.

Sleep. 2018 Oct 1;41(10). doi: 10.1093/sleep/zsy141.


Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states.

Giardino WJ, Eban-Rothschild A, Christoffel DJ, Li SB, Malenka RC, de Lecea L.

Nat Neurosci. 2018 Aug;21(8):1084-1095. doi: 10.1038/s41593-018-0198-x. Epub 2018 Jul 23.


Hypocretin as a Hub for Arousal and Motivation.

Tyree SM, Borniger JC, de Lecea L.

Front Neurol. 2018 Jun 6;9:413. doi: 10.3389/fneur.2018.00413. eCollection 2018. Review.


Hypocretin/orexin deficiency decreases cocaine abuse liability.

Steiner N, Rossetti C, Sakurai T, Yanagisawa M, de Lecea L, Magistretti PJ, Halfon O, Boutrel B.

Neuropharmacology. 2018 May 1;133:395-403. doi: 10.1016/j.neuropharm.2018.02.010. Epub 2018 Feb 15.


Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive.

Eban-Rothschild A, Appelbaum L, de Lecea L.

Neuropsychopharmacology. 2018 Apr;43(5):937-952. doi: 10.1038/npp.2017.294. Epub 2017 Dec 5. Review.


Hypothalamic Tuberomammillary Nucleus Neurons: Electrophysiological Diversity and Essential Role in Arousal Stability.

Fujita A, Bonnavion P, Wilson MH, Mickelsen LE, Bloit J, de Lecea L, Jackson AC.

J Neurosci. 2017 Sep 27;37(39):9574-9592. doi: 10.1523/JNEUROSCI.0580-17.2017. Epub 2017 Sep 5.


Optogenetic Investigation of Arousal Circuits.

Tyree SM, de Lecea L.

Int J Mol Sci. 2017 Aug 15;18(8). pii: E1773. doi: 10.3390/ijms18081773. Review.


Lateral Hypothalamic Control of the Ventral Tegmental Area: Reward Evaluation and the Driving of Motivated Behavior.

Tyree SM, de Lecea L.

Front Syst Neurosci. 2017 Jul 6;11:50. doi: 10.3389/fnsys.2017.00050. eCollection 2017. Review.


Rat intersubjective decisions are encoded by frequency-specific oscillatory contexts.

Schaich Borg J, Srivastava S, Lin L, Heffner J, Dunson D, Dzirasa K, de Lecea L.

Brain Behav. 2017 May 5;7(6):e00710. doi: 10.1002/brb3.710. eCollection 2017 Jun.


To sleep or not to sleep: neuronal and ecological insights.

Eban-Rothschild A, Giardino WJ, de Lecea L.

Curr Opin Neurobiol. 2017 Jun;44:132-138. doi: 10.1016/j.conb.2017.04.010. Epub 2017 May 10. Review.


Neuronal substrates for initiation, maintenance, and structural organization of sleep/wake states.

Eban-Rothschild A, de Lecea L.

F1000Res. 2017 Mar 3;6:212. doi: 10.12688/f1000research.9677.1. eCollection 2017. Review.


Hypocretins and Arousal.

Li SB, Giardino WJ, de Lecea L.

Curr Top Behav Neurosci. 2017;33:93-104. doi: 10.1007/7854_2016_58. Review.


Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice.

Luque RM, Cordoba-Chacon J, Pozo-Salas AI, Porteiro B, de Lecea L, Nogueiras R, Gahete MD, Castaño JP.

Sci Rep. 2016 Nov 30;6:37992. doi: 10.1038/srep37992.


VTA dopaminergic neurons regulate ethologically relevant sleep-wake behaviors.

Eban-Rothschild A, Rothschild G, Giardino WJ, Jones JR, de Lecea L.

Nat Neurosci. 2016 Oct;19(10):1356-66. doi: 10.1038/nn.4377. Epub 2016 Sep 5.


In vivo assessment of behavioral recovery and circulatory exchange in the peritoneal parabiosis model.

Castellano JM, Palner M, Li SB, Freeman GM Jr, Nguyen A, Shen B, Stan T, Mosher KI, Chin FT, de Lecea L, Luo J, Wyss-Coray T.

Sci Rep. 2016 Jul 1;6:29015. doi: 10.1038/srep29015.


Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour.

Bonnavion P, Mickelsen LE, Fujita A, de Lecea L, Jackson AC.

J Physiol. 2016 Nov 15;594(22):6443-6462. doi: 10.1113/JP271946. Epub 2016 Jul 19. Review.


Fasting modulates GH/IGF-I axis and its regulatory systems in the mammary gland of female mice: Influence of endogenous cortistatin.

Villa-Osaba A, Gahete MD, Cordoba-Chacon J, de Lecea L, Castaño JP, Luque RM.

Mol Cell Endocrinol. 2016 Oct 15;434:14-24. doi: 10.1016/j.mce.2016.06.014. Epub 2016 Jun 9.


Cortistatin Is a Key Factor Regulating the Sex-Dependent Response of the GH and Stress Axes to Fasting in Mice.

Cordoba-Chacón J, Gahete MD, Pozo-Salas AI, de Lecea L, Castaño JP, Luque RM.

Endocrinology. 2016 Jul;157(7):2810-23. doi: 10.1210/en.2016-1195. Epub 2016 May 13.


Lack of cortistatin or somatostatin differentially influences DMBA-induced mammary gland tumorigenesis in mice in an obesity-dependent mode.

Luque RM, Villa-Osaba A, L-López F, Pozo-Salas AI, Sánchez-Sánchez R, Ortega-Salas R, de Lecea L, Álvarez-Benito M, López-Miranda J, Gahete MD, Castaño JP.

Breast Cancer Res. 2016 Mar 8;18(1):29. doi: 10.1186/s13058-016-0689-1.


Hypocretins, Neural Systems, Physiology, and Psychiatric Disorders.

Li SB, Jones JR, de Lecea L.

Curr Psychiatry Rep. 2016 Jan;18(1):7. doi: 10.1007/s11920-015-0639-0. Review.


Resting easy with a sleep regulator.

Giardino WJ, de Lecea L.

Elife. 2015 Dec 10;4:e12093. doi: 10.7554/eLife.12093. No abstract available.


Sleep disruption impairs haematopoietic stem cell transplantation in mice.

Rolls A, Pang WW, Ibarra I, Colas D, Bonnavion P, Korin B, Heller HC, Weissman IL, de Lecea L.

Nat Commun. 2015 Oct 14;6:8516. doi: 10.1038/ncomms9516.


Optogenetics in Freely Moving Mammals: Dopamine and Reward.

Zhang F, Tsai HC, Airan RD, Stuber GD, Adamantidis AR, de Lecea L, Bonci A, Deisseroth K.

Cold Spring Harb Protoc. 2015 Aug 3;2015(8):715-24. doi: 10.1101/pdb.top086330.


Not So Giants: Mice Lacking Both Somatostatin and Cortistatin Have High GH Levels but Show No Changes in Growth Rate or IGF-1 Levels.

Pedraza-Arévalo S, Córdoba-Chacón J, Pozo-Salas AI, L-López F, de Lecea L, Gahete MD, Castaño JP, Luque RM.

Endocrinology. 2015 Jun;156(6):1958-64. doi: 10.1210/en.2015-1132. Epub 2015 Apr 1.


Obesity alters gene expression for GH/IGF-I axis in mouse mammary fat pads: differential role of cortistatin and somatostatin.

Villa-Osaba A, Gahete MD, Córdoba-Chacón J, de Lecea L, Pozo-Salas AI, Delgado-Lista FJ, Álvarez-Benito M, López-Miranda J, Luque RM, Castaño JP.

PLoS One. 2015 Mar 25;10(3):e0120955. doi: 10.1371/journal.pone.0120955. eCollection 2015.


A Framework for Quantitative Modeling of Neural Circuits Involved in Sleep-to-Wake Transition.

Sorooshyari S, Huerta R, de Lecea L.

Front Neurol. 2015 Feb 26;6:32. doi: 10.3389/fneur.2015.00032. eCollection 2015. Review.


Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regulates stress responses.

Bonnavion P, Jackson AC, Carter ME, de Lecea L.

Nat Commun. 2015 Feb 19;6:6266. doi: 10.1038/ncomms7266.


Control of sleep-to-wake transitions via fast aminoacid and slow neuropeptide transmission.

Mosqueiro T, de Lecea L, Huerta R.

New J Phys. 2014 Nov;16. pii: 115010.


Superficial Layer-Specific Histaminergic Modulation of Medial Entorhinal Cortex Required for Spatial Learning.

He C, Luo F, Chen X, Chen F, Li C, Ren S, Qiao Q, Zhang J, de Lecea L, Gao D, Hu Z.

Cereb Cortex. 2016 Apr;26(4):1590-1608. doi: 10.1093/cercor/bhu322. Epub 2015 Jan 16.


Optogenetic control of hypocretin (orexin) neurons and arousal circuits.

de Lecea L.

Curr Top Behav Neurosci. 2015;25:367-78. doi: 10.1007/7854_2014_364. Review.


Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease.

Roh JH, Jiang H, Finn MB, Stewart FR, Mahan TE, Cirrito JR, Heda A, Snider BJ, Li M, Yanagisawa M, de Lecea L, Holtzman DM.

J Exp Med. 2014 Dec 15;211(13):2487-96. doi: 10.1084/jem.20141788. Epub 2014 Nov 24. Erratum in: J Exp Med. 2015 Jan 12;212(1):121.


Basal forebrain cholinergic modulation of sleep transitions.

Irmak SO, de Lecea L.

Sleep. 2014 Dec 1;37(12):1941-51. doi: 10.5665/sleep.4246.


Light and chemical control of neuronal circuits: possible applications in neurotherapy.

Whittle AJ, Walsh J, de Lecea L.

Expert Rev Neurother. 2014 Sep;14(9):1007-17. doi: 10.1586/14737175.2014.948850. Epub 2014 Aug 13. Review.


Optogenetics: opsins and optical interfaces in neuroscience.

Adamantidis AR, Zhang F, de Lecea L, Deisseroth K.

Cold Spring Harb Protoc. 2014 Aug 1;2014(8):815-22. doi: 10.1101/pdb.top083329.


Establishing a fiber-optic-based optical neural interface.

Adamantidis AR, Zhang F, de Lecea L, Deisseroth K.

Cold Spring Harb Protoc. 2014 Aug 1;2014(8):839-44. doi: 10.1101/pdb.prot083337.


Hypocretin (orexin) neuromodulation of stress and reward pathways.

Giardino WJ, de Lecea L.

Curr Opin Neurobiol. 2014 Dec;29:103-8. doi: 10.1016/j.conb.2014.07.006. Epub 2014 Jul 20. Review.


The hypocretin/orexin system: an increasingly important role in neuropsychiatry.

Chen Q, de Lecea L, Hu Z, Gao D.

Med Res Rev. 2015 Jan;35(1):152-97. doi: 10.1002/med.21326. Epub 2014 Jul 12. Review.


Hypocretin (orexin) regulation of sleep-to-wake transitions.

de Lecea L, Huerta R.

Front Pharmacol. 2014 Feb 12;5:16. doi: 10.3389/fphar.2014.00016. eCollection 2014. Review.


Cortistatin attenuates inflammatory pain via spinal and peripheral actions.

Morell M, Camprubí-Robles M, Culler MD, de Lecea L, Delgado M.

Neurobiol Dis. 2014 Mar;63:141-54. doi: 10.1016/j.nbd.2013.11.022. Epub 2013 Dec 9.


Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus.

Sears RM, Fink AE, Wigestrand MB, Farb CR, de Lecea L, Ledoux JE.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20260-5. doi: 10.1073/pnas.1320325110. Epub 2013 Nov 25.


The hypocretins/orexins: integrators of multiple physiological functions.

Li J, Hu Z, de Lecea L.

Br J Pharmacol. 2014 Jan;171(2):332-50. doi: 10.1111/bph.12415. Review.


Sleep to forget: interference of fear memories during sleep.

Rolls A, Makam M, Kroeger D, Colas D, de Lecea L, Heller HC.

Mol Psychiatry. 2013 Nov;18(11):1166-70. doi: 10.1038/mp.2013.121. Epub 2013 Oct 1.


Paradoxical effect of cortistatin treatment and its deficiency on experimental autoimmune encephalomyelitis.

Souza-Moreira L, Morell M, Delgado-Maroto V, Pedreño M, Martinez-Escudero L, Caro M, O'Valle F, Luque R, Gallo M, de Lecea L, Castaño JP, Gonzalez-Rey E.

J Immunol. 2013 Sep 1;191(5):2144-54. doi: 10.4049/jimmunol.1300384. Epub 2013 Aug 5.


Functional wiring of hypocretin and LC-NE neurons: implications for arousal.

Carter ME, de Lecea L, Adamantidis A.

Front Behav Neurosci. 2013 May 20;7:43. doi: 10.3389/fnbeh.2013.00043. eCollection 2013.

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