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Items: 43


An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes.

Futch HS, McFarland KN, Moore BD, Kuhn MZ, Giasson BI, Ladd TB, Scott KA, Shapiro MR, Nosacka RL, Goodwin MS, Ran Y, Cruz PE, Ryu DH, Croft CL, Levites Y, Janus C, Chakrabarty P, Judge AR, Brusko TM, de Kloet AD, Krause EG, Golde TE.

J Exp Med. 2019 Aug 29. pii: jem.20190430. doi: 10.1084/jem.20190430. [Epub ahead of print]


Oxytocin Receptors Are Expressed by Glutamatergic Prefrontal Cortical Neurons That Selectively Modulate Social Recognition.

Tan Y, Singhal SM, Harden SW, Cahill KM, Nguyen DM, Colon-Perez LM, Sahagian TJ, Thinschmidt JS, de Kloet AD, Febo M, Frazier CJ, Krause EG.

J Neurosci. 2019 Apr 24;39(17):3249-3263. doi: 10.1523/JNEUROSCI.2944-18.2019. Epub 2019 Feb 25.


Top-down and bottom-up control of stress-coping.

de Kloet ER, de Kloet SF, de Kloet CS, de Kloet AD.

J Neuroendocrinol. 2019 Mar;31(3):e12675. doi: 10.1111/jne.12675. Epub 2019 Feb 1. Review.


Macrophage angiotensin II type 2 receptor triggers neuropathic pain.

Shepherd AJ, Mickle AD, Golden JP, Mack MR, Halabi CM, de Kloet AD, Samineni VK, Kim BS, Krause EG, Gereau RW 4th, Mohapatra DP.

Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E8057-E8066. doi: 10.1073/pnas.1721815115. Epub 2018 Aug 6.


Angiotensin II Triggers Peripheral Macrophage-to-Sensory Neuron Redox Crosstalk to Elicit Pain.

Shepherd AJ, Copits BA, Mickle AD, Karlsson P, Kadunganattil S, Haroutounian S, Tadinada SM, de Kloet AD, Valtcheva MV, McIlvried LA, Sheahan TD, Jain S, Ray PR, Usachev YM, Dussor G, Krause EG, Price TJ, Gereau RW 4th, Mohapatra DP.

J Neurosci. 2018 Aug 8;38(32):7032-7057. doi: 10.1523/JNEUROSCI.3542-17.2018. Epub 2018 Jul 5.


New horizons for future research - Critical issues to consider for maximizing research excellence and impact.

Langhans W, Adan R, Arnold M, Banks WA, Card JP, Dailey MJ, Daniels D, de Kloet AD, de Lartigue G, Dickson S, Fedele S, Grill HJ, Jansson JO, Kaufman S, Kolar G, Krause E, Lee SJ, Le Foll C, Levin BE, Lutz TA, Mansouri A, Moran TH, Pacheco-López G, Ramachandran D, Raybould H, Rinaman L, Samson WK, Sanchez-Watts G, Seeley RJ, Skibicka KP, Small D, Spector AC, Tamashiro KL, Templeton B, Trapp S, Tso P, Watts AG, Weissfeld N, Williams D, Wolfrum C, Yosten G, Woods SC.

Mol Metab. 2018 Aug;14:53-59. doi: 10.1016/j.molmet.2018.05.007. Epub 2018 May 12. No abstract available.


Coupling corticotropin-releasing-hormone and angiotensin converting enzyme 2 dampens stress responsiveness in male mice.

Wang LA, de Kloet AD, Smeltzer MD, Cahill KM, Hiller H, Bruce EB, Pioquinto DJ, Ludin JA, Katovich MJ, Raizada MK, Krause EG.

Neuropharmacology. 2018 May 1;133:85-93. doi: 10.1016/j.neuropharm.2018.01.025.


Fat-brain connections: Adipocyte glucocorticoid control of stress and metabolism.

de Kloet AD, Herman JP.

Front Neuroendocrinol. 2018 Jan;48:50-57. doi: 10.1016/j.yfrne.2017.10.005. Epub 2017 Oct 16. Review.


Post-stroke angiotensin II type 2 receptor activation provides long-term neuroprotection in aged rats.

Bennion DM, Isenberg JD, Harmel AT, DeMars K, Dang AN, Jones CH, Pignataro ME, Graham JT, Steckelings UM, Alexander JC, Febo M, Krause EG, de Kloet AD, Candelario-Jalil E, Sumners C.

PLoS One. 2017 Jul 3;12(7):e0180738. doi: 10.1371/journal.pone.0180738. eCollection 2017.


Protective Angiotensin Type 2 Receptors in the Brain and Hypertension.

de Kloet AD, Steckelings UM, Sumners C.

Curr Hypertens Rep. 2017 Jun;19(6):46. doi: 10.1007/s11906-017-0746-x. Review.


Susceptibility or resilience? Prenatal stress predisposes male rats to social subordination, but facilitates adaptation to subordinate status.

Scott KA, de Kloet AD, Smeltzer MD, Krause EG, Flak JN, Melhorn SJ, Foster MT, Tamashiro KLK, Sakai RR.

Physiol Behav. 2017 Sep 1;178:117-125. doi: 10.1016/j.physbeh.2017.03.006. Epub 2017 Mar 8.


A Unique "Angiotensin-Sensitive" Neuronal Population Coordinates Neuroendocrine, Cardiovascular, and Behavioral Responses to Stress.

de Kloet AD, Wang L, Pitra S, Hiller H, Smith JA, Tan Y, Nguyen D, Cahill KM, Sumners C, Stern JE, Krause EG.

J Neurosci. 2017 Mar 29;37(13):3478-3490. doi: 10.1523/JNEUROSCI.3674-16.2017. Epub 2017 Feb 20.


The intricacies of the renin-angiotensin-system in metabolic regulation.

Bruce EB, de Kloet AD.

Physiol Behav. 2017 Sep 1;178:157-165. doi: 10.1016/j.physbeh.2016.11.020. Epub 2016 Nov 22. Review.


Oxytocin receptors are expressed on dopamine and glutamate neurons in the mouse ventral tegmental area that project to nucleus accumbens and other mesolimbic targets.

Peris J, MacFadyen K, Smith JA, de Kloet AD, Wang L, Krause EG.

J Comp Neurol. 2017 Apr 1;525(5):1094-1108. doi: 10.1002/cne.24116. Epub 2016 Sep 27.


Angiotensin type 1a receptors in the paraventricular nucleus of the hypothalamus control cardiovascular reactivity and anxiety-like behavior in male mice.

Wang L, Hiller H, Smith JA, de Kloet AD, Krause EG.

Physiol Genomics. 2016 Sep 1;48(9):667-76. doi: 10.1152/physiolgenomics.00029.2016. Epub 2016 Jul 28.


Angiotensin Type-2 Receptors Influence the Activity of Vasopressin Neurons in the Paraventricular Nucleus of the Hypothalamus in Male Mice.

de Kloet AD, Pitra S, Wang L, Hiller H, Pioquinto DJ, Smith JA, Sumners C, Stern JE, Krause EG.

Endocrinology. 2016 Aug;157(8):3167-80. doi: 10.1210/en.2016-1131. Epub 2016 Jun 6.


Increasing brain angiotensin converting enzyme 2 activity decreases anxiety-like behavior in male mice by activating central Mas receptors.

Wang L, de Kloet AD, Pati D, Hiller H, Smith JA, Pioquinto DJ, Ludin JA, Oh SP, Katovich MJ, Frazier CJ, Raizada MK, Krause EG.

Neuropharmacology. 2016 Jun;105:114-123. doi: 10.1016/j.neuropharm.2015.12.026. Epub 2016 Jan 6.


Cross talk between AT1 receptors and Toll-like receptor 4 in microglia contributes to angiotensin II-derived ROS production in the hypothalamic paraventricular nucleus.

Biancardi VC, Stranahan AM, Krause EG, de Kloet AD, Stern JE.

Am J Physiol Heart Circ Physiol. 2016 Feb 1;310(3):H404-15. doi: 10.1152/ajpheart.00247.2015. Epub 2015 Dec 4.


Role of neurons and glia in the CNS actions of the renin-angiotensin system in cardiovascular control.

de Kloet AD, Liu M, Rodríguez V, Krause EG, Sumners C.

Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R444-58. doi: 10.1152/ajpregu.00078.2015. Epub 2015 Jun 17. Review.


Neuroendocrine Function After Hypothalamic Depletion of Glucocorticoid Receptors in Male and Female Mice.

Solomon MB, Loftspring M, de Kloet AD, Ghosal S, Jankord R, Flak JN, Wulsin AC, Krause EG, Zhang R, Rice T, McKlveen J, Myers B, Tasker JG, Herman JP.

Endocrinology. 2015 Aug;156(8):2843-53. doi: 10.1210/en.2015-1276. Epub 2015 Jun 5.


Hydration and beyond: neuropeptides as mediators of hydromineral balance, anxiety and stress-responsiveness.

Smith JA, Pati D, Wang L, de Kloet AD, Frazier CJ, Krause EG.

Front Syst Neurosci. 2015 Mar 31;9:46. doi: 10.3389/fnsys.2015.00046. eCollection 2015. Review.


Adipocyte glucocorticoid receptors mediate fat-to-brain signaling.

de Kloet AD, Krause EG, Solomon MB, Flak JN, Scott KA, Kim DH, Myers B, Ulrich-Lai YM, Woods SC, Seeley RJ, Herman JP.

Psychoneuroendocrinology. 2015 Jun;56:110-9. doi: 10.1016/j.psyneuen.2015.03.008. Epub 2015 Mar 12.


Angiotensin type 2 receptors: blood pressure regulation and end organ damage.

Sumners C, de Kloet AD, Krause EG, Unger T, Steckelings UM.

Curr Opin Pharmacol. 2015 Apr;21:115-21. doi: 10.1016/j.coph.2015.01.004. Epub 2015 Feb 9. Review.


Reporter mouse strain provides a novel look at angiotensin type-2 receptor distribution in the central nervous system.

de Kloet AD, Wang L, Ludin JA, Smith JA, Pioquinto DJ, Hiller H, Steckelings UM, Scheuer DA, Sumners C, Krause EG.

Brain Struct Funct. 2016 Mar;221(2):891-912. doi: 10.1007/s00429-014-0943-1. Epub 2014 Nov 27.


Acute hypernatremia promotes anxiolysis and attenuates stress-induced activation of the hypothalamic-pituitary-adrenal axis in male mice.

Smith JA, Wang L, Hiller H, Taylor CT, de Kloet AD, Krause EG.

Physiol Behav. 2014 Sep;136:91-6. doi: 10.1016/j.physbeh.2014.03.027. Epub 2014 Apr 2.


Obesity induces neuroinflammation mediated by altered expression of the renin-angiotensin system in mouse forebrain nuclei.

de Kloet AD, Pioquinto DJ, Nguyen D, Wang L, Smith JA, Hiller H, Sumners C.

Physiol Behav. 2014 Sep;136:31-8. doi: 10.1016/j.physbeh.2014.01.016. Epub 2014 Feb 6.


Subcutaneous Adipose Tissue Transplantation in Diet-Induced Obese Mice Attenuates Metabolic Dysregulation While Removal Exacerbates It.

Foster MT, Softic S, Caldwell J, Kohli R, de Kloet AD, Seeley RJ.

Physiol Rep. 2013 Aug;1(2). pii: e00015.


Acute hypernatremia exerts an inhibitory oxytocinergic tone that is associated with anxiolytic mood in male rats.

Frazier CJ, Pati D, Hiller H, Nguyen D, Wang L, Smith JA, MacFadyen K, de Kloet AD, Krause EG.

Endocrinology. 2013 Jul;154(7):2457-67. doi: 10.1210/en.2013-1049. Epub 2013 May 7.


Angiotensin type 1a receptors in the paraventricular nucleus of the hypothalamus protect against diet-induced obesity.

de Kloet AD, Pati D, Wang L, Hiller H, Sumners C, Frazier CJ, Seeley RJ, Herman JP, Woods SC, Krause EG.

J Neurosci. 2013 Mar 13;33(11):4825-33. doi: 10.1523/JNEUROSCI.3806-12.2013.


Neuroimmune communication in hypertension and obesity: a new therapeutic angle?

de Kloet AD, Krause EG, Shi PD, Zubcevic J, Raizada MK, Sumners C.

Pharmacol Ther. 2013 Jun;138(3):428-40. doi: 10.1016/j.pharmthera.2013.02.005. Epub 2013 Feb 28. Review.


Female rats are relatively more sensitive to reduced lipid versus reduced carbohydrate availability.

Sandoval DA, Ryan KK, de Kloet AD, Woods SC, Seeley RJ.

Nutr Diabetes. 2012 Feb 13;2:e27. doi: 10.1038/nutd.2011.23.


Blood-borne angiotensin II acts in the brain to influence behavioral and endocrine responses to psychogenic stress.

Krause EG, de Kloet AD, Scott KA, Flak JN, Jones K, Smeltzer MD, Ulrich-Lai YM, Woods SC, Wilson SP, Reagan LP, Herman JP, Sakai RR.

J Neurosci. 2011 Oct 19;31(42):15009-15. doi: 10.1523/JNEUROSCI.0892-11.2011.


Central angiotensin II has catabolic action at white and brown adipose tissue.

de Kloet AD, Krause EG, Scott KA, Foster MT, Herman JP, Sakai RR, Seeley RJ, Woods SC.

Am J Physiol Endocrinol Metab. 2011 Dec;301(6):E1081-91. doi: 10.1152/ajpendo.00307.2011. Epub 2011 Aug 23.


Hydration state controls stress responsiveness and social behavior.

Krause EG, de Kloet AD, Flak JN, Smeltzer MD, Solomon MB, Evanson NK, Woods SC, Sakai RR, Herman JP.

J Neurosci. 2011 Apr 6;31(14):5470-6. doi: 10.1523/JNEUROSCI.6078-10.2011.


The effect of TNFα on food intake and central insulin sensitivity in rats.

de Kloet AD, Pacheco-López G, Langhans W, Brown LM.

Physiol Behav. 2011 Apr 18;103(1):17-20. doi: 10.1016/j.physbeh.2010.11.037. Epub 2010 Dec 14.


Pleasurable behaviors reduce stress via brain reward pathways.

Ulrich-Lai YM, Christiansen AM, Ostrander MM, Jones AA, Jones KR, Choi DC, Krause EG, Evanson NK, Furay AR, Davis JF, Solomon MB, de Kloet AD, Tamashiro KL, Sakai RR, Seeley RJ, Woods SC, Herman JP.

Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20529-34. doi: 10.1073/pnas.1007740107. Epub 2010 Nov 8.


Molecular neuroendocrine targets for obesity therapy.

de Kloet AD, Woods SC.

Curr Opin Endocrinol Diabetes Obes. 2010 Oct;17(5):441-5. doi: 10.1097/MED.0b013e32833c3013. Review.


The renin angiotensin system and the metabolic syndrome.

de Kloet AD, Krause EG, Woods SC.

Physiol Behav. 2010 Jul 14;100(5):525-34. doi: 10.1016/j.physbeh.2010.03.018. Epub 2010 Apr 8. Review.


Post-ingestive signals and satiation of water and sodium intake of male rats.

Krause EG, de Kloet AD, Sakai RR.

Physiol Behav. 2010 Apr 19;99(5):657-62. doi: 10.1016/j.physbeh.2010.01.030. Epub 2010 Feb 4.


Introduction - obesity and food intake: basic and clinical approaches.

De Kloet AD, Woods SC.

Forum Nutr. 2010;63:1-8. doi: 10.1159/000264391. Epub 2009 Nov 27. No abstract available.


The effect of angiotensin-converting enzyme inhibition using captopril on energy balance and glucose homeostasis.

de Kloet AD, Krause EG, Kim DH, Sakai RR, Seeley RJ, Woods SC.

Endocrinology. 2009 Sep;150(9):4114-23. doi: 10.1210/en.2009-0065. Epub 2009 Jun 4.


Minireview: Endocannabinoids and their receptors as targets for obesity therapy.

de Kloet AD, Woods SC.

Endocrinology. 2009 Jun;150(6):2531-6. doi: 10.1210/en.2009-0046. Epub 2009 Apr 16. Review.


Angiotensin type 1 receptors in the subfornical organ mediate the drinking and hypothalamic-pituitary-adrenal response to systemic isoproterenol.

Krause EG, Melhorn SJ, Davis JF, Scott KA, Ma LY, de Kloet AD, Benoit SC, Woods SC, Sakai RR.

Endocrinology. 2008 Dec;149(12):6416-24. doi: 10.1210/en.2008-0477. Epub 2008 Aug 7.

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