Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 90

1.

Functional Architecture and Encoding of Tactile Sensorimotor Behavior in Rat Posterior Parietal Cortex.

Mohan H, de Haan R, Broersen R, Pieneman AW, Helmchen F, Staiger JF, Mansvelder HD, de Kock CPJ.

J Neurosci. 2019 Sep 11;39(37):7332-7343. doi: 10.1523/JNEUROSCI.0693-19.2019. Epub 2019 Jul 22.

PMID:
31332000
2.

Development of pyridyl thiosemicarbazones as highly potent agents for the treatment of malaria after oral administration.

Parkinson CJ, Birrell GW, Chavchich M, Mackenzie D, Haynes RK, de Kock C, Richardson DR, Edstein MD.

J Antimicrob Chemother. 2019 Oct 1;74(10):2965-2973. doi: 10.1093/jac/dkz290.

PMID:
31325302
3.

Affecting patients with work-related problems by educational training of their GPs: a cost-effectiveness study.

de Kock C, Noben C, Lagro-Janssen A, Lucassen P, Knottnerus A, de Rijk A, Nijhuis F, Steenbeek R, Evers S.

BMC Fam Pract. 2019 Mar 2;20(1):38. doi: 10.1186/s12875-019-0924-9.

4.

Large and fast human pyramidal neurons associate with intelligence.

Goriounova NA, Heyer DB, Wilbers R, Verhoog MB, Giugliano M, Verbist C, Obermayer J, Kerkhofs A, Smeding H, Verberne M, Idema S, Baayen JC, Pieneman AW, de Kock CP, Klein M, Mansvelder HD.

Elife. 2018 Dec 18;7. pii: e41714. doi: 10.7554/eLife.41714.

5.

Training GPs to improve their management of work-related problems: results of a cluster randomized controlled trial.

de Kock CA, Lucassen PLBJ, Bor H, Knottnerus JA, Buijs PC, Steenbeek R, Lagro-Janssen ALM.

Eur J Gen Pract. 2018 Dec;24(1):258-265. doi: 10.1080/13814788.2018.1517153.

6.

Synthesis of five libraries of 6,5-fused heterocycles to establish the importance of the heterocyclic core for antiplasmodial activity.

Jacobs L, de Kock C, Taylor D, Pelly SC, Blackie MAL.

Bioorg Med Chem. 2018 Nov 15;26(21):5730-5741. doi: 10.1016/j.bmc.2018.10.029. Epub 2018 Oct 27.

PMID:
30391094
7.

Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".

Brunschwig C, Lawrence N, Taylor D, Abay E, Njoroge M, Basarab GS, Le Manach C, Paquet T, Gonzàlez Cabrera D, Nchinda AT, de Kock C, Wiesner L, Denti P, Waterson D, Blasco B, Leroy D, Witty MJ, Donini C, Duffy J, Wittlin S, White KL, Charman SA, Jiménez-Díaz MB, Angulo-Barturen I, Herreros E, Gamo FJ, Rochford R, Mancama D, Coetzer TL, van der Watt ME, Reader J, Birkholtz LM, Marsh KC, Solapure SM, Burke JE, McPhail JA, Vanaerschot M, Fidock DA, Fish PV, Siegl P, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Silue KD, Street LJ, Chibale K.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01941-18. doi: 10.1128/AAC.01941-18. Print 2018 Nov. No abstract available.

8.

Neural Representation of Motor Output, Context and Behavioral Adaptation in Rat Medial Prefrontal Cortex During Learned Behavior.

de Haan R, Lim J, van der Burg SA, Pieneman AW, Nigade V, Mansvelder HD, de Kock CPJ.

Front Neural Circuits. 2018 Oct 1;12:75. doi: 10.3389/fncir.2018.00075. eCollection 2018.

9.

Human Cortical Pyramidal Neurons: From Spines to Spikes via Models.

Eyal G, Verhoog MB, Testa-Silva G, Deitcher Y, Benavides-Piccione R, DeFelipe J, de Kock CPJ, Mansvelder HD, Segev I.

Front Cell Neurosci. 2018 Jun 29;12:181. doi: 10.3389/fncel.2018.00181. eCollection 2018.

10.

UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.

Brunschwig C, Lawrence N, Taylor D, Abay E, Njoroge M, Basarab GS, Le Manach C, Paquet T, Cabrera DG, Nchinda AT, de Kock C, Wiesner L, Denti P, Waterson D, Blasco B, Leroy D, Witty MJ, Donini C, Duffy J, Wittlin S, White KL, Charman SA, Jiménez-Díaz MB, Angulo-Barturen I, Herreros E, Gamo FJ, Rochford R, Mancama D, Coetzer TL, van der Watt ME, Reader J, Birkholtz LM, Marsh KC, Solapure SM, Burke JE, McPhail JA, Vanaerschot M, Fidock DA, Fish PV, Siegl P, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Silue KD, Street LJ, Chibale K.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00012-18. doi: 10.1128/AAC.00012-18. Print 2018 Sep. Erratum in: Antimicrob Agents Chemother. 2018 Oct 24;62(11):.

11.

The Evaluation of Metal Co-ordinating Bis-Thiosemicarbazones as Potential Anti-malarial Agents.

Akladios FN, Andrew SD, Boog SJ, de Kock C, Haynes RK, Parkinson CJ.

Med Chem. 2019;15(1):51-58. doi: 10.2174/1573406414666180525132204.

PMID:
29804537
12.

Sensory representation of an auditory cued tactile stimulus in the posterior parietal cortex of the mouse.

Mohan H, Gallero-Salas Y, Carta S, Sacramento J, Laurenczy B, Sumanovski LT, de Kock CPJ, Helmchen F, Sachidhanandam S.

Sci Rep. 2018 May 17;8(1):7739. doi: 10.1038/s41598-018-25891-x.

13.

Editorial.

de Kock CPJ, Luhmann HJ, Maravall M.

Neuroscience. 2018 Jan 1;368:1-2. doi: 10.1016/j.neuroscience.2017.11.006. Epub 2017 Nov 7. No abstract available.

PMID:
29122593
14.

Comprehensive Morpho-Electrotonic Analysis Shows 2 Distinct Classes of L2 and L3 Pyramidal Neurons in Human Temporal Cortex.

Deitcher Y, Eyal G, Kanari L, Verhoog MB, Atenekeng Kahou GA, Mansvelder HD, de Kock CPJ, Segev I.

Cereb Cortex. 2017 Nov 1;27(11):5398-5414. doi: 10.1093/cercor/bhx226.

15.

Calcium Dynamics in Basal Dendrites of Layer 5A and 5B Pyramidal Neurons Is Tuned to the Cell-Type Specific Physiological Action Potential Discharge.

Krieger P, de Kock CPJ, Frick A.

Front Cell Neurosci. 2017 Jul 11;11:194. doi: 10.3389/fncel.2017.00194. eCollection 2017.

16.

A Belgian Story of CBPR Among People with a Migration Background.

De Kock C.

Narrat Inq Bioeth. 2017;7(1):E9-E12. doi: 10.1353/nib.2017.0026. No abstract available.

PMID:
28713124
17.

The posterior parietal cortex as integrative hub for whisker sensorimotor information.

Mohan H, de Haan R, Mansvelder HD, de Kock CPJ.

Neuroscience. 2018 Jan 1;368:240-245. doi: 10.1016/j.neuroscience.2017.06.020. Epub 2017 Jun 19. Review.

18.

Synthesis and biological characterisation of ester and amide derivatives of fusidic acid as antiplasmodial agents.

Espinoza-Moraga M, Singh K, Njoroge M, Kaur G, Okombo J, De Kock C, Smith PJ, Wittlin S, Chibale K.

Bioorg Med Chem Lett. 2017 Feb 1;27(3):658-661. doi: 10.1016/j.bmcl.2016.11.077. Epub 2016 Nov 25.

PMID:
28012840
19.

Bioisosteric ferrocenyl-containing quinolines with antiplasmodial and antitrichomonal properties.

Adams M, Stringer T, de Kock C, Smith PJ, Land KM, Liu N, Tam C, Cheng LW, Njoroge M, Chibale K, Smith GS.

Dalton Trans. 2016 Nov 29;45(47):19086-19095.

PMID:
27858010
20.

Unique membrane properties and enhanced signal processing in human neocortical neurons.

Eyal G, Verhoog MB, Testa-Silva G, Deitcher Y, Lodder JC, Benavides-Piccione R, Morales J, DeFelipe J, de Kock CP, Mansvelder HD, Segev I.

Elife. 2016 Oct 6;5. pii: e16553. doi: 10.7554/eLife.16553.

21.

Sustained Attentional States Require Distinct Temporal Involvement of the Dorsal and Ventral Medial Prefrontal Cortex.

Luchicchi A, Mnie-Filali O, Terra H, Bruinsma B, de Kloet SF, Obermayer J, Heistek TS, de Haan R, de Kock CP, Deisseroth K, Pattij T, Mansvelder HD.

Front Neural Circuits. 2016 Aug 31;10:70. doi: 10.3389/fncir.2016.00070. eCollection 2016.

22.

Layer-specific cholinergic control of human and mouse cortical synaptic plasticity.

Verhoog MB, Obermayer J, Kortleven CA, Wilbers R, Wester J, Baayen JC, De Kock CPJ, Meredith RM, Mansvelder HD.

Nat Commun. 2016 Sep 8;7:12826. doi: 10.1038/ncomms12826.

23.

Mono- and multimeric ferrocene congeners of quinoline-based polyamines as potential antiparasitics.

Stringer T, De Kock C, Guzgay H, Okombo J, Liu J, Kanetake S, Kim J, Tam C, Cheng LW, Smith PJ, Hendricks DT, Land KM, Egan TJ, Smith GS.

Dalton Trans. 2016 Sep 14;45(34):13415-26. doi: 10.1039/c6dt02685k. Epub 2016 Aug 3.

PMID:
27485032
24.

Synthesis and biological evaluation of a series of non-hemiacetal ester derivatives of artemisinin.

Zuma NH, Smit FJ, de Kock C, Combrinck J, Smith PJ, N'Da DD.

Eur J Med Chem. 2016 Oct 21;122:635-646. doi: 10.1016/j.ejmech.2016.07.027. Epub 2016 Jul 14.

PMID:
27448920
25.

Design, synthesis, and In vitro antituberculosis activity of 2(5H)-Furanone derivatives.

Ngwane AH, Panayides JL, Chouteau F, Macingwana L, Viljoen A, Baker B, Madikane E, de Kock C, Wiesner L, Chibale K, Parkinson CJ, Mmutlane EM, van Helden P, Wiid I.

IUBMB Life. 2016 Aug;68(8):612-20. doi: 10.1002/iub.1526. Epub 2016 Jun 27.

26.

How do Dutch GPs address work-related problems? A focus group study.

de Kock CA, Lucassen PL, Spinnewijn L, Knottnerus JA, Buijs PC, Steenbeek R, Lagro-Janssen AL.

Eur J Gen Pract. 2016 Sep;22(3):169-75. doi: 10.1080/13814788.2016.1177507. Epub 2016 Jun 1.

PMID:
27248862
27.

Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening.

Pavadai E, El Mazouni F, Wittlin S, de Kock C, Phillips MA, Chibale K.

J Chem Inf Model. 2016 Mar 28;56(3):548-62. doi: 10.1021/acs.jcim.5b00680. Epub 2016 Mar 8.

28.

Cyclopalladated organosilane-tethered thiosemicarbazones: novel strategies for improving antiplasmodial activity.

Adams M, Barnard L, de Kock C, Smith PJ, Wiesner L, Chibale K, Smith GS.

Dalton Trans. 2016 Apr 7;45(13):5514-20. doi: 10.1039/c5dt04918k. Epub 2016 Feb 25.

PMID:
26911403
29.

Pentamethylcyclopentadienyl-rhodium and iridium complexes containing (N^N and N^O) bound chloroquine analogue ligands: synthesis, characterization and antimalarial properties.

Ekengard E, Kumar K, Fogeron T, de Kock C, Smith PJ, Haukka M, Monari M, Nordlander E.

Dalton Trans. 2016 Mar 7;45(9):3905-17. doi: 10.1039/c5dt03739e. Epub 2016 Feb 2.

PMID:
26829897
30.

Copper(ii) mixed-ligand polypyridyl complexes with doxycycline - structures and biological evaluation.

Abosede OO, Vyas NA, Singh SB, Kumbhar AS, Kate A, Kumbhar AA, Khan A, Erxleben A, Smith P, de Kock C, Hoffmann F, Obaleye JA.

Dalton Trans. 2016 Feb 21;45(7):3003-12. doi: 10.1039/c5dt04405g. Epub 2016 Jan 13.

PMID:
26758215
31.

Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration.

van der Westhuyzen R, Winks S, Wilson CR, Boyle GA, Gessner RK, Soares de Melo C, Taylor D, de Kock C, Njoroge M, Brunschwig C, Lawrence N, Rao SP, Sirgel F, van Helden P, Seldon R, Moosa A, Warner DF, Arista L, Manjunatha UH, Smith PW, Street LJ, Chibale K.

J Med Chem. 2015 Dec 10;58(23):9371-81. doi: 10.1021/acs.jmedchem.5b01542. Epub 2015 Nov 20.

PMID:
26551248
32.

Antimalarial activity of ruthenium(II) and osmium(II) arene complexes with mono- and bidentate chloroquine analogue ligands.

Ekengard E, Glans L, Cassells I, Fogeron T, Govender P, Stringer T, Chellan P, Lisensky GC, Hersh WH, Doverbratt I, Lidin S, de Kock C, Smith PJ, Smith GS, Nordlander E.

Dalton Trans. 2015 Nov 28;44(44):19314-29. doi: 10.1039/c5dt02410b. Epub 2015 Oct 22.

PMID:
26491831
33.

Design, Synthesis, and Evaluation of Novel Ferroquine and Phenylequine Analogues as Potential Antiplasmodial Agents.

Jacobs L, de Kock C, de Villiers KA, Smith PJ, Smith VJ, van Otterlo WA, Blackie MA.

ChemMedChem. 2015 Dec;10(12):2099-110. doi: 10.1002/cmdc.201500349. Epub 2015 Oct 8.

PMID:
26447782
34.

Dendritic and Axonal Architecture of Individual Pyramidal Neurons across Layers of Adult Human Neocortex.

Mohan H, Verhoog MB, Doreswamy KK, Eyal G, Aardse R, Lodder BN, Goriounova NA, Asamoah B, B Brakspear AB, Groot C, van der Sluis S, Testa-Silva G, Obermayer J, Boudewijns ZS, Narayanan RT, Baayen JC, Segev I, Mansvelder HD, de Kock CP.

Cereb Cortex. 2015 Dec;25(12):4839-53. doi: 10.1093/cercor/bhv188. Epub 2015 Aug 28.

35.

Syntheses and in Vitro Antiplasmodial Activity of Aminoalkylated Chalcones and Analogues.

Wilhelm A, Kendrekar P, Noreljaleel AE, Abay ET, Bonnet SL, Wiesner L, de Kock C, Swart KJ, van der Westhuizen JH.

J Nat Prod. 2015 Aug 28;78(8):1848-58. doi: 10.1021/acs.jnatprod.5b00114. Epub 2015 Aug 3.

PMID:
26235033
36.

In vitro antiplasmodial activity of triazole-linked chloroquinoline derivatives synthesized from 7-chloro-N-(prop-2-yn-1-yl)quinolin-4-amine.

Taleli L, de Kock C, Smith PJ, Pelly SC, Blackie MA, van Otterlo WA.

Bioorg Med Chem. 2015 Aug 1;23(15):4163-71. doi: 10.1016/j.bmc.2015.06.044. Epub 2015 Jun 27.

PMID:
26174655
37.

Primaquine-pyrimidine hybrids: synthesis and dual-stage antiplasmodial activity.

Kaur H, Machado M, de Kock C, Smith P, Chibale K, Prudêncio M, Singh K.

Eur J Med Chem. 2015 Aug 28;101:266-73. doi: 10.1016/j.ejmech.2015.06.045. Epub 2015 Jun 29.

PMID:
26142491
38.

Synthesis, antiplasmodial activity and mechanistic studies of pyrimidine-5-carbonitrile and quinoline hybrids.

Kaur H, Balzarini J, de Kock C, Smith PJ, Chibale K, Singh K.

Eur J Med Chem. 2015 Aug 28;101:52-62. doi: 10.1016/j.ejmech.2015.06.024. Epub 2015 Jun 12.

PMID:
26114811
39.

Ferrocene-pyrimidine conjugates: Synthesis, electrochemistry, physicochemical properties and antiplasmodial activities.

Chopra R, de Kock C, Smith P, Chibale K, Singh K.

Eur J Med Chem. 2015 Jul 15;100:1-9. doi: 10.1016/j.ejmech.2015.05.043. Epub 2015 May 30.

PMID:
26057222
40.

Beyond Columnar Organization: Cell Type- and Target Layer-Specific Principles of Horizontal Axon Projection Patterns in Rat Vibrissal Cortex.

Narayanan RT, Egger R, Johnson AS, Mansvelder HD, Sakmann B, de Kock CP, Oberlaender M.

Cereb Cortex. 2015 Nov;25(11):4450-68. doi: 10.1093/cercor/bhv053. Epub 2015 Apr 1.

41.

Alpha-glucosidase inhibitory and antiplasmodial properties of terpenoids from the leaves of Buddleja saligna Willd.

Chukwujekwu JC, Rengasamy KR, de Kock CA, Smith PJ, Slavětínská LP, van Staden J.

J Enzyme Inhib Med Chem. 2016;31(1):63-6. doi: 10.3109/14756366.2014.1003927. Epub 2015 Feb 19.

PMID:
25694064
42.

Improved antiparasitic activity by incorporation of organosilane entities into half-sandwich ruthenium(II) and rhodium(III) thiosemicarbazone complexes.

Adams M, de Kock C, Smith PJ, Land KM, Liu N, Hopper M, Hsiao A, Burgoyne AR, Stringer T, Meyer M, Wiesner L, Chibale K, Smith GS.

Dalton Trans. 2015 Feb 7;44(5):2456-68. doi: 10.1039/c4dt03234a.

PMID:
25559246
43.

Synthesis of functionalized 3-, 5-, 6- and 8-aminoquinolines via intermediate (3-pyrrolin-1-yl)- and (2-oxopyrrolidin-1-yl)quinolines and evaluation of their antiplasmodial and antifungal activity.

Vandekerckhove S, Van Herreweghe S, Willems J, Danneels B, Desmet T, de Kock C, Smith PJ, Chibale K, D'hooghe M.

Eur J Med Chem. 2015 Mar 6;92:91-102. doi: 10.1016/j.ejmech.2014.12.020. Epub 2014 Dec 12.

PMID:
25544689
44.

Synthesis of novel triazole-linked mefloquine derivatives: biological evaluation against Plasmodium falciparum.

Hamann AR, de Kock C, Smith PJ, van Otterlo WA, Blackie MA.

Bioorg Med Chem Lett. 2014 Dec 1;24(23):5466-9. doi: 10.1016/j.bmcl.2014.10.015. Epub 2014 Oct 13.

PMID:
25455485
45.

High bandwidth synaptic communication and frequency tracking in human neocortex.

Testa-Silva G, Verhoog MB, Linaro D, de Kock CP, Baayen JC, Meredith RM, De Zeeuw CI, Giugliano M, Mansvelder HD.

PLoS Biol. 2014 Nov 25;12(11):e1002007. doi: 10.1371/journal.pbio.1002007. eCollection 2014 Nov.

46.

Mice with megalencephalic leukoencephalopathy with cysts: a developmental angle.

Dubey M, Bugiani M, Ridder MC, Postma NL, Brouwers E, Polder E, Jacobs JG, Baayen JC, Klooster J, Kamermans M, Aardse R, de Kock CP, Dekker MP, van Weering JR, Heine VM, Abbink TE, Scheper GC, Boor I, Lodder JC, Mansvelder HD, van der Knaap MS.

Ann Neurol. 2015 Jan;77(1):114-31. doi: 10.1002/ana.24307. Epub 2014 Dec 4.

PMID:
25382142
47.

Dendrites impact the encoding capabilities of the axon.

Eyal G, Mansvelder HD, de Kock CP, Segev I.

J Neurosci. 2014 Jun 11;34(24):8063-71. doi: 10.1523/JNEUROSCI.5431-13.2014.

48.

Juxtasomal biocytin labeling to study the structure-function relationship of individual cortical neurons.

Narayanan RT, Mohan H, Broersen R, de Haan R, Pieneman AW, de Kock CP.

J Vis Exp. 2014 Feb 25;(84):e51359. doi: 10.3791/51359.

49.

Synthesis, in vitro antiplasmodial activity and cytotoxicity of a series of artemisinin-triazine hybrids and hybrid-dimers.

Cloete TT, de Kock C, Smith PJ, N'Da DD.

Eur J Med Chem. 2014 Apr 9;76:470-81. doi: 10.1016/j.ejmech.2014.01.040. Epub 2014 Feb 18.

PMID:
24602791
50.

Synthesis of halogenated 4-quinolones and evaluation of their antiplasmodial activity.

Vandekerckhove S, Desmet T, Tran HG, de Kock C, Smith PJ, Chibale K, D'hooghe M.

Bioorg Med Chem Lett. 2014 Feb 15;24(4):1214-7. doi: 10.1016/j.bmcl.2013.12.067. Epub 2014 Jan 4.

PMID:
24468411

Supplemental Content

Loading ...
Support Center