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Performance measures for endoscopy services: a European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative.

Valori R, Cortas G, de Lange T, Balfaqih OS, de Pater M, Eisendrath P, Falt P, Koruk I, Ono A, Rustemović N, Schoon E, Veitch A, Senore C, Bellisario C, Minozzi S, Bennett C, Bretthauer M, Dinis-Ribeiro M, Domagk D, Hassan C, Kaminski MF, Rees CJ, Spada C, Bisschops R, Rutter M.

Endoscopy. 2018 Dec;50(12):1186-1204. doi: 10.1055/a-0755-7515. Epub 2018 Nov 13.


Evaluating gut microbiota profiles from archived fecal samples.

Rounge TB, Meisal R, Nordby JI, Ambur OH, de Lange T, Hoff G.

BMC Gastroenterol. 2018 Nov 8;18(1):171. doi: 10.1186/s12876-018-0896-6.


Improving Cancer Preventive Behaviors: A Randomized Trial of Tailored Lifestyle Feedback in Colorectal Cancer Screening.

Knudsen MD, Hjartåker A, Robb KA, de Lange T, Hoff G, Berstad P.

Cancer Epidemiol Biomarkers Prev. 2018 Dec;27(12):1442-1449. doi: 10.1158/1055-9965.EPI-18-0268. Epub 2018 Nov 2.


Welcoming talent? A comparative study of immigrant entrepreneurs' entry policies in France, Germany and the Netherlands.

de Lange T.

Comp Migr Stud. 2018;6(1):27. doi: 10.1186/s40878-018-0092-4. Epub 2018 Sep 18.


Shelterin-Mediated Telomere Protection.

de Lange T.

Annu Rev Genet. 2018 Nov 23;52:223-247. doi: 10.1146/annurev-genet-032918-021921. Epub 2018 Sep 12.


Protection of telomeres 1 proteins POT1a and POT1b can repress ATR signaling by RPA exclusion, but binding to CST limits ATR repression by POT1b.

Kratz K, de Lange T.

J Biol Chem. 2018 Sep 14;293(37):14384-14392. doi: 10.1074/jbc.RA118.004598. Epub 2018 Aug 6.


53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in.

Mirman Z, Lottersberger F, Takai H, Kibe T, Gong Y, Takai K, Bianchi A, Zimmermann M, Durocher D, de Lange T.

Nature. 2018 Aug;560(7716):112-116. doi: 10.1038/s41586-018-0324-7. Epub 2018 Jul 18.


What I got wrong about shelterin.

de Lange T.

J Biol Chem. 2018 Jul 6;293(27):10453-10456. doi: 10.1074/jbc.AW118.003234. Epub 2018 May 24.


Exploring the effect of a lifestyle intervention on cancer risk: 43-year follow-up of the randomized Oslo diet and antismoking study.

Botteri E, de Lange T, Tonstad S, Berstad P.

J Intern Med. 2018 May 22. doi: 10.1111/joim.12765. [Epub ahead of print]


Electronic checklists improve referral letters in gastroenterology: a randomized vignette survey.

Eskeland SL, Rueegg CS, Brunborg C, Aabakken L, de Lange T.

Int J Qual Health Care. 2018 Jul 1;30(6):450-456. doi: 10.1093/intqhc/mzy057.


Endoscopy assistants influence the quality of colonoscopy.

Holme Ø, Pedersen IB, Medhus AW, Aabakken L, Glomsaker T, Kvamme JM, Løberg M, Bretthauer M, Seip B, Kjellevold Ø, Jørgensen A, Furholm S, Hoff G, de Lange T.

Endoscopy. 2018 Sep;50(9):871-877. doi: 10.1055/s-0044-101706. Epub 2018 Feb 14.


Increasing clinical relevance in oral radiology: Benefits and challenges when implementing digital assessment.

de Lange T, Møystad A, Torgersen GR.

Eur J Dent Educ. 2018 Aug;22(3):198-208. doi: 10.1111/eje.12326. Epub 2018 Feb 13.


Menopausal hormone therapy and colorectal cancer: a linkage between nationwide registries in Norway.

Botteri E, Støer NC, Sakshaug S, Graff-Iversen S, Vangen S, Hofvind S, de Lange T, Bagnardi V, Ursin G, Weiderpass E.

BMJ Open. 2017 Nov 15;7(11):e017639. doi: 10.1136/bmjopen-2017-017639.


Acceptability of two colorectal cancer screening tests: pain as a key determinant in sigmoidoscopy.

Kirkøen B, Berstad P, Botteri E, Dalén E, Nilsen JA, Hoff G, de Lange T, Bernklev T.

Endoscopy. 2017 Nov;49(11):1075-1086. doi: 10.1055/s-0043-117400. Epub 2017 Sep 22.


Nuclear Envelope Rupture Is Enhanced by Loss of p53 or Rb.

Yang Z, Maciejowski J, de Lange T.

Mol Cancer Res. 2017 Nov;15(11):1579-1586. doi: 10.1158/1541-7786.MCR-17-0084. Epub 2017 Aug 15.


TRF2 binds branched DNA to safeguard telomere integrity.

Schmutz I, Timashev L, Xie W, Patel DJ, de Lange T.

Nat Struct Mol Biol. 2017 Sep;24(9):734-742. doi: 10.1038/nsmb.3451. Epub 2017 Aug 14.


Lifestyle predictors for non-participation and outcome in the second round of faecal immunochemical test in colorectal cancer screening.

Knudsen MD, Berstad P, Hjartåker A, Gulichsen EH, Hoff G, de Lange T, Bernklev T, Botteri E.

Br J Cancer. 2017 Aug 8;117(4):461-469. doi: 10.1038/bjc.2017.189. Epub 2017 Jul 13.


Quality Indicators in Colonoscopy.

Garborg K, de Lange T, Bretthauer M.

Curr Treat Options Gastroenterol. 2017 Sep;15(3):416-428. doi: 10.1007/s11938-017-0140-4. Review.


Telomere Protection by TPP1/POT1 Requires Tethering to TIN2.

Takai KK, Kibe T, Donigian JR, Frescas D, de Lange T.

Mol Cell. 2017 Jul 6;67(1):162. doi: 10.1016/j.molcel.2017.05.033. No abstract available.


How Many Deaths from Colorectal Cancer Can Be Prevented by 2030? A Scenario-Based Quantification of Risk Factor Modification, Screening, and Treatment in Norway.

Skyrud KD, Myklebust TÅ, Bray F, Eriksen MT, de Lange T, Larsen IK, Møller B.

Cancer Epidemiol Biomarkers Prev. 2017 Sep;26(9):1420-1426. doi: 10.1158/1055-9965.EPI-17-0265. Epub 2017 Jun 16.


Cecum intubation rate as quality indicator in clinical versus screening colonoscopy.

Hoff G, Holme Ø, Bretthauer M, Sandvei P, Darre-Næss O, Stallemo A, Wiig H, Høie O, Noraberg G, Moritz V, de Lange T.

Endosc Int Open. 2017 Jun;5(6):E489-E495. doi: 10.1055/s-0043-106180. Epub 2017 May 31.


Patient-reported adverse events after colonoscopy in Norway.

Hoff G, de Lange T, Bretthauer M, Buset M, Dahler S, Halvorsen FA, Halwe JM, Heibert M, Høie O, Kjellevold Ø, Moritz V, Sandvei P, Seip B, Aabakken L, Holme Ø.

Endoscopy. 2017 Aug;49(8):745-753. doi: 10.1055/s-0043-105265. Epub 2017 Apr 26.


TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres.

Kibe T, Zimmermann M, de Lange T.

Mol Cell. 2017 Apr 20;66(2):300. doi: 10.1016/j.molcel.2017.04.004. No abstract available.


Clinical characteristics of patients with suspected cardiac chest pain and angiographically normal coronary arteries in a secondary care hospital.

de Lange TS, Tijssen RYG, Damman P, van Bergen PFMM.

Neth Heart J. 2017 Jun;25(6):370-375. doi: 10.1007/s12471-017-0988-x.


The DDR at telomeres lacking intact shelterin does not require substantial chromatin decompaction.

Timashev LA, Babcock H, Zhuang X, de Lange T.

Genes Dev. 2017 Mar 15;31(6):578-589. doi: 10.1101/gad.294108.116. Epub 2017 Apr 5.


PHF11 promotes DSB resection, ATR signaling, and HR.

Gong Y, Handa N, Kowalczykowski SC, de Lange T.

Genes Dev. 2017 Jan 1;31(1):46-58. doi: 10.1101/gad.291807.116. Epub 2017 Jan 23.


Telomeres in cancer: tumour suppression and genome instability.

Maciejowski J, de Lange T.

Nat Rev Mol Cell Biol. 2017 Mar;18(3):175-186. doi: 10.1038/nrm.2016.171. Epub 2017 Jan 18. Review.


Telomere Recognition and Assembly Mechanism of Mammalian Shelterin.

Erdel F, Kratz K, Willcox S, Griffith JD, Greene EC, de Lange T.

Cell Rep. 2017 Jan 3;18(1):41-53. doi: 10.1016/j.celrep.2016.12.005.


Psychological effects of colorectal cancer screening: Participants vs individuals not invited.

Kirkøen B, Berstad P, Botteri E, Bernklev L, El-Safadi B, Hoff G, de Lange T, Bernklev T.

World J Gastroenterol. 2016 Nov 21;22(43):9631-9641.


First quality score for referral letters in gastroenterology-a validation study.

Eskeland SL, Brunborg C, Seip B, Wiencke K, Hovde Ø, Owen T, Skogestad E, Huppertz-Hauss G, Halvorsen FA, Garborg K, Aabakken L, de Lange T.

BMJ Open. 2016 Oct 8;6(10):e012835. doi: 10.1136/bmjopen-2016-012835.


Changes in health behavior 1 year after testing negative at a colorectal cancer screening: a randomized-controlled study.

Knudsen MD, Hjartåker A, Olsen MKE, Hoff G, de Lange T, Bernklev T, Berstad P.

Eur J Cancer Prev. 2018 Jul;27(4):316-322. doi: 10.1097/CEJ.0000000000000328.


Telomere-Internal Double-Strand Breaks Are Repaired by Homologous Recombination and PARP1/Lig3-Dependent End-Joining.

Doksani Y, de Lange T.

Cell Rep. 2016 Nov 1;17(6):1646-1656. doi: 10.1016/j.celrep.2016.10.008.


Nifedipine versus placebo in the treatment of preterm prelabor rupture of membranes: a randomized controlled trial: Assessment of perinatal outcome by use of tocolysis in early labor-APOSTEL IV trial.

Nijman TA, van Vliet EO, Naaktgeboren CA, Oude Rengerink K, de Lange TS, Bax CJ, Bloemenkamp KW, van Eyck J, Kok M, Scheepers HC, Woiski M, Franx A, Mol BW, Oudijk MA.

Eur J Obstet Gynecol Reprod Biol. 2016 Oct;205:79-84. doi: 10.1016/j.ejogrb.2016.08.024. Epub 2016 Aug 9.


Favorable lifestyle before diagnosis associated with lower risk of screen-detected advanced colorectal neoplasia.

Knudsen MD, de Lange T, Botteri E, Nguyen DH, Evensen H, Steen CB, Hoff G, Bernklev T, Hjartåker A, Berstad P.

World J Gastroenterol. 2016 Jul 21;22(27):6276-86. doi: 10.3748/wjg.v22.i27.6276.


Routine vs. on-demand analgesia in colonoscopy: a randomized clinical trial.

Holme Ø, de Lange T, Stallemo A, Wiig H, Hasund A, Dvergsnes K, Garborg K, Ystrøm CM, Løberg M, Hoff G, Bretthauer M, Kalager M.

Endoscopy. 2016 Sep;48(9):823-8. doi: 10.1055/s-0042-108433. Epub 2016 Jun 15.



Schmutz I, de Lange T.

Curr Biol. 2016 May 23;26(10):R397-9. doi: 10.1016/j.cub.2016.01.056.


A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plus.

Takai H, Jenkinson E, Kabir S, Babul-Hirji R, Najm-Tehrani N, Chitayat DA, Crow YJ, de Lange T.

Genes Dev. 2016 Apr 1;30(7):812-26. doi: 10.1101/gad.276873.115. Epub 2016 Mar 24.


Time trends in quality indicators of colonoscopy.

Moritz V, Bretthauer M, Holme Ø, Wang Fagerland M, Løberg M, Glomsaker T, de Lange T, Seip B, Sandvei P, Hoff G.

United European Gastroenterol J. 2016 Feb;4(1):110-20. doi: 10.1177/2050640615570147. Epub 2015 Feb 5.


Do no harm: no psychological harm from colorectal cancer screening.

Kirkøen B, Berstad P, Botteri E, Åvitsland TL, Ossum AM, de Lange T, Hoff G, Bernklev T.

Br J Cancer. 2016 Mar 1;114(5):497-504. doi: 10.1038/bjc.2016.14. Epub 2016 Feb 11.


TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres.

Kibe T, Zimmermann M, de Lange T.

Mol Cell. 2016 Jan 21;61(2):236-46. doi: 10.1016/j.molcel.2015.12.016. Epub 2016 Jan 14. Erratum in: Mol Cell. 2017 Apr 20;66(2):300.


Chromothripsis and Kataegis Induced by Telomere Crisis.

Maciejowski J, Li Y, Bosco N, Campbell PJ, de Lange T.

Cell. 2015 Dec 17;163(7):1641-54. doi: 10.1016/j.cell.2015.11.054.


ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres.

Tong AS, Stern JL, Sfeir A, Kartawinata M, de Lange T, Zhu XD, Bryan TM.

Cell Rep. 2015 Nov 24;13(8):1633-46. doi: 10.1016/j.celrep.2015.10.041. Epub 2015 Nov 12.


53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair.

Lottersberger F, Karssemeijer RA, Dimitrova N, de Lange T.

Cell. 2015 Nov 5;163(4):880-93. doi: 10.1016/j.cell.2015.09.057.


A loopy view of telomere evolution.

de Lange T.

Front Genet. 2015 Oct 20;6:321. doi: 10.3389/fgene.2015.00321. eCollection 2015.


TALEN gene knockouts reveal no requirement for the conserved human shelterin protein Rap1 in telomere protection and length regulation.

Kabir S, Hockemeyer D, de Lange T.

Cell Rep. 2014 Nov 20;9(4):1273-80. doi: 10.1016/j.celrep.2014.10.014. Epub 2014 Nov 6.


TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling.

Zimmermann M, Kibe T, Kabir S, de Lange T.

Genes Dev. 2014 Nov 15;28(22):2477-91. doi: 10.1101/gad.251611.114. Epub 2014 Oct 24.


The role of double-strand break repair pathways at functional and dysfunctional telomeres.

Doksani Y, de Lange T.

Cold Spring Harb Perspect Biol. 2014 Sep 16;6(12):a016576. doi: 10.1101/cshperspect.a016576. Review.


Binding of TPP1 protein to TIN2 protein is required for POT1a,b protein-mediated telomere protection.

Frescas D, de Lange T.

J Biol Chem. 2014 Aug 29;289(35):24180-7. doi: 10.1074/jbc.M114.592592. Epub 2014 Jul 23.


European panel on the appropriateness of gastrointestinal endoscopy II guidelines help in selecting and prioritizing patients referred to colonoscopy--a quality control study.

Eskeland SL, Dalén E, Sponheim J, Lind E, Brunborg C, de Lange T.

Scand J Gastroenterol. 2014 Apr;49(4):492-500. doi: 10.3109/00365521.2014.886715. Epub 2014 Mar 6.


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